AI-Based Fully Automatic Analysis of Retinal Vascular Morphology in Pediatric High Myopia

Purpose: To investigate the changes in retinal vascular structures associated various stages of myopia by designing automated software based on an artif intelligencemodel. Methods: The study involved 1324 pediatric participants from the National Childr Medical Center in China, and 2366 high-quality retinal images and correspon refractive parameters were obtained and analyzed. Spherical equivalent refrac(SER) degree was calculated. We proposed a data analysis model based c combination of the Convolutional Neural Networks (CNN) model and the atter module to classify images, segment vascular structures, and measure vasc parameters, such as main angle (MA), branching angle (BA), bifurcation edge al(BEA) and bifurcation edge coefficient (BEC). One-way ANOVA compared param measurements betweenthenormalfundus,lowmyopia,moderate myopia,and high myopia group. Results: There were 279 (12.38%) images in normal group and 384 (16.23%) images in the high myopia group. Compared normal fundus, the MA of fundus vessels in different myopic refractive groups significantly reduced (P = 0.006, P = 0.004, P = 0.019, respectively), and performance of the venous system was particularly obvious (P<0.001). At the sa time, the BEC decreased disproportionately (P<0.001). Further analysis of fundus vascular parameters at different degrees of myopia showed that there were also significant differences in BA and branching coefficient (BC). The arterial BA value of the fundus vessel in the high myopia group was lower than that of other groups (P : 0.032, 95% confidence interval [Ci], 0.22-4.86), while the venous BA values increased(P = 0.026). The BEC values of high myopia were higher than those of low and moderate myopia groups. When the loss function of our data classification model converged to 0.09,the model accuracy reached 94.19%

Will Large Language Models be a Panacea to Autonomous Driving?

Artificial intelligence (AI) plays a crucial role in autonomous driving (AD) research, propelling its development towards intelligence and efficiency. Currently, the development of AD technology follows two main technical paths: modularization and end-to-end. Modularization decompose the driving task into modules such as perception, prediction, planning, and control, and train them separately. Due to the inconsistency of training objectives between modules, the integrated effect suffers from bias. End-to-end attempts to address this issue by utilizing a single model that directly maps from sensor data to control signals. This path has limited learning capabilities in a comprehensive set of features and struggles to handle unpredictable long-tail events and complex urban traffic scenarios. In the face of challenges encountered in both paths, many researchers believe that large language models (LLMs) with powerful reasoning capabilities and extensive knowledge understanding may be the solution, expecting LLMs to provide AD systems with deeper levels of understanding and decision-making capabilities. In light of the challenges faced by both paths, many researchers believe that LLMs, with their powerful reasoning abilities and extensive knowledge, could offer a solution. To understand if LLMs could enhance AD, this paper conducts a thorough analysis of the potential applications of LLMs in AD systems, including exploring their optimization strategies in both modular and end-to-end approaches, with a particular focus on how LLMs can tackle the problems and challenges present in current solutions. Furthermore, we discuss an important question: Can LLM-based artificial general intelligence (AGI) be a key to achieve high-level AD? We further analyze the potential limitations and challenges that LLMs may encounter in promoting the development of AD technology.

PathSeeker: Exploring LLM Security Vulnerabilities with a Reinforcement Learning-Based Jailbreak Approach

In recent years, Large Language Models (LLMs) have gained widespread use, accompanied by increasing concerns over their security. Traditional jailbreak attacks rely on internal model details or have limitations when exploring the unsafe behavior of the victim model, limiting their generalizability. In this paper, we introduce PathSeeker, a novel black-box jailbreak method inspired by the concept of escaping a security maze. This work is inspired by the game of rats escaping a maze. We think that each LLM has its unique "security maze", and attackers attempt to find the exit learning from the received feedback and their accumulated experience to compromise the target LLM's security defences. Our approach leverages multi-agent reinforcement learning, where smaller models collaborate to guide the main LLM in performing mutation operations to achieve the attack objectives. By progressively modifying inputs based on the model's feedback, our system induces richer, harmful responses. During our manual attempts to perform jailbreak attacks, we found that the vocabulary of the response of the target model gradually became richer and eventually produced harmful responses. Based on the observation, we also introduce a reward mechanism that exploits the expansion of vocabulary richness in LLM responses to weaken security constraints. Our method outperforms five state-of-the-art attack techniques when tested across 13 commercial and open-source LLMs, achieving high attack success rates, especially in strongly aligned commercial models like GPT-4o-mini, Claude-3.5, and GLM-4-air with strong safety alignment. This study aims to improve the understanding of LLM security vulnerabilities and we hope that this sturdy can contribute to the development of more robust defenses.

