Personalized Multimodal Large Language Models: A Survey

Multimodal Large Language Models (MLLMs) have become increasingly important due to their state-of-the-art performance and ability to integrate multiple data modalities, such as text, images, and audio, to perform complex tasks with high accuracy. This paper presents a comprehensive survey on personalized multimodal large language models, focusing on their architecture, training methods, and applications. We propose an intuitive taxonomy for categorizing the techniques used to personalize MLLMs to individual users, and discuss the techniques accordingly. Furthermore, we discuss how such techniques can be combined or adapted when appropriate, highlighting their advantages and underlying rationale. We also provide a succinct summary of personalization tasks investigated in existing research, along with the evaluation metrics commonly used. Additionally, we summarize the datasets that are useful for benchmarking personalized MLLMs. Finally, we outline critical open challenges. This survey aims to serve as a valuable resource for researchers and practitioners seeking to understand and advance the development of personalized multimodal large language models.

Jailbreak Large Vision-Language Models Through Multi-Modal Linkage

With the significant advancement of Large Vision-Language Models (VLMs), concerns about their potential misuse and abuse have grown rapidly. Previous studies have highlighted VLMs' vulnerability to jailbreak attacks, where carefully crafted inputs can lead the model to produce content that violates ethical and legal standards. However, existing methods struggle against state-of-the-art VLMs like GPT-4o, due to the over-exposure of harmful content and lack of stealthy malicious guidance. In this work, we propose a novel jailbreak attack framework: Multi-Modal Linkage (MML) Attack. Drawing inspiration from cryptography, MML utilizes an encryption-decryption process across text and image modalities to mitigate over-exposure of malicious information. To align the model's output with malicious intent covertly, MML employs a technique called "evil alignment", framing the attack within a video game production scenario. Comprehensive experiments demonstrate MML's effectiveness. Specifically, MML jailbreaks GPT-4o with attack success rates of 97.80% on SafeBench, 98.81% on MM-SafeBench and 99.07% on HADES-Dataset. Our code is available at https://github.com/wangyu-ovo/MML

DHCP: Detecting Hallucinations by Cross-modal Attention Pattern in Large Vision-Language Models

Large vision-language models (LVLMs) have demonstrated exceptional performance on complex multimodal tasks. However, they continue to suffer from significant hallucination issues, including object, attribute, and relational hallucinations. To accurately detect these hallucinations, we investigated the variations in cross-modal attention patterns between hallucination and non-hallucination states. Leveraging these distinctions, we developed a lightweight detector capable of identifying hallucinations. Our proposed method, Detecting Hallucinations by Cross-modal Attention Patterns (DHCP), is straightforward and does not require additional LVLM training or extra LVLM inference steps. Experimental results show that DHCP achieves remarkable performance in hallucination detection. By offering novel insights into the identification and analysis of hallucinations in LVLMs, DHCP contributes to advancing the reliability and trustworthiness of these models.

LiteVAR: Compressing Visual Autoregressive Modelling with Efficient Attention and Quantization

Visual Autoregressive (VAR) has emerged as a promising approach in image generation, offering competitive potential and performance comparable to diffusion-based models. However, current AR-based visual generation models require substantial computational resources, limiting their applicability on resource-constrained devices. To address this issue, we conducted analysis and identified significant redundancy in three dimensions of the VAR model: (1) the attention map, (2) the attention outputs when using classifier free guidance, and (3) the data precision. Correspondingly, we proposed efficient attention mechanism and low-bit quantization method to enhance the efficiency of VAR models while maintaining performance. With negligible performance lost (less than 0.056 FID increase), we could achieve 85.2% reduction in attention computation, 50% reduction in overall memory and 1.5x latency reduction. To ensure deployment feasibility, we developed efficient training-free compression techniques and analyze the deployment feasibility and efficiency gain of each technique.

