EyecareGPT: Boosting Comprehensive Ophthalmology Understanding with Tailored Dataset, Benchmark and Model

Medical Large Vision-Language Models (Med-LVLMs) demonstrate significant potential in healthcare, but their reliance on general medical data and coarse-grained global visual understanding limits them in intelligent ophthalmic diagnosis. Currently, intelligent ophthalmic diagnosis faces three major challenges: (i) Data. The lack of deeply annotated, high-quality, multi-modal ophthalmic visual instruction data; (ii) Benchmark. The absence of a comprehensive and systematic benchmark for evaluating diagnostic performance; (iii) Model. The difficulty of adapting holistic visual architectures to fine-grained, region-specific ophthalmic lesion identification. In this paper, we propose the Eyecare Kit, which systematically tackles the aforementioned three key challenges with the tailored dataset, benchmark and model: First, we construct a multi-agent data engine with real-life ophthalmology data to produce Eyecare-100K, a high-quality ophthalmic visual instruction dataset. Subsequently, we design Eyecare-Bench, a benchmark that comprehensively evaluates the overall performance of LVLMs on intelligent ophthalmic diagnosis tasks across multiple dimensions. Finally, we develop the EyecareGPT, optimized for fine-grained ophthalmic visual understanding thoroughly, which incorporates an adaptive resolution mechanism and a layer-wise dense connector. Extensive experimental results indicate that the EyecareGPT achieves state-of-the-art performance in a range of ophthalmic tasks, underscoring its significant potential for the advancement of open research in intelligent ophthalmic diagnosis. Our project is available at https://github.com/DCDmllm/EyecareGPT.

Open-Medical-R1: How to Choose Data for RLVR Training at Medicine Domain

This paper explores optimal data selection strategies for Reinforcement Learning with Verified Rewards (RLVR) training in the medical domain. While RLVR has shown exceptional potential for enhancing reasoning capabilities in large language models, most prior implementations have focused on mathematics and logical puzzles, with limited exploration of domain-specific applications like medicine. We investigate four distinct data sampling strategies from MedQA-USMLE: random sampling (baseline), and filtering using Phi-4, Gemma-3-27b-it, and Gemma-3-12b-it models. Using Gemma-3-12b-it as our base model and implementing Group Relative Policy Optimization (GRPO), we evaluate performance across multiple benchmarks including MMLU, GSM8K, MMLU-Pro, and CMMLU. Our findings demonstrate that models trained on filtered data generally outperform those trained on randomly selected samples. Notably, training on self-filtered samples (using Gemma-3-12b-it for filtering) achieved superior performance in medical domains but showed reduced robustness across different benchmarks, while filtering with larger models from the same series yielded better overall robustness. These results provide valuable insights into effective data organization strategies for RLVR in specialized domains and highlight the importance of thoughtful data selection in achieving optimal performance. You can access our repository (https://github.com/Qsingle/open-medical-r1) to get the codes.

KeyVID: Keyframe-Aware Video Diffusion for Audio-Synchronized Visual Animation

Generating video from various conditions, such as text, image, and audio, enables both spatial and temporal control, leading to high-quality generation results. Videos with dramatic motions often require a higher frame rate to ensure smooth motion. Currently, most audio-to-visual animation models use uniformly sampled frames from video clips. However, these uniformly sampled frames fail to capture significant key moments in dramatic motions at low frame rates and require significantly more memory when increasing the number of frames directly. In this paper, we propose KeyVID, a keyframe-aware audio-to-visual animation framework that significantly improves the generation quality for key moments in audio signals while maintaining computation efficiency. Given an image and an audio input, we first localize keyframe time steps from the audio. Then, we use a keyframe generator to generate the corresponding visual keyframes. Finally, we generate all intermediate frames using the motion interpolator. Through extensive experiments, we demonstrate that KeyVID significantly improves audio-video synchronization and video quality across multiple datasets, particularly for highly dynamic motions. The code is released in https://github.com/XingruiWang/KeyVID.

