Advances in Multiple Instance Learning for Whole Slide Image Analysis: Techniques, Challenges, and Future Directions

Whole slide images (WSIs) are gigapixel-scale digital images of H\&E-stained tissue samples widely used in pathology. The substantial size and complexity of WSIs pose unique analytical challenges. Multiple Instance Learning (MIL) has emerged as a powerful approach for addressing these challenges, particularly in cancer classification and detection. This survey provides a comprehensive overview of the challenges and methodologies associated with applying MIL to WSI analysis, including attention mechanisms, pseudo-labeling, transformers, pooling functions, and graph neural networks. Additionally, it explores the potential of MIL in discovering cancer cell morphology, constructing interpretable machine learning models, and quantifying cancer grading. By summarizing the current challenges, methodologies, and potential applications of MIL in WSI analysis, this survey aims to inform researchers about the state of the field and inspire future research directions.

xGen-MM (BLIP-3): A Family of Open Large Multimodal Models

This report introduces xGen-MM (also known as BLIP-3), a framework for developing Large Multimodal Models (LMMs). The framework comprises meticulously curated datasets, a training recipe, model architectures, and a resulting suite of LMMs. xGen-MM, short for xGen-MultiModal, expands the Salesforce xGen initiative on foundation AI models. Our models undergo rigorous evaluation across a range of tasks, including both single and multi-image benchmarks. Our pre-trained base model exhibits strong in-context learning capabilities and the instruction-tuned model demonstrates competitive performance among open-source LMMs with similar model sizes. In addition, we introduce a safety-tuned model with DPO, aiming to mitigate harmful behaviors such as hallucinations and improve safety. We open-source our models, curated large-scale datasets, and our fine-tuning codebase to facilitate further advancements in LMM research. Associated resources will be available on our project page above.

LLM4DSR: Leveraing Large Language Model for Denoising Sequential Recommendation

Sequential recommendation systems fundamentally rely on users' historical interaction sequences, which are often contaminated by noisy interactions. Identifying these noisy interactions accurately without additional information is particularly difficult due to the lack of explicit supervisory signals to denote noise. Large Language Models (LLMs), equipped with extensive open knowledge and semantic reasoning abilities, present a promising avenue to bridge this information gap. However, employing LLMs for denoising in sequential recommendation introduces notable challenges: 1) Direct application of pretrained LLMs may not be competent for the denoising task, frequently generating nonsensical responses; 2) Even after fine-tuning, the reliability of LLM outputs remains questionable, especially given the complexity of the task and th inherent hallucinatory issue of LLMs. To tackle these challenges, we propose LLM4DSR, a tailored approach for denoising sequential recommendation using LLMs. We constructed a self-supervised fine-tuning task to activate LLMs' capabilities to identify noisy items and suggest replacements. Furthermore, we developed an uncertainty estimation module that ensures only high-confidence responses are utilized for sequence corrections. Remarkably, LLM4DSR is model-agnostic, allowing the corrected sequences to be flexibly applied across various recommendation models. Extensive experiments validate the superiority of LLM4DSR over existing methods across three datasets and three recommendation backbones.

An Efficient Continuous Control Perspective for Reinforcement-Learning-based Sequential Recommendation

Sequential recommendation, where user preference is dynamically inferred from sequential historical behaviors, is a critical task in recommender systems (RSs). To further optimize long-term user engagement, offline reinforcement-learning-based RSs have become a mainstream technique as they provide an additional advantage in avoiding global explorations that may harm online users' experiences. However, previous studies mainly focus on discrete action and policy spaces, which might have difficulties in handling dramatically growing items efficiently. To mitigate this issue, in this paper, we aim to design an algorithmic framework applicable to continuous policies. To facilitate the control in the low-dimensional but dense user preference space, we propose an \underline{\textbf{E}}fficient \underline{\textbf{Co}}ntinuous \underline{\textbf{C}}ontrol framework (ECoC). Based on a statistically tested assumption, we first propose the novel unified action representation abstracted from normalized user and item spaces. Then, we develop the corresponding policy evaluation and policy improvement procedures. During this process, strategic exploration and directional control in terms of unified actions are carefully designed and crucial to final recommendation decisions. Moreover, beneficial from unified actions, the conservatism regularization for policies and value functions are combined and perfectly compatible with the continuous framework. The resulting dual regularization ensures the successful offline training of RL-based recommendation policies. Finally, we conduct extensive experiments to validate the effectiveness of our framework. The results show that compared to the discrete baselines, our ECoC is trained far more efficiently. Meanwhile, the final policies outperform baselines in both capturing the offline data and gaining long-term rewards.

