A Survey of Scientific Large Language Models: From Data Foundations to Agent Frontiers

Scientific Large Language Models (Sci-LLMs) are transforming how knowledge is represented, integrated, and applied in scientific research, yet their progress is shaped by the complex nature of scientific data. This survey presents a comprehensive, data-centric synthesis that reframes the development of Sci-LLMs as a co-evolution between models and their underlying data substrate. We formulate a unified taxonomy of scientific data and a hierarchical model of scientific knowledge, emphasizing the multimodal, cross-scale, and domain-specific challenges that differentiate scientific corpora from general natural language processing datasets. We systematically review recent Sci-LLMs, from general-purpose foundations to specialized models across diverse scientific disciplines, alongside an extensive analysis of over 270 pre-/post-training datasets, showing why Sci-LLMs pose distinct demands -- heterogeneous, multi-scale, uncertainty-laden corpora that require representations preserving domain invariance and enabling cross-modal reasoning. On evaluation, we examine over 190 benchmark datasets and trace a shift from static exams toward process- and discovery-oriented assessments with advanced evaluation protocols. These data-centric analyses highlight persistent issues in scientific data development and discuss emerging solutions involving semi-automated annotation pipelines and expert validation. Finally, we outline a paradigm shift toward closed-loop systems where autonomous agents based on Sci-LLMs actively experiment, validate, and contribute to a living, evolving knowledge base. Collectively, this work provides a roadmap for building trustworthy, continually evolving artificial intelligence (AI) systems that function as a true partner in accelerating scientific discovery.

UniC-RAG: Universal Knowledge Corruption Attacks to Retrieval-Augmented Generation

Retrieval-augmented generation (RAG) systems are widely deployed in real-world applications in diverse domains such as finance, healthcare, and cybersecurity. However, many studies showed that they are vulnerable to knowledge corruption attacks, where an attacker can inject adversarial texts into the knowledge database of a RAG system to induce the LLM to generate attacker-desired outputs. Existing studies mainly focus on attacking specific queries or queries with similar topics (or keywords). In this work, we propose UniC-RAG, a universal knowledge corruption attack against RAG systems. Unlike prior work, UniC-RAG jointly optimizes a small number of adversarial texts that can simultaneously attack a large number of user queries with diverse topics and domains, enabling an attacker to achieve various malicious objectives, such as directing users to malicious websites, triggering harmful command execution, or launching denial-of-service attacks. We formulate UniC-RAG as an optimization problem and further design an effective solution to solve it, including a balanced similarity-based clustering method to enhance the attack's effectiveness. Our extensive evaluations demonstrate that UniC-RAG is highly effective and significantly outperforms baselines. For instance, UniC-RAG could achieve over 90% attack success rate by injecting 100 adversarial texts into a knowledge database with millions of texts to simultaneously attack a large set of user queries (e.g., 2,000). Additionally, we evaluate existing defenses and show that they are insufficient to defend against UniC-RAG, highlighting the need for new defense mechanisms in RAG systems.

Vivid-VR: Distilling Concepts from Text-to-Video Diffusion Transformer for Photorealistic Video Restoration

We present Vivid-VR, a DiT-based generative video restoration method built upon an advanced T2V foundation model, where ControlNet is leveraged to control the generation process, ensuring content consistency. However, conventional fine-tuning of such controllable pipelines frequently suffers from distribution drift due to limitations in imperfect multimodal alignment, resulting in compromised texture realism and temporal coherence. To tackle this challenge, we propose a concept distillation training strategy that utilizes the pretrained T2V model to synthesize training samples with embedded textual concepts, thereby distilling its conceptual understanding to preserve texture and temporal quality. To enhance generation controllability, we redesign the control architecture with two key components: 1) a control feature projector that filters degradation artifacts from input video latents to minimize their propagation through the generation pipeline, and 2) a new ControlNet connector employing a dual-branch design. This connector synergistically combines MLP-based feature mapping with cross-attention mechanism for dynamic control feature retrieval, enabling both content preservation and adaptive control signal modulation. Extensive experiments show that Vivid-VR performs favorably against existing approaches on both synthetic and real-world benchmarks, as well as AIGC videos, achieving impressive texture realism, visual vividness, and temporal consistency. The codes and checkpoints are publicly available at https://github.com/csbhr/Vivid-VR.

