One-shot synthesis of rare gastrointestinal lesions improves diagnostic accuracy and clinical training

Rare gastrointestinal lesions are infrequently encountered in routine endoscopy, restricting the data available for developing reliable artificial intelligence (AI) models and training novice clinicians. Here we present EndoRare, a one-shot, retraining-free generative framework that synthesizes diverse, high-fidelity lesion exemplars from a single reference image. By leveraging language-guided concept disentanglement, EndoRare separates pathognomonic lesion features from non-diagnostic attributes, encoding the former into a learnable prototype embedding while varying the latter to ensure diversity. We validated the framework across four rare pathologies (calcifying fibrous tumor, juvenile polyposis syndrome, familial adenomatous polyposis, and Peutz-Jeghers syndrome). Synthetic images were judged clinically plausible by experts and, when used for data augmentation, significantly enhanced downstream AI classifiers, improving the true positive rate at low false-positive rates. Crucially, a blinded reader study demonstrated that novice endoscopists exposed to EndoRare-generated cases achieved a 0.400 increase in recall and a 0.267 increase in precision. These results establish a practical, data-efficient pathway to bridge the rare-disease gap in both computer-aided diagnostics and clinical education.

Entropy-Guided Token Dropout: Training Autoregressive Language Models with Limited Domain Data

As access to high-quality, domain-specific data grows increasingly scarce, multi-epoch training has become a practical strategy for adapting large language models (LLMs). However, autoregressive models often suffer from performance degradation under repeated data exposure, where overfitting leads to a marked decline in model capability. Through empirical analysis, we trace this degradation to an imbalance in learning dynamics: predictable, low-entropy tokens are learned quickly and come to dominate optimization, while the model's ability to generalize on high-entropy tokens deteriorates with continued training. To address this, we introduce EntroDrop, an entropy-guided token dropout method that functions as structured data regularization. EntroDrop selectively masks low-entropy tokens during training and employs a curriculum schedule to adjust regularization strength in alignment with training progress. Experiments across model scales from 0.6B to 8B parameters show that EntroDrop consistently outperforms standard regularization baselines and maintains robust performance throughout extended multi-epoch training. These findings underscore the importance of aligning regularization with token-level learning dynamics when training on limited data. Our approach offers a promising pathway toward more effective adaptation of LLMs in data-constrained domains.

Enabling Ultra-Fast Cardiovascular Imaging Across Heterogeneous Clinical Environments with a Generalist Foundation Model and Multimodal Database

Multimodal cardiovascular magnetic resonance (CMR) imaging provides comprehensive and non-invasive insights into cardiovascular disease (CVD) diagnosis and underlying mechanisms. Despite decades of advancements, its widespread clinical adoption remains constrained by prolonged scan times and heterogeneity across medical environments. This underscores the urgent need for a generalist reconstruction foundation model for ultra-fast CMR imaging, one capable of adapting across diverse imaging scenarios and serving as the essential substrate for all downstream analyses. To enable this goal, we curate MMCMR-427K, the largest and most comprehensive multimodal CMR k-space database to date, comprising 427,465 multi-coil k-space data paired with structured metadata across 13 international centers, 12 CMR modalities, 15 scanners, and 17 CVD categories in populations across three continents. Building on this unprecedented resource, we introduce CardioMM, a generalist reconstruction foundation model capable of dynamically adapting to heterogeneous fast CMR imaging scenarios. CardioMM unifies semantic contextual understanding with physics-informed data consistency to deliver robust reconstructions across varied scanners, protocols, and patient presentations. Comprehensive evaluations demonstrate that CardioMM achieves state-of-the-art performance in the internal centers and exhibits strong zero-shot generalization to unseen external settings. Even at imaging acceleration up to 24x, CardioMM reliably preserves key cardiac phenotypes, quantitative myocardial biomarkers, and diagnostic image quality, enabling a substantial increase in CMR examination throughput without compromising clinical integrity. Together, our open-access MMCMR-427K database and CardioMM framework establish a scalable pathway toward high-throughput, high-quality, and clinically accessible cardiovascular imaging.

