Accurate and Efficient Hybrid-Ensemble Atmospheric Data Assimilation in Latent Space with Uncertainty Quantification

Data assimilation (DA) combines model forecasts and observations to estimate the optimal state of the atmosphere with its uncertainty, providing initial conditions for weather prediction and reanalyses for climate research. Yet, existing traditional and machine-learning DA methods struggle to achieve accuracy, efficiency and uncertainty quantification simultaneously. Here, we propose HLOBA (Hybrid-Ensemble Latent Observation-Background Assimilation), a three-dimensional hybrid-ensemble DA method that operates in an atmospheric latent space learned via an autoencoder (AE). HLOBA maps both model forecasts and observations into a shared latent space via the AE encoder and an end-to-end Observation-to-Latent-space mapping network (O2Lnet), respectively, and fuses them through a Bayesian update with weights inferred from time-lagged ensemble forecasts. Both idealized and real-observation experiments demonstrate that HLOBA matches dynamically constrained four-dimensional DA methods in both analysis and forecast skill, while achieving end-to-end inference-level efficiency and theoretical flexibility applies to any forecasting model. Moreover, by exploiting the error decorrelation property of latent variables, HLOBA enables element-wise uncertainty estimates for its latent analysis and propagates them to model space via the decoder. Idealized experiments show that this uncertainty highlights large-error regions and captures their seasonal variability.

Organizing, Orchestrating, and Benchmarking Agent Skills at Ecosystem Scale

The rapid proliferation of Claude agent skills has raised the central question of how to effectively leverage, manage, and scale the agent skill ecosystem. In this paper, we propose AgentSkillOS, the first principled framework for skill selection, orchestration, and ecosystem-level management. AgentSkillOS comprises two stages: (i) Manage Skills, which organizes skills into a capability tree via node-level recursive categorization for efficient discovery; and (ii) Solve Tasks, which retrieves, orchestrates, and executes multiple skills through DAG-based pipelines. To evaluate the agent's ability to invoke skills, we construct a benchmark of 30 artifact-rich tasks across five categories: data computation, document creation, motion video, visual design, and web interaction. We assess the quality of task outputs using LLM-based pairwise evaluation, and the results are aggregated via a Bradley-Terry model to produce unified quality scores. Experiments across three skill ecosystem scales (200 to 200K skills) show that tree-based retrieval effectively approximates oracle skill selection, and that DAG-based orchestration substantially outperforms native flat invocation even when given the identical skill set. Our findings confirm that structured composition is the key to unlocking skill potential. Our GitHub repository is available at:https://github.com/ynulihao/AgentSkillOS.

Discovery of Interpretable Physical Laws in Materials via Language-Model-Guided Symbolic Regression

Discovering interpretable physical laws from high-dimensional data is a fundamental challenge in scientific research. Traditional methods, such as symbolic regression, often produce complex, unphysical formulas when searching a vast space of possible forms. We introduce a framework that guides the search process by leveraging the embedded scientific knowledge of large language models, enabling efficient identification of physical laws in the data. We validate our approach by modeling key properties of perovskite materials. Our method mitigates the combinatorial explosion commonly encountered in traditional symbolic regression, reducing the effective search space by a factor of approximately $10^5$. A set of novel formulas for bulk modulus, band gap, and oxygen evolution reaction activity are identified, which not only provide meaningful physical insights but also outperform previous formulas in accuracy and simplicity.

One Brain, Omni Modalities: Towards Unified Non-Invasive Brain Decoding with Large Language Models

Deciphering brain function through non-invasive recordings requires synthesizing complementary high-frequency electromagnetic (EEG/MEG) and low-frequency metabolic (fMRI) signals. However, despite their shared neural origins, extreme discrepancies have traditionally confined these modalities to isolated analysis pipelines, hindering a holistic interpretation of brain activity. To bridge this fragmentation, we introduce \textbf{NOBEL}, a \textbf{n}euro-\textbf{o}mni-modal \textbf{b}rain-\textbf{e}ncoding \textbf{l}arge language model (LLM) that unifies these heterogeneous signals within the LLM's semantic embedding space. Our architecture integrates a unified encoder for EEG and MEG with a novel dual-path strategy for fMRI, aligning non-invasive brain signals and external sensory stimuli into a shared token space, then leverages an LLM as a universal backbone. Extensive evaluations demonstrate that NOBEL serves as a robust generalist across standard single-modal tasks. We also show that the synergistic fusion of electromagnetic and metabolic signals yields higher decoding accuracy than unimodal baselines, validating the complementary nature of multiple neural modalities. Furthermore, NOBEL exhibits strong capabilities in stimulus-aware decoding, effectively interpreting visual semantics from multi-subject fMRI data on the NSD and HAD datasets while uniquely leveraging direct stimulus inputs to verify causal links between sensory signals and neural responses. NOBEL thus takes a step towards unifying non-invasive brain decoding, demonstrating the promising potential of omni-modal brain understanding.

