University of Oregon
Abstract:Gastric cancer remains a major cause of cancer mortality, yet its histological and molecular heterogeneity complicates diagnosis and risk stratification. General-purpose pathology foundation models (PFMs) often plateau on fine-grained endpoints central to gastric cancer care, and few have undergone rigorous prospective validation or clinical reader studies. We present GRACE, a Gastric-specific foundation model for Real-world Assessment and Clinical dEcision support. GRACE was developed from multicenter gastric pathology datasets totaling 48,364 primarily HE-stained whole-slide images from 37,493 patients. When evaluated on 28 clinically relevant tasks, GRACE consistently outperformed representative pancancer PFMs, achieving a macro-AUC of 0.9188, with strong performance for precancerous lesion diagnosis (macro-AUC 0.9322), tumor histopathological assessment (macro-AUC 0.9119), molecular profiling (macro-AUC 0.8682), and prognostic prediction. Beyond benchmarking, GRACE's translational value was substantiated through a rigorous evidence chain. Under safety-gated criteria requiring 100% NPV for rule-out and 100% PPV for rule-in, GRACE streamlined review for up to 69.6% of malignancy-diagnosis cases and triaged 46.8% of MMR-IHC follow-up requests. This translational feasibility was further strengthened by a randomized crossover reader study of pathologist-AI collaboration. With GRACE assistance, diagnostic accuracy improved from 82.0% to 89.9%, yielding nearly twofold higher adjusted odds of a correct diagnosis (OR 1.987) alongside concurrent gains in sensitivity and specificity. AI assistance also reduced diagnostic time by 14.9%, elevated diagnostic confidence by 9.0%, and markedly improved inter-rater agreement. When calibrated to maintain non-inferior performance to senior pathologists, the AI-assisted workflow could triage 60.7% of atrophy and 82.7% of intestinal metaplasia cases.
Abstract:Preference modeling plays a central role in reinforcement learning from human feedback (RLHF), enabling large language models (LLMs) to align with human values. However, most existing approaches assume a universal reward function, neglecting the diversity and heterogeneity of human preferences. To address this limitation without additional annotation costs, recent work has proposed learning multiple preference components from binary data and combining them to model individual preferences. Nevertheless, these components often fail to capture coherent and disentangled patterns, limiting their interpretability and effectiveness for personalization. In this work, we propose a sparse Mixture-of-Experts (MoE) reward model that encourages sparse routing and expert diversity during training on binary preference data. Across controlled and real-world experiments, sparse MoE learns interpretable routing patterns and specialized experts. It also improves test-time personalization, and post-adaptation shifts in expert weights provide a qualitative lens for analyzing how the model adapts to personalized preferences.
Abstract:Retargeting human motion to humanoid robots is critical for teleoperation, imitation learning and human-robot interaction. However, it remains challenging because of substantial morphological discrepancies between humans and robots, including differences in skeletal topology, limb proportions and degrees of freedom, as well as the scarcity of paired motion data. This paper presents Human2Humanoid, an unsupervised motion retargeting framework that transfers human motions to humanoid robot behaviors with high fidelity. To bridge the domain gap under unpaired data, we adopt a CycleGAN-based architecture equipped with a skeleton-aware graph convolutional network to capture topology-dependent motion features. To address cross-domain scale mismatches, we introduce a morphology-invariant end-effector consistency loss that aligns normalized end-effector trajectories to preserve motion semantics across embodiments. To improve physical plausibility and reduce contact artifacts, we impose explicit physics-aware feasibility constraints to encourage reproduction of the contact patterns in the source motion. Experimental results show that the proposed method successfully retargets human motion to the Unitree G1 humanoid robot without paired data, and outperforms existing methods in both downstream controllability and physical feasibility.
