Intern-S2-Preview: Scientific Agentic Foundation Model

Scientific discovery increasingly requires AI systems that can reason over scientific evidence of heterogeneous modalities, interact with scientific tools and environments, and sustain progress across long task horizons. We present Intern-S2-Preview, a series of scientific agentic foundation models designed to support multimodal scientific understanding, reasoning, generation, and long-horizon tasks. The training pipeline begins with scientific multimodal pre-training over rendered scientific documents, interleaved image-text data, and diverse scientific corpora. Starting from the pretrained checkpoint, we apply a unified post-training pipeline consisting of supervised fine-tuning, scalable multi-task reinforcement learning (RL), black- and white-box agentic RL, and on-policy distillation. This pipeline is supported by practical techniques that improve rollout and training stability and efficiency, including partial rollout with off-policy correction, adaptive length regularization, online speculative decoding, robust multi-task optimization, and trace-aware experience assembly for agentic tasks. At the architecture level, Intern-S2-Preview-397B extends time series modelling from efficient long-sequence understanding to numerical forecasting, while Memory Decoder is studied as a separate memory-augmented path for rapid scientific specialization without modifying the frozen 397B backbone. Evaluations across scientific, multimodal, agentic, and general-purpose benchmarks show that Intern-S2-Preview-397B achieves competitive or leading results in multiple settings. The time series modules improve scientific signal understanding and forecasting on SciTS, while the separate Intern-MemDec-4B extension improves the Biology-Instructions average score from 56.92 to 60.32 without modifying the frozen 397B backbone.

Sequential Modality Dropout for Robust Multi-Modal Sequential Recommendation

Multi-modal sequential recommenders assume every item carries every modality, but real product catalogs often miss images or text, and a model trained on complete data loses much of its recommendation accuracy when a modality is unavailable at serving time. We propose Sequential Modality Dropout (SMD): during training, each modality stream (image and text) is independently erased with probability p for an entire user interaction history, so the model learns to predict the next item without relying on any single modality. We measure robustness by retention, the fraction of a model's full-modality accuracy (HR@10) that survives when a modality is removed at test time. Across four backbones (MM-SASRec, IISAN, MISSRec, and fMRLRec) on four Amazon domains, SMD raises text retention by 1.0 to 3.2x at essentially no cost to full-modality accuracy; under an extreme 95% per-item missing rate, it retains 61% of HR@10 versus 22% without (a 2.8x improvement). An optional cross-modal reconstruction loss further lifts retention from 90% to 98% on a simple additive backbone under severe text missingness. SMD is a four-line, architecture-agnostic change that makes multi-modal sequential recommenders robust to the missing modalities they actually encounter in deployment.

SeekBrain: An Autonomous Multi-Agent System for Accelerating Neuroscience Discovery

Modern neuroscience relies on integrating multi-scale, multimodal datasets to uncover the neural principles underlying intelligence. However, analytical challenges posed by highly heterogeneous data and fragmented workflows increasingly constrain discoveries. Here we introduce SeekBrain, an autonomous multi-agent framework designed to accelerate neuroscience discovery through domain-grounded hierarchical planning and cross-modal data analysis. SeekBrain dynamically constructs a repertoire of analysis recipes extracted from code-paper pairs. By coupling this codified expertise with agentic planning and execution engines, the framework scalably generates hypotheses and analytical pipelines on demand. Systematic evaluation on the expert-annotated BrainArena benchmark demonstrates that SeekBrain substantially outperforms state-of-the-art agent baselines across various analysis tasks. Crucially, when deployed in real-world research, SeekBrain integrated behavioral, neural, and anatomical data to reveal structured, distributed neural representations of larval zebrafish behavior and a shared axis of regional decoding strength across the brain in a mouse decision-making task. These results establish SeekBrain as a scalable and practical tool for accelerating data-driven discoveries in neuroscience.