Beyond Endpoints: Path-Centric Reasoning for Vectorized Off-Road Network Extraction

Deep learning has advanced vectorized road extraction in urban settings, yet off-road environments remain underexplored and challenging. A significant domain gap causes advanced models to fail in wild terrains due to two key issues: lack of large-scale vectorized datasets and structural weakness in prevailing methods. Models such as SAM-Road employ a node-centric paradigm that reasons at sparse endpoints, making them fragile to occlusions and ambiguous junctions in off-road scenes, leading to topological errors. This work addresses these limitations in two complementary ways. First, we release WildRoad, a global off-road road network dataset constructed efficiently with a dedicated interactive annotation tool tailored for road-network labeling. Second, we introduce MaGRoad (Mask-aware Geodesic Road network extractor), a path-centric framework that aggregates multi-scale visual evidence along candidate paths to infer connectivity robustly. Extensive experiments show that MaGRoad achieves state-of-the-art performance on our challenging WildRoad benchmark while generalizing well to urban datasets. A streamlined pipeline also yields roughly 2.5x faster inference, improving practical applicability. Together, the dataset and path-centric paradigm provide a stronger foundation for mapping roads in the wild. We release both the dataset and code at https://github.com/xiaofei-guan/MaGRoad.

RoleRMBench & RoleRM: Towards Reward Modeling for Profile-Based Role Play in Dialogue Systems

Reward modeling has become a cornerstone of aligning large language models (LLMs) with human preferences. Yet, when extended to subjective and open-ended domains such as role play, existing reward models exhibit severe degradation, struggling to capture nuanced and persona-grounded human judgments. To address this gap, we introduce RoleRMBench, the first systematic benchmark for reward modeling in role-playing dialogue, covering seven fine-grained capabilities from narrative management to role consistency and engagement. Evaluation on RoleRMBench reveals large and consistent gaps between general-purpose reward models and human judgment, particularly in narrative and stylistic dimensions. We further propose RoleRM, a reward model trained with Continuous Implicit Preferences (CIP), which reformulates subjective evaluation as continuous consistent pairwise supervision under multiple structuring strategies. Comprehensive experiments show that RoleRM surpasses strong open- and closed-source reward models by over 24% on average, demonstrating substantial gains in narrative coherence and stylistic fidelity. Our findings highlight the importance of continuous preference representation and annotation consistency, establishing a foundation for subjective alignment in human-centered dialogue systems.

UPETrack: Unidirectional Position Estimation for Tracking Occluded Deformable Linear Objects

Real-time state tracking of Deformable Linear Objects (DLOs) is critical for enabling robotic manipulation of DLOs in industrial assembly, medical procedures, and daily-life applications. However, the high-dimensional configuration space, nonlinear dynamics, and frequent partial occlusions present fundamental barriers to robust real-time DLO tracking. To address these limitations, this study introduces UPETrack, a geometry-driven framework based on Unidirectional Position Estimation (UPE), which facilitates tracking without the requirement for physical modeling, virtual simulation, or visual markers. The framework operates in two phases: (1) visible segment tracking is based on a Gaussian Mixture Model (GMM) fitted via the Expectation Maximization (EM) algorithm, and (2) occlusion region prediction employing UPE algorithm we proposed. UPE leverages the geometric continuity inherent in DLO shapes and their temporal evolution patterns to derive a closed-form positional estimator through three principal mechanisms: (i) local linear combination displacement term, (ii) proximal linear constraint term, and (iii) historical curvature term. This analytical formulation allows efficient and stable estimation of occluded nodes through explicit linear combinations of geometric components, eliminating the need for additional iterative optimization. Experimental results demonstrate that UPETrack surpasses two state-of-the-art tracking algorithms, including TrackDLO and CDCPD2, in both positioning accuracy and computational efficiency.

CompTrack: Information Bottleneck-Guided Low-Rank Dynamic Token Compression for Point Cloud Tracking

3D single object tracking (SOT) in LiDAR point clouds is a critical task in computer vision and autonomous driving. Despite great success having been achieved, the inherent sparsity of point clouds introduces a dual-redundancy challenge that limits existing trackers: (1) vast spatial redundancy from background noise impairs accuracy, and (2) informational redundancy within the foreground hinders efficiency. To tackle these issues, we propose CompTrack, a novel end-to-end framework that systematically eliminates both forms of redundancy in point clouds. First, CompTrack incorporates a Spatial Foreground Predictor (SFP) module to filter out irrelevant background noise based on information entropy, addressing spatial redundancy. Subsequently, its core is an Information Bottleneck-guided Dynamic Token Compression (IB-DTC) module that eliminates the informational redundancy within the foreground. Theoretically grounded in low-rank approximation, this module leverages an online SVD analysis to adaptively compress the redundant foreground into a compact and highly informative set of proxy tokens. Extensive experiments on KITTI, nuScenes and Waymo datasets demonstrate that CompTrack achieves top-performing tracking performance with superior efficiency, running at a real-time 90 FPS on a single RTX 3090 GPU.