Experimental evaluation of offline reinforcement learning for HVAC control in buildings

Reinforcement learning (RL) techniques have been increasingly investigated for dynamic HVAC control in buildings. However, most studies focus on exploring solutions in online or off-policy scenarios without discussing in detail the implementation feasibility or effectiveness of dealing with purely offline datasets or trajectories. The lack of these works limits the real-world deployment of RL-based HVAC controllers, especially considering the abundance of historical data. To this end, this paper comprehensively evaluates the strengths and limitations of state-of-the-art offline RL algorithms by conducting analytical and numerical studies. The analysis is conducted from two perspectives: algorithms and dataset characteristics. As a prerequisite, the necessity of applying offline RL algorithms is first confirmed in two building environments. The ability of observation history modeling to reduce violations and enhance performance is subsequently studied. Next, the performance of RL-based controllers under datasets with different qualitative and quantitative conditions is investigated, including constraint satisfaction and power consumption. Finally, the sensitivity of certain hyperparameters is also evaluated. The results indicate that datasets of a certain suboptimality level and relatively small scale can be utilized to effectively train a well-performed RL-based HVAC controller. Specifically, such controllers can reduce at most 28.5% violation ratios of indoor temperatures and achieve at most 12.1% power savings compared to the baseline controller. In summary, this paper presents our well-structured investigations and new findings when applying offline reinforcement learning to building HVAC systems.

Neural Architecture Search based Global-local Vision Mamba for Palm-Vein Recognition

Due to the advantages such as high security, high privacy, and liveness recognition, vein recognition has been received more and more attention in past years. Recently, deep learning models, e.g., Mamba has shown robust feature representation with linear computational complexity and successfully applied for visual tasks. However, vision Manba can capture long-distance feature dependencies but unfortunately deteriorate local feature details. Besides, manually designing a Mamba architecture based on human priori knowledge is very time-consuming and error-prone. In this paper, first, we propose a hybrid network structure named Global-local Vision Mamba (GLVM), to learn the local correlations in images explicitly and global dependencies among tokens for vein feature representation. Secondly, we design a Multi-head Mamba to learn the dependencies along different directions, so as to improve the feature representation ability of vision Mamba. Thirdly, to learn the complementary features, we propose a ConvMamba block consisting of three branches, named Multi-head Mamba branch (MHMamba), Feature Iteration Unit branch (FIU), and Convolutional Neural Network (CNN) branch, where the Feature Iteration Unit branch aims to fuse convolutional local features with Mamba-based global representations. Finally, a Globallocal Alternate Neural Architecture Search (GLNAS) method is proposed to search the optimal architecture of GLVM alternately with the evolutionary algorithm, thereby improving the recognition performance for vein recognition tasks. We conduct rigorous experiments on three public palm-vein databases to estimate the performance. The experimental results demonstrate that the proposed method outperforms the representative approaches and achieves state-of-the-art recognition accuracy.

