CoFEND: A Cross-Modal Fusion End-to-End Network for Cold-Start Drug-Drug Interaction Prediction

Cold-start drug-drug interaction (DDI) prediction for new drugs is critical for minimizing unexpected adverse drug reactions. The key challenge is to capture similarity between new and known drugs. However, such similarity is closely associated with complex relationships and mechanisms among drugs, enzymes, transporters, molecular structures, and other biomedical entities. Existing methods have three limitations in capturing such similarity: (1) only partial relationships and mechanisms are considered, which overlooks cross-modal information and yields incomplete or biased similarity modeling; (2) similarity computation between new and known drugs is conducted separately across modalities and performed offline for cold-start DDI prediction, leading to misalignment between similarity computation and DDI prediction; and (3) existing interpretability analyses are typically single-modality and focus primarily on key determinants of the perpetrator drug, while the underlying causes of susceptibility for the victim drug are seldom investigated. To address these issues, this paper proposes a novel Cross-Modal-Fused End-to-End Learning Network (CMF-ELN) with three components. First, diverse multimodal information is leveraged to construct four types of drug-centered knowledge graphs, enabling comprehensive similarity modeling under reconstruction-based supervision. Second, a four-channel graph autoencoder is designed to fuse cross-modal similarity within an end-to-end learning framework. Finally, a two-stage interpretability scheme is devised to precisely localize key factors for both perpetrator and victim drugs. Extensive experiments on two real datasets demonstrate that CMF-ELN achieves significantly higher prediction accuracy and more comprehensive interpretability of mechanisms than its peers.

EO-VGGT: Orbital Ray-Conditioned 3D Foundation Models for Satellite Multi-View Reconstruction

In the era of satellite constellations, multi-view optical satellite imagery is pivotal for Earth Observation (EO) and high-quality Digital Surface Model (DSM) reconstruction. Although feed-forward 3D foundation models have transformed computer vision, their deployment in satellite remote sensing is inherently constrained by the structural discrepancy between implicit perspective assumptions and explicit orbital pushbroom geometry. This geometric incongruity is further compounded by pronounced view-set heterogeneity. We present EO-VGGT, a framework that adapts a frozen perspective-driven model to orbital observations via explicit physical geometry embedding.First, the Geometry-Correlation Constrained Selection (GCCS) strategy prunes sub-optimal observations by balancing geometric diversity and radiometric consistency to optimize the input sequence. Second, a Sensor-Ray Encoder (SRE) parameterizes pixel-level pushbroom lines of sight derived from the Rational Function Model (RFM) into high-dimensional space-geometric tokens, reconciling the mathematical discrepancy between central projection and orbital kinematics. Third, a lightweight Ray-Pointing-Aware Adapter (RPAA) employs gated residual blocks to integrate these tokens directly into the frozen transformer backbone. Our findings underscore that integrating explicit physical geometry with optimized view selection is essential for robust feed-forward satellite 3D reconstruction.

GKDT: General Keypoint Detection Transformer

With the emergence of various pre-trained vision and language models, computer vision is shifting from narrow-domain to open-domain recognition. The construction of a more powerful yet general keypoint detection (GKD) model to support diverse tasks has become increasingly important in the field. To this end, we firstly present a large-scale unified keypoint dataset called MegaKPT. The dataset is composed of over 1.3 million diverse object instances from twenty-nine existing datasets, and enjoys high-quality unified annotations with keypoint text descriptions. Based on MegaKPT, we develop GKDT, a simple, flexible and powerful DINOv3 based Transformer model for General Keypoint Detection. Our GKDT supports visual prompts, text prompts, or both. To enhance model training, we also propose a suite of useful strategies such as mix-modal prompted training and dynamic importance sampling. By testing over 22 test sets with seen or unseen objects, our single GKDT model shows strong performance and generality in detecting keypoints on broad categories, with most categories over 90\% PCK@0.1 accuracy, offering high practical applicability to real-world problems. The dataset, models, and codes will be released at https://github.com/AlanLuSun/General-Keypoint-Detection.