Adaptive Wavelet Filters as Practical Texture Feature Amplifiers for Parkinson's Disease Screening in OCT

Parkinson's disease (PD) is a prevalent neurodegenerative disorder globally. The eye's retina is an extension of the brain and has great potential in PD screening. Recent studies have suggested that texture features extracted from retinal layers can be adopted as biomarkers for PD diagnosis under optical coherence tomography (OCT) images. Frequency domain learning techniques can enhance the feature representations of deep neural networks (DNNs) by decomposing frequency components involving rich texture features. Additionally, previous works have not exploited texture features for automated PD screening in OCT. Motivated by the above analysis, we propose a novel Adaptive Wavelet Filter (AWF) that serves as the Practical Texture Feature Amplifier to fully leverage the merits of texture features to boost the PD screening performance of DNNs with the aid of frequency domain learning. Specifically, AWF first enhances texture feature representation diversities via channel mixer, then emphasizes informative texture feature representations with the well-designed adaptive wavelet filtering token mixer. By combining the AWFs with the DNN stem, AWFNet is constructed for automated PD screening. Additionally, we introduce a novel Balanced Confidence (BC) Loss by mining the potential of sample-wise predicted probabilities of all classes and class frequency prior, to further boost the PD screening performance and trustworthiness of AWFNet. The extensive experiments manifest the superiority of our AWFNet and BC over state-of-the-art methods in terms of PD screening performance and trustworthiness.

Hierarchical Context Transformer for Multi-level Semantic Scene Understanding

A comprehensive and explicit understanding of surgical scenes plays a vital role in developing context-aware computer-assisted systems in the operating theatre. However, few works provide systematical analysis to enable hierarchical surgical scene understanding. In this work, we propose to represent the tasks set [phase recognition --> step recognition --> action and instrument detection] as multi-level semantic scene understanding (MSSU). For this target, we propose a novel hierarchical context transformer (HCT) network and thoroughly explore the relations across the different level tasks. Specifically, a hierarchical relation aggregation module (HRAM) is designed to concurrently relate entries inside multi-level interaction information and then augment task-specific features. To further boost the representation learning of the different tasks, inter-task contrastive learning (ICL) is presented to guide the model to learn task-wise features via absorbing complementary information from other tasks. Furthermore, considering the computational costs of the transformer, we propose HCT+ to integrate the spatial and temporal adapter to access competitive performance on substantially fewer tunable parameters. Extensive experiments on our cataract dataset and a publicly available endoscopic PSI-AVA dataset demonstrate the outstanding performance of our method, consistently exceeding the state-of-the-art methods by a large margin. The code is available at https://github.com/Aurora-hao/HCT.

Self-Taught Agentic Long Context Understanding

Answering complex, long-context questions remains a major challenge for large language models (LLMs) as it requires effective question clarifications and context retrieval. We propose Agentic Long-Context Understanding (AgenticLU), a framework designed to enhance an LLM's understanding of such queries by integrating targeted self-clarification with contextual grounding within an agentic workflow. At the core of AgenticLU is Chain-of-Clarifications (CoC), where models refine their understanding through self-generated clarification questions and corresponding contextual groundings. By scaling inference as a tree search where each node represents a CoC step, we achieve 97.8% answer recall on NarrativeQA with a search depth of up to three and a branching factor of eight. To amortize the high cost of this search process to training, we leverage the preference pairs for each step obtained by the CoC workflow and perform two-stage model finetuning: (1) supervised finetuning to learn effective decomposition strategies, and (2) direct preference optimization to enhance reasoning quality. This enables AgenticLU models to generate clarifications and retrieve relevant context effectively and efficiently in a single inference pass. Extensive experiments across seven long-context tasks demonstrate that AgenticLU significantly outperforms state-of-the-art prompting methods and specialized long-context LLMs, achieving robust multi-hop reasoning while sustaining consistent performance as context length grows.

