Department of Computer and Data Science, Case Western Reserve University, Cleveland, Ohio 44106, United States, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, United States
Abstract:Reliable visual monitoring of chemical experiments remains challenging in transparent glassware, where weak phase boundaries and optical artifacts degrade conventional segmentation. We formulate laboratory phenomena as the time evolution of phase interfaces and introduce the Chemical Transparent Glasses dataset 2.0 (CTG 2.0), a vessel-aware benchmark with 3,668 images, 23 glassware categories, and five multiphase interface types for phase-interface instance segmentation. Building on YOLO11m-seg, we propose LGA-RCM-YOLO, which combines Local-Global Attention (LGA) for robust semantic representation and a Rectangular Self-Calibration Module (RCM) for boundary refinement of thin, elongated interfaces. On CTG 2.0, the proposed model achieves 84.4% AP@0.5 and 58.43% AP@0.5-0.95, improving over the YOLO11m baseline by 6.42 and 8.75 AP points, respectively, while maintaining near real-time inference (13.67 FPS, RTX 3060). An auxiliary color-attribute head further labels liquid instances as colored or colorless with 98.71% precision and 98.32% recall. Finally, we demonstrate continuous process monitoring in separatory-funnel phase separation and crystallization, showing that phase-interface instance segmentation can serve as a practical visual sensor for laboratory automation.
Abstract:Large Multimodal Models (LMMs) struggle to adapt varying computational budgets due to numerous visual tokens. Previous methods attempted to reduce the number of visual tokens before or within LLMs. However, these strategies inevitably result in the loss of visual semantic. To address these issues, we introduce FMVR, a plug-and-play and extremely simple Frequency-Modulated Visual Restoration strategy to boost the reasoning ability of LMMs under visual token reduction. Specifically, FMVR disentangles the visual representation of fewer visual tokens into low- and high-frequency components through AvgPool and MaxPool. The derived frequencies are subsequently modulated using lightweight learnable parameters. The high-frequency from AvgPool acts as a saliency filter to enhance saliency visual semantics, while the low-frequency from MaxPool acts as an anti-saliency filter to strengthen weak visual semantics. It enables the preservation of visual semantics dominated by few visual tokens and the restoration of diluted visual semantics. Additionally, we inject FMVR into Matryoshka Representation Learning to learn coarse-to-fine visual token sets, thus enabling to elastically adjust the number of visual tokens during inference while maintaining comparable performance. Experiments across 10 image-based and 4 video-based bench marks demonstrate that FMVR-LLaVA reduce the FLOPs of LLaVA-1.5-7B by 89%, while maintaining almost 100% of the original accuracy. The code will be open.
Abstract:Reinforcement learning (RL) has emerged as a powerful paradigm for achieving online agile navigation with quadrotors. Despite this success, policies trained via standard RL typically fail to generalize across significant dynamic variations, exhibiting a critical lack of adaptability. This work introduces MAVEN, a meta-RL framework that enables a single policy to achieve robust end-to-end navigation across a wide range of quadrotor dynamics. Our approach features a novel predictive context encoder, which learns to infer a latent representation of the system dynamics from interaction history. We demonstrate our method in agile waypoint traversal tasks under two challenging scenarios: large variations in quadrotor mass and severe single-rotor thrust loss. We leverage a GPU-vectorized simulator to distribute tasks across thousands of parallel environments, overcoming the long training times of meta-RL to converge in less than an hour. Through extensive experiments in both simulation and the real world, we validate that MAVEN achieves superior adaptation and agility. The policy successfully executes zero-shot sim-to-real transfer, demonstrating robust online adaptation by performing high-speed maneuvers despite mass variations of up to 66.7% and single-rotor thrust losses as severe as 70%.
