Skill-Augmented AI Agents for Medical Research Analysis: An Exploratory Multi-Model Human Evaluation in an NSCLC Transcriptomic Biomarker Task

Background. Large language models and AI agents are increasingly used to support biomedical research, but native model outputs may omit key analytical steps, misuse methods, or overstate conclusions. We evaluated whether autonomous access to a medical research skill package was associated with higher-quality AI-generated transcriptomic research-analysis outputs compared with native AI without skills. Methods. We conducted an exploratory multi-model human evaluation using a non-small cell lung cancer immunotherapy biomarker task. Six model backbones were tested. The evaluation included 21 anonymized outputs: 9 native-AI outputs and 12 skill-augmented outputs generated through an AI agent implementation represented by OpenClaw. Four non-expert biomedical reviewers and two blinded experts evaluated each output, with two ratings from each reviewer type. The primary outcome was expert-rated overall quality. Results. Skill-augmented outputs showed directionally higher expert overall quality than native-AI outputs (mean 5.50 vs 5.11; difference=0.39; bootstrap 95\% CI, -0.04 to 0.90; Welch p=0.156). Non-expert reviewer quality showed the same direction (mean 4.72 vs 4.47; difference=0.26; bootstrap 95\% CI, -0.25 to 0.80; Welch p=0.373). Expert agreement was limited (single-rating ICC=-0.15), and model-specific effects were descriptive and heterogeneous. Conclusions. Autonomous skill access showed a directional quality signal in this exploratory sample, but the signal was smaller than expert-rating noise and should not be interpreted as confirmatory evidence. The findings primarily motivate larger evaluations of skill-augmented AI agents with stronger reliability controls, platform replication, and biological-validity assessment.

Kwai Keye-VL-2.0 Technical Report

We introduce Kwai Keye-VL-2.0-30B-A3B, an open-source Mixture-of-Experts (MoE) multimodal foundation model designed to advance long-video understanding and agentic intelligence. To address the challenges of ultra-long contexts, information redundancy, and prohibitive computational costs inherent in hour-level videos, Keye-VL-2.0 is the first to adapt DeepSeek Sparse Attention (DSA) to GQA-based multimodal architectures, enabling lossless 256K context processing while capturing critical frames and long-range temporal dependencies. This architecture is underpinned by a highly optimized training and inference infrastructure, including scalable video I/O, heterogeneous ViT-LM parallelism, and custom DSA kernels that significantly maximize throughput and minimize computational overhead. Furthermore, to overcome the algorithmic dilemma of catastrophic forgetting during multi-task alignment, we introduce Cross-Modal Multi-Teacher On-Policy Distillation (MOPD) paired with Context-RL and Video-RL. By distilling dense token-level teacher feedback from on-policy rollouts back into the MoE backbone, which activates only 3B parameters, Keye-VL-2.0 natively empowers advanced agent collaboration across Code, Tool, and Search scenarios with multimodal self-correction. Extensive evaluations across video understanding, temporal grounding, reasoning, STEM, and agent benchmarks demonstrate that Keye-VL-2.0-30B-A3B achieves state-of-the-art performance among models of similar scale, particularly excelling in fine-grained temporal localization on TimeLens and long-video comprehension on Video-MME-v2 and LongVideoBench. We release our model checkpoints to accelerate community progress toward scalable and robust multimodal agentic applications.

EPS3D: End-to-End Feed-Forward 3D Panoptic Segmentation

This paper introduces EPS3D, a new end-to-end feed-forward framework for open-vocabulary 3D panoptic segmentation. Unlike existing methods relying on additional preprocessing, we design an end-to-end architecture, with a distillation-based training strategy on diverse 3D scenes to predict 3D-aware semantic and instance features from multi-view images, improving 3D consistency and avoiding error accumulation. We further propose a mutual enhancement module to enforce inherent semantic-instance consistency. By aligning semantics within instances (Ins2Sem) and refining instance features with semantic guidance (Sem2Ins), we achieve more coherent 3D scene understanding. Ultimately, EPS3D outperforms SOTA baselines on two benchmarks (e.g., +13% mIoU for semantics on Replica) with high efficiency (e.g., 1s per scene), supporting tasks like robotic manipulation and 3D scene editing.

