Weakly Supervised Teacher-Student Framework with Progressive Pseudo-mask Refinement for Gland Segmentation

Background and objectives: Colorectal cancer histopathological grading depends on accurate segmentation of glandular structures. Current deep learning approaches rely on large scale pixel level annotations that are labor intensive and difficult to obtain in routine clinical practice. Weakly supervised semantic segmentation offers a promising alternative. However, class activation map based methods often produce incomplete pseudo masks that emphasize highly discriminative regions and fail to supervise unannotated glandular structures. We propose a weakly supervised teacher student framework that leverages sparse pathologist annotations and an Exponential Moving Average stabilized teacher network to generate refined pseudo masks. Methods: The framework integrates confidence based filtering, adaptive fusion of teacher predictions with limited ground truth, and curriculum guided refinement to progressively segment unannotated glandular regions. The method was evaluated on an institutional colorectal cancer cohort from The Ohio State University Wexner Medical Center consisting of 60 hematoxylin and eosin stained whole slide images and on public datasets including the Gland Segmentation dataset, TCGA COAD, TCGA READ, and SPIDER. Results: On the Gland Segmentation dataset the framework achieved a mean Intersection over Union of 80.10 and a mean Dice coefficient of 89.10. Cross cohort evaluation demonstrated robust generalization on TCGA COAD and TCGA READ without additional annotations, while reduced performance on SPIDER reflected domain shift. Conclusions: The proposed framework provides an annotation efficient and generalizable approach for gland segmentation in colorectal histopathology.

Learning Bimanual Cloth Manipulation with Vision-based Tactile Sensing via Single Robotic Arm

Robotic cloth manipulation remains challenging due to the high-dimensional state space of fabrics, their deformable nature, and frequent occlusions that limit vision-based sensing. Although dual-arm systems can mitigate some of these issues, they increase hardware and control complexity. This paper presents Touch G.O.G., a compact vision-based tactile gripper and perception/control framework for single-arm bimanual cloth manipulation. The proposed framework combines three key components: (1) a novel gripper design and control strategy for in-gripper cloth sliding with a single robot arm, (2) a Vision Foundation Model-backboned Vision Transformer pipeline for cloth part classification (PC-Net) and edge pose estimation (PE-Net) using real and synthetic tactile images, and (3) an encoder-decoder synthetic data generator (SD-Net) that reduces manual annotation by producing high-fidelity tactile images. Experiments show 96% accuracy in distinguishing edges, corners, interior regions, and grasp failures, together with sub-millimeter edge localization and 4.5° orientation error. Real-world results demonstrate reliable cloth unfolding, even for crumpled fabrics, using only a single robotic arm. These results highlight Touch G.O.G. as a compact and cost-effective solution for deformable object manipulation.

PathoScribe: Transforming Pathology Data into a Living Library with a Unified LLM-Driven Framework for Semantic Retrieval and Clinical Integration

Pathology underpins modern diagnosis and cancer care, yet its most valuable asset, the accumulated experience encoded in millions of narrative reports, remains largely inaccessible. Although institutions are rapidly digitizing pathology workflows, storing data without effective mechanisms for retrieval and reasoning risks transforming archives into a passive data repository, where institutional knowledge exists but cannot meaningfully inform patient care. True progress requires not only digitization, but the ability for pathologists to interrogate prior similar cases in real time while evaluating a new diagnostic dilemma. We present PathoScribe, a unified retrieval-augmented large language model (LLM) framework designed to transform static pathology archives into a searchable, reasoning-enabled living library. PathoScribe enables natural language case exploration, automated cohort construction, clinical question answering, immunohistochemistry (IHC) panel recommendation, and prompt-controlled report transformation within a single architecture. Evaluated on 70,000 multi-institutional surgical pathology reports, PathoScribe achieved perfect Recall@10 for natural language case retrieval and demonstrated high-quality retrieval-grounded reasoning (mean reviewer score 4.56/5). Critically, the system operationalized automated cohort construction from free-text eligibility criteria, assembling research-ready cohorts in minutes (mean 9.2 minutes) with 91.3% agreement to human reviewers and no eligible cases incorrectly excluded, representing orders-of-magnitude reductions in time and cost compared to traditional manual chart review. This work establishes a scalable foundation for converting digital pathology archives from passive storage systems into active clinical intelligence platforms.

