Abstract:Generating cross-shot videos that are logically connected is essential for content creation. Currently, most cross-shot video-generation workflows, such as short-drama production, still rely on isolated textual scripts or explicit reference images to specify the generated content. Consequently, when user instructions are underspecified or ambiguous, a generated clip may appear visually plausible on its own but fail to align with the overall narrative, leading to disjointed content. We argue that achieving cross-shot logical coherence in video generation requires establishing logical connections across shots and maintaining visual consistency. To this end, we propose LogiShot, which incorporates information through two complementary paths: 1) LogiShot jointly encodes the context video and other conditioning signals, yielding dense multimodal cues that provide visual-semantic evidence for cross-shot generation; 2) the model maintains a visual memory of the context video throughout generation to preserve visual consistency across shots. Additionally, we construct a dataset with 110K samples and a dedicated benchmark for evaluating cross-shot logical coherence. Experiments demonstrate that LogiShot consistently outperforms existing baselines in terms of logical coherence across multiple shots. Model and data will be made publicly available.
Abstract:Debt collection is a critical negotiation task in the financial industry, with strong practical relevance and exceptional academic value as a behaviorally rich, high-stakes testbed for human-centered dialogue systems. While large language models (LLMs) have shown promise in dialogue and negotiation, effectively evaluating their performance in this complex scenarios remains a major challenge: existing benchmarks uniformly assume users to be static, rational agents with fixed preferences, failing to capture the rich behavioral heterogeneity inherent in real-world debt collection. To bridge this gap, we propose DebtBench, the first public persona-enriched debt collection benchmark, that highlights behavioral heterogeneity in negotiation. Moreover, we develop DebtGPT, a debt collection agent trained to jointly optimize financial recovery and interaction experience. Our experimental results, using 16 state-of-the-art LLMs, find that most existing models struggle in this complex but realistic scenarios, whereas DebtGPT outperforms all open-source baselines and achieves performance on par with GPT-4o. The code and data are available at https://github.com/YYuHhhh/DebtNegotiation.
Abstract:Rubric-based RL has recently shown promise in improving LLMs on open-ended tasks. A widely recognized limitation of rubric-based RL is limited exploration: criteria that no rollout manages to satisfy (Unexplored Criteria, UC) receive no optimization signal. Recent methods address this by incorporating rubric information as external guidance during rollout, yet they introduce a train-inference mismatch: the policy is optimized on rollouts produced under external guidance while this guidance is absent at inference time, causing error accumulation through autoregressive decoding. Moreover, these exploration-focused approaches overlook a fundamentally different failure mode that we term Suppressed Criteria (SC) -- criteria that are satisfied by some rollouts yet whose learning signals are lost during optimization because scalar reward aggregation assigns them non-positive aggregate advantages. Our analysis reveals that SC are remarkably prevalent: over 57% of samples exhibit this failure mode throughout training, with an average of 1.8 SC per sample. To simultaneously address both UC and SC without introducing training-inference mismatch, we propose Criterion-Distilled Policy Optimization (CriPO), which enhances rubric-based RL via on-policy self-distillation. For UC, CriPO constructs a criterion-injection self-teacher and computes a localized forward-KL loss to inject missing behaviors into the policy. For SC, CriPO employs a counterfactual self-teacher to locate criterion-relevant tokens in negative-advantage rollouts and flips their token-level advantages to positive values, preserving useful patterns that would otherwise be suppressed. Experiments on medicine and science benchmarks demonstrate that CriPO consistently outperforms rubric-based RL, achieving stronger final performance with approximately $2\times$ fewer optimization steps.
