TransNRank: Towards Accurate Neoantigen Ranking with Transformer

Personalized neoantigen prediction is challenging due to the scarcity of positive samples, the noise of the experimental data, the severe class imbalance trait and the complex of immunogenicity features. Prior arts, such as linear regression and XGBoost fail to model long-range dependencies and contextual relationships within peptide features, therefore the performance of neoantigen positive recall rate is limited. In this paper, we present a novel deep learning framework based on Transformer, coined as TransNRank. By leveraging the self-attention mechanism, our model captures both local and global feature contexts, enabling more accurate recognition of immunogenic neoantigens. A positive-aware training objective is utilized to handle the class imbalance problem, assigning more weights to those few positive samples. Extensive experiments are performed on NCI, TESLA and HiTIDE datasets. Notably, our TransNRank can push the upper bound top 20 recall rate of neoantigen prediction from 46.9% (45 from 96) to 53.1% (51 from 96), while reducing the training epochs from 200 epochs to 20 epochs. Furthermore, we analyze the features contribution based on TransNRank and find that the mutation at anchor and TCGA expression level play an unexpected important role in neoantigen prediction, and removing insignificant features to reduce the input dimensionality of peptides does not drastically impair the overall performance of the model. Our paradigm not only streamlines the prediction pipeline but also sets a new state-of-the-art for neoantigen discovery, with broad implications for accurate immuno-oncology.

PVCap: Towards Accurate 3D Dense Captioning via PseudoCap and VoxelCapNet

3D dense captioning, an emerging vision-language task, aims to generate descriptive sentences for each object in the 3D scene. Despite the impressive results achieved by previous methods, they suffer from two limitations. First, current research often employs global rigid transformations, such as rotation, to augment scenes without changing their spatial layouts. However, diverse spatial layouts are crucial for training a 3D dense captioning model to describe spatial relations between objects. Second, previous works mainly focus on the design of the caption generation pipeline while utilizing a simple network architecture for other components, i.e., backbone and detection head, which is crucial for extracting rich semantic information for captioning. In this paper, we propose PVCap to alleviate the aforementioned problems. Our PVCap consists of PseudoCap and VoxelCapNet. Specifically, PseudoCap employs a random mixing technique on instances within the dataset, generating numerous pseudo frames with diverse spatial layouts at the instance level. By utilizing a teacher-student framework, PseudoCap obtains pseudo caption labels for these pseudo frames. This data augmentation approach significantly increases the number of training samples and enhances the model's ability to describe the environment effectively. Regarding VoxelCapNet, we introduce a robust caption network that utilizes voxel features and adapts the caption head to the voxel-based network architecture. Our VoxelCapNet can serve as a competitive baseline for future research on 3D dense captioning. Extensive experiments are conducted on two prevalent benchmarks, i.e., ScanRefer and Nr3D. Notably, our method surpasses current state-of-the-art by 11.41% and 13.99% in CIDEr@0.5IoU, respectively. Codes will be made publicly available.

CMTFormer: Marrying Transformer with Hierarchical Information Interaction for RGB-Event Object Detection

Event cameras capture sparse brightness changes with high temporal resolution and high dynamic range, compensating for the deficiencies of the conventional RGB frames. However, previous multi-modal fusion techniques typically fail to handle the inherent heterogeneity between RGB frames and event streams, thus easily leading to noise amplification or redundant feature integration during cross-modal fusion. In this paper, we propose a Cross-Modal information inTeraction transFormer, coined as CMTFormer, which hierarchically integrates RGB and event information to achieve efficient and stable multimodal collaboration. Specifically, we design a shallow-to-deep information interaction scheme. In the shallow stage, we present the Shallow Alignment Module (SAM) to achieve an efficient fusion of RGB and event low-level features, which mitigates attribute disparities and prevents noisy information. In the middle stage, we devise the Cross-modal Enhancement Module (CEM) that utilizes texture and edge information to produce mutually reinforced middle-level features. In the deep stage, we present the Learnable Deep Fusion Module (LDFM) which performs high-level information aggregation through learnable weights, thus enabling the network to adaptively fuse RGB and event clues. A Spatial Prior Module is further designed to utilize global spatial information to enhance localization accuracy. Extensive experiments are conducted on two prevalent event-based object detection benchmarks, i.e., DSEC-Detection and PKU-DAVIS-SOD. Our CMTFormer consistently surpasses the detection counterparts in both uni-modal and multi-modal settings, strongly demonstrating the effectiveness of our paradigm. Codes will be available upon publication.