SciHazard: A Benchmark for Measuring Scientific Safety Risks with Decomposed Harm Scoring

Large language models (LLMs) increasingly support science, but they can also convert hazardous scientific knowledge into actionable misuse guidance. Existing benchmarks often rely on templated queries disconnected from real-world hazards, and employ LLM-as-a-Judge paradigms without domain grounding. To address this, we introduce SciHazard, a real-world-grounded benchmark for scientific risks and a dataset agnostic evaluation framework for measuring harmfulness. SciHazard contains 2400 hazardous questions and 600 oversafety questions across 12 disciplines, with both queries grounded in regulated entities and documented failure scenarios. To compute \textsc{DeHarm-Score} , we develop a decomposed evaluating procedure that combines query hazard severity, refusal behavior, and response-level risk. For non-refused responses, it further decomposes response-level harm into \textsc{Executability}, quantified via dynamic checklists with importance weighting, and \textsc{Net-new risk}, assessed through retrieval-augmented claim extraction and synthesis-barrier verification. An expert-validation study shows that \textsc{DeHarm-Score} improves agreement with expert annotations by 90.17\% over the strongest baseline. We benchmark 31 frontier LLMs and deep research agents in an extensive scientific safety evaluation. Notably, deep research agents yield 32.3\% higher mean \textsc{DeHarm-Score} than standard LLMs, exposing autonomous agents as a critical blind spot in current safety defenses. Code and dataset are available at https://anonymous.4open.science/r/DeharmScore-7B55.

Ideas Have Genomes: Benchmarking Scientific Lineage Reasoning and Lineage-Grounded Idea Generation

Scientific ideas rarely start from a blank page. They inherit mechanisms, repair known limitations, and recombine pieces of earlier work, much like biological genomes. Current benchmarks still say little about whether AI systems can follow this inheritance structure. We present IdeaGene-Bench (IG-Bench), a benchmark for scientific lineage reasoning and lineage-grounded idea generation. IG-Bench is organized around the IdeaGene framework: each paper or proposal is represented as a set of minimal, typed, evidence-grounded Idea Genome objects, and a GenomeDiff aligns these objects to record inheritance, mutation, loss, external import, and novel insertion under six operational evolutionary dynamics. The benchmark contains 1,961 golden lineage traces, 1,085 curated Idea Genome objects, and 920 pairwise GenomeDiff records across 10 scientific domains. It supports two evaluations. IG-Exam (42 task types, 1,029 instances) tests closed-form lineage reasoning across Idea Genome abstraction, inheritance tracing, evolutionary reasoning, and lineage verification. IG-Arena evaluates generation with a lineage-conditioned Population-Evolution Score(PES), asking whether a proposal can be inserted as a coherent descendant of a given lineage population: it should inherit the right Idea Genome objects, vary meaningfully from nearby work, and offer selection value for future research. Experiments on 14 LLM-based scientists expose a compositional bottleneck. The strongest system reaches only 27.3% exact accuracy on lineage reasoning, and structured lineage context reshuffles system rankings rather than helping every participant uniformly.

Scaling the Horizon, Not the Parameters: Reaching Trillion-Parameter Performance with a 35B Agent

We introduce Agents-A1, a 35B Mixture-of-Experts Agentic Model that reaches trillion-parameter-level performance by scaling the agent horizon. We investigate agent-horizon scaling from two perspectives: scaling long-horizon trajectories and scaling heterogeneous agent abilities. To support this goal, we build a long-horizon knowledge-action infrastructure that connects external knowledge, actions, observations, and verifier outcomes, producing agentic trajectories with an average length of 45K tokens. Based on this, we train Agents-A1 with a three-stage recipe. First, we perform full-domain supervised fine-tuning to align the base model with broad agentic behaviors. Second, we train domain-level teacher models to capture specialized expertise in each domain. Third, we propose a multi-teacher domain-routed on-policy distillation with salient vocabulary alignment to improve knowledge transfer efficiency across different domains, unifying six heterogeneous domains into one deployable student model. Agents-A1 achieves strong and broad performance for long-horizon agent benchmarks. Compared with 1T-parameter model such as Kimi-K2.6 and DeepSeek-V4-pro, Agents-A1 achieves leading results on SEAL-0 (56.4), IFBench (80.6), HiPhO (46.4), FrontierScience-Olympiad (79.0), and MolBench-Bind (56.8), and remains highly competitive on SciCode (44.3), HLE (47.6) and BrowseComp (75.5). We hope this work provides the community with a practical path for scaling the horizon using a 35B agent that can reach or match the performance of 1T models on long-horizon tasks.

