Attention Basin: Why Contextual Position Matters in Large Language Models

The performance of Large Language Models (LLMs) is significantly sensitive to the contextual position of information in the input. To investigate the mechanism behind this positional bias, our extensive experiments reveal a consistent phenomenon we term the attention basin: when presented with a sequence of structured items (e.g., retrieved documents or few-shot examples), models systematically assign higher attention to the items at the beginning and end of the sequence, while neglecting those in the middle. Crucially, our analysis further reveals that allocating higher attention to critical information is key to enhancing model performance. Based on these insights, we introduce Attention-Driven Reranking (AttnRank), a two-stage framework that (i) estimates a model's intrinsic positional attention preferences using a small calibration set, and (ii) reorders retrieved documents or few-shot examples to align the most salient content with these high-attention positions. AttnRank is a model-agnostic, training-free, and plug-and-play method with minimal computational overhead. Experiments on multi-hop QA and few-shot in-context learning tasks demonstrate that AttnRank achieves substantial improvements across 10 large language models of varying architectures and scales, without modifying model parameters or training procedures.

A Versatile Pathology Co-pilot via Reasoning Enhanced Multimodal Large Language Model

Multimodal large language models (MLLMs) have emerged as powerful tools for computational pathology, offering unprecedented opportunities to integrate pathological images with language context for comprehensive diagnostic analysis. These models hold particular promise for automating complex tasks that traditionally require expert interpretation of pathologists. However, current MLLM approaches in pathology demonstrate significantly constrained reasoning capabilities, primarily due to their reliance on expensive chain-of-thought annotations. Additionally, existing methods remain limited to simplex application of visual question answering (VQA) at region-of-interest (ROI) level, failing to address the full spectrum of diagnostic needs such as ROI classification, detection, segmentation, whole-slide-image (WSI) classification and VQA in clinical practice. In this study, we present SmartPath-R1, a versatile MLLM capable of simultaneously addressing both ROI-level and WSI-level tasks while demonstrating robust pathological reasoning capability. Our framework combines scale-dependent supervised fine-tuning and task-aware reinforcement fine-tuning, which circumvents the requirement for chain-of-thought supervision by leveraging the intrinsic knowledge within MLLM. Furthermore, SmartPath-R1 integrates multiscale and multitask analysis through a mixture-of-experts mechanism, enabling dynamic processing for diverse tasks. We curate a large-scale dataset comprising 2.3M ROI samples and 188K WSI samples for training and evaluation. Extensive experiments across 72 tasks validate the effectiveness and superiority of the proposed approach. This work represents a significant step toward developing versatile, reasoning-enhanced AI systems for precision pathology.

Flow Matching Meets Biology and Life Science: A Survey

Over the past decade, advances in generative modeling, such as generative adversarial networks, masked autoencoders, and diffusion models, have significantly transformed biological research and discovery, enabling breakthroughs in molecule design, protein generation, drug discovery, and beyond. At the same time, biological applications have served as valuable testbeds for evaluating the capabilities of generative models. Recently, flow matching has emerged as a powerful and efficient alternative to diffusion-based generative modeling, with growing interest in its application to problems in biology and life sciences. This paper presents the first comprehensive survey of recent developments in flow matching and its applications in biological domains. We begin by systematically reviewing the foundations and variants of flow matching, and then categorize its applications into three major areas: biological sequence modeling, molecule generation and design, and peptide and protein generation. For each, we provide an in-depth review of recent progress. We also summarize commonly used datasets and software tools, and conclude with a discussion of potential future directions. The corresponding curated resources are available at https://github.com/Violet24K/Awesome-Flow-Matching-Meets-Biology.

