Concept-Attention Whitening for Interpretable Skin Lesion Diagnosis

The black-box nature of deep learning models has raised concerns about their interpretability for successful deployment in real-world clinical applications. To address the concerns, eXplainable Artificial Intelligence (XAI) aims to provide clear and understandable explanations of the decision-making process. In the medical domain, concepts such as attributes of lesions or abnormalities serve as key evidence for deriving diagnostic results. However, existing concept-based models mainly depend on concepts that appear independently and require fine-grained concept annotations such as bounding boxes. A medical image usually contains multiple concepts and the fine-grained concept annotations are difficult to acquire. In this paper, we propose a novel Concept-Attention Whitening (CAW) framework for interpretable skin lesion diagnosis. CAW is comprised of a disease diagnosis branch and a concept alignment branch. In the former branch, we train the CNN with a CAW layer inserted to perform skin lesion diagnosis. The CAW layer decorrelates features and aligns image features to conceptual meanings via an orthogonal matrix. In the latter branch, we calculate the orthogonal matrix under the guidance of the concept attention mask. We particularly introduce a weakly-supervised concept mask generator that only leverages coarse concept labels for filtering local regions that are relevant to certain concepts, improving the optimization of the orthogonal matrix. Extensive experiments on two public skin lesion diagnosis datasets demonstrated that CAW not only enhanced interpretability but also maintained a state-of-the-art diagnostic performance.

QMix: Quality-aware Learning with Mixed Noise for Robust Retinal Disease Diagnosis

Due to the complexity of medical image acquisition and the difficulty of annotation, medical image datasets inevitably contain noise. Noisy data with wrong labels affects the robustness and generalization ability of deep neural networks. Previous noise learning methods mainly considered noise arising from images being mislabeled, i.e. label noise, assuming that all mislabeled images are of high image quality. However, medical images are prone to suffering extreme quality issues, i.e. data noise, where discriminative visual features are missing for disease diagnosis. In this paper, we propose a noise learning framework, termed as QMix, that learns a robust disease diagnosis model under mixed noise. QMix alternates between sample separation and quality-aware semisupervised training in each training epoch. In the sample separation phase, we design a joint uncertainty-loss criterion to effectively separate (1) correctly labeled images; (2) mislabeled images with high quality and (3) mislabeled images with low quality. In the semi-supervised training phase, we train a disease diagnosis model to learn robust feature representation from the separated samples. Specifically, we devise a sample-reweighing loss to mitigate the effect of mislabeled images with low quality during training. Meanwhile, a contrastive enhancement loss is proposed to further distinguish mislabeled images with low quality from correctly labeled images. QMix achieved state-of-the-art disease diagnosis performance on five public retinal image datasets and exhibited substantial improvement on robustness against mixed noise.

Advancing COVID-19 Detection in 3D CT Scans

To make a more accurate diagnosis of COVID-19, we propose a straightforward yet effective model. Firstly, we analyse the characteristics of 3D CT scans and remove the non-lung parts, facilitating the model to focus on lesion-related areas and reducing computational cost. We use ResNeSt50 as the strong feature extractor, initializing it with pretrained weights which have COVID-19-specific prior knowledge. Our model achieves a Macro F1 Score of 0.94 on the validation set of the 4th COV19D Competition Challenge $\mathrm{I}$, surpassing the baseline by 16%. This indicates its effectiveness in distinguishing between COVID-19 and non-COVID-19 cases, making it a robust method for COVID-19 detection.

Domain Adaptation Using Pseudo Labels for COVID-19 Detection

In response to the need for rapid and accurate COVID-19 diagnosis during the global pandemic, we present a two-stage framework that leverages pseudo labels for domain adaptation to enhance the detection of COVID-19 from CT scans. By utilizing annotated data from one domain and non-annotated data from another, the model overcomes the challenge of data scarcity and variability, common in emergent health crises. The innovative approach of generating pseudo labels enables the model to iteratively refine its learning process, thereby improving its accuracy and adaptability across different hospitals and medical centres. Experimental results on COV19-CT-DB database showcase the model's potential to achieve high diagnostic precision, significantly contributing to efficient patient management and alleviating the strain on healthcare systems. Our method achieves 0.92 Macro F1 Score on the validation set of Covid-19 domain adaptation challenge.

Retrieval-Augmented Egocentric Video Captioning

Understanding human actions from videos of first-person view poses significant challenges. Most prior approaches explore representation learning on egocentric videos only, while overlooking the potential benefit of exploiting existing large-scale third-person videos. In this paper, (1) we develop EgoInstructor, a retrieval-augmented multimodal captioning model that automatically retrieves semantically relevant third-person instructional videos to enhance the video captioning of egocentric videos. (2) For training the cross-view retrieval module, we devise an automatic pipeline to discover ego-exo video pairs from distinct large-scale egocentric and exocentric datasets. (3) We train the cross-view retrieval module with a novel EgoExoNCE loss that pulls egocentric and exocentric video features closer by aligning them to shared text features that describe similar actions. (4) Through extensive experiments, our cross-view retrieval module demonstrates superior performance across seven benchmarks. Regarding egocentric video captioning, EgoInstructor exhibits significant improvements by leveraging third-person videos as references.