Latent-DARM: Bridging Discrete Diffusion And Autoregressive Models For Reasoning

Most multi-agent systems rely exclusively on autoregressive language models (ARMs) that are based on sequential generation. Although effective for fluent text, ARMs limit global reasoning and plan revision. On the other hand, Discrete Diffusion Language Models (DDLMs) enable non-sequential, globally revisable generation and have shown strong planning capabilities, but their limited text fluency hinders direct collaboration with ARMs. We introduce Latent-DARM, a latent-space communication framework bridging DDLM (planners) and ARM (executors), maximizing collaborative benefits. Across mathematical, scientific, and commonsense reasoning benchmarks, Latent-DARM outperforms text-based interfaces on average, improving accuracy from 27.0% to 36.0% on DART-5 and from 0.0% to 14.0% on AIME2024. Latent-DARM approaches the results of state-of-the-art reasoning models while using less than 2.2% of its token budget. This work advances multi-agent collaboration among agents with heterogeneous models.

Unifying Language-Action Understanding and Generation for Autonomous Driving

Vision-Language-Action (VLA) models are emerging as a promising paradigm for end-to-end autonomous driving, valued for their potential to leverage world knowledge and reason about complex driving scenes. However, existing methods suffer from two critical limitations: a persistent misalignment between language instructions and action outputs, and the inherent inefficiency of typical auto-regressive action generation. In this paper, we introduce LinkVLA, a novel architecture that directly addresses these challenges to enhance both alignment and efficiency. First, we establish a structural link by unifying language and action tokens into a shared discrete codebook, processed within a single multi-modal model. This structurally enforces cross-modal consistency from the ground up. Second, to create a deep semantic link, we introduce an auxiliary action understanding objective that trains the model to generate descriptive captions from trajectories, fostering a bidirectional language-action mapping. Finally, we replace the slow, step-by-step generation with a two-step coarse-to-fine generation method C2F that efficiently decodes the action sequence, saving 86% inference time. Experiments on closed-loop driving benchmarks show consistent gains in instruction following accuracy and driving performance, alongside reduced inference latency.

Demonstrating ViviDoc: Generating Interactive Documents through Human-Agent Collaboration

Interactive articles help readers engage with complex ideas through exploration, yet creating them remains costly, requiring both domain expertise and web development skills. Recent LLM-based agents can automate content creation, but naively applying them yields uncontrollable and unverifiable outputs. We present ViviDoc, a human-agent collaborative system that generates interactive educational documents from a single topic input. ViviDoc introduces a multi-agent pipeline (Planner, Executor, Evaluator) and the Document Specification (DocSpec), a human-readable intermediate representation that decomposes each interactive visualization into State, Render, Transition, and Constraint components. The DocSpec enables educators to review and refine generation plans before code is produced, bridging the gap between pedagogical intent and executable output. Expert evaluation and a user study show that ViviDoc substantially outperforms naive agentic generation and provides an intuitive editing experience. Our project homepage is available at https://vividoc-homepage.vercel.app/.

