Comparing roughness descriptors for distinct terrain surfaces in point cloud data

Terrain surface roughness, often described abstractly, poses challenges in quantitative characterisation with various descriptors found in the literature. This study compares five commonly used roughness descriptors, exploring correlations among their quantified terrain surface roughness maps across three terrains with distinct spatial variations. Additionally, the study investigates the impacts of spatial scales and interpolation methods on these correlations. Dense point cloud data obtained through Light Detection and Ranging technique are used in this study. The findings highlight both global pattern similarities and local pattern distinctions in the derived roughness maps, emphasizing the significance of incorporating multiple descriptors in studies where local roughness values play a crucial role in subsequent analyses. The spatial scales were found to have a smaller impact on rougher terrain, while interpolation methods had minimal influence on roughness maps derived from different descriptors.

De novo Drug Design using Reinforcement Learning with Multiple GPT Agents

De novo drug design is a pivotal issue in pharmacology and a new area of focus in AI for science research. A central challenge in this field is to generate molecules with specific properties while also producing a wide range of diverse candidates. Although advanced technologies such as transformer models and reinforcement learning have been applied in drug design, their potential has not been fully realized. Therefore, we propose MolRL-MGPT, a reinforcement learning algorithm with multiple GPT agents for drug molecular generation. To promote molecular diversity, we encourage the agents to collaborate in searching for desirable molecules in diverse directions. Our algorithm has shown promising results on the GuacaMol benchmark and exhibits efficacy in designing inhibitors against SARS-CoV-2 protein targets. The codes are available at: https://github.com/HXYfighter/MolRL-MGPT.

Multi-Modal Domain Adaptation Across Video Scenes for Temporal Video Grounding

Temporal Video Grounding (TVG) aims to localize the temporal boundary of a specific segment in an untrimmed video based on a given language query. Since datasets in this domain are often gathered from limited video scenes, models tend to overfit to scene-specific factors, which leads to suboptimal performance when encountering new scenes in real-world applications. In a new scene, the fine-grained annotations are often insufficient due to the expensive labor cost, while the coarse-grained video-query pairs are easier to obtain. Thus, to address this issue and enhance model performance on new scenes, we explore the TVG task in an unsupervised domain adaptation (UDA) setting across scenes for the first time, where the video-query pairs in the source scene (domain) are labeled with temporal boundaries, while those in the target scene are not. Under the UDA setting, we introduce a novel Adversarial Multi-modal Domain Adaptation (AMDA) method to adaptively adjust the model's scene-related knowledge by incorporating insights from the target data. Specifically, we tackle the domain gap by utilizing domain discriminators, which help identify valuable scene-related features effective across both domains. Concurrently, we mitigate the semantic gap between different modalities by aligning video-query pairs with related semantics. Furthermore, we employ a mask-reconstruction approach to enhance the understanding of temporal semantics within a scene. Extensive experiments on Charades-STA, ActivityNet Captions, and YouCook2 demonstrate the effectiveness of our proposed method.

Chat-3D v2: Bridging 3D Scene and Large Language Models with Object Identifiers

Recent research has evidenced the significant potentials of Large Language Models (LLMs) in handling challenging tasks within 3D scenes. However, current models are constrained to addressing object-centric tasks, where each question-answer pair focuses solely on an individual object. In real-world applications, users may pose queries involving multiple objects or expect for answers that precisely reference various objects. We introduce the use of object identifiers to freely reference objects during a conversation. While this solution appears straightforward, it presents two main challenges: 1) How to establish a reliable one-to-one correspondence between each object and its identifier? 2) How to incorporate complex spatial relationships among dozens of objects into the embedding space of the LLM? To address these challenges, we propose a two-stage alignment method, which involves learning an attribute-aware token and a relation-aware token for each object. These tokens capture the object's attributes and spatial relationships with surrounding objects in the 3D scene. Once the alignment is established, we can fine-tune our model on various downstream tasks using instruction tuning. Experiments conducted on traditional datasets like ScanQA, ScanRefer, and Nr3D/Sr3D showcase the effectiveness of our proposed method. Additionally, we create a 3D scene captioning dataset annotated with rich object identifiers, with the assistant of GPT-4. This dataset aims to further explore the capability of object identifiers in effective object referencing and precise scene understanding.

CoRTEx: Contrastive Learning for Representing Terms via Explanations with Applications on Constructing Biomedical Knowledge Graphs

Objective: Biomedical Knowledge Graphs play a pivotal role in various biomedical research domains. Concurrently, term clustering emerges as a crucial step in constructing these knowledge graphs, aiming to identify synonymous terms. Due to a lack of knowledge, previous contrastive learning models trained with Unified Medical Language System (UMLS) synonyms struggle at clustering difficult terms and do not generalize well beyond UMLS terms. In this work, we leverage the world knowledge from Large Language Models (LLMs) and propose Contrastive Learning for Representing Terms via Explanations (CoRTEx) to enhance term representation and significantly improves term clustering. Materials and Methods: The model training involves generating explanations for a cleaned subset of UMLS terms using ChatGPT. We employ contrastive learning, considering term and explanation embeddings simultaneously, and progressively introduce hard negative samples. Additionally, a ChatGPT-assisted BIRCH algorithm is designed for efficient clustering of a new ontology. Results: We established a clustering test set and a hard negative test set, where our model consistently achieves the highest F1 score. With CoRTEx embeddings and the modified BIRCH algorithm, we grouped 35,580,932 terms from the Biomedical Informatics Ontology System (BIOS) into 22,104,559 clusters with O(N) queries to ChatGPT. Case studies highlight the model's efficacy in handling challenging samples, aided by information from explanations. Conclusion: By aligning terms to their explanations, CoRTEx demonstrates superior accuracy over benchmark models and robustness beyond its training set, and it is suitable for clustering terms for large-scale biomedical ontologies.

