IHC Matters: Incorporating IHC analysis to H&E Whole Slide Image Analysis for Improved Cancer Grading via Two-stage Multimodal Bilinear Pooling Fusion

Immunohistochemistry (IHC) plays a crucial role in pathology as it detects the over-expression of protein in tissue samples. However, there are still fewer machine learning model studies on IHC's impact on accurate cancer grading. We discovered that IHC and H\&E possess distinct advantages and disadvantages while possessing certain complementary qualities. Building on this observation, we developed a two-stage multi-modal bilinear model with a feature pooling module. This model aims to maximize the potential of both IHC and HE's feature representation, resulting in improved performance compared to their individual use. Our experiments demonstrate that incorporating IHC data into machine learning models, alongside H\&E stained images, leads to superior predictive results for cancer grading. The proposed framework achieves an impressive ACC higher of 0.953 on the public dataset BCI.

Pre-processing matters: A segment search method for WSI classification

Pre-processing for whole slide images can affect classification performance both in the training and inference stages. Our study analyzes the impact of pre-processing parameters on inference and training across single- and multiple-domain datasets. However, searching for an optimal parameter set is time-consuming. To overcome this, we propose a novel Similarity-based Simulated Annealing approach for fast parameter tuning to enhance inference performance on single-domain data. Our method demonstrates significant performance improvements in accuracy, which raise accuracy from 0.512 to 0.847 in a single domain. We further extend our insight into training performance in multi-domain data by employing a novel Bayesian optimization to search optimal pre-processing parameters, resulting in a high AUC of 0.967. We highlight that better pre-processing for WSI can contribute to further accuracy improvement in the histology area.

On the Compressibility of Quantized Large Language Models

Deploying Large Language Models (LLMs) on edge or mobile devices offers significant benefits, such as enhanced data privacy and real-time processing capabilities. However, it also faces critical challenges due to the substantial memory requirement of LLMs. Quantization is an effective way of reducing the model size while maintaining good performance. However, even after quantization, LLMs may still be too big to fit entirely into the limited memory of edge or mobile devices and have to be partially loaded from the storage to complete the inference. In this case, the I/O latency of model loading becomes the bottleneck of the LLM inference latency. In this work, we take a preliminary step of studying applying data compression techniques to reduce data movement and thus speed up the inference of quantized LLM on memory-constrained devices. In particular, we discussed the compressibility of quantized LLMs, the trade-off between the compressibility and performance of quantized LLMs, and opportunities to optimize both of them jointly.

Gemini: A Family of Highly Capable Multimodal Models

This report introduces a new family of multimodal models, Gemini, that exhibit remarkable capabilities across image, audio, video, and text understanding. The Gemini family consists of Ultra, Pro, and Nano sizes, suitable for applications ranging from complex reasoning tasks to on-device memory-constrained use-cases. Evaluation on a broad range of benchmarks shows that our most-capable Gemini Ultra model advances the state of the art in 30 of 32 of these benchmarks - notably being the first model to achieve human-expert performance on the well-studied exam benchmark MMLU, and improving the state of the art in every one of the 20 multimodal benchmarks we examined. We believe that the new capabilities of Gemini models in cross-modal reasoning and language understanding will enable a wide variety of use cases and we discuss our approach toward deploying them responsibly to users.

2D-Empowered 3D Object Detection on the Edge

3D object detection has a pivotal role in a wide range of applications, most notably autonomous driving and robotics. These applications are commonly deployed on edge devices to promptly interact with the environment, and often require near real-time response. With limited computation power, it is challenging to execute 3D detection on the edge using highly complex neural networks. Common approaches such as offloading to the cloud brings latency overheads due to the large amount of 3D point cloud data during transmission. To resolve the tension between wimpy edge devices and compute-intensive inference workloads, we explore the possibility of transforming fast 2D detection results to extrapolate 3D bounding boxes. To this end, we present Moby, a novel system that demonstrates the feasibility and potential of our approach. Our main contributions are two-fold: First, we design a 2D-to-3D transformation pipeline that takes as input the point cloud data from LiDAR and 2D bounding boxes from camera that are captured at exactly the same time, and generate 3D bounding boxes efficiently and accurately based on detection results of the previous frames without running 3D detectors. Second, we design a frame offloading scheduler that dynamically launches a 3D detection when the error of 2D-to-3D transformation accumulates to a certain level, so the subsequent transformations can draw upon the latest 3D detection results with better accuracy. Extensive evaluation on NVIDIA Jetson TX2 with the autonomous driving dataset KITTI and real-world 4G/LTE traces shows that, Moby reduces the end-to-end latency by up to 91.9% with mild accuracy drop compared to baselines. Further, Moby shows excellent energy efficiency by saving power consumption and memory footprint up to 75.7% and 48.1%, respectively.

