CellAgent: An LLM-driven Multi-Agent Framework for Automated Single-cell Data Analysis

Single-cell RNA sequencing (scRNA-seq) data analysis is crucial for biological research, as it enables the precise characterization of cellular heterogeneity. However, manual manipulation of various tools to achieve desired outcomes can be labor-intensive for researchers. To address this, we introduce CellAgent (http://cell.agent4science.cn/), an LLM-driven multi-agent framework, specifically designed for the automatic processing and execution of scRNA-seq data analysis tasks, providing high-quality results with no human intervention. Firstly, to adapt general LLMs to the biological field, CellAgent constructs LLM-driven biological expert roles - planner, executor, and evaluator - each with specific responsibilities. Then, CellAgent introduces a hierarchical decision-making mechanism to coordinate these biological experts, effectively driving the planning and step-by-step execution of complex data analysis tasks. Furthermore, we propose a self-iterative optimization mechanism, enabling CellAgent to autonomously evaluate and optimize solutions, thereby guaranteeing output quality. We evaluate CellAgent on a comprehensive benchmark dataset encompassing dozens of tissues and hundreds of distinct cell types. Evaluation results consistently show that CellAgent effectively identifies the most suitable tools and hyperparameters for single-cell analysis tasks, achieving optimal performance. This automated framework dramatically reduces the workload for science data analyses, bringing us into the "Agent for Science" era.

MFE-ETP: A Comprehensive Evaluation Benchmark for Multi-modal Foundation Models on Embodied Task Planning

In recent years, Multi-modal Foundation Models (MFMs) and Embodied Artificial Intelligence (EAI) have been advancing side by side at an unprecedented pace. The integration of the two has garnered significant attention from the AI research community. In this work, we attempt to provide an in-depth and comprehensive evaluation of the performance of MFM s on embodied task planning, aiming to shed light on their capabilities and limitations in this domain. To this end, based on the characteristics of embodied task planning, we first develop a systematic evaluation framework, which encapsulates four crucial capabilities of MFMs: object understanding, spatio-temporal perception, task understanding, and embodied reasoning. Following this, we propose a new benchmark, named MFE-ETP, characterized its complex and variable task scenarios, typical yet diverse task types, task instances of varying difficulties, and rich test case types ranging from multiple embodied question answering to embodied task reasoning. Finally, we offer a simple and easy-to-use automatic evaluation platform that enables the automated testing of multiple MFMs on the proposed benchmark. Using the benchmark and evaluation platform, we evaluated several state-of-the-art MFMs and found that they significantly lag behind human-level performance. The MFE-ETP is a high-quality, large-scale, and challenging benchmark relevant to real-world tasks.

CleanDiffuser: An Easy-to-use Modularized Library for Diffusion Models in Decision Making

Leveraging the powerful generative capability of diffusion models (DMs) to build decision-making agents has achieved extensive success. However, there is still a demand for an easy-to-use and modularized open-source library that offers customized and efficient development for DM-based decision-making algorithms. In this work, we introduce CleanDiffuser, the first DM library specifically designed for decision-making algorithms. By revisiting the roles of DMs in the decision-making domain, we identify a set of essential sub-modules that constitute the core of CleanDiffuser, allowing for the implementation of various DM algorithms with simple and flexible building blocks. To demonstrate the reliability and flexibility of CleanDiffuser, we conduct comprehensive evaluations of various DM algorithms implemented with CleanDiffuser across an extensive range of tasks. The analytical experiments provide a wealth of valuable design choices and insights, reveal opportunities and challenges, and lay a solid groundwork for future research. CleanDiffuser will provide long-term support to the decision-making community, enhancing reproducibility and fostering the development of more robust solutions. The code and documentation of CleanDiffuser are open-sourced on the https://github.com/CleanDiffuserTeam/CleanDiffuser.

Masked Graph Transformer for Large-Scale Recommendation

Graph Transformers have garnered significant attention for learning graph-structured data, thanks to their superb ability to capture long-range dependencies among nodes. However, the quadratic space and time complexity hinders the scalability of Graph Transformers, particularly for large-scale recommendation. Here we propose an efficient Masked Graph Transformer, named MGFormer, capable of capturing all-pair interactions among nodes with a linear complexity. To achieve this, we treat all user/item nodes as independent tokens, enhance them with positional embeddings, and feed them into a kernelized attention module. Additionally, we incorporate learnable relative degree information to appropriately reweigh the attentions. Experimental results show the superior performance of our MGFormer, even with a single attention layer.

SheetAgent: A Generalist Agent for Spreadsheet Reasoning and Manipulation via Large Language Models

Spreadsheet manipulation is widely existing in most daily works and significantly improves working efficiency. Large language model (LLM) has been recently attempted for automatic spreadsheet manipulation but has not yet been investigated in complicated and realistic tasks where reasoning challenges exist (e.g., long horizon manipulation with multi-step reasoning and ambiguous requirements). To bridge the gap with the real-world requirements, we introduce $\textbf{SheetRM}$, a benchmark featuring long-horizon and multi-category tasks with reasoning-dependent manipulation caused by real-life challenges. To mitigate the above challenges, we further propose $\textbf{SheetAgent}$, a novel autonomous agent that utilizes the power of LLMs. SheetAgent consists of three collaborative modules: $\textit{Planner}$, $\textit{Informer}$, and $\textit{Retriever}$, achieving both advanced reasoning and accurate manipulation over spreadsheets without human interaction through iterative task reasoning and reflection. Extensive experiments demonstrate that SheetAgent delivers 20-30% pass rate improvements on multiple benchmarks over baselines, achieving enhanced precision in spreadsheet manipulation and demonstrating superior table reasoning abilities. More details and visualizations are available at https://sheetagent.github.io.