Order Matters in Retrosynthesis: Structure-aware Generation via Reaction-Center-Guided Discrete Flow Matching

Template-free retrosynthesis methods treat the task as black-box sequence generation, limiting learning efficiency, while semi-template approaches rely on rigid reaction libraries that constrain generalization. We address this gap with a key insight: atom ordering in neural representations matters. Building on this insight, we propose a structure-aware template-free framework that encodes the two-stage nature of chemical reactions as a positional inductive bias. By placing reaction center atoms at the sequence head, our method transforms implicit chemical knowledge into explicit positional patterns that the model can readily capture. The proposed RetroDiT backbone, a graph transformer with rotary position embeddings, exploits this ordering to prioritize chemically critical regions. Combined with discrete flow matching, our approach decouples training from sampling and enables generation in 20--50 steps versus 500 for prior diffusion methods. Our method achieves state-of-the-art performance on both USPTO-50k (61.2% top-1) and the large-scale USPTO-Full (51.3% top-1) with predicted reaction centers. With oracle centers, performance reaches 71.1% and 63.4% respectively, surpassing foundation models trained on 10 billion reactions while using orders of magnitude less data. Ablation studies further reveal that structural priors outperform brute-force scaling: a 280K-parameter model with proper ordering matches a 65M-parameter model without it.

SciAgentGym: Benchmarking Multi-Step Scientific Tool-use in LLM Agents

Scientific reasoning inherently demands integrating sophisticated toolkits to navigate domain-specific knowledge. Yet, current benchmarks largely overlook agents' ability to orchestrate tools for such rigorous workflows. To bridge this gap, we introduce SciAgentGym, a scalable interactive environment featuring 1,780 domain-specific tools across four natural science disciplines, supported by a robust execution infrastructure. Complementing this, we present SciAgentBench, a tiered evaluation suite designed to stress-test agentic capabilities from elementary actions to long-horizon workflows. Our evaluation identifies a critical bottleneck: state-of-the-art models struggle with complex scientific tool-use. Even for a leading model like GPT-5, success rates drop sharply from 60.6% to 30.9% as interaction horizons extend, primarily due to failures in multi-step workflow execution. To address this, we propose SciForge, a data synthesis method that models the tool action space as a dependency graph to generate logic-aware training trajectories. By fine-tuning on these trajectories, our SciAgent-8B outperforms the significantly larger Qwen3-VL-235B-Instruct while exhibiting positive cross-domain transfer of scientific tool-use capabilities. These results underscore the promising potential of next-generation autonomous scientific agents.

Sci-CoE: Co-evolving Scientific Reasoning LLMs via Geometric Consensus with Sparse Supervision

Large language models (LLMs) have demonstrated exceptional reasoning capabilities, and co-evolving paradigms have shown promising results in domains such as code and math. However, in scientific reasoning tasks, these models remain fragile due to unreliable solution evaluation and limited diversity in verification strategies. In this work, we propose Sci-CoE, a two-stage scientific co-evolving framework that enables models to self-evolve as both solver and verifier through a transition from sparse supervision to unsupervised learning. In the first stage, the model uses a small set of annotated data to establish fundamental correctness judgment anchors for the Verifier. In the second stage, we introduce a geometric reward mechanism that jointly considers consensus, reliability, and diversity, driving large-scale self-iteration on unlabeled data. Experiments on several general scientific benchmarks demonstrate that Sci-CoE enhances complex reasoning capabilities and exhibits strong scalability, facilitating the construction of more robust and diverse evaluation systems. Codes are available at https://github.com/InternScience/Sci-CoE.

