Dynamic Stream Network for Combinatorial Explosion Problem in Deformable Medical Image Registration

Combinatorial explosion problem caused by dual inputs presents a critical challenge in Deformable Medical Image Registration (DMIR). Since DMIR processes two images simultaneously as input, the combination relationships between features has grown exponentially, ultimately the model considers more interfering features during the feature modeling process. Introducing dynamics in the receptive fields and weights of the network enable the model to eliminate the interfering features combination and model the potential feature combination relationships. In this paper, we propose the Dynamic Stream Network (DySNet), which enables the receptive fields and weights to be dynamically adjusted. This ultimately enables the model to ignore interfering feature combinations and model the potential feature relationships. With two key innovations: 1) Adaptive Stream Basin (AdSB) module dynamically adjusts the shape of the receptive field, thereby enabling the model to focus on the feature relationships with greater correlation. 2) Dynamic Stream Attention (DySA) mechanism generates dynamic weights to search for more valuable feature relationships. Extensive experiments have shown that DySNet consistently outperforms the most advanced DMIR methods, highlighting its outstanding generalization ability. Our code will be released on the website: https://github.com/ShaochenBi/DySNet.

MambaMIL+: Modeling Long-Term Contextual Patterns for Gigapixel Whole Slide Image

Whole-slide images (WSIs) are an important data modality in computational pathology, yet their gigapixel resolution and lack of fine-grained annotations challenge conventional deep learning models. Multiple instance learning (MIL) offers a solution by treating each WSI as a bag of patch-level instances, but effectively modeling ultra-long sequences with rich spatial context remains difficult. Recently, Mamba has emerged as a promising alternative for long sequence learning, scaling linearly to thousands of tokens. However, despite its efficiency, it still suffers from limited spatial context modeling and memory decay, constraining its effectiveness to WSI analysis. To address these limitations, we propose MambaMIL+, a new MIL framework that explicitly integrates spatial context while maintaining long-range dependency modeling without memory forgetting. Specifically, MambaMIL+ introduces 1) overlapping scanning, which restructures the patch sequence to embed spatial continuity and instance correlations; 2) a selective stripe position encoder (S2PE) that encodes positional information while mitigating the biases of fixed scanning orders; and 3) a contextual token selection (CTS) mechanism, which leverages supervisory knowledge to dynamically enlarge the contextual memory for stable long-range modeling. Extensive experiments on 20 benchmarks across diagnostic classification, molecular prediction, and survival analysis demonstrate that MambaMIL+ consistently achieves state-of-the-art performance under three feature extractors (ResNet-50, PLIP, and CONCH), highlighting its effectiveness and robustness for large-scale computational pathology

Probing Scientific General Intelligence of LLMs with Scientist-Aligned Workflows

Despite advances in scientific AI, a coherent framework for Scientific General Intelligence (SGI)-the ability to autonomously conceive, investigate, and reason across scientific domains-remains lacking. We present an operational SGI definition grounded in the Practical Inquiry Model (PIM: Deliberation, Conception, Action, Perception) and operationalize it via four scientist-aligned tasks: deep research, idea generation, dry/wet experiments, and experimental reasoning. SGI-Bench comprises over 1,000 expert-curated, cross-disciplinary samples inspired by Science's 125 Big Questions, enabling systematic evaluation of state-of-the-art LLMs. Results reveal gaps: low exact match (10--20%) in deep research despite step-level alignment; ideas lacking feasibility and detail; high code executability but low execution result accuracy in dry experiments; low sequence fidelity in wet protocols; and persistent multimodal comparative-reasoning challenges. We further introduce Test-Time Reinforcement Learning (TTRL), which optimizes retrieval-augmented novelty rewards at inference, enhancing hypothesis novelty without reference answer. Together, our PIM-grounded definition, workflow-centric benchmark, and empirical insights establish a foundation for AI systems that genuinely participate in scientific discovery.