Towards Voxel Spacing Consistency for Medical Image Segmentation

Volumetric medical image segmentation is essential for both preoperative diagnosis and intraoperative guidance. While recent years have witnessed rapid progress in segmentation architectures, comparatively little attention is paid to the physical voxel spacing of anatomical data. Indeed, volumetric image resampling is a ubiquitous preprocessing step before segmentation, yet its interaction with downstream segmentation has not been systematically exploited. In this work, we study the correlation between image resampling and segmentation, and propose Consispace, a semantic-aware resampling framework that achieves consistent voxel spacing in the axial direction while preserving anatomical and semantic consistency. Consispace introduces an ODE-based anatomical constraint to model inter-slice dynamics with a continuous interpolator, enabling faithful reconstruction under complex anatomical transitions beyond discrete interpolation. To further couple resampling with segmentation objectives, we leverage dense features from a pretrained vision model to build intra-slice semantic correlation maps and inject class-wise semantic consistency via feature reweighting during resampling. Both intra-slice and inter-slice constraints are integrated into an implicit neural network, supporting arbitrary-scale resampling. Extensive experiments on multiple datasets demonstrate that Consispace achieves superior reconstruction quality and perceptual fidelity, produces smoother inter-slice anatomy, and improves downstream segmentation performance when used as a preprocessing step.

Multi-Modal Environment-Aware Beam Management for Massive MIMO: A Geometry-Driven Virtual Base Station Framework

High-frequency massive multiple-input multiple-output (MIMO) systems promise ultra-high data rates. However, efficient beam management remains challenging due to the prohibitive beam training overhead and intricate coordination required in multi-user MIMO (MU-MIMO) scenarios. To address these bottlenecks, environment-aware communications have emerged as a promising paradigm, leveraging site-specific knowledge to circumvent exhaustive pilot-based beam training and streamline multi-user communications. In this paper, we propose an interpretable and geometry-driven framework that utilizes multi-modal environmental data, specifically regional 3D light detection and ranging (LiDAR) point clouds and location information, to construct an offline virtual base station (VBS) database. By modeling dominant reflection paths via mirror symmetry across building facades reconstructed from the point clouds, the VBS database provides a compact and sparse description of the wireless propagation environment. To bridge the semantic gap between geometric information and wireless channels, we develop a coarse channel reconstruction mechanism that estimates channel parameters directly from VBS-derived geometric relationships. Based on the resulting coarse beamspace representation, we design a VBS-assisted orthogonal-pilot (VOP)-based partial beam training scheme to refine the coarse estimates with minimal online training overhead. Finally, to tackle the combinatorial beam selection problem and manage inter-user interference, we propose a hierarchical deep reinforcement learning framework, namely a dual-agent dueling double deep Q-network, for coordinated beam selection (DD3QN-CBS). Simulation results demonstrate consistent gains in both beam training efficiency and beam selection performance over heuristic and learning-based baselines.

MEMPROBE: Probing Long-Term Agent Memory via Hidden User-State Recovery

Long-term memory promises LLM agents that grow more capable across sessions, maintaining an accurate, evolving understanding of the user that interaction forms. In practice, however, this memory is evaluated mostly through downstream behavior, such as later answers, personalization quality, or task success, which tests that understanding only indirectly and leaves the memory artifact itself largely unaudited. We argue that long-term memory should instead be evaluated as an auditable post-interaction artifact: after ordinary assistance, what structured user state can be reconstructed from the memory the agent leaves behind? We instantiate this view in MEMPROBE, a benchmark in which a memory-equipped agent assists simulated users, each carrying a hidden, taxonomy-anchored user-state bank, across a trajectory of leak-controlled tasks, after which that bank is reconstructed from the agent's resulting memory under both full-store and top-k access. Built on synthetic ground truth for efficient, scalable measurement, MEMPROBE spans 50 simulated users with 31 hidden dimensions each (1,550 recovery targets) and tests 5 representative memory systems. Testing state-of-the-art memory agents, we find that successful assistance and recoverable memory behave as distinct capabilities. Task completion nearly saturates, even for a memoryless baseline, while category-balanced recovery stays moderate (about 0.6) and drops further under top-k retrieval. MEMPROBE is the first benchmark to study memory recovery directly, reconstructing the user state a system retains and scoring it against ground truth. We see recovery as a concrete objective for future memory agents to optimize, and MEMPROBE as a step toward an environment where agents are trained to remember their users, growing more faithful the longer they know them.