Abstract:As foundation models scale toward fusing more heterogeneous visual streams, understanding how diverse encoders interact under joint training becomes a prerequisite for principled design. Yet large vision-language models (LVLMs) currently lack the tools to do so, and parameter-efficient encoder configurations remain hard to identify before training. To re-examine encoder roles under joint training, on the 16-benchmark Cambrian-1 suite we retrain and evaluate all 31 non-empty subsets of five common vision encoders under a unified pipeline (~20k GPU-hours total), and report three findings. First, retraining each subset from scratch reveals encoder rankings that differ from those obtained by masking encoders on a fixed checkpoint, including which encoder ranks first overall. Second, we decompose each encoder's contribution into two axes, Capacity, the score an encoder reaches on its own, and Necessity, the drop when it is removed from the full pool. The two axes are not interchangeable. Pairing the two highest-Capacity encoders is suboptimal, while pairing a high-Capacity anchor with an adaptive complement matches the full five-encoder model. Adding further encoders beyond this pair yields only marginal gains. Third, at fixed parameter count, per-encoder pre-projector effective rank explains the residual score variation. The strongest pairs combine an anchor whose rank survives joint training with a complement whose rank expands under it, suggesting that higher-rank, less-collapsed projector inputs correspond to a more favorable optimization regime at the encoder-projector interface. Together, the Capacity-Necessity decomposition and the pre-projector rank analysis, along with comprehensive evaluation through retraining, expose a methodological gap in multi-encoder LVLM design, and offer concrete primitives for closing it.
Abstract:Expressive whole-body motion is important for humanoid robots operating in human environments, where robots are expected to move stably while presenting readable and adjustable body behaviors. However, most expressive motions are still obtained from fixed demonstrations or manually designed scripts, making it difficult to reuse a demonstrated style across different motion contents. Inspired by the way human motion styles convey affective and intentional cues through gait rhythm, posture, arm swing and body sway, this paper proposes a bionic generation-to-control framework for exemplar-driven style transfer on humanoid robots. Given a short human style exemplar and a target content motion, the proposed framework generates a stylized whole-body reference that preserves the intended motion content while transferring the demonstrated style. A physics-aware multi-condition latent diffusion model is developed to fuse style, content and trajectory conditions, and classifier-free guidance is used to adjust the style intensity without retraining. To improve hardware executability, contact-consistency and temporal-smoothness regularization are imposed on decoded motions during training. The generated references are then converted into G1-compatible robot references and executed by a preview-based whole-body tracking policy trained with a cluster-and-distill strategy. Simulation and Unitree G1 experiments show that the proposed method can transfer short human style exemplars to diverse robot motion contents, reduce contact and jitter artifacts compared with animation-oriented style-transfer baselines, and achieve a 96.0% success rate over 125 reported real-robot trials. The results demonstrate the feasibility of using short human motion exemplars as reusable bionic sources for physically executable expressive humanoid motion.
Abstract:Recent advances in Speech Large Language Models (Speech LLMs) have significantly enhanced spoken language understanding and reasoning. However, their contextual awareness is limited, struggling to perform speech recognition that effectively reflects the speaker's intent and topical context. In this paper, we propose LaSR (Latent Speech Reasoning), a novel training paradigm featuring a context-aware reasoning trajectory that leverages the latent reasoning process. Instead of generating explicit intermediate tokens, LaSR aligns chain-of-thought (CoT) supervision around the acoustic feature region of the targeted word, and introduces latent reasoning periods for context information grounding and transcriptional transition. Furthermore, to effectively benchmark contextual recognition on specialized vocabulary, we propose Spoken Darwin-Science, a large-scale corpus focusing on academic terminologies. Preliminary experiments on Fun-Audio-Chat demonstrate that LaSR significantly improves terminology recognition without introducing additional latency and consistently outperforms standard supervised fine-tuning baselines. Our findings highlight the potential of latent reasoning in building efficient, context-aware speech assistants.