A Fast Transformer-based General-Purpose Lossless Compressor

Deep-learning-based compressor has received interests recently due to much improved compression ratio. However, modern approaches suffer from long execution time. To ease this problem, this paper targets on cutting down the execution time of deep-learning-based compressors. Building history-dependencies sequentially (e.g., recurrent neural networks) is responsible for long inference latency. Instead, we introduce transformer into deep learning compressors to build history-dependencies in parallel. However, existing transformer is too heavy in computation and incompatible to compression tasks. This paper proposes a fast general-purpose lossless compressor, TRACE, by designing a compression-friendly structure based on a single-layer transformer. We first design a new metric to advise the selection part of compression model structures. Byte-grouping and Shared-ffn schemes are further proposed to fully utilize the capacity of the single-layer transformer. These features allow TRACE to achieve competitive compression ratio and a much faster speed. In addition, we further accelerate the compression procedure by designing a controller to reduce the parameter updating overhead. Experiments show that TRACE achieves an overall $\sim$3x speedup while keeps a comparable compression ratio to the state-of-the-art compressors. The source code for TRACE and links to the datasets are available at https://github.com/mynotwo/A-Fast-Transformer-based-General-Purpose-LosslessCompressor.

The Implicit Biases of Stochastic Gradient Descent on Deep Neural Networks with Batch Normalization

Deep neural networks with batch normalization (BN-DNNs) are invariant to weight rescaling due to their normalization operations. However, using weight decay (WD) benefits these weight-scale-invariant networks, which is often attributed to an increase of the effective learning rate when the weight norms are decreased. In this paper, we demonstrate the insufficiency of the previous explanation and investigate the implicit biases of stochastic gradient descent (SGD) on BN-DNNs to provide a theoretical explanation for the efficacy of weight decay. We identity two implicit biases of SGD on BN-DNNs: 1) the weight norms in SGD training remain constant in the continuous-time domain and keep increasing in the discrete-time domain; 2) SGD optimizes weight vectors in fully-connected networks or convolution kernels in convolution neural networks by updating components lying in the input feature span, while leaving those components orthogonal to the input feature span unchanged. Thus, SGD without WD accumulates weight noise orthogonal to the input feature span, and cannot eliminate such noise. Our empirical studies corroborate the hypothesis that weight decay suppresses weight noise that is left untouched by SGD. Furthermore, we propose to use weight rescaling (WRS) instead of weight decay to achieve the same regularization effect, while avoiding performance degradation of WD on some momentum-based optimizers. Our empirical results on image recognition show that regardless of optimization methods and network architectures, training BN-DNNs using WRS achieves similar or better performance compared with using WD. We also show that training with WRS generalizes better compared to WD, on other computer vision tasks.

Bayesian Nested Neural Networks for Uncertainty Calibration and Adaptive Compression

Nested networks or slimmable networks are neural networks whose architectures can be adjusted instantly during testing time, e.g., based on computational constraints. Recent studies have focused on a "nested dropout" layer, which is able to order the nodes of a layer by importance during training, thus generating a nested set of sub-networks that are optimal for different configurations of resources. However, the dropout rate is fixed as a hyper-parameter over different layers during the whole training process. Therefore, when nodes are removed, the performance decays in a human-specified trajectory rather than in a trajectory learned from data. Another drawback is the generated sub-networks are deterministic networks without well-calibrated uncertainty. To address these two problems, we develop a Bayesian approach to nested neural networks. We propose a variational ordering unit that draws samples for nested dropout at a low cost, from a proposed Downhill distribution, which provides useful gradients to the parameters of nested dropout. Based on this approach, we design a Bayesian nested neural network that learns the order knowledge of the node distributions. In experiments, we show that the proposed approach outperforms the nested network in terms of accuracy, calibration, and out-of-domain detection in classification tasks. It also outperforms the related approach on uncertainty-critical tasks in computer vision.

Robust Semi-Supervised Graph Classifier Learning with Negative Edge Weights

In a semi-supervised learning scenario, (possibly noisy) partially observed labels are used as input to train a classifier, in order to assign labels to unclassified samples. In this paper, we study this classifier learning problem from a graph signal processing (GSP) perspective. Specifically, by viewing a binary classifier as a piecewise constant graph-signal in a high-dimensional feature space, we cast classifier learning as a signal restoration problem via a classical maximum a posteriori (MAP) formulation. Unlike previous graph-signal restoration works, we consider in addition edges with negative weights that signify anti-correlation between samples. One unfortunate consequence is that the graph Laplacian matrix $\mathbf{L}$ can be indefinite, and previously proposed graph-signal smoothness prior $\mathbf{x}^T \mathbf{L} \mathbf{x}$ for candidate signal $\mathbf{x}$ can lead to pathological solutions. In response, we derive an optimal perturbation matrix $\boldsymbol{\Delta}$ - based on a fast lower-bound computation of the minimum eigenvalue of $\mathbf{L}$ via a novel application of the Haynsworth inertia additivity formula---so that $\mathbf{L} + \boldsymbol{\Delta}$ is positive semi-definite, resulting in a stable signal prior. Further, instead of forcing a hard binary decision for each sample, we define the notion of generalized smoothness on graph that promotes ambiguity in the classifier signal. Finally, we propose an algorithm based on iterative reweighted least squares (IRLS) that solves the posed MAP problem efficiently. Extensive simulation results show that our proposed algorithm outperforms both SVM variants and graph-based classifiers using positive-edge graphs noticeably.