Run, Ruminate, and Regulate: A Dual-process Thinking System for Vision-and-Language Navigation

Vision-and-Language Navigation (VLN) requires an agent to dynamically explore complex 3D environments following human instructions. Recent research underscores the potential of harnessing large language models (LLMs) for VLN, given their commonsense knowledge and general reasoning capabilities. Despite their strengths, a substantial gap in task completion performance persists between LLM-based approaches and domain experts, as LLMs inherently struggle to comprehend real-world spatial correlations precisely. Additionally, introducing LLMs is accompanied with substantial computational cost and inference latency. To address these issues, we propose a novel dual-process thinking framework dubbed R3, integrating LLMs' generalization capabilities with VLN-specific expertise in a zero-shot manner. The framework comprises three core modules: Runner, Ruminator, and Regulator. The Runner is a lightweight transformer-based expert model that ensures efficient and accurate navigation under regular circumstances. The Ruminator employs a powerful multimodal LLM as the backbone and adopts chain-of-thought (CoT) prompting to elicit structured reasoning. The Regulator monitors the navigation progress and controls the appropriate thinking mode according to three criteria, integrating Runner and Ruminator harmoniously. Experimental results illustrate that R3 significantly outperforms other state-of-the-art methods, exceeding 3.28% and 3.30% in SPL and RGSPL respectively on the REVERIE benchmark. This pronounced enhancement highlights the effectiveness of our method in handling challenging VLN tasks.

Understanding InfoNCE: Transition Probability Matrix Induced Feature Clustering

Contrastive learning has emerged as a cornerstone of unsupervised representation learning across vision, language, and graph domains, with InfoNCE as its dominant objective. Despite its empirical success, the theoretical underpinnings of InfoNCE remain limited. In this work, we introduce an explicit feature space to model augmented views of samples and a transition probability matrix to capture data augmentation dynamics. We demonstrate that InfoNCE optimizes the probability of two views sharing the same source toward a constant target defined by this matrix, naturally inducing feature clustering in the representation space. Leveraging this insight, we propose Scaled Convergence InfoNCE (SC-InfoNCE), a novel loss function that introduces a tunable convergence target to flexibly control feature similarity alignment. By scaling the target matrix, SC-InfoNCE enables flexible control over feature similarity alignment, allowing the training objective to better match the statistical properties of downstream data. Experiments on benchmark datasets, including image, graph, and text tasks, show that SC-InfoNCE consistently achieves strong and reliable performance across diverse domains.

Accelerating Controllable Generation via Hybrid-grained Cache

Controllable generative models have been widely used to improve the realism of synthetic visual content. However, such models must handle control conditions and content generation computational requirements, resulting in generally low generation efficiency. To address this issue, we propose a Hybrid-Grained Cache (HGC) approach that reduces computational overhead by adopting cache strategies with different granularities at different computational stages. Specifically, (1) we use a coarse-grained cache (block-level) based on feature reuse to dynamically bypass redundant computations in encoder-decoder blocks between each step of model reasoning. (2) We design a fine-grained cache (prompt-level) that acts within a module, where the fine-grained cache reuses cross-attention maps within consecutive reasoning steps and extends them to the corresponding module computations of adjacent steps. These caches of different granularities can be seamlessly integrated into each computational link of the controllable generation process. We verify the effectiveness of HGC on four benchmark datasets, especially its advantages in balancing generation efficiency and visual quality. For example, on the COCO-Stuff segmentation benchmark, our HGC significantly reduces the computational cost (MACs) by 63% (from 18.22T to 6.70T), while keeping the loss of semantic fidelity (quantized performance degradation) within 1.5%.