Heterogeneous and Adept Snapshot Distillation for 3D Semantic Segmentation

Multi-modal fusion and multi-model ensembling are prevalent in enhancing the performance of 3D semantic segmentation. Despite the impressive performance, these methods either rely on auxiliary input signals or suffer from costly computational expense. To efficaciously enhance the segmentation performance without introducing intolerable costs, we propose to transfer the rich knowledge from the multi-modal model (i.e., point clouds and images) and multiple model experts to the point-cloudbased network through knowledge distillation. Specifically, we present Information-oriented Heterogeneous Distillation (IHD) to help the uni-modal model absorb the complementary knowledge from the multi-modal teacher. We design the Information-Oriented Filtering (IOF) strategy to select informative images from the continuous image sequence for multi-modal fusion. This practice can boost the performance of the multi-modal teacher, thus benefiting the learning of the student. Besides, as opposed to vanilla model ensembling that requires the separate training of each expert, we propose Adept Snapshot Distillation (ASD). ASD treats the freely available model snapshots generated during the training phase as multiple experts, which significantly reduces the training cost for model ensembling. For each expert teacher, it only provides supervision to the student in the class where it is adept. The resulting Heterogeneous and Adept Snapshot Knowledge Distillation, dubbed HAS-KD, attains state-of-the-art results on ScanNetV2 and S3DIS datasets. HAS-KD can be seamlessly integrated into contemporary 3D segmentation algorithms and bring considerable gains without introducing extra inference burdens. The code will be made publicly available upon publication.

Segment and Select: Vision-Language Segmentation in 3D Scenarios

3D vision-language segmentation aims to segment target objects in 3D scenarios according to the linguistic instructions and visual observations. Prior art heavily relies on the coarse superpoint representation to reduce the computation complexity, which suffers from poor segmentation quality and messy object boundaries. In this paper, we propose the SEGment-And-select (SEGA3D) paradigm for 3D visionlanguage segmentation that directly operates on the fine-grained visual information and is free from the superpoint dependency. Specifically, we first leverage a mask candidate generator to provide fine-grained categorical mask candidates, substantially improving the quality of candidate masks over the superpoint counterparts. Then, a Large Language Model (LLM) is utilized to generate the semantic and spatial information based on the linguistic description and visual features. The LLM output and visual features are fed to the Semantic-Spatial Selector (SSS) to produce the top-ranking mask candidates. Eventually, the Loopback Verification Module (LVM) is designed to yield the segmentation mask from the selected candidate masks. Our SEGA3D attains competitive performance on ScanRefer, ScanNet and Matterport3D benchmarks. Notably, our SEGA3D surpasses the top-performing counterpart by 8.3 mIoU and 5.3 mIoU on ScanNet and Matterport3D, respectively. Codes will be available upon publication.

Learning Multi-Modal Trajectory Policies for Data-Efficient Robotic Manipulation

Robotic manipulation requires the effective integration of heterogeneous inputs, including visual observations, language instructions, and trajectory representations, to generate accurate actions. Existing transformer-based policies typically process these heterogeneous modalities within a shared parameter space, which often leads to modality interference and inefficient representation learning, especially in data-scarce scenarios. While Mixture-of-Experts (MoE) offers a scalable solution through expert specialization, conventional routing mechanisms are often sensitive to such cross-modal representation discrepancies, resulting in unstable expert assignment and expert collapse. In this work, we propose MATE (Multi-ModAl TrajEctory Policies), a novel trajectory prediction framework built upon MoE. Specifically, we introduce a Multi-Modal MoE architecture to achieve fine-grained sub-token feature decoupling, and design a cross-modal cosine router for stable and scale-invariant expert assignment across heterogeneous modalities. We further employ temperature-controlled routing and stochastic noise injection to improve expert balance and prevent premature routing collapse under scarce demonstrations. Experiments on the LIBERO benchmark show that our MATE consistently outperforms prior work under data scarcity. It achieves a 4.75% improvement in average success rate over the trajectory-guided counterpart. Real-world experiments on robotic ping-pong also suggest that the predicted trajectories can provide useful guidance for downstream robotic execution, further indicating the practical feasibility of our algorithm.