Biomechanical Comparisons Reveal Divergence of Human and Humanoid Gaits

It remains challenging to achieve human-like locomotion in legged robots due to fundamental discrepancies between biological and mechanical structures. Although imitation learning has emerged as a promising approach for generating natural robotic movements, simply replicating joint angle trajectories fails to capture the underlying principles of human motion. This study proposes a Gait Divergence Analysis Framework (GDAF), a unified biomechanical evaluation framework that systematically quantifies kinematic and kinetic discrepancies between humans and bipedal robots. We apply GDAF to systematically compare human and humanoid locomotion across 28 walking speeds. To enable reproducible analysis, we collect and release a speed-continuous humanoid locomotion dataset from a state-of-the-art humanoid controller. We further provide an open-source implementation of GDAF, including analysis, visualization, and MuJoCo-based tools, enabling quantitative, interpretable, and reproducible biomechanical analysis of humanoid locomotion. Results demonstrate that despite visually human-like motion generated by modern humanoid controllers, significant biomechanical divergence persists across speeds. Robots exhibit systematic deviations in gait symmetry, energy distribution, and joint coordination, indicating that substantial room remains for improving the biomechanical fidelity and energetic efficiency of humanoid locomotion. This work provides a quantitative benchmark for evaluating humanoid locomotion and offers data and versatile tools to support the development of more human-like and energetically efficient locomotion controllers. The data and code will be made publicly available upon acceptance of the paper.

UrbanFM: Scaling Urban Spatio-Temporal Foundation Models

Urban systems, as dynamic complex systems, continuously generate spatio-temporal data streams that encode the fundamental laws of human mobility and city evolution. While AI for Science has witnessed the transformative power of foundation models in disciplines like genomics and meteorology, urban computing remains fragmented due to "scenario-specific" models, which are overfitted to specific regions or tasks, hindering their generalizability. To bridge this gap and advance spatio-temporal foundation models for urban systems, we adopt scaling as the central perspective and systematically investigate two key questions: what to scale and how to scale. Grounded in first-principles analysis, we identify three critical dimensions: heterogeneity, correlation, and dynamics, aligning these principles with the fundamental scientific properties of urban spatio-temporal data. Specifically, to address heterogeneity through data scaling, we construct WorldST. This billion-scale corpus standardizes diverse physical signals, such as traffic flow and speed, from over 100 global cities into a unified data format. To enable computation scaling for modeling correlations, we introduce the MiniST unit, a novel split mechanism that discretizes continuous spatio-temporal fields into learnable computational units to unify representations of grid-based and sensor-based observations. Finally, addressing dynamics via architecture scaling, we propose UrbanFM, a minimalist self-attention architecture designed with limited inductive biases to autonomously learn dynamic spatio-temporal dependencies from massive data. Furthermore, we establish EvalST, the largest-scale urban spatio-temporal benchmark to date. Extensive experiments demonstrate that UrbanFM achieves remarkable zero-shot generalization across unseen cities and tasks, marking a pivotal first step toward large-scale urban spatio-temporal foundation models.

Test-Time Learning of Causal Structure from Interventional Data

Supervised causal learning has shown promise in causal discovery, yet it often struggles with generalization across diverse interventional settings, particularly when intervention targets are unknown. To address this, we propose TICL (Test-time Interventional Causal Learning), a novel method that synergizes Test-Time Training with Joint Causal Inference. Specifically, we design a self-augmentation strategy to generate instance-specific training data at test time, effectively avoiding distribution shifts. Furthermore, by integrating joint causal inference, we developed a PC-inspired two-phase supervised learning scheme, which effectively leverages self-augmented training data while ensuring theoretical identifiability. Extensive experiments on bnlearn benchmarks demonstrate TICL's superiority in multiple aspects of causal discovery and intervention target detection.

Learning from Complexity: Exploring Dynamic Sample Pruning of Spatio-Temporal Training

Spatio-temporal forecasting is fundamental to intelligent systems in transportation, climate science, and urban planning. However, training deep learning models on the massive, often redundant, datasets from these domains presents a significant computational bottleneck. Existing solutions typically focus on optimizing model architectures or optimizers, while overlooking the inherent inefficiency of the training data itself. This conventional approach of iterating over the entire static dataset each epoch wastes considerable resources on easy-to-learn or repetitive samples. In this paper, we explore a novel training-efficiency techniques, namely learning from complexity with dynamic sample pruning, ST-Prune, for spatio-temporal forecasting. Through dynamic sample pruning, we aim to intelligently identify the most informative samples based on the model's real-time learning state, thereby accelerating convergence and improving training efficiency. Extensive experiments conducted on real-world spatio-temporal datasets show that ST-Prune significantly accelerates the training speed while maintaining or even improving the model performance, and it also has scalability and universality.