Towards Medical Artificial General Intelligence via Knowledge-Enhanced Multimodal Pretraining

Medical artificial general intelligence (MAGI) enables one foundation model to solve different medical tasks, which is very practical in the medical domain. It can significantly reduce the requirement of large amounts of task-specific data by sufficiently sharing medical knowledge among different tasks. However, due to the challenges of designing strongly generalizable models with limited and complex medical data, most existing approaches tend to develop task-specific models. To take a step towards MAGI, we propose a new paradigm called Medical-knOwledge-enhanced mulTimOdal pretRaining (MOTOR). In MOTOR, we combine two kinds of basic medical knowledge, i.e., general and specific knowledge, in a complementary manner to boost the general pretraining process. As a result, the foundation model with comprehensive basic knowledge can learn compact representations from pretraining radiographic data for better cross-modal alignment. MOTOR unifies the understanding and generation, which are two kinds of core intelligence of an AI system, into a single medical foundation model, to flexibly handle more diverse medical tasks. To enable a comprehensive evaluation and facilitate further research, we construct a medical multimodal benchmark including a wide range of downstream tasks, such as chest x-ray report generation and medical visual question answering. Extensive experiments on our benchmark show that MOTOR obtains promising results through simple task-oriented adaptation. The visualization shows that the injected knowledge successfully highlights key information in the medical data, demonstrating the excellent interpretability of MOTOR. Our MOTOR successfully mimics the human practice of fulfilling a "medical student" to accelerate the process of becoming a "specialist". We believe that our work makes a significant stride in realizing MAGI.

Face Animation with an Attribute-Guided Diffusion Model

Face animation has achieved much progress in computer vision. However, prevailing GAN-based methods suffer from unnatural distortions and artifacts due to sophisticated motion deformation. In this paper, we propose a Face Animation framework with an attribute-guided Diffusion Model (FADM), which is the first work to exploit the superior modeling capacity of diffusion models for photo-realistic talking-head generation. To mitigate the uncontrollable synthesis effect of the diffusion model, we design an Attribute-Guided Conditioning Network (AGCN) to adaptively combine the coarse animation features and 3D face reconstruction results, which can incorporate appearance and motion conditions into the diffusion process. These specific designs help FADM rectify unnatural artifacts and distortions, and also enrich high-fidelity facial details through iterative diffusion refinements with accurate animation attributes. FADM can flexibly and effectively improve existing animation videos. Extensive experiments on widely used talking-head benchmarks validate the effectiveness of FADM over prior arts.

Recovering Continuous Scene Dynamics from A Single Blurry Image with Events

This paper aims at demystifying a single motion-blurred image with events and revealing temporally continuous scene dynamics encrypted behind motion blurs. To achieve this end, an Implicit Video Function (IVF) is learned to represent a single motion blurred image with concurrent events, enabling the latent sharp image restoration of arbitrary timestamps in the range of imaging exposures. Specifically, a dual attention transformer is proposed to efficiently leverage merits from both modalities, i.e., the high temporal resolution of event features and the smoothness of image features, alleviating temporal ambiguities while suppressing the event noise. The proposed network is trained only with the supervision of ground-truth images of limited referenced timestamps. Motion- and texture-guided supervisions are employed simultaneously to enhance restorations of the non-referenced timestamps and improve the overall sharpness. Experiments on synthetic, semi-synthetic, and real-world datasets demonstrate that our proposed method outperforms state-of-the-art methods by a large margin in terms of both objective PSNR and SSIM measurements and subjective evaluations.

Implicit Diffusion Models for Continuous Super-Resolution

Image super-resolution (SR) has attracted increasing attention due to its wide applications. However, current SR methods generally suffer from over-smoothing and artifacts, and most work only with fixed magnifications. This paper introduces an Implicit Diffusion Model (IDM) for high-fidelity continuous image super-resolution. IDM integrates an implicit neural representation and a denoising diffusion model in a unified end-to-end framework, where the implicit neural representation is adopted in the decoding process to learn continuous-resolution representation. Furthermore, we design a scale-controllable conditioning mechanism that consists of a low-resolution (LR) conditioning network and a scaling factor. The scaling factor regulates the resolution and accordingly modulates the proportion of the LR information and generated features in the final output, which enables the model to accommodate the continuous-resolution requirement. Extensive experiments validate the effectiveness of our IDM and demonstrate its superior performance over prior arts.

Learning to Super-Resolve Blurry Images with Events

Super-Resolution from a single motion Blurred image (SRB) is a severely ill-posed problem due to the joint degradation of motion blurs and low spatial resolution. In this paper, we employ events to alleviate the burden of SRB and propose an Event-enhanced SRB (E-SRB) algorithm, which can generate a sequence of sharp and clear images with High Resolution (HR) from a single blurry image with Low Resolution (LR). To achieve this end, we formulate an event-enhanced degeneration model to consider the low spatial resolution, motion blurs, and event noises simultaneously. We then build an event-enhanced Sparse Learning Network (eSL-Net++) upon a dual sparse learning scheme where both events and intensity frames are modeled with sparse representations. Furthermore, we propose an event shuffle-and-merge scheme to extend the single-frame SRB to the sequence-frame SRB without any additional training process. Experimental results on synthetic and real-world datasets show that the proposed eSL-Net++ outperforms state-of-the-art methods by a large margin. Datasets, codes, and more results are available at https://github.com/ShinyWang33/eSL-Net-Plusplus.