Random Projection Layers for Multidimensional Time Series Forecasting

All-Multi-Layer Perceptron (all-MLP) mixer models have been shown to be effective for time series forecasting problems. However, when such a model is applied to high-dimensional time series (e.g., the time series in a spatial-temporal dataset), its performance is likely to degrade due to overfitting issues. In this paper, we propose an all-MLP time series forecasting architecture, referred to as RPMixer. Our method leverages the ensemble-like behavior of deep neural networks, where each individual block within the network acts like a base learner in an ensemble model, especially when identity mapping residual connections are incorporated. By integrating random projection layers into our model, we increase the diversity among the blocks' outputs, thereby enhancing the overall performance of RPMixer. Extensive experiments conducted on large-scale spatial-temporal forecasting benchmark datasets demonstrate that our proposed method outperforms alternative methods, including both spatial-temporal graph models and general forecasting models.

Enhancing Robotic Manipulation with AI Feedback from Multimodal Large Language Models

Recently, there has been considerable attention towards leveraging large language models (LLMs) to enhance decision-making processes. However, aligning the natural language text instructions generated by LLMs with the vectorized operations required for execution presents a significant challenge, often necessitating task-specific details. To circumvent the need for such task-specific granularity, inspired by preference-based policy learning approaches, we investigate the utilization of multimodal LLMs to provide automated preference feedback solely from image inputs to guide decision-making. In this study, we train a multimodal LLM, termed CriticGPT, capable of understanding trajectory videos in robot manipulation tasks, serving as a critic to offer analysis and preference feedback. Subsequently, we validate the effectiveness of preference labels generated by CriticGPT from a reward modeling perspective. Experimental evaluation of the algorithm's preference accuracy demonstrates its effective generalization ability to new tasks. Furthermore, performance on Meta-World tasks reveals that CriticGPT's reward model efficiently guides policy learning, surpassing rewards based on state-of-the-art pre-trained representation models.

Uni-RLHF: Universal Platform and Benchmark Suite for Reinforcement Learning with Diverse Human Feedback

Reinforcement Learning with Human Feedback (RLHF) has received significant attention for performing tasks without the need for costly manual reward design by aligning human preferences. It is crucial to consider diverse human feedback types and various learning methods in different environments. However, quantifying progress in RLHF with diverse feedback is challenging due to the lack of standardized annotation platforms and widely used unified benchmarks. To bridge this gap, we introduce Uni-RLHF, a comprehensive system implementation tailored for RLHF. It aims to provide a complete workflow from real human feedback, fostering progress in the development of practical problems. Uni-RLHF contains three packages: 1) a universal multi-feedback annotation platform, 2) large-scale crowdsourced feedback datasets, and 3) modular offline RLHF baseline implementations. Uni-RLHF develops a user-friendly annotation interface tailored to various feedback types, compatible with a wide range of mainstream RL environments. We then establish a systematic pipeline of crowdsourced annotations, resulting in large-scale annotated datasets comprising more than 15 million steps across 30+ popular tasks. Through extensive experiments, the results in the collected datasets demonstrate competitive performance compared to those from well-designed manual rewards. We evaluate various design choices and offer insights into their strengths and potential areas of improvement. We wish to build valuable open-source platforms, datasets, and baselines to facilitate the development of more robust and reliable RLHF solutions based on realistic human feedback. The website is available at https://uni-rlhf.github.io/.

DiffuserLite: Towards Real-time Diffusion Planning

Diffusion planning has been recognized as an effective decision-making paradigm in various domains. The capability of conditionally generating high-quality long-horizon trajectories makes it a promising research direction. However, existing diffusion planning methods suffer from low decision-making frequencies due to the expensive iterative sampling cost. To address this issue, we introduce DiffuserLite, a super fast and lightweight diffusion planning framework. DiffuserLite employs a planning refinement process (PRP) to generate coarse-to-fine-grained trajectories, significantly reducing the modeling of redundant information and leading to notable increases in decision-making frequency. Our experimental results demonstrate that DiffuserLite achieves a decision-making frequency of $122$Hz ($112.7$x faster than previous mainstream frameworks) and reaches state-of-the-art performance on D4RL benchmarks. In addition, our neat DiffuserLite framework can serve as a flexible plugin to enhance decision frequency in other diffusion planning algorithms, providing a structural design reference for future works. More details and visualizations are available at https://diffuserlite.github.io/.

Bridging Evolutionary Algorithms and Reinforcement Learning: A Comprehensive Survey

Evolutionary Reinforcement Learning (ERL), which integrates Evolutionary Algorithms (EAs) and Reinforcement Learning (RL) for optimization, has demonstrated remarkable performance advancements. By fusing the strengths of both approaches, ERL has emerged as a promising research direction. This survey offers a comprehensive overview of the diverse research branches in ERL. Specifically, we systematically summarize recent advancements in relevant algorithms and identify three primary research directions: EA-assisted optimization of RL, RL-assisted optimization of EA, and synergistic optimization of EA and RL. Following that, we conduct an in-depth analysis of each research direction, organizing multiple research branches. We elucidate the problems that each branch aims to tackle and how the integration of EA and RL addresses these challenges. In conclusion, we discuss potential challenges and prospective future research directions across various research directions.