ToolForge: A Data Synthesis Pipeline for Multi-Hop Search without Real-World APIs

Training LLMs to invoke tools and leverage retrieved information necessitates high-quality, diverse data. However, existing pipelines for synthetic data generation often rely on tens of thousands of real API calls to enhance generalization, incurring prohibitive costs while lacking multi-hop reasoning and self-reflection. To address these limitations, we introduce ToolForge, an automated synthesis framework that achieves strong real-world tool-calling performance by constructing only a small number of virtual tools, eliminating the need for real API calls. ToolForge leverages a (question, golden context, answer) triple to synthesize large-scale tool-learning data specifically designed for multi-hop search scenarios, further enriching the generated data through multi-hop reasoning and self-reflection mechanisms. To ensure data fidelity, we employ a Multi-Layer Validation Framework that integrates both rule-based and model-based assessments. Empirical results show that a model with only 8B parameters, when trained on our synthesized data, outperforms GPT-4o on multiple benchmarks. Our code and dataset are publicly available at https://github.com/Buycar-arb/ToolForge .

LLM-driven Knowledge Enhancement for Multimodal Cancer Survival Prediction

Current multimodal survival prediction methods typically rely on pathology images (WSIs) and genomic data, both of which are high-dimensional and redundant, making it difficult to extract discriminative features from them and align different modalities. Moreover, using a simple survival follow-up label is insufficient to supervise such a complex task. To address these challenges, we propose KEMM, an LLM-driven Knowledge-Enhanced Multimodal Model for cancer survival prediction, which integrates expert reports and prognostic background knowledge. 1) Expert reports, provided by pathologists on a case-by-case basis and refined by large language model (LLM), offer succinct and clinically focused diagnostic statements. This information may typically suggest different survival outcomes. 2) Prognostic background knowledge (PBK), generated concisely by LLM, provides valuable prognostic background knowledge on different cancer types, which also enhances survival prediction. To leverage these knowledge, we introduce the knowledge-enhanced cross-modal (KECM) attention module. KECM can effectively guide the network to focus on discriminative and survival-relevant features from highly redundant modalities. Extensive experiments on five datasets demonstrate that KEMM achieves state-of-the-art performance. The code will be released upon acceptance.

Bridging Fidelity-Reality with Controllable One-Step Diffusion for Image Super-Resolution

Recent diffusion-based one-step methods have shown remarkable progress in the field of image super-resolution, yet they remain constrained by three critical limitations: (1) inferior fidelity performance caused by the information loss from compression encoding of low-quality (LQ) inputs; (2) insufficient region-discriminative activation of generative priors; (3) misalignment between text prompts and their corresponding semantic regions. To address these limitations, we propose CODSR, a controllable one-step diffusion network for image super-resolution. First, we propose an LQ-guided feature modulation module that leverages original uncompressed information from LQ inputs to provide high-fidelity conditioning for the diffusion process. We then develop a region-adaptive generative prior activation method to effectively enhance perceptual richness without sacrificing local structural fidelity. Finally, we employ a text-matching guidance strategy to fully harness the conditioning potential of text prompts. Extensive experiments demonstrate that CODSR achieves superior perceptual quality and competitive fidelity compared with state-of-the-art methods with efficient one-step inference.

Bi-Erasing: A Bidirectional Framework for Concept Removal in Diffusion Models

Concept erasure, which fine-tunes diffusion models to remove undesired or harmful visual concepts, has become a mainstream approach to mitigating unsafe or illegal image generation in text-to-image models.However, existing removal methods typically adopt a unidirectional erasure strategy by either suppressing the target concept or reinforcing safe alternatives, making it difficult to achieve a balanced trade-off between concept removal and generation quality. To address this limitation, we propose a novel Bidirectional Image-Guided Concept Erasure (Bi-Erasing) framework that performs concept suppression and safety enhancement simultaneously. Specifically, based on the joint representation of text prompts and corresponding images, Bi-Erasing introduces two decoupled image branches: a negative branch responsible for suppressing harmful semantics and a positive branch providing visual guidance for safe alternatives. By jointly optimizing these complementary directions, our approach achieves a balance between erasure efficacy and generation usability. In addition, we apply mask-based filtering to the image branches to prevent interference from irrelevant content during the erasure process. Across extensive experiment evaluations, the proposed Bi-Erasing outperforms baseline methods in balancing concept removal effectiveness and visual fidelity.

