CrownGen: Patient-customized Crown Generation via Point Diffusion Model

Digital crown design remains a labor-intensive bottleneck in restorative dentistry. We present \textbf{CrownGen}, a generative framework that automates patient-customized crown design using a denoising diffusion model on a novel tooth-level point cloud representation. The system employs two core components: a boundary prediction module to establish spatial priors and a diffusion-based generative module to synthesize high-fidelity morphology for multiple teeth in a single inference pass. We validated CrownGen through a quantitative benchmark on 496 external scans and a clinical study of 26 restoration cases. Results demonstrate that CrownGen surpasses state-of-the-art models in geometric fidelity and significantly reduces active design time. Clinical assessments by trained dentists confirmed that CrownGen-assisted crowns are statistically non-inferior in quality to those produced by expert technicians using manual workflows. By automating complex prosthetic modeling, CrownGen offers a scalable solution to lower costs, shorten turnaround times, and enhance patient access to high-quality dental care.

Multimodal Contrastive Pretraining of CBCT and IOS for Enhanced Tooth Segmentation

Digital dentistry represents a transformative shift in modern dental practice. The foundational step in this transformation is the accurate digital representation of the patient's dentition, which is obtained from segmented Cone-Beam Computed Tomography (CBCT) and Intraoral Scans (IOS). Despite the growing interest in digital dental technologies, existing segmentation methodologies frequently lack rigorous validation and demonstrate limited performance and clinical applicability. To the best of our knowledge, this is the first work to introduce a multimodal pretraining framework for tooth segmentation. We present ToothMCL, a Tooth Multimodal Contrastive Learning for pretraining that integrates volumetric (CBCT) and surface-based (IOS) modalities. By capturing modality-invariant representations through multimodal contrastive learning, our approach effectively models fine-grained anatomical features, enabling precise multi-class segmentation and accurate identification of F\'ed\'eration Dentaire Internationale (FDI) tooth numbering. Along with the framework, we curated CBCT-IOS3.8K, the largest paired CBCT and IOS dataset to date, comprising 3,867 patients. We then evaluated ToothMCL on a comprehensive collection of independent datasets, representing the largest and most diverse evaluation to date. Our method achieves state-of-the-art performance in both internal and external testing, with an increase of 12\% for CBCT segmentation and 8\% for IOS segmentation in the Dice Similarity Coefficient (DSC). Furthermore, ToothMCL consistently surpasses existing approaches in tooth groups and demonstrates robust generalizability across varying imaging conditions and clinical scenarios.

Large-scale Multi-sequence Pretraining for Generalizable MRI Analysis in Versatile Clinical Applications

Multi-sequence Magnetic Resonance Imaging (MRI) offers remarkable versatility, enabling the distinct visualization of different tissue types. Nevertheless, the inherent heterogeneity among MRI sequences poses significant challenges to the generalization capability of deep learning models. These challenges undermine model performance when faced with varying acquisition parameters, thereby severely restricting their clinical utility. In this study, we present PRISM, a foundation model PRe-trained with large-scale multI-Sequence MRI. We collected a total of 64 datasets from both public and private sources, encompassing a wide range of whole-body anatomical structures, with scans spanning diverse MRI sequences. Among them, 336,476 volumetric MRI scans from 34 datasets (8 public and 26 private) were curated to construct the largest multi-organ multi-sequence MRI pretraining corpus to date. We propose a novel pretraining paradigm that disentangles anatomically invariant features from sequence-specific variations in MRI, while preserving high-level semantic representations. We established a benchmark comprising 44 downstream tasks, including disease diagnosis, image segmentation, registration, progression prediction, and report generation. These tasks were evaluated on 32 public datasets and 5 private cohorts. PRISM consistently outperformed both non-pretrained models and existing foundation models, achieving first-rank results in 39 out of 44 downstream benchmarks with statistical significance improvements. These results underscore its ability to learn robust and generalizable representations across unseen data acquired under diverse MRI protocols. PRISM provides a scalable framework for multi-sequence MRI analysis, thereby enhancing the translational potential of AI in radiology. It delivers consistent performance across diverse imaging protocols, reinforcing its clinical applicability.