HaDM-ST: Histology-Assisted Differential Modeling for Spatial Transcriptomics Generation

Spatial transcriptomics (ST) reveals spatial heterogeneity of gene expression, yet its resolution is limited by current platforms. Recent methods enhance resolution via H&E-stained histology, but three major challenges persist: (1) isolating expression-relevant features from visually complex H&E images; (2) achieving spatially precise multimodal alignment in diffusion-based frameworks; and (3) modeling gene-specific variation across expression channels. We propose HaDM-ST (Histology-assisted Differential Modeling for ST Generation), a high-resolution ST generation framework conditioned on H&E images and low-resolution ST. HaDM-ST includes: (i) a semantic distillation network to extract predictive cues from H&E; (ii) a spatial alignment module enforcing pixel-wise correspondence with low-resolution ST; and (iii) a channel-aware adversarial learner for fine-grained gene-level modeling. Experiments on 200 genes across diverse tissues and species show HaDM-ST consistently outperforms prior methods, enhancing spatial fidelity and gene-level coherence in high-resolution ST predictions.

QuProFS: An Evolutionary Training-free Approach to Efficient Quantum Feature Map Search

The quest for effective quantum feature maps for data encoding presents significant challenges, particularly due to the flat training landscapes and lengthy training processes associated with parameterised quantum circuits. To address these issues, we propose an evolutionary training-free quantum architecture search (QAS) framework that employs circuit-based heuristics focused on trainability, hardware robustness, generalisation ability, expressivity, complexity, and kernel-target alignment. By ranking circuit architectures with various proxies, we reduce evaluation costs and incorporate hardware-aware circuits to enhance robustness against noise. We evaluate our approach on classification tasks (using quantum support vector machine) across diverse datasets using both artificial and quantum-generated datasets. Our approach demonstrates competitive accuracy on both simulators and real quantum hardware, surpassing state-of-the-art QAS methods in terms of sampling efficiency and achieving up to a 2x speedup in architecture search runtime.

Parameter-Efficient Fine-Tuning of 3D DDPM for MRI Image Generation Using Tensor Networks

We address the challenge of parameter-efficient fine-tuning (PEFT) for three-dimensional (3D) U-Net-based denoising diffusion probabilistic models (DDPMs) in magnetic resonance imaging (MRI) image generation. Despite its practical significance, research on parameter-efficient representations of 3D convolution operations remains limited. To bridge this gap, we propose Tensor Volumetric Operator (TenVOO), a novel PEFT method specifically designed for fine-tuning DDPMs with 3D convolutional backbones. Leveraging tensor network modeling, TenVOO represents 3D convolution kernels with lower-dimensional tensors, effectively capturing complex spatial dependencies during fine-tuning with few parameters. We evaluate TenVOO on three downstream brain MRI datasets-ADNI, PPMI, and BraTS2021-by fine-tuning a DDPM pretrained on 59,830 T1-weighted brain MRI scans from the UK Biobank. Our results demonstrate that TenVOO achieves state-of-the-art performance in multi-scale structural similarity index measure (MS-SSIM), outperforming existing approaches in capturing spatial dependencies while requiring only 0.3% of the trainable parameters of the original model. Our code is available at: https://github.com/xiaovhua/tenvoo

EarthLink: A Self-Evolving AI Agent for Climate Science

Modern Earth science is at an inflection point. The vast, fragmented, and complex nature of Earth system data, coupled with increasingly sophisticated analytical demands, creates a significant bottleneck for rapid scientific discovery. Here we introduce EarthLink, the first AI agent designed as an interactive copilot for Earth scientists. It automates the end-to-end research workflow, from planning and code generation to multi-scenario analysis. Unlike static diagnostic tools, EarthLink can learn from user interaction, continuously refining its capabilities through a dynamic feedback loop. We validated its performance on a number of core scientific tasks of climate change, ranging from model-observation comparisons to the diagnosis of complex phenomena. In a multi-expert evaluation, EarthLink produced scientifically sound analyses and demonstrated an analytical competency that was rated as comparable to specific aspects of a human junior researcher's workflow. Additionally, its transparent, auditable workflows and natural language interface empower scientists to shift from laborious manual execution to strategic oversight and hypothesis generation. EarthLink marks a pivotal step towards an efficient, trustworthy, and collaborative paradigm for Earth system research in an era of accelerating global change. The system is accessible at our website https://earthlink.intern-ai.org.cn.