Abstract:Vision-language pretraining has driven significant progress in medical image analysis. However, current methods typically supervise visual encoders using one-hot labels or free-form text, neither of which effectively captures the complex semantic relationships among clinical findings. In this study, we introduce VIVID-Med, a novel framework that leverages a frozen large language model (LLM) as a structured semantic teacher to pretrain medical vision transformers (ViTs). VIVID-Med translates clinical findings into verifiable JSON field-state pairs via a Unified Medical Schema (UMS), utilizing answerability-aware masking to focus optimization. It then employs Structured Prediction Decomposition (SPD) to partition cross-attention into orthogonality-regularized query groups, extracting complementary visual aspects. Crucially, the LLM is discarded post-training, yielding a lightweight, deployable ViT-only backbone. We evaluated VIVID-Med across multiple settings: on CheXpert linear probing, it achieves a macro-AUC of 0.8588, outperforming BiomedCLIP by +6.65 points while using 500x less data. It also demonstrates robust zero-shot cross-domain transfer to NIH ChestX-ray14 (0.7225 macro-AUC) and strong cross-modality generalization to CT, achieving 0.8413 AUC on LIDC-IDRI lung nodule classification and 0.9969 macro-AUC on OrganAMNIST 11-organ classification. VIVID-Med offers a highly efficient, scalable alternative to deploying resource-heavy vision-language models in clinical settings.
Abstract:Agile maneuvering of the quadrotor cable-suspended system is significantly hindered by its non-smooth hybrid dynamics. While model-free Reinforcement Learning (RL) circumvents explicit differentiation of complex models, achieving attitude-constrained or inverted flight remains an open challenge due to the extreme reward sparsity under strict orientation requirements. This paper presents ASTER, a robust RL framework that achieves, to our knowledge, the first successful autonomous inverted flight for the cable-suspended system. We propose hybrid-dynamics-informed state seeding (HDSS), an initialization strategy that back-propagates target configurations through physics-consistent kinematic inversions across both taut and slack cable phases. HDSS enables the policy to discover aggressive maneuvers that are unreachable via standard exploration. Extensive simulations and real-world experiments demonstrate remarkable agility, precise attitude alignment, and robust zero-shot sim-to-real transfer across complex trajectories.
Abstract:We introduce \CFE{} (\textbf{C}lassroom \textbf{F}inal \textbf{E}xam), a multimodal benchmark for evaluating the reasoning capabilities of large language models across more than 20 STEM domains. \CFE{} is curated from repeatedly used, authentic university homework and exam problems, together with reference solutions provided by course instructors. \CFE{} presents a significant challenge even for frontier models: the newly released Gemini-3.1-pro-preview achieves an overall accuracy of 59.69\%, while the second-best model, Gemini-3-flash-preview, reaches 55.46\%, leaving considerable room for improvement. Beyond leaderboard results, we perform a diagnostic analysis by decomposing reference solutions into reasoning flows. We find that although frontier models can often answer intermediate sub-questions correctly, they struggle to reliably derive and maintain correct intermediate states throughout multi-step solutions. We further observe that model-generated solutions typically have more reasoning steps than those provided by the instructor, indicating suboptimal step efficiency and a higher risk of error accumulation. The data and code are available at https://github.com/Analogy-AI/CFE_Bench.
Abstract:Clinical MRI contrast acquisition suffers from inefficient information yield, which presents as a mismatch between the risky and costly acquisition protocol and the fixed and sparse acquisition sequence. Applying world models to simulate the contrast enhancement kinetics in the human body enables continuous contrast-free dynamics. However, the low temporal resolution in MRI acquisition restricts the training of world models, leading to a sparsely sampled dataset. Directly training a generative model to capture the kinetics leads to two limitations: (a) Due to the absence of data on missing time, the model tends to overfit to irrelevant features, leading to content distortion. (b) Due to the lack of continuous temporal supervision, the model fails to learn the continuous kinetics law over time, causing temporal discontinuities. For the first time, we propose MRI Contrast Enhancement Kinetics World model (MRI CEKWorld) with SpatioTemporal Consistency Learning (STCL). For (a), guided by the spatial law that patient-level structures remain consistent during enhancement, we propose Latent Alignment Learning (LAL) that constructs a patient-specific template to constrain contents to align with this template. For (b), guided by the temporal law that the kinetics follow a consistent smooth trend, we propose Latent Difference Learning (LDL) which extends the unobserved intervals by interpolation and constrains smooth variations in the latent space among interpolated sequences. Extensive experiments on two datasets show our MRI CEKWorld achieves better realistic contents and kinetics. Codes will be available at https://github.com/DD0922/MRI-Contrast-Enhancement-Kinetics-World-Model.