M$^3$Exam: Benchmarking Multimodal Memory for Realistic User-Agent Interactions

Language agents are increasingly deployed over accumulating multimodal information, yet existing benchmarks assume a human-human form with sparse visuals and straightforward content, evaluating neither reasoning over authentic multimodal file interaction nor the interpretation of concealed user information. We therefore introduce M$^3$Exam, a query-centric multimodal conversational memory benchmark built on realistic user-agent interaction, with multi-dimensional evaluation spanning cross-modal grounding and implicit information inference. Benchmarking MLLMs and memory systems reveals persistent gaps in cross-modal grounding, cross session reasoning, and the efficiency cost of accumulating multimodal context. We further propose M$^3$Proctor, a multimodal memory method that detects query modality bias and consumes raw visual sources only on demand, improving accuracy by 13% while cutting index-construction time and retrieved tokens by over 70%.

Beyond Matching: Category-Guided Latent Intent Reasoning for Generative Retrieval in E-Commerce

Generative retrieval offers a new paradigm for e-commerce search by mapping user queries directly to product Semantic Identifiers (SIDs). However, e-commerce queries are often short, noisy, attribute-heavy, and associated with multiple category-consistent products, creating a substantial representation gap between natural-language shopping intent and artificially constructed item SIDs. Explicit Chain-of-Thought (CoT) reasoning can help bridge this gap, but its extra generation cost is difficult to reconcile with the low-latency requirements of online e-commerce systems. To address this challenge, we propose CaLIR (Category-guided Latent Intent Reasoning), a category-guided latent intent reasoning framework for e-commerce generative retrieval. Rather than generating explicit textual rationales, CaLIR learns continuous latent intent states before SID decoding and uses product category hierarchies as a natural scaffold for coarse-to-fine intent reasoning. Specifically, we introduce hierarchical semantic reasoning to align latent states with category-level shopping intent, and query-wise reasoning enhancement to model diverse intent paths under multi-positive queries. CaLIR further combines a query-specific dynamic prefix trie, assembled from pre-indexed category-level tries, with reasoning-aware constrained decoding. Experiments on multilingual e-commerce search datasets show that CaLIR achieves a better balance between retrieval effectiveness and inference efficiency than existing methods, while also demonstrating transferability and robustness across induced hierarchies and different generative backbones.

ProSPy: A Profiling-Driven SQL-Python Agentic Framework for Enterprise Text-to-SQL

Large language models have substantially advanced Text-to-SQL systems, yet applying them to enterprise-scale databases remains challenging. Real-world databases often contain large and heterogeneous schemas, incomplete metadata, dialect-specific SQL syntax, and complex analytical questions that are difficult to solve with a single SQL query. To address these challenges, we propose ProSPy, a Profiling-driven SQL--Python agentic framework for enterprise-scale Text-to-SQL. ProSPy structures the reasoning process into four stages: it first extracts fine-grained data evidence through automatic profiling, progressively prunes large schemas into task-relevant contexts, fetches intermediate views through a dialect-agnostic SQL interface, and finally performs flexible downstream analysis with Python. This design combines the efficiency of SQL over large databases with the flexibility of Python-based analysis, while reducing reliance on unreliable metadata and improving robustness across SQL dialects. Experiments on Spider 2.0-Lite and Spider 2.0-Snow show that ProSPy consistently outperforms strong baselines with both open-source and proprietary models, achieving execution accuracies of 60.15% and 60.51% with Claude-4.5-Opus, without majority voting. Further analysis shows that ProSPy is robust to SQL dialect variations and achieves a favorable trade-off between schema recall and precision.