Abstract:Spatial Transcriptomics (ST) measures gene expression while preserving spatial context, but its high cost and low throughput leave public datasets small. Inferring expression directly from widely available Hematoxylin and Eosin (H&E) stained histology offers a cost-effective alternative. However, existing approaches face several limitations: regression methods over-smooth toward the conditional mean, while generative methods are faithful but require slow multi-step inference; most methods treat genes as independent and equally important, ignoring inter-gene dependencies and heterogeneous gene informativeness; and most are tailored to a single resolution, either spot-level or cell-level. To address these issues, we propose DriftST, a unified framework for inferring spatially resolved gene expression from H&E images. DriftST builds on a Cellular Drifting generative model that learns a direct drift from a histology-conditioned source to the expression distribution, retaining generative expressiveness while enabling efficient one-step generation. To capture gene structure, we introduce the STransformer, which combines a co-expression attention module for inter-gene dependencies with a gene residual gate for differential gene importance. Operating on a generic gene-panel representation, DriftST applies directly to both spot-level and cell-level data in one framework, and extensive experiments across diverse tissues and platforms show that it achieves state-of-the-art performance at both resolutions.
Abstract:Sequential decision problems often exhibit an asymmetric evolution of information and decision flexibility: as a decision cycle unfolds, the agent receives richer information while feasible actions expire due to operational cutoffs, commitments, or resource constraints. Standard MDP formulations typically flatten this structure into stage-dependent state descriptions and action masks, thereby obscuring the nested information--action asymmetry that determines which decisions are urgent and which can be deferred. We introduce Maturing Markov Decision Processes (MMDPs), a formulation built around this information--action asymmetry. We characterize one of its key consequences through an expiring-action priority principle, which identifies the actions that must be resolved before the next stage. Motivated by this structure, we develop a structure-aware reinforcement learning framework with stage-aware policy design, expiring-action abstraction, and search-augmented learning with distillation. Experiments on a controlled multi-supplier replenishment problem, simplified cash-management environments of increasing complexity, and a production-scale simulator show that explicitly modeling this asymmetry improves learning efficiency and becomes increasingly valuable as decision problems scale.
Abstract:Existing affective understanding studies have mainly focused on recognizing emotions from images, audio signals, or pre-cliped video clips, where the affective evidence is already given. This passive and clip-centered setting does not fully reflect real-world scenarios, in which users often interact with long videos and express their needs through natural-language queries. In this paper, we study \textbf{Vague-Query-driven video Affective Understanding (VQAU)}, a new task that requires models to localize affective moments in long videos, predict their emotion categories, and generate evidence-grounded rationales under vague user queries. To support this task, we construct \textbf{VQAU-Bench}, a benchmark that integrates long videos, vague affective queries, temporal clip annotations, emotion labels, and rationale explanations into a unified evaluation framework. VQAU-Bench enables systematic assessment of semantic-temporal-affective alignment, affective moment localization, emotion classification, and rationale generation. To address the multi-step reasoning challenges of VQAU, we further propose \textbf{AffectSeek}, an agentic framework that actively seeks, verifies, and explains affective moments in long videos. AffectSeek decomposes VQAU into intent interpretation, candidate localization, clip verification, emotion reasoning, and rationale generation, and progressively aligns vague user intent with long-video evidence through role-specialized reasoning and cross-stage verification. Experiments show that VQAU remains challenging for existing affective recognition models and single-step vision-language models, while AffectSeek provides a simple yet effective framework for agentic long-video affective understanding.
Abstract:Protein-ligand bioactivity data published in the literature are essential for drug discovery, yet manual curation struggles to keep pace with rapidly growing literature. Automated bioactivity extraction remains challenging because it requires not only interpreting biochemical semantics distributed across text, tables, and figures, but also reconstructing chemically exact ligand structures (e.g., Markush structures). To address this bottleneck, we introduce BioMiner, a multi-modal extraction framework that explicitly separates bioactivity semantic interpretation from ligand structure construction. Within BioMiner, bioactivity semantics are inferred through direct reasoning, while chemical structures are resolved via a chemical-structure-grounded visual semantic reasoning paradigm, in which multi-modal large language models operate on chemically grounded visual representations to infer inter-structure relationships, and exact molecular construction is delegated to domain chemistry tools. For rigorous evaluation and method development, we further establish BioVista, a comprehensive benchmark comprising 16,457 bioactivity entries curated from 500 publications. BioMiner validates its extraction ability and provides a quantitative baseline, achieving an F1 score of 0.32 for bioactivity triplets. BioMiner's practical utility is demonstrated via three applications: (1) extracting 82,262 data from 11,683 papers to build a pre-training database that improves downstream models performance by 3.9%; (2) enabling a human-in-the-loop workflow that doubles the number of high-quality NLRP3 bioactivity data, helping 38.6% improvement over 28 QSAR models and identification of 16 hit candidates with novel scaffolds; and (3) accelerating protein-ligand complex bioactivity annotation, achieving a 5.59-fold speed increase and 5.75% accuracy improvement over manual workflows in PoseBusters dataset.