Actional Atomic-Concept Learning for Demystifying Vision-Language Navigation

Vision-Language Navigation (VLN) is a challenging task which requires an agent to align complex visual observations to language instructions to reach the goal position. Most existing VLN agents directly learn to align the raw directional features and visual features trained using one-hot labels to linguistic instruction features. However, the big semantic gap among these multi-modal inputs makes the alignment difficult and therefore limits the navigation performance. In this paper, we propose Actional Atomic-Concept Learning (AACL), which maps visual observations to actional atomic concepts for facilitating the alignment. Specifically, an actional atomic concept is a natural language phrase containing an atomic action and an object, e.g., ``go up stairs''. These actional atomic concepts, which serve as the bridge between observations and instructions, can effectively mitigate the semantic gap and simplify the alignment. AACL contains three core components: 1) a concept mapping module to map the observations to the actional atomic concept representations through the VLN environment and the recently proposed Contrastive Language-Image Pretraining (CLIP) model, 2) a concept refining adapter to encourage more instruction-oriented object concept extraction by re-ranking the predicted object concepts by CLIP, and 3) an observation co-embedding module which utilizes concept representations to regularize the observation representations. Our AACL establishes new state-of-the-art results on both fine-grained (R2R) and high-level (REVERIE and R2R-Last) VLN benchmarks. Moreover, the visualization shows that AACL significantly improves the interpretability in action decision.

Feature Calibration Network for Occluded Pedestrian Detection

Pedestrian detection in the wild remains a challenging problem especially for scenes containing serious occlusion. In this paper, we propose a novel feature learning method in the deep learning framework, referred to as Feature Calibration Network (FC-Net), to adaptively detect pedestrians under various occlusions. FC-Net is based on the observation that the visible parts of pedestrians are selective and decisive for detection, and is implemented as a self-paced feature learning framework with a self-activation (SA) module and a feature calibration (FC) module. In a new self-activated manner, FC-Net learns features which highlight the visible parts and suppress the occluded parts of pedestrians. The SA module estimates pedestrian activation maps by reusing classifier weights, without any additional parameter involved, therefore resulting in an extremely parsimony model to reinforce the semantics of features, while the FC module calibrates the convolutional features for adaptive pedestrian representation in both pixel-wise and region-based ways. Experiments on CityPersons and Caltech datasets demonstrate that FC-Net improves detection performance on occluded pedestrians up to 10% while maintaining excellent performance on non-occluded instances.

CoupAlign: Coupling Word-Pixel with Sentence-Mask Alignments for Referring Image Segmentation

Referring image segmentation aims at localizing all pixels of the visual objects described by a natural language sentence. Previous works learn to straightforwardly align the sentence embedding and pixel-level embedding for highlighting the referred objects, but ignore the semantic consistency of pixels within the same object, leading to incomplete masks and localization errors in predictions. To tackle this problem, we propose CoupAlign, a simple yet effective multi-level visual-semantic alignment method, to couple sentence-mask alignment with word-pixel alignment to enforce object mask constraint for achieving more accurate localization and segmentation. Specifically, the Word-Pixel Alignment (WPA) module performs early fusion of linguistic and pixel-level features in intermediate layers of the vision and language encoders. Based on the word-pixel aligned embedding, a set of mask proposals are generated to hypothesize possible objects. Then in the Sentence-Mask Alignment (SMA) module, the masks are weighted by the sentence embedding to localize the referred object, and finally projected back to aggregate the pixels for the target. To further enhance the learning of the two alignment modules, an auxiliary loss is designed to contrast the foreground and background pixels. By hierarchically aligning pixels and masks with linguistic features, our CoupAlign captures the pixel coherence at both visual and semantic levels, thus generating more accurate predictions. Extensive experiments on popular datasets (e.g., RefCOCO and G-Ref) show that our method achieves consistent improvements over state-of-the-art methods, e.g., about 2% oIoU increase on the validation and testing set of RefCOCO. Especially, CoupAlign has remarkable ability in distinguishing the target from multiple objects of the same class.

FNeVR: Neural Volume Rendering for Face Animation

Face animation, one of the hottest topics in computer vision, has achieved a promising performance with the help of generative models. However, it remains a critical challenge to generate identity preserving and photo-realistic images due to the sophisticated motion deformation and complex facial detail modeling. To address these problems, we propose a Face Neural Volume Rendering (FNeVR) network to fully explore the potential of 2D motion warping and 3D volume rendering in a unified framework. In FNeVR, we design a 3D Face Volume Rendering (FVR) module to enhance the facial details for image rendering. Specifically, we first extract 3D information with a well-designed architecture, and then introduce an orthogonal adaptive ray-sampling module for efficient rendering. We also design a lightweight pose editor, enabling FNeVR to edit the facial pose in a simple yet effective way. Extensive experiments show that our FNeVR obtains the best overall quality and performance on widely used talking-head benchmarks.

Structure-Preserving Graph Representation Learning

Though graph representation learning (GRL) has made significant progress, it is still a challenge to extract and embed the rich topological structure and feature information in an adequate way. Most existing methods focus on local structure and fail to fully incorporate the global topological structure. To this end, we propose a novel Structure-Preserving Graph Representation Learning (SPGRL) method, to fully capture the structure information of graphs. Specifically, to reduce the uncertainty and misinformation of the original graph, we construct a feature graph as a complementary view via k-Nearest Neighbor method. The feature graph can be used to contrast at node-level to capture the local relation. Besides, we retain the global topological structure information by maximizing the mutual information (MI) of the whole graph and feature embeddings, which is theoretically reduced to exchanging the feature embeddings of the feature and the original graphs to reconstruct themselves. Extensive experiments show that our method has quite superior performance on semi-supervised node classification task and excellent robustness under noise perturbation on graph structure or node features.