Abstract:Tuning algorithms such as stochastic gradient descent (SGD) and stochastic gradient Langevin dynamics (SGLD) for approximate sampling and uncertainty quantification remains challenging, particularly in the practically relevant settings when the batch size is large or the model is misspecified. Existing theory that provides tuning guidance relies on continuous-time limits or strong statistical assumptions, which can become quantitatively inaccurate in these regimes. We address these shortcomings by proposing new discrete-time approximations to SG(L)D with and without momentum, which enables accurate predictions of the stationary covariance, iterate average covariance, and integrated autocorrelation time. Moreover, we prove quantitative, non-asymptotic error bounds showing that these estimates are sufficiently accurate for practical tuning and uncertainty quantification. Numerical experiments demonstrate that our theory yields improved tuning guidance across a range of models and data-generating distributions where existing approaches fail, including when using the $β$-divergence rather than log-loss to obtain statistically robust inferences.
Abstract:Multi-hop audio-visual reasoning remains challenging for Omni-LLMs, as relevant evidence is often sparse, temporally dispersed, and distributed across both audio and visual streams. Existing benchmarks provide limited investigation of this setting, typically involving only a limited number of modalities, relevant temporal segments, or reasoning steps. In this work, we introduce MOV-Bench, a benchmark containing 519 carefully curated questions that require multi-hop reasoning over temporally dispersed audio-visual evidence. Evaluations on MOV-Bench reveal that current Omni-LLMs still struggle with multi-hop cross-modal reasoning. To address this challenge, we further propose AOP-Agent, an efficient agentic framework built on open-source Omni-LLMs for active omni-modal perception. By combining a hierarchical omni-modal memory with a collaborative observe-reflect-replan loop, AOP-Agent enables open-source Omni-LLMs to perform active perception without additional training or proprietary models. Experiments on MOV-Bench and OmniVideoBench demonstrate that AOP-Agent consistently improves reasoning performance, with particularly notable gains on long videos and reasoning-intensive questions.
Abstract:Recent advances in large language models (LLMs) have facilitated the widespread deployment of LLMs as interactive agents capable of reasoning, planning, and tool use. Despite strong performance on existing benchmarks, such agents often exhibit notable degradation when deployed in real-world settings, where environments are inherently stochastic and imperfect. We argue that this discrepancy arises from a fundamental mismatch between idealized training settings and real-world interaction dynamics, where current paradigms rely on carefully curated task instructions and stable, well-controlled environments. To address this gap, we propose NoisyAgent, an agentic training framework that explicitly incorporates environmental imperfections into the agent learning process. We identify two major sources of interaction noise in real-world scenarios: user noise, which captures ambiguity and variability in user interaction, and tool noise, which reflects failures and anomalies in tool execution. We introduce such perturbations into the training pipeline by modifying user interaction patterns and simulating tool execution results within the training environment. To stabilize training while encouraging agents to handle increasingly challenging imperfections, noise is applied to only a subset of rollouts and progressively increased in difficulty as the model adapts to the current noise level. Extensive experiments demonstrate that our approach consistently improves agent robustness under noisy and dynamic environments. Our analysis reveals that training under noise conditions also yields performance gains on idealized benchmarks, suggesting that controlled exposure to environmental noise promotes more generalizable reasoning and decision-making behaviors. Our findings highlight the importance of modeling interaction imperfections for bridging the gap between agent training and real-world deployment.
Abstract:We introduce JetViT, a novel family of hybrid-architecture Vision Transformer (ViT) models that match the accuracy of state-of-the-art full-attention vision foundation models while achieving substantially higher inference efficiency on high-resolution images. At the core of our approach is Post-Training Attention Search, a post-training acceleration framework that converts pre-trained full-attention ViTs into efficient hybrid-attention variants by identifying and replacing redundant full-attention blocks with linear or window-attention blocks. By inheriting the MLP and attention weights from the base model, Post-Training Attention Search efficiently explores the architectural design space through three key steps: (1) optimizing the linear-attention block design; (2) finding the best combination of linear-attention and window-attention blocks; and (3) identifying and preserving critical full-attention blocks. We evaluate JetViT on two representative high-resolution vision foundation models, DINOv3 and DepthAnythingV2. On the NVIDIA H100 GPU, JetViT achieves up to 1.79x higher throughput and up to 44.81% lower latency without sacrificing accuracy. We will release our code and accelerated ViT models soon.