S2-UniSeg: Fast Universal Agglomerative Pooling for Scalable Segment Anything without Supervision

Recent self-supervised image segmentation models have achieved promising performance on semantic segmentation and class-agnostic instance segmentation. However, their pretraining schedule is multi-stage, requiring a time-consuming pseudo-masks generation process between each training epoch. This time-consuming offline process not only makes it difficult to scale with training dataset size, but also leads to sub-optimal solutions due to its discontinuous optimization routine. To solve these, we first present a novel pseudo-mask algorithm, Fast Universal Agglomerative Pooling (UniAP). Each layer of UniAP can identify groups of similar nodes in parallel, allowing to generate both semantic-level and instance-level and multi-granular pseudo-masks within ens of milliseconds for one image. Based on the fast UniAP, we propose the Scalable Self-Supervised Universal Segmentation (S2-UniSeg), which employs a student and a momentum teacher for continuous pretraining. A novel segmentation-oriented pretext task, Query-wise Self-Distillation (QuerySD), is proposed to pretrain S2-UniSeg to learn the local-to-global correspondences. Under the same setting, S2-UniSeg outperforms the SOTA UnSAM model, achieving notable improvements of AP+6.9 on COCO, AR+11.1 on UVO, PixelAcc+4.5 on COCOStuff-27, RQ+8.0 on Cityscapes. After scaling up to a larger 2M-image subset of SA-1B, S2-UniSeg further achieves performance gains on all four benchmarks. Our code and pretrained models are available at https://github.com/bio-mlhui/S2-UniSeg

S3CE-Net: Spike-guided Spatiotemporal Semantic Coupling and Expansion Network for Long Sequence Event Re-Identification

In this paper, we leverage the advantages of event cameras to resist harsh lighting conditions, reduce background interference, achieve high time resolution, and protect facial information to study the long-sequence event-based person re-identification (Re-ID) task. To this end, we propose a simple and efficient long-sequence event Re-ID model, namely the Spike-guided Spatiotemporal Semantic Coupling and Expansion Network (S3CE-Net). To better handle asynchronous event data, we build S3CE-Net based on spiking neural networks (SNNs). The S3CE-Net incorporates the Spike-guided Spatial-temporal Attention Mechanism (SSAM) and the Spatiotemporal Feature Sampling Strategy (STFS). The SSAM is designed to carry out semantic interaction and association in both spatial and temporal dimensions, leveraging the capabilities of SNNs. The STFS involves sampling spatial feature subsequences and temporal feature subsequences from the spatiotemporal dimensions, driving the Re-ID model to perceive broader and more robust effective semantics. Notably, the STFS introduces no additional parameters and is only utilized during the training stage. Therefore, S3CE-Net is a low-parameter and high-efficiency model for long-sequence event-based person Re-ID. Extensive experiments have verified that our S3CE-Net achieves outstanding performance on many mainstream long-sequence event-based person Re-ID datasets. Code is available at:https://github.com/Mhsunshine/SC3E_Net.

S2R-Bench: A Sim-to-Real Evaluation Benchmark for Autonomous Driving

Safety is a long-standing and the final pursuit in the development of autonomous driving systems, with a significant portion of safety challenge arising from perception. How to effectively evaluate the safety as well as the reliability of perception algorithms is becoming an emerging issue. Despite its critical importance, existing perception methods exhibit a limitation in their robustness, primarily due to the use of benchmarks are entierly simulated, which fail to align predicted results with actual outcomes, particularly under extreme weather conditions and sensor anomalies that are prevalent in real-world scenarios. To fill this gap, in this study, we propose a Sim-to-Real Evaluation Benchmark for Autonomous Driving (S2R-Bench). We collect diverse sensor anomaly data under various road conditions to evaluate the robustness of autonomous driving perception methods in a comprehensive and realistic manner. This is the first corruption robustness benchmark based on real-world scenarios, encompassing various road conditions, weather conditions, lighting intensities, and time periods. By comparing real-world data with simulated data, we demonstrate the reliability and practical significance of the collected data for real-world applications. We hope that this dataset will advance future research and contribute to the development of more robust perception models for autonomous driving. This dataset is released on https://github.com/adept-thu/S2R-Bench.