Abstract:Mobile Graphical User Interface (GUI) agents have demonstrated strong capabilities in automating complex smartphone tasks by leveraging multimodal large language models (MLLMs) and system-level control interfaces. However, this paradigm introduces significant privacy risks, as agents typically capture and process entire screen contents, thereby exposing sensitive personal data such as phone numbers, addresses, messages, and financial information. Existing defenses either reduce UI exposure, obfuscate only task-irrelevant content, or rely on user authorization, but none can protect task-critical sensitive information while preserving seamless agent usability. We propose an anonymization-based privacy protection framework that enforces the principle of available-but-invisible access to sensitive data: sensitive information remains usable for task execution but is never directly visible to the cloud-based agent. Our system detects sensitive UI content using a PII-aware recognition model and replaces it with deterministic, type-preserving placeholders (e.g., PHONE_NUMBER#a1b2c) that retain semantic categories while removing identifying details. A layered architecture comprising a PII Detector, UI Transformer, Secure Interaction Proxy, and Privacy Gatekeeper ensures consistent anonymization across user instructions, XML hierarchies, and screenshots, mediates all agent actions over anonymized interfaces, and supports narrowly scoped local computations when reasoning over raw values is necessary. Extensive experiments on the AndroidLab and PrivScreen benchmarks show that our framework substantially reduces privacy leakage across multiple models while incurring only modest utility degradation, achieving the best observed privacy-utility trade-off among existing methods. Code available at: https://github.com/one-step-beh1nd/gui_privacy_protection
Abstract:The evolution of Large Language Models (LLMs) has shifted mobile computing from App-centric interactions to system-level autonomous agents. Current implementations predominantly rely on a "Screen-as-Interface" paradigm, which inherits structural vulnerabilities and conflicts with the mobile ecosystem's economic foundations. In this paper, we conduct a systematic security analysis of state-of-the-art mobile agents using Doubao Mobile Assistant as a representative case. We decompose the threat landscape into four dimensions - Agent Identity, External Interface, Internal Reasoning, and Action Execution - revealing critical flaws such as fake App identity, visual spoofing, indirect prompt injection, and unauthorized privilege escalation stemming from a reliance on unstructured visual data. To address these challenges, we propose Aura, an Agent Universal Runtime Architecture for a clean-slate secure agent OS. Aura replaces brittle GUI scraping with a structured, agent-native interaction model. It adopts a Hub-and-Spoke topology where a privileged System Agent orchestrates intent, sandboxed App Agents execute domain-specific tasks, and the Agent Kernel mediates all communication. The Agent Kernel enforces four defense pillars: (i) cryptographic identity binding via a Global Agent Registry; (ii) semantic input sanitization through a multilayer Semantic Firewall; (iii) cognitive integrity via taint-aware memory and plan-trajectory alignment; and (iv) granular access control with non-deniable auditing. Evaluation on MobileSafetyBench shows that, compared to Doubao, Aura improves low-risk Task Success Rate from roughly 75% to 94.3%, reduces high-risk Attack Success Rate from roughly 40% to 4.4%, and achieves near-order-of-magnitude latency gains. These results demonstrate Aura as a viable, secure alternative to the "Screen-as-Interface" paradigm.
Abstract:A substantial proportion (45\%) of maternal deaths, neonatal deaths, and stillbirths occur during the intrapartum phase, with a particularly high burden in low- and middle-income countries. Intrapartum biometry plays a critical role in monitoring labor progression; however, the routine use of ultrasound in resource-limited settings is hindered by a shortage of trained sonographers. To address this challenge, the Intrapartum Ultrasound Grand Challenge (IUGC), co-hosted with MICCAI 2024, was launched. The IUGC introduces a clinically oriented multi-task automatic measurement framework that integrates standard plane classification, fetal head-pubic symphysis segmentation, and biometry, enabling algorithms to exploit complementary task information for more accurate estimation. Furthermore, the challenge releases the largest multi-center intrapartum ultrasound video dataset to date, comprising 774 videos (68,106 frames) collected from three hospitals, providing a robust foundation for model training and evaluation. In this study, we present a comprehensive overview of the challenge design, review the submissions from eight participating teams, and analyze their methods from five perspectives: preprocessing, data augmentation, learning strategy, model architecture, and post-processing. In addition, we perform a systematic analysis of the benchmark results to identify key bottlenecks, explore potential solutions, and highlight open challenges for future research. Although encouraging performance has been achieved, our findings indicate that the field remains at an early stage, and further in-depth investigation is required before large-scale clinical deployment. All benchmark solutions and the complete dataset have been publicly released to facilitate reproducible research and promote continued advances in automatic intrapartum ultrasound biometry.