ΩSFormer: Dual-Modal Ω-like Super-Resolution Transformer Network for Cross-scale and High-accuracy Terraced Field Vectorization Extraction

Terraced field is a significant engineering practice for soil and water conservation (SWC). Terraced field extraction from remotely sensed imagery is the foundation for monitoring and evaluating SWC. This study is the first to propose a novel dual-modal {\Omega}-like super-resolution Transformer network for intelligent TFVE, offering the following advantages: (1) reducing edge segmentation error from conventional multi-scale downsampling encoder, through fusing original high-resolution features with downsampling features at each step of encoder and leveraging a multi-head attention mechanism; (2) improving the accuracy of TFVE by proposing a {\Omega}-like network structure, which fully integrates rich high-level features from both spectral and terrain data to form cross-scale super-resolution features; (3) validating an optimal fusion scheme for cross-modal and cross-scale (i.e., inconsistent spatial resolution between remotely sensed imagery and DEM) super-resolution feature extraction; (4) mitigating uncertainty between segmentation edge pixels by a coarse-to-fine and spatial topological semantic relationship optimization (STSRO) segmentation strategy; (5) leveraging contour vibration neural network to continuously optimize parameters and iteratively vectorize terraced fields from semantic segmentation results. Moreover, a DMRVD for deep-learning-based TFVE was created for the first time, which covers nine study areas in four provinces of China, with a total coverage area of 22441 square kilometers. To assess the performance of {\Omega}SFormer, classic and SOTA networks were compared. The mIOU of {\Omega}SFormer has improved by 0.165, 0.297 and 0.128 respectively, when compared with best accuracy single-modal remotely sensed imagery, single-modal DEM and dual-modal result.

Glo-In-One-v2: Holistic Identification of Glomerular Cells, Tissues, and Lesions in Human and Mouse Histopathology

Segmenting glomerular intraglomerular tissue and lesions traditionally depends on detailed morphological evaluations by expert nephropathologists, a labor-intensive process susceptible to interobserver variability. Our group previously developed the Glo-In-One toolkit for integrated detection and segmentation of glomeruli. In this study, we leverage the Glo-In-One toolkit to version 2 with fine-grained segmentation capabilities, curating 14 distinct labels for tissue regions, cells, and lesions across a dataset of 23,529 annotated glomeruli across human and mouse histopathology data. To our knowledge, this dataset is among the largest of its kind to date.In this study, we present a single dynamic head deep learning architecture designed to segment 14 classes within partially labeled images of human and mouse pathology data. Our model was trained using a training set derived from 368 annotated kidney whole-slide images (WSIs) to identify 5 key intraglomerular tissues covering Bowman's capsule, glomerular tuft, mesangium, mesangial cells, and podocytes. Additionally, the network segments 9 glomerular lesion classes including adhesion, capsular drop, global sclerosis, hyalinosis, mesangial lysis, microaneurysm, nodular sclerosis, mesangial expansion, and segmental sclerosis. The glomerulus segmentation model achieved a decent performance compared with baselines, and achieved a 76.5 % average Dice Similarity Coefficient (DSC). Additional, transfer learning from rodent to human for glomerular lesion segmentation model has enhanced the average segmentation accuracy across different types of lesions by more than 3 %, as measured by Dice scores. The Glo-In-One-v2 model and trained weight have been made publicly available at https: //github.com/hrlblab/Glo-In-One_v2.

Continual SFT Matches Multimodal RLHF with Negative Supervision

Multimodal RLHF usually happens after supervised finetuning (SFT) stage to continually improve vision-language models' (VLMs) comprehension. Conventional wisdom holds its superiority over continual SFT during this preference alignment stage. In this paper, we observe that the inherent value of multimodal RLHF lies in its negative supervision, the logit of the rejected responses. We thus propose a novel negative supervised finetuning (nSFT) approach that fully excavates these information resided. Our nSFT disentangles this negative supervision in RLHF paradigm, and continually aligns VLMs with a simple SFT loss. This is more memory efficient than multimodal RLHF where 2 (e.g., DPO) or 4 (e.g., PPO) large VLMs are strictly required. The effectiveness of nSFT is rigorously proved by comparing it with various multimodal RLHF approaches, across different dataset sources, base VLMs and evaluation metrics. Besides, fruitful of ablations are provided to support our hypothesis. We hope this paper will stimulate further research to properly align large vision language models.