LifeSide: Benchmarking Agents as Lifelong Digital Companions

Lifelong digital companions must integrate cross-session cues, continually update their understanding of users, and adapt to shifting privacy boundaries. Existing evaluations fail to capture this, testing memory recall and short-term empathy in isolation. To bridge this gap, we introduce \benchmark, a benchmark centered on multi-session \textit{Memory-Emotion-Environment} loops. By modeling users as persistent worlds with layered profiles and event trajectories, \benchmark uses multi-agent simulation to project environmental dynamics into dialogue, preserving the critical gap between latent thoughts and observable expressions. Evaluating 2,000 personas and 111K tasks across memory tracking, user understanding, privacy control, and emotional companionship, our experiment results reveal a stark reality: even models that saturate current memory benchmarks fail to sustain accurate user understanding and true companionship over long horizons.

Message Tuning Outshines Graph Prompt Tuning: A Prismatic Space Perspective

Graph Foundation Models (GFMs), built upon the Pre-training and Adaptation paradigm, have emerged as a research hotspot in graph learning. For GNN-based GFMs, graph prompt tuning has become the prevailing adaptation method for downstream tasks. Although recent methods explain why graph prompt tuning works, how to rigorously measure its adaptation capacity remains an open problem. Addressing this problem is critical for understanding the capability limits of graph prompt tuning and for developing more powerful adaptation methods. In this paper, we propose Prismatic Space Theory (PS-Theory), a novel mathematical framework to quantify the capacity of adaptation methods, while focusing on establishing the upper bound for the adaptation capacity of graph prompt tuning. Building upon the proposed PS-Theory, we further introduce Message Tuning for GFMs (MTG), a lightweight approach that injects a small set of learnable message prototypes into each layer of the GNN backbone to adaptively guide message fusion without updating pre-trained weights. Through our PS-Theory, we prove that the adaptation capacity of MTG can exceed the theoretical upper bound of graph prompt tuning. Extensive experiments demonstrate that MTG consistently outperforms graph prompt baselines across diverse benchmark datasets, providing strong empirical support for our theoretical findings.

EviLink: Multi-Path Schema Linking with Uncertainty-Guided Evidence Acquisition for Large-Scale Text-to-SQL

Schema linking is a difficult and important step in large-scale Text-to-SQL, where systems must identify a compact yet sufficient schema context from large and ambiguous databases. Existing methods often treat schema linking as deterministic selection around a single SQL path, but complex questions may admit multiple valid realizations with different schema needs. We reframe schema linking as uncertainty-aware schema-need inference over multiple plausible SQL paths, where the system distinguishes required schema items from path-dependent uncertain ones and acquires evidence only where needed. We instantiate this reframing with EviLink, which combines multi-hypothesis schema grounding with uncertainty-guided evidence acquisition. Experiments on BIRD-Dev and Spider2-Snow show that this perspective improves the balance among schema completeness, schema relevance, and token cost. On Spider2-Snow, EviLink achieves 90.15% field-level strict recall rate, uses 123.30K average tokens, and improves downstream SQL generation under a fixed generator.

The Stability of Singular Distribution: A Spectral Perspective on the Two-Phase Dynamics of Language Model Pre-training

Large language model pre-training typically exhibits a two-phase trajectory: a fast initial loss drop followed by a prolonged slow improvement. We identify an underlying spectral phenomenon, Stability of Singular Distribution (SoSD), where the trace-normalized singular value spectrum stabilizes early, even as parameter matrices continue to evolve. We demonstrate that synchronization between SoSD and the slow-descent regime is widely observed across diverse architectures (GPT-2, LLaMA) and settings, including various schedules (Step-wise, WSD, Cosine Decay), weight decays, and optimizers (AdamW, Muon). By analyzing a simplified Transformer, we prove that growing weight norms inevitably precipitate an early SoSD threshold, after which the rate of loss decrease becomes theoretically bounded by the variation in the singular distribution. We further interpret strategies like WSD and Muon through their ability to modulate the SoSD scale, offering a spectral lens for understanding efficient pre-training dynamics.