GlitchProber: Advancing Effective Detection and Mitigation of Glitch Tokens in Large Language Models

Large language models (LLMs) have achieved unprecedented success in the field of natural language processing. However, the black-box nature of their internal mechanisms has brought many concerns about their trustworthiness and interpretability. Recent research has discovered a class of abnormal tokens in the model's vocabulary space and named them "glitch tokens". Those tokens, once included in the input, may induce the model to produce incorrect, irrelevant, or even harmful results, drastically undermining the reliability and practicality of LLMs. In this work, we aim to enhance the understanding of glitch tokens and propose techniques for their detection and mitigation. We first reveal the characteristic features induced by glitch tokens on LLMs, which are evidenced by significant deviations in the distributions of attention patterns and dynamic information from intermediate model layers. Based on the insights, we develop GlitchProber, a tool for efficient glitch token detection and mitigation. GlitchProber utilizes small-scale sampling, principal component analysis for accelerated feature extraction, and a simple classifier for efficient vocabulary screening. Taking one step further, GlitchProber rectifies abnormal model intermediate layer values to mitigate the destructive effects of glitch tokens. Evaluated on five mainstream open-source LLMs, GlitchProber demonstrates higher efficiency, precision, and recall compared to existing approaches, with an average F1 score of 0.86 and an average repair rate of 50.06%. GlitchProber unveils a novel path to address the challenges posed by glitch tokens and inspires future research toward more robust and interpretable LLMs.

HMDN: Hierarchical Multi-Distribution Network for Click-Through Rate Prediction

As the recommendation service needs to address increasingly diverse distributions, such as multi-population, multi-scenario, multitarget, and multi-interest, more and more recent works have focused on multi-distribution modeling and achieved great progress. However, most of them only consider modeling in a single multi-distribution manner, ignoring that mixed multi-distributions often coexist and form hierarchical relationships. To address these challenges, we propose a flexible modeling paradigm, named Hierarchical Multi-Distribution Network (HMDN), which efficiently models these hierarchical relationships and can seamlessly integrate with existing multi-distribution methods, such as Mixture of-Experts (MoE) and Dynamic-Weight (DW) models. Specifically, we first design a hierarchical multi-distribution representation refinement module, employing a multi-level residual quantization to obtain fine-grained hierarchical representation. Then, the refined hierarchical representation is integrated into the existing single multi-distribution models, seamlessly expanding them into mixed multi-distribution models. Experimental results on both public and industrial datasets validate the effectiveness and flexibility of HMDN.

Lessons from Learning to Spin "Pens"

In-hand manipulation of pen-like objects is an important skill in our daily lives, as many tools such as hammers and screwdrivers are similarly shaped. However, current learning-based methods struggle with this task due to a lack of high-quality demonstrations and the significant gap between simulation and the real world. In this work, we push the boundaries of learning-based in-hand manipulation systems by demonstrating the capability to spin pen-like objects. We first use reinforcement learning to train an oracle policy with privileged information and generate a high-fidelity trajectory dataset in simulation. This serves two purposes: 1) pre-training a sensorimotor policy in simulation; 2) conducting open-loop trajectory replay in the real world. We then fine-tune the sensorimotor policy using these real-world trajectories to adapt it to the real world dynamics. With less than 50 trajectories, our policy learns to rotate more than ten pen-like objects with different physical properties for multiple revolutions. We present a comprehensive analysis of our design choices and share the lessons learned during development.

SQLfuse: Enhancing Text-to-SQL Performance through Comprehensive LLM Synergy

Text-to-SQL conversion is a critical innovation, simplifying the transition from complex SQL to intuitive natural language queries, especially significant given SQL's prevalence in the job market across various roles. The rise of Large Language Models (LLMs) like GPT-3.5 and GPT-4 has greatly advanced this field, offering improved natural language understanding and the ability to generate nuanced SQL statements. However, the potential of open-source LLMs in Text-to-SQL applications remains underexplored, with many frameworks failing to leverage their full capabilities, particularly in handling complex database queries and incorporating feedback for iterative refinement. Addressing these limitations, this paper introduces SQLfuse, a robust system integrating open-source LLMs with a suite of tools to enhance Text-to-SQL translation's accuracy and usability. SQLfuse features four modules: schema mining, schema linking, SQL generation, and a SQL critic module, to not only generate but also continuously enhance SQL query quality. Demonstrated by its leading performance on the Spider Leaderboard and deployment by Ant Group, SQLfuse showcases the practical merits of open-source LLMs in diverse business contexts.