DRAC: Diabetic Retinopathy Analysis Challenge with Ultra-Wide Optical Coherence Tomography Angiography Images

Computer-assisted automatic analysis of diabetic retinopathy (DR) is of great importance in reducing the risks of vision loss and even blindness. Ultra-wide optical coherence tomography angiography (UW-OCTA) is a non-invasive and safe imaging modality in DR diagnosis system, but there is a lack of publicly available benchmarks for model development and evaluation. To promote further research and scientific benchmarking for diabetic retinopathy analysis using UW-OCTA images, we organized a challenge named "DRAC - Diabetic Retinopathy Analysis Challenge" in conjunction with the 25th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI 2022). The challenge consists of three tasks: segmentation of DR lesions, image quality assessment and DR grading. The scientific community responded positively to the challenge, with 11, 12, and 13 teams from geographically diverse institutes submitting different solutions in these three tasks, respectively. This paper presents a summary and analysis of the top-performing solutions and results for each task of the challenge. The obtained results from top algorithms indicate the importance of data augmentation, model architecture and ensemble of networks in improving the performance of deep learning models. These findings have the potential to enable new developments in diabetic retinopathy analysis. The challenge remains open for post-challenge registrations and submissions for benchmarking future methodology developments.

Learning Open-vocabulary Semantic Segmentation Models From Natural Language Supervision

In this paper, we consider the problem of open-vocabulary semantic segmentation (OVS), which aims to segment objects of arbitrary classes instead of pre-defined, closed-set categories. The main contributions are as follows: First, we propose a transformer-based model for OVS, termed as OVSegmentor, which only exploits web-crawled image-text pairs for pre-training without using any mask annotations. OVSegmentor assembles the image pixels into a set of learnable group tokens via a slot-attention based binding module, and aligns the group tokens to the corresponding caption embedding. Second, we propose two proxy tasks for training, namely masked entity completion and cross-image mask consistency. The former aims to infer all masked entities in the caption given the group tokens, that enables the model to learn fine-grained alignment between visual groups and text entities. The latter enforces consistent mask predictions between images that contain shared entities, which encourages the model to learn visual invariance. Third, we construct CC4M dataset for pre-training by filtering CC12M with frequently appeared entities, which significantly improves training efficiency. Fourth, we perform zero-shot transfer on three benchmark datasets, PASCAL VOC 2012, PASCAL Context, and COCO Object. Our model achieves superior segmentation results over the state-of-the-art method by using only 3\% data (4M vs 134M) for pre-training. Code and pre-trained models will be released for future research.

Cross-Field Transformer for Diabetic Retinopathy Grading on Two-field Fundus Images

Automatic diabetic retinopathy (DR) grading based on fundus photography has been widely explored to benefit the routine screening and early treatment. Existing researches generally focus on single-field fundus images, which have limited field of view for precise eye examinations. In clinical applications, ophthalmologists adopt two-field fundus photography as the dominating tool, where the information from each field (i.e.,macula-centric and optic disc-centric) is highly correlated and complementary, and benefits comprehensive decisions. However, automatic DR grading based on two-field fundus photography remains a challenging task due to the lack of publicly available datasets and effective fusion strategies. In this work, we first construct a new benchmark dataset (DRTiD) for DR grading, consisting of 3,100 two-field fundus images. To the best of our knowledge, it is the largest public DR dataset with diverse and high-quality two-field images. Then, we propose a novel DR grading approach, namely Cross-Field Transformer (CrossFiT), to capture the correspondence between two fields as well as the long-range spatial correlations within each field. Considering the inherent two-field geometric constraints, we particularly define aligned position embeddings to preserve relative consistent position in fundus. Besides, we perform masked cross-field attention during interaction to flter the noisy relations between fields. Extensive experiments on our DRTiD dataset and a public DeepDRiD dataset demonstrate the effectiveness of our CrossFiT network. The new dataset and the source code of CrossFiT will be publicly available at https://github.com/FDU-VTS/DRTiD.

Boosting COVID-19 Severity Detection with Infection-aware Contrastive Mixup Classification

This paper presents our solution for the 2nd COVID-19 Severity Detection Competition. This task aims to distinguish the Mild, Moderate, Severe, and Critical grades in COVID-19 chest CT images. In our approach, we devise a novel infection-aware 3D Contrastive Mixup Classification network for severity grading. Specifcally, we train two segmentation networks to first extract the lung region and then the inner lesion region. The lesion segmentation mask serves as complementary information for the original CT slices. To relieve the issue of imbalanced data distribution, we further improve the advanced Contrastive Mixup Classification network by weighted cross-entropy loss. On the COVID-19 severity detection leaderboard, our approach won the first place with a Macro F1 Score of 51.76%. It significantly outperforms the baseline method by over 11.46%.

CMC v2: Towards More Accurate COVID-19 Detection with Discriminative Video Priors

This paper presents our solution for the 2nd COVID-19 Competition, occurring in the framework of the AIMIA Workshop at the European Conference on Computer Vision (ECCV 2022). In our approach, we employ the winning solution last year which uses a strong 3D Contrastive Mixup Classifcation network (CMC v1) as the baseline method, composed of contrastive representation learning and mixup classification. In this paper, we propose CMC v2 by introducing natural video priors to COVID-19 diagnosis. Specifcally, we adapt a pre-trained (on video dataset) video transformer backbone to COVID-19 detection. Moreover, advanced training strategies, including hybrid mixup and cutmix, slicelevel augmentation, and small resolution training are also utilized to boost the robustness and the generalization ability of the model. Among 14 participating teams, CMC v2 ranked 1st in the 2nd COVID-19 Competition with an average Macro F1 Score of 89.11%.