P1-VL: Bridging Visual Perception and Scientific Reasoning in Physics Olympiads

The transition from symbolic manipulation to science-grade reasoning represents a pivotal frontier for Large Language Models (LLMs), with physics serving as the critical test anchor for binding abstract logic to physical reality. Physics demands that a model maintain physical consistency with the laws governing the universe, a task that fundamentally requires multimodal perception to ground abstract logic in reality. At the Olympiad level, diagrams are often constitutive rather than illustrative, containing essential constraints, such as boundary conditions and spatial symmetries, that are absent from the text. To bridge this visual-logical gap, we introduce P1-VL, a family of open-source vision-language models engineered for advanced scientific reasoning. Our method harmonizes Curriculum Reinforcement Learning, which employs progressive difficulty expansion to stabilize post-training, with Agentic Augmentation, enabling iterative self-verification at inference. Evaluated on HiPhO, a rigorous benchmark of 13 exams from 2024-2025, our flagship P1-VL-235B-A22B becomes the first open-source Vision-Language Model (VLM) to secure 12 gold medals and achieves the state-of-the-art performance in the open-source models. Our agent-augmented system achieves the No.2 overall rank globally, trailing only Gemini-3-Pro. Beyond physics, P1-VL demonstrates remarkable scientific reasoning capacity and generalizability, establishing significant leads over base models in STEM benchmarks. By open-sourcing P1-VL, we provide a foundational step toward general-purpose physical intelligence to better align visual perceptions with abstract physical laws for machine scientific discovery.

InternAgent-1.5: A Unified Agentic Framework for Long-Horizon Autonomous Scientific Discovery

We introduce InternAgent-1.5, a unified system designed for end-to-end scientific discovery across computational and empirical domains. The system is built on a structured architecture composed of three coordinated subsystems for generation, verification, and evolution. These subsystems are supported by foundational capabilities for deep research, solution optimization, and long horizon memory. The architecture allows InternAgent-1.5 to operate continuously across extended discovery cycles while maintaining coherent and improving behavior. It also enables the system to coordinate computational modeling and laboratory experimentation within a single unified system. We evaluate InternAgent-1.5 on scientific reasoning benchmarks such as GAIA, HLE, GPQA, and FrontierScience, and the system achieves leading performance that demonstrates strong foundational capabilities. Beyond these benchmarks, we further assess two categories of discovery tasks. In algorithm discovery tasks, InternAgent-1.5 autonomously designs competitive methods for core machine learning problems. In empirical discovery tasks, it executes complete computational or wet lab experiments and produces scientific findings in earth, life, biological, and physical domains. Overall, these results show that InternAgent-1.5 provides a general and scalable framework for autonomous scientific discovery.

MARTI-MARS$^2$: Scaling Multi-Agent Self-Search via Reinforcement Learning for Code Generation

While the complex reasoning capability of Large Language Models (LLMs) has attracted significant attention, single-agent systems often encounter inherent performance ceilings in complex tasks such as code generation. Multi-agent collaboration offers a promising avenue to transcend these boundaries. However, existing frameworks typically rely on prompt-based test-time interactions or multi-role configurations trained with homogeneous parameters, limiting error correction capabilities and strategic diversity. In this paper, we propose a Multi-Agent Reinforced Training and Inference Framework with Self-Search Scaling (MARTI-MARS2), which integrates policy learning with multi-agent tree search by formulating the multi-agent collaborative exploration process as a dynamic and learnable environment. By allowing agents to iteratively explore and refine within the environment, the framework facilitates evolution from parameter-sharing homogeneous multi-role training to heterogeneous multi-agent training, breaking through single-agent capability limits. We also introduce an efficient inference strategy MARTI-MARS2-T+ to fully exploit the scaling potential of multi-agent collaboration at test time. We conduct extensive experiments across varied model scales (8B, 14B, and 32B) on challenging code generation benchmarks. Utilizing two collaborating 32B models, MARTI-MARS2 achieves 77.7%, outperforming strong baselines like GPT-5.1. Furthermore, MARTI-MARS2 reveals a novel scaling law: shifting from single-agent to homogeneous multi-role and ultimately to heterogeneous multi-agent paradigms progressively yields higher RL performance ceilings, robust TTS capabilities, and greater policy diversity, suggesting that policy diversity is critical for scaling intelligence via multi-agent reinforcement learning.