Neural Internal Model Control: Learning a Robust Control Policy via Predictive Error Feedback

Accurate motion control in the face of disturbances within complex environments remains a major challenge in robotics. Classical model-based approaches often struggle with nonlinearities and unstructured disturbances, while RL-based methods can be fragile when encountering unseen scenarios. In this paper, we propose a novel framework, Neural Internal Model Control, which integrates model-based control with RL-based control to enhance robustness. Our framework streamlines the predictive model by applying Newton-Euler equations for rigid-body dynamics, eliminating the need to capture complex high-dimensional nonlinearities. This internal model combines model-free RL algorithms with predictive error feedback. Such a design enables a closed-loop control structure to enhance the robustness and generalizability of the control system. We demonstrate the effectiveness of our framework on both quadrotors and quadrupedal robots, achieving superior performance compared to state-of-the-art methods. Furthermore, real-world deployment on a quadrotor with rope-suspended payloads highlights the framework's robustness in sim-to-real transfer. Our code is released at https://github.com/thu-uav/NeuralIMC.

Towards Accurate and Efficient Sub-8-Bit Integer Training

Neural network training is a memory- and compute-intensive task. Quantization, which enables low-bitwidth formats in training, can significantly mitigate the workload. To reduce quantization error, recent methods have developed new data formats and additional pre-processing operations on quantizers. However, it remains quite challenging to achieve high accuracy and efficiency simultaneously. In this paper, we explore sub-8-bit integer training from its essence of gradient descent optimization. Our integer training framework includes two components: ShiftQuant to realize accurate gradient estimation, and L1 normalization to smoothen the loss landscape. ShiftQuant attains performance that approaches the theoretical upper bound of group quantization. Furthermore, it liberates group quantization from inefficient memory rearrangement. The L1 normalization facilitates the implementation of fully quantized normalization layers with impressive convergence accuracy. Our method frees sub-8-bit integer training from pre-processing and supports general devices. This framework achieves negligible accuracy loss across various neural networks and tasks ($0.92\%$ on 4-bit ResNets, $0.61\%$ on 6-bit Transformers). The prototypical implementation of ShiftQuant achieves more than $1.85\times/15.3\%$ performance improvement on CPU/GPU compared to its FP16 counterparts, and $33.9\%$ resource consumption reduction on FPGA than the FP16 counterparts. The proposed fully-quantized L1 normalization layers achieve more than $35.54\%$ improvement in throughout on CPU compared to traditional L2 normalization layers. Moreover, theoretical analysis verifies the advancement of our method.

WelQrate: Defining the Gold Standard in Small Molecule Drug Discovery Benchmarking

While deep learning has revolutionized computer-aided drug discovery, the AI community has predominantly focused on model innovation and placed less emphasis on establishing best benchmarking practices. We posit that without a sound model evaluation framework, the AI community's efforts cannot reach their full potential, thereby slowing the progress and transfer of innovation into real-world drug discovery. Thus, in this paper, we seek to establish a new gold standard for small molecule drug discovery benchmarking, WelQrate. Specifically, our contributions are threefold: WelQrate Dataset Collection - we introduce a meticulously curated collection of 9 datasets spanning 5 therapeutic target classes. Our hierarchical curation pipelines, designed by drug discovery experts, go beyond the primary high-throughput screen by leveraging additional confirmatory and counter screens along with rigorous domain-driven preprocessing, such as Pan-Assay Interference Compounds (PAINS) filtering, to ensure the high-quality data in the datasets; WelQrate Evaluation Framework - we propose a standardized model evaluation framework considering high-quality datasets, featurization, 3D conformation generation, evaluation metrics, and data splits, which provides a reliable benchmarking for drug discovery experts conducting real-world virtual screening; Benchmarking - we evaluate model performance through various research questions using the WelQrate dataset collection, exploring the effects of different models, dataset quality, featurization methods, and data splitting strategies on the results. In summary, we recommend adopting our proposed WelQrate as the gold standard in small molecule drug discovery benchmarking. The WelQrate dataset collection, along with the curation codes, and experimental scripts are all publicly available at WelQrate.org.