Physical formula enhanced multi-task learning for pharmacokinetics prediction

Artificial intelligence (AI) technology has demonstrated remarkable potential in drug dis-covery, where pharmacokinetics plays a crucial role in determining the dosage, safety, and efficacy of new drugs. A major challenge for AI-driven drug discovery (AIDD) is the scarcity of high-quality data, which often requires extensive wet-lab work. A typical example of this is pharmacokinetic experiments. In this work, we develop a physical formula enhanced mul-ti-task learning (PEMAL) method that predicts four key parameters of pharmacokinetics simultaneously. By incorporating physical formulas into the multi-task framework, PEMAL facilitates effective knowledge sharing and target alignment among the pharmacokinetic parameters, thereby enhancing the accuracy of prediction. Our experiments reveal that PEMAL significantly lowers the data demand, compared to typical Graph Neural Networks. Moreover, we demonstrate that PEMAL enhances the robustness to noise, an advantage that conventional Neural Networks do not possess. Another advantage of PEMAL is its high flexibility, which can be potentially applied to other multi-task machine learning scenarios. Overall, our work illustrates the benefits and potential of using PEMAL in AIDD and other scenarios with data scarcity and noise.

ICMC-ASR: The ICASSP 2024 In-Car Multi-Channel Automatic Speech Recognition Challenge

To promote speech processing and recognition research in driving scenarios, we build on the success of the Intelligent Cockpit Speech Recognition Challenge (ICSRC) held at ISCSLP 2022 and launch the ICASSP 2024 In-Car Multi-Channel Automatic Speech Recognition (ICMC-ASR) Challenge. This challenge collects over 100 hours of multi-channel speech data recorded inside a new energy vehicle and 40 hours of noise for data augmentation. Two tracks, including automatic speech recognition (ASR) and automatic speech diarization and recognition (ASDR) are set up, using character error rate (CER) and concatenated minimum permutation character error rate (cpCER) as evaluation metrics, respectively. Overall, the ICMC-ASR Challenge attracts 98 participating teams and receives 53 valid results in both tracks. In the end, first-place team USTCiflytek achieves a CER of 13.16% in the ASR track and a cpCER of 21.48% in the ASDR track, showing an absolute improvement of 13.08% and 51.4% compared to our challenge baseline, respectively.

Knowledge Enhanced Conditional Imputation for Healthcare Time-series

This study presents a novel approach to addressing the challenge of missing data in multivariate time series, with a particular focus on the complexities of healthcare data. Our Conditional Self-Attention Imputation (CSAI) model, grounded in a transformer-based framework, introduces a conditional hidden state initialization tailored to the intricacies of medical time series data. This methodology diverges from traditional imputation techniques by specifically targeting the imbalance in missing data distribution, a crucial aspect often overlooked in healthcare datasets. By integrating advanced knowledge embedding and a non-uniform masking strategy, CSAI adeptly adjusts to the distinct patterns of missing data in Electronic Health Records (EHRs).

U2-KWS: Unified Two-pass Open-vocabulary Keyword Spotting with Keyword Bias

Open-vocabulary keyword spotting (KWS), which allows users to customize keywords, has attracted increasingly more interest. However, existing methods based on acoustic models and post-processing train the acoustic model with ASR training criteria to model all phonemes, making the acoustic model under-optimized for the KWS task. To solve this problem, we propose a novel unified two-pass open-vocabulary KWS (U2-KWS) framework inspired by the two-pass ASR model U2. Specifically, we employ the CTC branch as the first stage model to detect potential keyword candidates and the decoder branch as the second stage model to validate candidates. In order to enhance any customized keywords, we redesign the U2 training procedure for U2-KWS and add keyword information by audio and text cross-attention into both branches. We perform experiments on our internal dataset and Aishell-1. The results show that U2-KWS can achieve a significant relative wake-up rate improvement of 41% compared to the traditional customized KWS systems when the false alarm rate is fixed to 0.5 times per hour.

NExT-Chat: An LMM for Chat, Detection and Segmentation

The development of large language models (LLMs) has greatly advanced the field of multimodal understanding, leading to the emergence of large multimodal models (LMMs). In order to enhance the level of visual comprehension, recent studies have equipped LMMs with region-level understanding capabilities by representing object bounding box coordinates as a series of text sequences (pixel2seq). In this paper, we introduce a novel paradigm for object location modeling called pixel2emb method, where we ask the LMM to output the location embeddings and then decoded by different decoders. This paradigm allows for different location formats (such as bounding boxes and masks) to be used in multimodal conversations Furthermore, this kind of embedding based location modeling enables the utilization of existing practices in localization tasks, such as detection and segmentation. In scenarios with limited resources, our pixel2emb demonstrates superior performance compared to existing state-of-the-art (SOTA) approaches in both the location input and output tasks under fair comparison. Leveraging the proposed pixel2emb method, we train an LMM named NExT-Chat and demonstrate its capability of handling multiple tasks like visual grounding, region caption, and grounded reasoning.

Spike-Triggered Contextual Biasing for End-to-End Mandarin Speech Recognition

The attention-based deep contextual biasing method has been demonstrated to effectively improve the recognition performance of end-to-end automatic speech recognition (ASR) systems on given contextual phrases. However, unlike shallow fusion methods that directly bias the posterior of the ASR model, deep biasing methods implicitly integrate contextual information, making it challenging to control the degree of bias. In this study, we introduce a spike-triggered deep biasing method that simultaneously supports both explicit and implicit bias. Moreover, both bias approaches exhibit significant improvements and can be cascaded with shallow fusion methods for better results. Furthermore, we propose a context sampling enhancement strategy and improve the contextual phrase filtering algorithm. Experiments on the public WenetSpeech Mandarin biased-word dataset show a 32.0% relative CER reduction compared to the baseline model, with an impressively 68.6% relative CER reduction on contextual phrases.

Adaptive Contextual Biasing for Transducer Based Streaming Speech Recognition

By incorporating additional contextual information, deep biasing methods have emerged as a promising solution for speech recognition of personalized words. However, for real-world voice assistants, always biasing on such personalized words with high prediction scores can significantly degrade the performance of recognizing common words. To address this issue, we propose an adaptive contextual biasing method based on Context-Aware Transformer Transducer (CATT) that utilizes the biased encoder and predictor embeddings to perform streaming prediction of contextual phrase occurrences. Such prediction is then used to dynamically switch the bias list on and off, enabling the model to adapt to both personalized and common scenarios. Experiments on Librispeech and internal voice assistant datasets show that our approach can achieve up to 6.7% and 20.7% relative reduction in WER and CER compared to the baseline respectively, mitigating up to 96.7% and 84.9% of the relative WER and CER increase for common cases. Furthermore, our approach has a minimal performance impact in personalized scenarios while maintaining a streaming inference pipeline with negligible RTF increase.

Contextualized End-to-End Speech Recognition with Contextual Phrase Prediction Network

Contextual information plays a crucial role in speech recognition technologies and incorporating it into the end-to-end speech recognition models has drawn immense interest recently. However, previous deep bias methods lacked explicit supervision for bias tasks. In this study, we introduce a contextual phrase prediction network for an attention-based deep bias method. This network predicts context phrases in utterances using contextual embeddings and calculates bias loss to assist in the training of the contextualized model. Our method achieved a significant word error rate (WER) reduction across various end-to-end speech recognition models. Experiments on the LibriSpeech corpus show that our proposed model obtains a 12.1% relative WER improvement over the baseline model, and the WER of the context phrases decreases relatively by 40.5%. Moreover, by applying a context phrase filtering strategy, we also effectively eliminate the WER degradation when using a larger biasing list.