Agents-K1: Towards Agent-native Knowledge Orchestration

Current LLM-based research agents have advanced through agent orchestration, yet largely overlook scientific knowledge orchestration. Existing works often reduce papers to abstracts, surface mentions, and flat \texttt{cites} edges, omitting key entities, claims, evidence, mechanisms, and method lineages essential for scientific reasoning. To this end, we introduce \textbf{Agents-K1}, an end-to-end knowledge orchestration pipeline that converts raw documents into agent-native scientific knowledge graphs. Agents-K1 integrates three components under a unifying theoretical foundation: a multimodal parser whose five-module schema captures entities, multimodal evidence, citations, and typed inter-entity relations across the full paper rather than abstracts alone; a 4B information-extraction backbone trained with GRPO under a rule-based reward; and a graphanything CLI, a tri-source agent interface that unifies web search, multimodal graph retrieval, and cross-document traversal. On top of this, we process 2.46 million scientific papers across six subjects to produce \textbf{Scholar-KG}, of which we release a one-million-paper subset, and the full Scholar-KG is accessible via the SCP link below. The same pipeline can be extended to general-domain corpora and to schema-conformant data synthesis. Extensive experiments demonstrate that Agents-K1 achieves superior performance in scientific information extraction, knowledge graph construction, and multi-hop scientific reasoning.

SCI-PRM: A Tool Aware Process Reward Model for Scientific Reasoning Verification

While Process Reward Models (PRMs) have achieved remarkable success in mathematical reasoning, their application in complex scientific domains-such as biology, chemistry, and physics remains largely unexplored. Scientific problems demand not only logical rigor but also factual consistency and the precise usage of domain-specific tools, areas where current models often suffer from hallucinations and lack of verification. In this paper, we first construct SCIPRM70K, a large-scale dataset featuring Chain-of-Tool trajectories that explicitly interleave reasoning with the execution of scientific tools. Building upon this, we train an efficient reward model called Sci-PRM to provide fine-grained supervision on tool selection, execution accuracy, and result interpretation at each step in one inference. Experiments demonstrate that Sci-PRM significantly enhances foundation models in two key aspects: (1) it enables effective test-time scaling via Best-of-N selection; and (2) when integrated into Reinforcement Learning, it serves as a dense reward signal that mitigates the critical issue of advantage disappearance, allowing the model to break through existing performance ceilings.

Earth-o1: A Grid-free Observation-native Atmospheric World Model

Despite the unprecedented volume of multimodal data provided by modern Earth observation systems, our ability to model atmospheric dynamics remains constrained. Traditional modeling frameworks force heterogeneous measurements into predefined spatial grids, inherently limiting the full exploitation of raw sensor data and creating severe computational bottlenecks. Here we present Earth-o1, an observation-native atmospheric world model that overcomes these structural limitations. Rather than relying on conventional atmospheric dynamical modeling systems or traditional data assimilation, Earth-o1 directly learns the continuous, three-dimensional physical evolution of the Earth system from ungridded observational data. By integrating diverse sensor inputs into a unified, grid-free dynamical field, the model autonomously advances the atmospheric state in space and time. We show that this fundamentally distinct paradigm enables direct, real-time forecasting and cross-sensor inference without the overhead of explicit numerical solvers. In hindcast evaluations, Earth-o1 achieves surface forecast skill comparable to the operational Integrated Forecasting System (IFS). These results establish that continuous, observation-driven world models -- a new class of fully observation-native geophysical simulators -- can match the fidelity of established physical frameworks, providing a scalable data-driven foundation for a digital twin of the Earth.

Project Imaging-X: A Survey of 1000+ Open-Access Medical Imaging Datasets for Foundation Model Development

Foundation models have demonstrated remarkable success across diverse domains and tasks, primarily due to the thrive of large-scale, diverse, and high-quality datasets. However, in the field of medical imaging, the curation and assembling of such medical datasets are highly challenging due to the reliance on clinical expertise and strict ethical and privacy constraints, resulting in a scarcity of large-scale unified medical datasets and hindering the development of powerful medical foundation models. In this work, we present the largest survey to date of medical image datasets, covering over 1,000 open-access datasets with a systematic catalog of their modalities, tasks, anatomies, annotations, limitations, and potential for integration. Our analysis exposes a landscape that is modest in scale, fragmented across narrowly scoped tasks, and unevenly distributed across organs and modalities, which in turn limits the utility of existing medical image datasets for developing versatile and robust medical foundation models. To turn fragmentation into scale, we propose a metadata-driven fusion paradigm (MDFP) that integrates public datasets with shared modalities or tasks, thereby transforming multiple small data silos into larger, more coherent resources. Building on MDFP, we release an interactive discovery portal that enables end-to-end, automated medical image dataset integration, and compile all surveyed datasets into a unified, structured table that clearly summarizes their key characteristics and provides reference links, offering the community an accessible and comprehensive repository. By charting the current terrain and offering a principled path to dataset consolidation, our survey provides a practical roadmap for scaling medical imaging corpora, supporting faster data discovery, more principled dataset creation, and more capable medical foundation models.