Fundus Image Quality Assessment and Enhancement: a Systematic Review

As an affordable and convenient eye scan, fundus photography holds the potential for preventing vision impairment, especially in resource-limited regions. However, fundus image degradation is common under intricate imaging environments, impacting following diagnosis and treatment. Consequently, image quality assessment (IQA) and enhancement (IQE) are essential for ensuring the clinical value and reliability of fundus images. While existing reviews offer some overview of this field, a comprehensive analysis of the interplay between IQA and IQE, along with their clinical deployment challenges, is lacking. This paper addresses this gap by providing a thorough review of fundus IQA and IQE algorithms, research advancements, and practical applications. We outline the fundamentals of the fundus photography imaging system and the associated interferences, and then systematically summarize the paradigms in fundus IQA and IQE. Furthermore, we discuss the practical challenges and solutions in deploying IQA and IQE, as well as offer insights into potential future research directions.

Agent Laboratory: Using LLM Agents as Research Assistants

Historically, scientific discovery has been a lengthy and costly process, demanding substantial time and resources from initial conception to final results. To accelerate scientific discovery, reduce research costs, and improve research quality, we introduce Agent Laboratory, an autonomous LLM-based framework capable of completing the entire research process. This framework accepts a human-provided research idea and progresses through three stages--literature review, experimentation, and report writing to produce comprehensive research outputs, including a code repository and a research report, while enabling users to provide feedback and guidance at each stage. We deploy Agent Laboratory with various state-of-the-art LLMs and invite multiple researchers to assess its quality by participating in a survey, providing human feedback to guide the research process, and then evaluate the final paper. We found that: (1) Agent Laboratory driven by o1-preview generates the best research outcomes; (2) The generated machine learning code is able to achieve state-of-the-art performance compared to existing methods; (3) Human involvement, providing feedback at each stage, significantly improves the overall quality of research; (4) Agent Laboratory significantly reduces research expenses, achieving an 84% decrease compared to previous autonomous research methods. We hope Agent Laboratory enables researchers to allocate more effort toward creative ideation rather than low-level coding and writing, ultimately accelerating scientific discovery.

COph100: A comprehensive fundus image registration dataset from infants constituting the "RIDIRP" database

Retinal image registration is vital for diagnostic therapeutic applications within the field of ophthalmology. Existing public datasets, focusing on adult retinal pathologies with high-quality images, have limited number of image pairs and neglect clinical challenges. To address this gap, we introduce COph100, a novel and challenging dataset known as the Comprehensive Ophthalmology Retinal Image Registration dataset for infants with a wide range of image quality issues constituting the public "RIDIRP" database. COph100 consists of 100 eyes, each with 2 to 9 examination sessions, amounting to a total of 491 image pairs carefully selected from the publicly available dataset. We manually labeled the corresponding ground truth image points and provided automatic vessel segmentation masks for each image. We have assessed COph100 in terms of image quality and registration outcomes using state-of-the-art algorithms. This resource enables a robust comparison of retinal registration methodologies and aids in the analysis of disease progression in infants, thereby deepening our understanding of pediatric ophthalmic conditions.

AIF-SFDA: Autonomous Information Filter-driven Source-Free Domain Adaptation for Medical Image Segmentation

Decoupling domain-variant information (DVI) from domain-invariant information (DII) serves as a prominent strategy for mitigating domain shifts in the practical implementation of deep learning algorithms. However, in medical settings, concerns surrounding data collection and privacy often restrict access to both training and test data, hindering the empirical decoupling of information by existing methods. To tackle this issue, we propose an Autonomous Information Filter-driven Source-free Domain Adaptation (AIF-SFDA) algorithm, which leverages a frequency-based learnable information filter to autonomously decouple DVI and DII. Information Bottleneck (IB) and Self-supervision (SS) are incorporated to optimize the learnable frequency filter. The IB governs the information flow within the filter to diminish redundant DVI, while SS preserves DII in alignment with the specific task and image modality. Thus, the autonomous information filter can overcome domain shifts relying solely on target data. A series of experiments covering various medical image modalities and segmentation tasks were conducted to demonstrate the benefits of AIF-SFDA through comparisons with leading algorithms and ablation studies. The code is available at https://github.com/JingHuaMan/AIF-SFDA.