Few-Shot Domain Adaptation for Learned Image Compression

Learned image compression (LIC) has achieved state-of-the-art rate-distortion performance, deemed promising for next-generation image compression techniques. However, pre-trained LIC models usually suffer from significant performance degradation when applied to out-of-training-domain images, implying their poor generalization capabilities. To tackle this problem, we propose a few-shot domain adaptation method for LIC by integrating plug-and-play adapters into pre-trained models. Drawing inspiration from the analogy between latent channels and frequency components, we examine domain gaps in LIC and observe that out-of-training-domain images disrupt pre-trained channel-wise decomposition. Consequently, we introduce a method for channel-wise re-allocation using convolution-based adapters and low-rank adapters, which are lightweight and compatible to mainstream LIC schemes. Extensive experiments across multiple domains and multiple representative LIC schemes demonstrate that our method significantly enhances pre-trained models, achieving comparable performance to H.266/VVC intra coding with merely 25 target-domain samples. Additionally, our method matches the performance of full-model finetune while transmitting fewer than $2\%$ of the parameters.

USTC-TD: A Test Dataset and Benchmark for Image and Video Coding in 2020s

Image/video coding has been a remarkable research area for both academia and industry for many years. Testing datasets, especially high-quality image/video datasets are desirable for the justified evaluation of coding-related research, practical applications, and standardization activities. We put forward a test dataset namely USTC-TD, which has been successfully adopted in the practical end-to-end image/video coding challenge of the IEEE International Conference on Visual Communications and Image Processing in 2022 and 2023. USTC-TD contains 40 images at 4K spatial resolution and 10 video sequences at 1080p spatial resolution, featuring various content due to the diverse environmental factors (scene type, texture, motion, view) and the designed imaging factors (illumination, shadow, lens). We quantitatively evaluate USTC-TD on different image/video features (spatial, temporal, color, lightness), and compare it with the previous image/video test datasets, which verifies the wider coverage and more diversity of the proposed dataset. We also evaluate both classic standardized and recent learned image/video coding schemes on USTC-TD with PSNR and MS-SSIM, and provide an extensive benchmark for the evaluated schemes. Based on the characteristics and specific design of the proposed test dataset, we analyze the benchmark performance and shed light on the future research and development of image/video coding. All the data are released online: https://esakak.github.io/USTC-TD.

Heterogeneity-Aware Coordination for Federated Learning via Stitching Pre-trained blocks

Federated learning (FL) coordinates multiple devices to collaboratively train a shared model while preserving data privacy. However, large memory footprint and high energy consumption during the training process excludes the low-end devices from contributing to the global model with their own data, which severely deteriorates the model performance in real-world scenarios. In this paper, we propose FedStitch, a hierarchical coordination framework for heterogeneous federated learning with pre-trained blocks. Unlike the traditional approaches that train the global model from scratch, for a new task, FedStitch composes the global model via stitching pre-trained blocks. Specifically, each participating client selects the most suitable block based on their local data from the candidate pool composed of blocks from pre-trained models. The server then aggregates the optimal block for stitching. This process iterates until a new stitched network is generated. Except for the new training paradigm, FedStitch consists of the following three core components: 1) an RL-weighted aggregator, 2) a search space optimizer deployed on the server side, and 3) a local energy optimizer deployed on each participating client. The RL-weighted aggregator helps to select the right block in the non-IID scenario, while the search space optimizer continuously reduces the size of the candidate block pool during stitching. Meanwhile, the local energy optimizer is designed to minimize energy consumption of each client while guaranteeing the overall training progress. The results demonstrate that compared to existing approaches, FedStitch improves the model accuracy up to 20.93%. At the same time, it achieves up to 8.12% speedup, reduces the memory footprint up to 79.5%, and achieves 89.41% energy saving at most during the learning procedure.