Geometric Consistency Protocol for Foundation Model Features in Multi-View Satellite Imagery

Standardized evaluation protocols are indispensable for robust benchmarking in remote sensing, particularly as foundation features are increasingly transferred across diverse sensors and complex imaging geometries. In satellite multi-view reconstruction, conventional evaluations relying on unconstrained 2D global matching are often misleading. The Rational Function Model (RFM) and its Rational Polynomial Coefficients (RPC) dictate a curved, height-dependent epipolar geometry that render flat 2D search spaces physically inconsistent. We propose a geometry-faithful and reproducible protocol tailored for the RPC framework. Our approach integrates an RPC-projected 3D consistency metric with a geometry-constrained dense matching proxy, specifically evaluating whether similarity responses remain localized and unique under physically plausible search manifolds. A pivotal finding of our joint reporting strategy is the decoupling of semantic agreement and geometric localization: high cross-view similarity at a projected 3D point does not guarantee reliable matchability in practical inference. Our benchmark demonstrates that incorporating geometric constraints is fundamental to the problem definition in satellite imagery. Furthermore, we show that state-of-the-art 2D backbones remain remarkably competitive against specialized 3D-aware models when subjected to this RPC-consistent evaluation.

SkySense: A Semi-Supervised Generative Framework for UAV Localization in ISAC Networks

Extreme data scarcity and inherent multipath spatial ambiguity severely limit existing deep learning-based channel state information (CSI) fingerprinting localization schemes for target unmanned aerial vehicles (UAVs). To overcome these challenges, we propose an end-to-end semi-supervised generative localization framework. First, by exploiting the temporal correlations inherent in continuous flight trajectories, a self-supervised encoder extracts robust spatial features from massive unlabeled CSI sequences to establish structured latent representations. Following this, we utilize a consistency model, a powerful derivative of diffusion architectures, as the core generative backbone to map the learned latent space to physical coordinates, jointly fine-tuning the pre-trained encoder with a strictly limited set of labeled CSI. This consistency formulation models the conditional distribution to resolve the mean collapse problem of discriminative models, while compressing the inference trajectory to 1-2 steps to avoid the latency bottleneck of traditional diffusion models. Furthermore, a lightweight distributed fusion mechanism is designed to aggregate spatial predictions across multiple base stations (BS) from a multi-view geometry perspective. Comprehensive evaluations on a real-world measurement dataset demonstrate that our framework achieves low latency and suppresses the mean localization error to 9.77 cm under a 3-BS fusion setup with only a 1\% label fraction, significantly outperforming existing fully supervised and semi-supervised discriminative baselines.

PAI-Studio: Cinematic Video Background Replacement with Camera-Aware Motion

We present PAI-Studio, a new reference-conditioned video synthesis task that addresses a long-standing challenge in cinematic background replacement: generating dynamic backgrounds aligned with foreground motion while preserving foreground identity, matching reference scene appearance, and achieving globally consistent illumination with realistic foreground relighting. Existing open-source systems and commercial APIs cannot simultaneously ensure motion-consistent background generation, high-fidelity foreground relighting and foreground identity preservation, often resulting in static backgrounds, inconsistent boundaries, and noticeable compositing artifacts. To bridge this gap, we build upon a Diffusion Transformer video backbone and reformulate the problem as an in-context conditional generation task. Through bidirectional attention, our model jointly captures foreground dynamics and background reference information within a unified architecture. We further construct a 30K-scale dataset sourced from high-quality films and online videos to support this task. Extensive evaluations demonstrate that our method significantly outperforms existing open-source and commercial API solutions.

GaMi: Geometry-Agnostic Material Identification via Cross-Modal Subtractive Disentanglement

Non-contact material identification enables adaptive interaction for embodied intelligence yet faces challenges from geometry-induced variations (e.g., orientation, shape, distance) and single-modality ambiguities. In this paper, we present GaMi, a multimodal material identification system integrating mmWave and acoustic sensing to robustly operate under unconstrained geometric conditions. By leveraging the insight of shared geometric consistency between co-located bimodal sensors, GaMi employs an intra-sample cross-modal subtractive disentanglement framework. By semantically aligning modalities and subtracting the shared geometric context, it isolates intrinsic material features. Furthermore, GaMi incorporates inter-sample contrastive learning to correct the residual interference caused by cross-modal misalignment. Additionally, a pairing-based adaptation strategy between two modalities enables few-shot generalization across devices. Extensive evaluations on 20 materials show that GaMi achieves 95.2% accuracy, outperforming single-modality baselines across unseen geometric conditions.