Decentralizing Multi-Agent Reinforcement Learning with Temporal Causal Information

Reinforcement learning (RL) algorithms can find an optimal policy for a single agent to accomplish a particular task. However, many real-world problems require multiple agents to collaborate in order to achieve a common goal. For example, a robot executing a task in a warehouse may require the assistance of a drone to retrieve items from high shelves. In Decentralized Multi-Agent RL (DMARL), agents learn independently and then combine their policies at execution time, but often must satisfy constraints on compatibility of local policies to ensure that they can achieve the global task when combined. In this paper, we study how providing high-level symbolic knowledge to agents can help address unique challenges of this setting, such as privacy constraints, communication limitations, and performance concerns. In particular, we extend the formal tools used to check the compatibility of local policies with the team task, making decentralized training with theoretical guarantees usable in more scenarios. Furthermore, we empirically demonstrate that symbolic knowledge about the temporal evolution of events in the environment can significantly expedite the learning process in DMARL.

MT$^{3}$: Scaling MLLM-based Text Image Machine Translation via Multi-Task Reinforcement Learning

Text Image Machine Translation (TIMT)-the task of translating textual content embedded in images-is critical for applications in accessibility, cross-lingual information access, and real-world document understanding. However, TIMT remains a complex challenge due to the need for accurate optical character recognition (OCR), robust visual-text reasoning, and high-quality translation, often requiring cascading multi-stage pipelines. Recent advances in large-scale Reinforcement Learning (RL) have improved reasoning in Large Language Models (LLMs) and Multimodal LLMs (MLLMs), but their application to end-to-end TIMT is still underexplored. To bridge this gap, we introduce MT$^{3}$, the first framework to apply Multi-Task RL to MLLMs for end-to-end TIMT. MT$^{3}$ adopts a multi-task optimization paradigm targeting three key sub-skills: text recognition, context-aware reasoning, and translation. It is trained using a novel multi-mixed reward mechanism that adapts rule-based RL strategies to TIMT's intricacies, offering fine-grained, non-binary feedback across tasks. Furthermore, to facilitate the evaluation of TIMT in authentic cross-cultural and real-world social media contexts, we introduced XHSPost, the first social media TIMT benchmark. Our MT$^{3}$-7B-Zero achieves state-of-the-art results on the latest in-domain MIT-10M benchmark, outperforming strong baselines such as Qwen2.5-VL-72B and InternVL2.5-78B by notable margins across multiple metrics. Additionally, the model shows strong generalization to out-of-distribution language pairs and datasets. In-depth analyses reveal how multi-task synergy, reinforcement learning initialization, curriculum design, and reward formulation contribute to advancing MLLM-driven TIMT.

Beyond Linearity: Squeeze-and-Recalibrate Blocks for Few-Shot Whole Slide Image Classification

Deep learning has advanced computational pathology but expert annotations remain scarce. Few-shot learning mitigates annotation burdens yet suffers from overfitting and discriminative feature mischaracterization. In addition, the current few-shot multiple instance learning (MIL) approaches leverage pretrained vision-language models to alleviate these issues, but at the cost of complex preprocessing and high computational cost. We propose a Squeeze-and-Recalibrate (SR) block, a drop-in replacement for linear layers in MIL models to address these challenges. The SR block comprises two core components: a pair of low-rank trainable matrices (squeeze pathway, SP) that reduces parameter count and imposes a bottleneck to prevent spurious feature learning, and a frozen random recalibration matrix that preserves geometric structure, diversifies feature directions, and redefines the optimization objective for the SP. We provide theoretical guarantees that the SR block can approximate any linear mapping to arbitrary precision, thereby ensuring that the performance of a standard MIL model serves as a lower bound for its SR-enhanced counterpart. Extensive experiments demonstrate that our SR-MIL models consistently outperform prior methods while requiring significantly fewer parameters and no architectural changes.

Discovering Pathology Rationale and Token Allocation for Efficient Multimodal Pathology Reasoning

Multimodal pathological image understanding has garnered widespread interest due to its potential to improve diagnostic accuracy and enable personalized treatment through integrated visual and textual data. However, existing methods exhibit limited reasoning capabilities, which hamper their ability to handle complex diagnostic scenarios. Additionally, the enormous size of pathological images leads to severe computational burdens, further restricting their practical deployment. To address these limitations, we introduce a novel bilateral reinforcement learning framework comprising two synergistic branches. One reinforcement branch enhances the reasoning capability by enabling the model to learn task-specific decision processes, i.e., pathology rationales, directly from labels without explicit reasoning supervision. While the other branch dynamically allocates a tailored number of tokens to different images based on both their visual content and task context, thereby optimizing computational efficiency. We apply our method to various pathological tasks such as visual question answering, cancer subtyping, and lesion detection. Extensive experiments show an average +41.7 absolute performance improvement with 70.3% lower inference costs over the base models, achieving both reasoning accuracy and computational efficiency.