Neural Quantum Digital Twins for Optimizing Quantum Annealing

Quantum annealers have shown potential in addressing certain combinatorial optimization problems, though their performance is often limited by scalability and errors rates. In this work, we propose a Neural Quantum Digital Twin (NQDT) framework that reconstructs the energy landscape of quantum many-body systems relevant to quantum annealing. The digital twin models both ground and excited state dynamics, enabling detailed simulation of the adiabatic evolution process. We benchmark NQDT on systems with known analytical solutions and demonstrate that it accurately captures key quantum phenomena, including quantum criticality and phase transitions. Leveraging this framework, one can identify optimal annealing schedules that minimize excitation-related errors. These findings highlight the utility of neural network-based digital twins as a diagnostic and optimization tool for improving the performance of quantum annealers.

ListenNet: A Lightweight Spatio-Temporal Enhancement Nested Network for Auditory Attention Detection

Auditory attention detection (AAD) aims to identify the direction of the attended speaker in multi-speaker environments from brain signals, such as Electroencephalography (EEG) signals. However, existing EEG-based AAD methods overlook the spatio-temporal dependencies of EEG signals, limiting their decoding and generalization abilities. To address these issues, this paper proposes a Lightweight Spatio-Temporal Enhancement Nested Network (ListenNet) for AAD. The ListenNet has three key components: Spatio-temporal Dependency Encoder (STDE), Multi-scale Temporal Enhancement (MSTE), and Cross-Nested Attention (CNA). The STDE reconstructs dependencies between consecutive time windows across channels, improving the robustness of dynamic pattern extraction. The MSTE captures temporal features at multiple scales to represent both fine-grained and long-range temporal patterns. In addition, the CNA integrates hierarchical features more effectively through novel dynamic attention mechanisms to capture deep spatio-temporal correlations. Experimental results on three public datasets demonstrate the superiority of ListenNet over state-of-the-art methods in both subject-dependent and challenging subject-independent settings, while reducing the trainable parameter count by approximately 7 times. Code is available at:https://github.com/fchest/ListenNet.

NTIRE 2025 Challenge on UGC Video Enhancement: Methods and Results

This paper presents an overview of the NTIRE 2025 Challenge on UGC Video Enhancement. The challenge constructed a set of 150 user-generated content videos without reference ground truth, which suffer from real-world degradations such as noise, blur, faded colors, compression artifacts, etc. The goal of the participants was to develop an algorithm capable of improving the visual quality of such videos. Given the widespread use of UGC on short-form video platforms, this task holds substantial practical importance. The evaluation was based on subjective quality assessment in crowdsourcing, obtaining votes from over 8000 assessors. The challenge attracted more than 25 teams submitting solutions, 7 of which passed the final phase with source code verification. The outcomes may provide insights into the state-of-the-art in UGC video enhancement and highlight emerging trends and effective strategies in this evolving research area. All data, including the processed videos and subjective comparison votes and scores, is made publicly available at https://github.com/msu-video-group/NTIRE25_UGC_Video_Enhancement.

Symbolic Representation for Any-to-Any Generative Tasks

We propose a symbolic generative task description language and a corresponding inference engine capable of representing arbitrary multimodal tasks as structured symbolic flows. Unlike conventional generative models that rely on large-scale training and implicit neural representations to learn cross-modal mappings, often at high computational cost and with limited flexibility, our framework introduces an explicit symbolic representation comprising three core primitives: functions, parameters, and topological logic. Leveraging a pre-trained language model, our inference engine maps natural language instructions directly to symbolic workflows in a training-free manner. Our framework successfully performs over 12 diverse multimodal generative tasks, demonstrating strong performance and flexibility without the need for task-specific tuning. Experiments show that our method not only matches or outperforms existing state-of-the-art unified models in content quality, but also offers greater efficiency, editability, and interruptibility. We believe that symbolic task representations provide a cost-effective and extensible foundation for advancing the capabilities of generative AI.