Adapting Vision Transformer for Efficient Change Detection

Most change detection models based on vision transformers currently follow a "pretraining then fine-tuning" strategy. This involves initializing the model weights using large scale classification datasets, which can be either natural images or remote sensing images. However, fully tuning such a model requires significant time and resources. In this paper, we propose an efficient tuning approach that involves freezing the parameters of the pretrained image encoder and introducing additional training parameters. Through this approach, we have achieved competitive or even better results while maintaining extremely low resource consumption across six change detection benchmarks. For example, training time on LEVIR-CD, a change detection benchmark, is only half an hour with 9 GB memory usage, which could be very convenient for most researchers. Additionally, the decoupled tuning framework can be extended to any pretrained model for semantic change detection and multi temporal change detection as well. We hope that our proposed approach will serve as a part of foundational model to inspire more unified training approaches on change detection in the future.

DreamInpainter: Text-Guided Subject-Driven Image Inpainting with Diffusion Models

This study introduces Text-Guided Subject-Driven Image Inpainting, a novel task that combines text and exemplar images for image inpainting. While both text and exemplar images have been used independently in previous efforts, their combined utilization remains unexplored. Simultaneously accommodating both conditions poses a significant challenge due to the inherent balance required between editability and subject fidelity. To tackle this challenge, we propose a two-step approach DreamInpainter. First, we compute dense subject features to ensure accurate subject replication. Then, we employ a discriminative token selection module to eliminate redundant subject details, preserving the subject's identity while allowing changes according to other conditions such as mask shape and text prompts. Additionally, we introduce a decoupling regularization technique to enhance text control in the presence of exemplar images. Our extensive experiments demonstrate the superior performance of our method in terms of visual quality, identity preservation, and text control, showcasing its effectiveness in the context of text-guided subject-driven image inpainting.

Synergistic Perception and Control Simplex for Verifiable Safe Vertical Landing

Perception, Planning, and Control form the essential components of autonomy in advanced air mobility. This work advances the holistic integration of these components to enhance the performance and robustness of the complete cyber-physical system. We adapt Perception Simplex, a system for verifiable collision avoidance amidst obstacle detection faults, to the vertical landing maneuver for autonomous air mobility vehicles. We improve upon this system by replacing static assumptions of control capabilities with dynamic confirmation, i.e., real-time confirmation of control limitations of the system, ensuring reliable fulfillment of safety maneuvers and overrides, without dependence on overly pessimistic assumptions. Parameters defining control system capabilities and limitations, e.g., maximum deceleration, are continuously tracked within the system and used to make safety-critical decisions. We apply these techniques to propose a verifiable collision avoidance solution for autonomous aerial mobility vehicles operating in cluttered and potentially unsafe environments.

HiFi Tuner: High-Fidelity Subject-Driven Fine-Tuning for Diffusion Models

This paper explores advancements in high-fidelity personalized image generation through the utilization of pre-trained text-to-image diffusion models. While previous approaches have made significant strides in generating versatile scenes based on text descriptions and a few input images, challenges persist in maintaining the subject fidelity within the generated images. In this work, we introduce an innovative algorithm named HiFi Tuner to enhance the appearance preservation of objects during personalized image generation. Our proposed method employs a parameter-efficient fine-tuning framework, comprising a denoising process and a pivotal inversion process. Key enhancements include the utilization of mask guidance, a novel parameter regularization technique, and the incorporation of step-wise subject representations to elevate the sample fidelity. Additionally, we propose a reference-guided generation approach that leverages the pivotal inversion of a reference image to mitigate unwanted subject variations and artifacts. We further extend our method to a novel image editing task: substituting the subject in an image through textual manipulations. Experimental evaluations conducted on the DreamBooth dataset using the Stable Diffusion model showcase promising results. Fine-tuning solely on textual embeddings improves CLIP-T score by 3.6 points and improves DINO score by 9.6 points over Textual Inversion. When fine-tuning all parameters, HiFi Tuner improves CLIP-T score by 1.2 points and improves DINO score by 1.2 points over DreamBooth, establishing a new state of the art.

UFOGen: You Forward Once Large Scale Text-to-Image Generation via Diffusion GANs

Text-to-image diffusion models have demonstrated remarkable capabilities in transforming textual prompts into coherent images, yet the computational cost of their inference remains a persistent challenge. To address this issue, we present UFOGen, a novel generative model designed for ultra-fast, one-step text-to-image synthesis. In contrast to conventional approaches that focus on improving samplers or employing distillation techniques for diffusion models, UFOGen adopts a hybrid methodology, integrating diffusion models with a GAN objective. Leveraging a newly introduced diffusion-GAN objective and initialization with pre-trained diffusion models, UFOGen excels in efficiently generating high-quality images conditioned on textual descriptions in a single step. Beyond traditional text-to-image generation, UFOGen showcases versatility in applications. Notably, UFOGen stands among the pioneering models enabling one-step text-to-image generation and diverse downstream tasks, presenting a significant advancement in the landscape of efficient generative models.