Confidence-driven Gradient Modulation for Multimodal Human Activity Recognition: A Dynamic Contrastive Dual-Path Learning Approach

Sensor-based Human Activity Recognition (HAR) is a core technology that enables intelligent systems to perceive and interact with their environment. However, multimodal HAR systems still encounter key challenges, such as difficulties in cross-modal feature alignment and imbalanced modality contributions. To address these issues, we propose a novel framework called the Dynamic Contrastive Dual-Path Network (DCDP-HAR). The framework comprises three key components. First, a dual-path feature extraction architecture is employed, where ResNet and DenseNet branches collaboratively process multimodal sensor data. Second, a multi-stage contrastive learning mechanism is introduced to achieve progressive alignment from local perception to semantic abstraction. Third, we present a confidence-driven gradient modulation strategy that dynamically monitors and adjusts the learning intensity of each modality branch during backpropagation, effectively alleviating modality competition. In addition, a momentum-based gradient accumulation strategy is adopted to enhance training stability. We conduct ablation studies to validate the effectiveness of each component and perform extensive comparative experiments on four public benchmark datasets.

MISCGrasp: Leveraging Multiple Integrated Scales and Contrastive Learning for Enhanced Volumetric Grasping

Robotic grasping faces challenges in adapting to objects with varying shapes and sizes. In this paper, we introduce MISCGrasp, a volumetric grasping method that integrates multi-scale feature extraction with contrastive feature enhancement for self-adaptive grasping. We propose a query-based interaction between high-level and low-level features through the Insight Transformer, while the Empower Transformer selectively attends to the highest-level features, which synergistically strikes a balance between focusing on fine geometric details and overall geometric structures. Furthermore, MISCGrasp utilizes multi-scale contrastive learning to exploit similarities among positive grasp samples, ensuring consistency across multi-scale features. Extensive experiments in both simulated and real-world environments demonstrate that MISCGrasp outperforms baseline and variant methods in tabletop decluttering tasks. More details are available at https://miscgrasp.github.io/.

USAD: An Unsupervised Data Augmentation Spatio-Temporal Attention Diffusion Network

The primary objective of human activity recognition (HAR) is to infer ongoing human actions from sensor data, a task that finds broad applications in health monitoring, safety protection, and sports analysis. Despite proliferating research, HAR still faces key challenges, including the scarcity of labeled samples for rare activities, insufficient extraction of high-level features, and suboptimal model performance on lightweight devices. To address these issues, this paper proposes a comprehensive optimization approach centered on multi-attention interaction mechanisms. First, an unsupervised, statistics-guided diffusion model is employed to perform data augmentation, thereby alleviating the problems of labeled data scarcity and severe class imbalance. Second, a multi-branch spatio-temporal interaction network is designed, which captures multi-scale features of sequential data through parallel residual branches with 3*3, 5*5, and 7*7 convolutional kernels. Simultaneously, temporal attention mechanisms are incorporated to identify critical time points, while spatial attention enhances inter-sensor interactions. A cross-branch feature fusion unit is further introduced to improve the overall feature representation capability. Finally, an adaptive multi-loss function fusion strategy is integrated, allowing for dynamic adjustment of loss weights and overall model optimization. Experimental results on three public datasets, WISDM, PAMAP2, and OPPORTUNITY, demonstrate that the proposed unsupervised data augmentation spatio-temporal attention diffusion network (USAD) achieves accuracies of 98.84%, 93.81%, and 80.92% respectively, significantly outperforming existing approaches. Furthermore, practical deployment on embedded devices verifies the efficiency and feasibility of the proposed method.