EvoDefense: Co-Evolving Black-Box Defense with Large Language Models

Large Language Models (LLMs) remain highly vulnerable to diverse attacks, particularly in black-box settings where the internals of target models are inaccessible. Existing black-box defenses typically rely on pre-defined filtering heuristics, which often fail to generalize to unseen attack types and target model architectures. We introduce EvoDefense, an experience-guided co-evolving black-box defense paradigm. EvoDefense employs a guard LLM to detect malicious queries and an experience memory module to accumulate defense knowledge from previous interactions. At the core of EvoDefense is a continuous attack-defense evolution loop, where an attack generator and the guard model iteratively refine their attack strategies and defense policies through experience-guided optimization. This design enables EvoDefense to generalize across unseen attacks and target models without retraining. Experiments on HarmBench, AdvBench, and AlpacaEval show that EvoDefense achieves consistently strong defense performance across seven popular models and five representative LLM attacks, while preserving competitive general capabilities. On HarmBench, EvoDefense reduces the attack success rate (ASR) of AutoDAN-turbo on Gemini-3-flash and LLaMA-3-8B-Instruct from 29.4% and 43.4% to 8.4% and 6.2%, respectively.

SafeWork-R1: Coevolving Safety and Intelligence under the AI-45$^{\circ}$ Law

We introduce SafeWork-R1, a cutting-edge multimodal reasoning model that demonstrates the coevolution of capabilities and safety. It is developed by our proposed SafeLadder framework, which incorporates large-scale, progressive, safety-oriented reinforcement learning post-training, supported by a suite of multi-principled verifiers. Unlike previous alignment methods such as RLHF that simply learn human preferences, SafeLadder enables SafeWork-R1 to develop intrinsic safety reasoning and self-reflection abilities, giving rise to safety `aha' moments. Notably, SafeWork-R1 achieves an average improvement of $46.54\%$ over its base model Qwen2.5-VL-72B on safety-related benchmarks without compromising general capabilities, and delivers state-of-the-art safety performance compared to leading proprietary models such as GPT-4.1 and Claude Opus 4. To further bolster its reliability, we implement two distinct inference-time intervention methods and a deliberative search mechanism, enforcing step-level verification. Finally, we further develop SafeWork-R1-InternVL3-78B, SafeWork-R1-DeepSeek-70B, and SafeWork-R1-Qwen2.5VL-7B. All resulting models demonstrate that safety and capability can co-evolve synergistically, highlighting the generalizability of our framework in building robust, reliable, and trustworthy general-purpose AI.

HexPlane Representation for 3D Semantic Scene Understanding

In this paper, we introduce the HexPlane representation for 3D semantic scene understanding. Specifically, we first design the View Projection Module (VPM) to project the 3D point cloud into six planes to maximally retain the original spatial information. Features of six planes are extracted by the 2D encoder and sent to the HexPlane Association Module (HAM) to adaptively fuse the most informative information for each point. The fused point features are further fed to the task head to yield the ultimate predictions. Compared to the popular point and voxel representation, the HexPlane representation is efficient and can utilize highly optimized 2D operations to process sparse and unordered 3D point clouds. It can also leverage off-the-shelf 2D models, network weights, and training recipes to achieve accurate scene understanding in 3D space. On ScanNet and SemanticKITTI benchmarks, our algorithm, dubbed HexNet3D, achieves competitive performance with previous algorithms. In particular, on the ScanNet 3D segmentation task, our method obtains 77.0 mIoU on the validation set, surpassing Point Transformer V2 by 1.6 mIoU. We also observe encouraging results in indoor 3D detection tasks. Note that our method can be seamlessly integrated into existing voxel-based, point-based, and range-based approaches and brings considerable gains without bells and whistles. The codes will be available upon publication.

OccMamba: Semantic Occupancy Prediction with State Space Models

Training deep learning models for semantic occupancy prediction is challenging due to factors such as a large number of occupancy cells, severe occlusion, limited visual cues, complicated driving scenarios, etc. Recent methods often adopt transformer-based architectures given their strong capability in learning input-conditioned weights and long-range relationships. However, transformer-based networks are notorious for their quadratic computation complexity, seriously undermining their efficacy and deployment in semantic occupancy prediction. Inspired by the global modeling and linear computation complexity of the Mamba architecture, we present the first Mamba-based network for semantic occupancy prediction, termed OccMamba. However, directly applying the Mamba architecture to the occupancy prediction task yields unsatisfactory performance due to the inherent domain gap between the linguistic and 3D domains. To relieve this problem, we present a simple yet effective 3D-to-1D reordering operation, i.e., height-prioritized 2D Hilbert expansion. It can maximally retain the spatial structure of point clouds as well as facilitate the processing of Mamba blocks. Our OccMamba achieves state-of-the-art performance on three prevalent occupancy prediction benchmarks, including OpenOccupancy, SemanticKITTI and SemanticPOSS. Notably, on OpenOccupancy, our OccMamba outperforms the previous state-of-the-art Co-Occ by 3.1% IoU and 3.2% mIoU, respectively. Codes will be released upon publication.