Abstract:Digital characters are central to modern media, yet generating character videos with long-duration, consistent multi-view appearance and expressive identity remains challenging. Existing approaches either provide insufficient context to preserve identity or leverage non-character-centric information as the memory, leading to suboptimal consistency. Recognizing that character video generation inherently resembles an outside-looking-in scenario. In this work, we propose representing the character visual attributes through a compact set of anchor frames. This design provides stable references for consistency, while reference-based video generation inherently faces challenges of copy-pasting and multi-reference conflicts. To address these, we introduce two mechanisms: Superset Content Anchoring, providing intra- and extra-training clip cues to prevent duplication, and RoPE as Weak Condition, encoding positional offsets to distinguish multiple anchors. Furthermore, we construct a scalable pipeline to extract these anchors from massive videos. Experiments show our method generates high-quality character videos exceeding 10 minutes, and achieves expressive identity and appearance consistency across views, surpassing existing methods.
Abstract:Integrating structural and functional connectomes remains challenging because their relationship is non-linear and organized over nested modular hierarchies. We propose a hierarchical multiscale structure-function coupling framework for connectome integration that jointly learns individualized modular organization and hierarchical coupling across structural connectivity (SC) and functional connectivity (FC). The framework includes: (i) Prototype-based Modular Pooling (PMPool), which learns modality-specific multiscale communities by selecting prototypical ROIs and optimizing a differentiable modularity-inspired objective; (ii) an Attention-based Hierarchical Coupling Module (AHCM) that models both within-hierarchy and cross-hierarchy SC-FC interactions to produce enriched hierarchical coupling representations; and (iii) a Coupling-guided Clustering loss (CgC-Loss) that regularizes SC and FC community assignments with coupling signals, allowing cross-modal interactions to shape community alignment across hierarchies. We evaluate the model's performance across four cohorts for predicting brain age, cognitive score, and disease classification. Our model consistently outperforms baselines and other state-of-the-art approaches across three tasks. Ablation and sensitivity analyses verify the contributions of key components. Finally, the visualizations of learned coupling reveal interpretable differences, suggesting that the framework captures biologically meaningful structure-function relationships.
Abstract:Monocular 4D human-object interaction (HOI) reconstruction - recovering a moving human and a manipulated object from a single RGB video - remains challenging due to depth ambiguity and frequent occlusions. Existing methods often rely on multi-stage pipelines or iterative optimization, leading to high inference latency, failing to meet real-time requirements, and susceptibility to error accumulation. To address these limitations, we propose THO, an end-to-end Spatial-Temporal Transformer that predicts human motion and coordinated object motion in a forward fashion from the given video and 3D template. THO achieves this by leveraging spatial-temporal HOI tuple priors. Spatial priors exploit contact-region proximity to infer occluded object features from human cues, while temporal priors capture cross-frame kinematic correlations to refine object representations and enforce physical coherence. Extensive experiments demonstrate that THO operates at an inference speed of 31.5 FPS on a single RTX 4090 GPU, achieving a >600x speedup over prior optimization-based methods while simultaneously improving reconstruction accuracy and temporal consistency. The project page is available at: https://nianheng.github.io/THO-project/