Clarifying Before Reasoning: A Coq Prover with Structural Context

In this work, we investigate whether improving task clarity can enhance reasoning ability of large language models, focusing on theorem proving in Coq. We introduce a concept-level metric to evaluate task clarity and show that adding structured semantic context to the standard input used by modern LLMs, leads to a 1.85$\times$ improvement in clarity score (44.5\%~$\rightarrow$~82.3\%). Using the general-purpose model \texttt{DeepSeek-V3}, our approach leads to a 2.1$\times$ improvement in proof success (21.8\%~$\rightarrow$~45.8\%) and outperforms the previous state-of-the-art \texttt{Graph2Tac} (33.2\%). We evaluate this on 1,386 theorems randomly sampled from 15 standard Coq packages, following the same evaluation protocol as \texttt{Graph2Tac}. Furthermore, fine-tuning smaller models on our structured data can achieve even higher performance (48.6\%). Our method uses selective concept unfolding to enrich task descriptions, and employs a Planner--Executor architecture. These findings highlight the value of structured task representations in bridging the gap between understanding and reasoning.

HieraEdgeNet: A Multi-Scale Edge-Enhanced Framework for Automated Pollen Recognition

Automated pollen recognition is vital to paleoclimatology, biodiversity monitoring, and public health, yet conventional methods are hampered by inefficiency and subjectivity. Existing deep learning models often struggle to achieve the requisite localization accuracy for microscopic targets like pollen, which are characterized by their minute size, indistinct edges, and complex backgrounds. To overcome this limitation, we introduce HieraEdgeNet, a multi-scale edge-enhancement framework. The framework's core innovation is the introduction of three synergistic modules: the Hierarchical Edge Module (HEM), which explicitly extracts a multi-scale pyramid of edge features that corresponds to the semantic hierarchy at early network stages; the Synergistic Edge Fusion (SEF) module, for deeply fusing these edge priors with semantic information at each respective scale; and the Cross Stage Partial Omni-Kernel Module (CSPOKM), which maximally refines the most detail-rich feature layers using an Omni-Kernel operator - comprising anisotropic large-kernel convolutions and mixed-domain attention - all within a computationally efficient Cross-Stage Partial (CSP) framework. On a large-scale dataset comprising 120 pollen classes, HieraEdgeNet achieves a mean Average Precision (mAP@.5) of 0.9501, significantly outperforming state-of-the-art baseline models such as YOLOv12n and RT-DETR. Furthermore, qualitative analysis confirms that our approach generates feature representations that are more precisely focused on object boundaries. By systematically integrating edge information, HieraEdgeNet provides a robust and powerful solution for high-precision, high-efficiency automated detection of microscopic objects.

Domain-Aware Tensor Network Structure Search

Tensor networks (TNs) provide efficient representations of high-dimensional data, yet identification of the optimal TN structures, the so called tensor network structure search (TN-SS) problem, remains a challenge. Current state-of-the-art (SOTA) algorithms are computationally expensive as they require extensive function evaluations, which is prohibitive for real-world applications. In addition, existing methods ignore valuable domain information inherent in real-world tensor data and lack transparency in their identified TN structures. To this end, we propose a novel TN-SS framework, termed the tnLLM, which incorporates domain information about the data and harnesses the reasoning capabilities of large language models (LLMs) to directly predict suitable TN structures. The proposed framework involves a domain-aware prompting pipeline which instructs the LLM to infer suitable TN structures based on the real-world relationships between tensor modes. In this way, our approach is capable of not only iteratively optimizing the objective function, but also generating domain-aware explanations for the identified structures. Experimental results demonstrate that tnLLM achieves comparable TN-SS objective function values with much fewer function evaluations compared to SOTA algorithms. Furthermore, we demonstrate that the LLM-enabled domain information can be used to find good initializations in the search space for sampling-based SOTA methods to accelerate their convergence while preserving theoretical performance guarantees.