Large Language Models in Drug Discovery and Development: From Disease Mechanisms to Clinical Trials

The integration of Large Language Models (LLMs) into the drug discovery and development field marks a significant paradigm shift, offering novel methodologies for understanding disease mechanisms, facilitating drug discovery, and optimizing clinical trial processes. This review highlights the expanding role of LLMs in revolutionizing various stages of the drug development pipeline. We investigate how these advanced computational models can uncover target-disease linkage, interpret complex biomedical data, enhance drug molecule design, predict drug efficacy and safety profiles, and facilitate clinical trial processes. Our paper aims to provide a comprehensive overview for researchers and practitioners in computational biology, pharmacology, and AI4Science by offering insights into the potential transformative impact of LLMs on drug discovery and development.

TraIL-Det: Transformation-Invariant Local Feature Networks for 3D LiDAR Object Detection with Unsupervised Pre-Training

3D point clouds are essential for perceiving outdoor scenes, especially within the realm of autonomous driving. Recent advances in 3D LiDAR Object Detection focus primarily on the spatial positioning and distribution of points to ensure accurate detection. However, despite their robust performance in variable conditions, these methods are hindered by their sole reliance on coordinates and point intensity, resulting in inadequate isometric invariance and suboptimal detection outcomes. To tackle this challenge, our work introduces Transformation-Invariant Local (TraIL) features and the associated TraIL-Det architecture. Our TraIL features exhibit rigid transformation invariance and effectively adapt to variations in point density, with a design focus on capturing the localized geometry of neighboring structures. They utilize the inherent isotropic radiation of LiDAR to enhance local representation, improve computational efficiency, and boost detection performance. To effectively process the geometric relations among points within each proposal, we propose a Multi-head self-Attention Encoder (MAE) with asymmetric geometric features to encode high-dimensional TraIL features into manageable representations. Our method outperforms contemporary self-supervised 3D object detection approaches in terms of mAP on KITTI (67.8, 20% label, moderate) and Waymo (68.9, 20% label, moderate) datasets under various label ratios (20%, 50%, and 100%).

LaneTCA: Enhancing Video Lane Detection with Temporal Context Aggregation

In video lane detection, there are rich temporal contexts among successive frames, which is under-explored in existing lane detectors. In this work, we propose LaneTCA to bridge the individual video frames and explore how to effectively aggregate the temporal context. Technically, we develop an accumulative attention module and an adjacent attention module to abstract the long-term and short-term temporal context, respectively. The accumulative attention module continuously accumulates visual information during the journey of a vehicle, while the adjacent attention module propagates this lane information from the previous frame to the current frame. The two modules are meticulously designed based on the transformer architecture. Finally, these long-short context features are fused with the current frame features to predict the lane lines in the current frame. Extensive quantitative and qualitative experiments are conducted on two prevalent benchmark datasets. The results demonstrate the effectiveness of our method, achieving several new state-of-the-art records. The codes and models are available at https://github.com/Alex-1337/LaneTCA

Bi-Directional Deep Contextual Video Compression

Deep video compression has made remarkable process in recent years, with the majority of advancements concentrated on P-frame coding. Although efforts to enhance B-frame coding are ongoing, their compression performance is still far behind that of traditional bi-directional video codecs. In this paper, we introduce a bi-directional deep contextual video compression scheme tailored for B-frames, termed DCVC-B, to improve the compression performance of deep B-frame coding. Our scheme mainly has three key innovations. First, we develop a bi-directional motion difference context propagation method for effective motion difference coding, which significantly reduces the bit cost of bi-directional motions. Second, we propose a bi-directional contextual compression model and a corresponding bi-directional temporal entropy model, to make better use of the multi-scale temporal contexts. Third, we propose a hierarchical quality structure-based training strategy, leading to an effective bit allocation across large groups of pictures (GOP). Experimental results show that our DCVC-B achieves an average reduction of 26.6% in BD-Rate compared to the reference software for H.265/HEVC under random access conditions. Remarkably, it surpasses the performance of the H.266/VVC reference software on certain test datasets under the same configuration.