PaRT: Enhancing Proactive Social Chatbots with Personalized Real-Time Retrieval

Social chatbots have become essential intelligent companions in daily scenarios ranging from emotional support to personal interaction. However, conventional chatbots with passive response mechanisms usually rely on users to initiate or sustain dialogues by bringing up new topics, resulting in diminished engagement and shortened dialogue duration. In this paper, we present PaRT, a novel framework enabling context-aware proactive dialogues for social chatbots through personalized real-time retrieval and generation. Specifically, PaRT first integrates user profiles and dialogue context into a large language model (LLM), which is initially prompted to refine user queries and recognize their underlying intents for the upcoming conversation. Guided by refined intents, the LLM generates personalized dialogue topics, which then serve as targeted queries to retrieve relevant passages from RedNote. Finally, we prompt LLMs with summarized passages to generate knowledge-grounded and engagement-optimized responses. Our approach has been running stably in a real-world production environment for more than 30 days, achieving a 21.77\% improvement in the average duration of dialogues.

MT-R1-Zero: Advancing LLM-based Machine Translation via R1-Zero-like Reinforcement Learning

Large-scale reinforcement learning (RL) methods have proven highly effective in enhancing the reasoning abilities of large language models (LLMs), particularly for tasks with verifiable solutions such as mathematics and coding. However, applying this idea to machine translation (MT), where outputs are flexibly formatted and difficult to automatically evaluate with explicit rules, remains underexplored. In this work, we introduce MT-R1-Zero, the first open-source adaptation of the R1-Zero RL framework for MT without supervised fine-tuning or cold-start. We propose a rule-metric mixed reward mechanism to guide LLMs towards improved translation quality via emergent reasoning. On the WMT 24 English-Chinese benchmark, our MT-R1-Zero-3B-Mix achieves competitive performance, surpassing TowerInstruct-7B-v0.2 by an average of 1.26 points. Meanwhile, our MT-R1-Zero-7B-Mix attains a high average score of 62.25 across all metrics, placing it on par with advanced proprietary models such as GPT-4o and Claude-3.5-Sonnet, while the MT-R1-Zero-7B-Sem variant achieves state-of-the-art scores on semantic metrics. Moreover, our work exhibits strong generalization capabilities on out-of-distribution MT tasks, robustly supporting multilingual and low-resource settings. Extensive analysis of model behavior across different initializations and reward metrics offers pioneering insight into the critical role of reward design, LLM adaptability, training dynamics, and emergent reasoning patterns within the R1-Zero paradigm for MT. Our code is available at https://github.com/fzp0424/MT-R1-Zero.

Redefining Machine Translation on Social Network Services with Large Language Models

The globalization of social interactions has heightened the need for machine translation (MT) on Social Network Services (SNS), yet traditional models struggle with culturally nuanced content like memes, slang, and pop culture references. While large language models (LLMs) have advanced general-purpose translation, their performance on SNS-specific content remains limited due to insufficient specialized training data and evaluation benchmarks. This paper introduces RedTrans, a 72B LLM tailored for SNS translation, trained on a novel dataset developed through three innovations: (1) Supervised Finetuning with Dual-LLM Back-Translation Sampling, an unsupervised sampling method using LLM-based back-translation to select diverse data for large-scale finetuning; (2) Rewritten Preference Optimization (RePO), an algorithm that identifies and corrects erroneous preference pairs through expert annotation, building reliable preference corpora; and (3) RedTrans-Bench, the first benchmark for SNS translation, evaluating phenomena like humor localization, emoji semantics, and meme adaptation. Experiments show RedTrans outperforms state-of-the-art LLMs. Besides, RedTrans has already been deployed in a real-world production environment, demonstrating that domain-specific adaptation, effectively bridges the gap between generic and culturally grounded translation systems.