DynaGen: Unifying Temporal Knowledge Graph Reasoning with Dynamic Subgraphs and Generative Regularization

Temporal Knowledge Graph Reasoning (TKGR) aims to complete missing factual elements along the timeline. Depending on the temporal position of the query, the task is categorized into interpolation and extrapolation. Existing interpolation methods typically embed temporal information into individual facts to complete missing historical knowledge, while extrapolation techniques often leverage sequence models over graph snapshots to identify recurring patterns for future event prediction. These methods face two critical challenges: limited contextual modeling in interpolation and cognitive generalization bias in extrapolation. To address these, we propose a unified method for TKGR, dubbed DynaGen. For interpolation, DynaGen dynamically constructs entity-centric subgraphs and processes them with a synergistic dual-branch GNN encoder to capture evolving structural context. For extrapolation, it applies a conditional diffusion process, which forces the model to learn underlying evolutionary principles rather than just superficial patterns, enhancing its ability to predict unseen future events. Extensive experiments on six benchmark datasets show DynaGen achieves state-of-the-art performance. On average, compared to the second-best models, DynaGen improves the Mean Reciprocal Rank (MRR) score by 2.61 points for interpolation and 1.45 points for extrapolation.

Learning Patient-Specific Disease Dynamics with Latent Flow Matching for Longitudinal Imaging Generation

Understanding disease progression is a central clinical challenge with direct implications for early diagnosis and personalized treatment. While recent generative approaches have attempted to model progression, key mismatches remain: disease dynamics are inherently continuous and monotonic, yet latent representations are often scattered, lacking semantic structure, and diffusion-based models disrupt continuity with random denoising process. In this work, we propose to treat the disease dynamic as a velocity field and leverage Flow Matching (FM) to align the temporal evolution of patient data. Unlike prior methods, it captures the intrinsic dynamic of disease, making the progression more interpretable. However, a key challenge remains: in latent space, Auto-Encoders (AEs) do not guarantee alignment across patients or correlation with clinical-severity indicators (e.g., age and disease conditions). To address this, we propose to learn patient-specific latent alignment, which enforces patient trajectories to lie along a specific axis, with magnitude increasing monotonically with disease severity. This leads to a consistent and semantically meaningful latent space. Together, we present $Δ$-LFM, a framework for modeling patient-specific latent progression with flow matching. Across three longitudinal MRI benchmarks, $Δ$-LFM demonstrates strong empirical performance and, more importantly, offers a new framework for interpreting and visualizing disease dynamics.

AlcheMinT: Fine-grained Temporal Control for Multi-Reference Consistent Video Generation

Recent advances in subject-driven video generation with large diffusion models have enabled personalized content synthesis conditioned on user-provided subjects. However, existing methods lack fine-grained temporal control over subject appearance and disappearance, which are essential for applications such as compositional video synthesis, storyboarding, and controllable animation. We propose AlcheMinT, a unified framework that introduces explicit timestamps conditioning for subject-driven video generation. Our approach introduces a novel positional encoding mechanism that unlocks the encoding of temporal intervals, associated in our case with subject identities, while seamlessly integrating with the pretrained video generation model positional embeddings. Additionally, we incorporate subject-descriptive text tokens to strengthen binding between visual identity and video captions, mitigating ambiguity during generation. Through token-wise concatenation, AlcheMinT avoids any additional cross-attention modules and incurs negligible parameter overhead. We establish a benchmark evaluating multiple subject identity preservation, video fidelity, and temporal adherence. Experimental results demonstrate that AlcheMinT achieves visual quality matching state-of-the-art video personalization methods, while, for the first time, enabling precise temporal control over multi-subject generation within videos. Project page is at https://snap-research.github.io/Video-AlcheMinT