A Toolbox for Surfacing Health Equity Harms and Biases in Large Language Models

Large language models (LLMs) hold immense promise to serve complex health information needs but also have the potential to introduce harm and exacerbate health disparities. Reliably evaluating equity-related model failures is a critical step toward developing systems that promote health equity. In this work, we present resources and methodologies for surfacing biases with potential to precipitate equity-related harms in long-form, LLM-generated answers to medical questions and then conduct an empirical case study with Med-PaLM 2, resulting in the largest human evaluation study in this area to date. Our contributions include a multifactorial framework for human assessment of LLM-generated answers for biases, and EquityMedQA, a collection of seven newly-released datasets comprising both manually-curated and LLM-generated questions enriched for adversarial queries. Both our human assessment framework and dataset design process are grounded in an iterative participatory approach and review of possible biases in Med-PaLM 2 answers to adversarial queries. Through our empirical study, we find that the use of a collection of datasets curated through a variety of methodologies, coupled with a thorough evaluation protocol that leverages multiple assessment rubric designs and diverse rater groups, surfaces biases that may be missed via narrower evaluation approaches. Our experience underscores the importance of using diverse assessment methodologies and involving raters of varying backgrounds and expertise. We emphasize that while our framework can identify specific forms of bias, it is not sufficient to holistically assess whether the deployment of an AI system promotes equitable health outcomes. We hope the broader community leverages and builds on these tools and methods towards realizing a shared goal of LLMs that promote accessible and equitable healthcare for all.

Enhanced Index Modulation Aided Non-Orthogonal Multiple Access via Constellation Rotation

Non-orthogonal multiple access (NOMA) has been widely nominated as an emerging spectral efficiency (SE) multiple access technique for the next generation of wireless communication network. To meet the growing demands in massive connectivity and huge data in transmission, a novel index modulation aided NOMA with the rotation of signal constellation of low power users (IM-NOMA-RC) is developed to the downlink transmission. In the proposed IM-NOMA-RC system, the users are classified into far-user group and near-user group according to their channel conditions, where the rotation constellation based IM operation is performed only on the users who belong to the near-user group that are allocated lower power compared with the far ones to transmit extra information. In the proposed IM-NOMA-RC, all the subcarriers are activated to transmit information to multiple users to achieve higher SE. With the aid of the multiple dimension modulation in IM-NOMA-RC, more users can be supported over an orthogonal resource block. Then, both maximum likelihood (ML) detector and successive interference cancellation (SIC) detector are studied for all the user. Numerical simulation results of the proposed IM-NOMARC scheme are investigate for the ML detector and the SIC detector for each users, which shows that proposed scheme can outperform conventional NOMA.

ContrastDiagnosis: Enhancing Interpretability in Lung Nodule Diagnosis Using Contrastive Learning

With the ongoing development of deep learning, an increasing number of AI models have surpassed the performance levels of human clinical practitioners. However, the prevalence of AI diagnostic products in actual clinical practice remains significantly lower than desired. One crucial reason for this gap is the so-called `black box' nature of AI models. Clinicians' distrust of black box models has directly hindered the clinical deployment of AI products. To address this challenge, we propose ContrastDiagnosis, a straightforward yet effective interpretable diagnosis framework. This framework is designed to introduce inherent transparency and provide extensive post-hoc explainability for deep learning model, making them more suitable for clinical medical diagnosis. ContrastDiagnosis incorporates a contrastive learning mechanism to provide a case-based reasoning diagnostic rationale, enhancing the model's transparency and also offers post-hoc interpretability by highlighting similar areas. High diagnostic accuracy was achieved with AUC of 0.977 while maintain a high transparency and explainability.

Rethinking Few-shot 3D Point Cloud Semantic Segmentation

This paper revisits few-shot 3D point cloud semantic segmentation (FS-PCS), with a focus on two significant issues in the state-of-the-art: foreground leakage and sparse point distribution. The former arises from non-uniform point sampling, allowing models to distinguish the density disparities between foreground and background for easier segmentation. The latter results from sampling only 2,048 points, limiting semantic information and deviating from the real-world practice. To address these issues, we introduce a standardized FS-PCS setting, upon which a new benchmark is built. Moreover, we propose a novel FS-PCS model. While previous methods are based on feature optimization by mainly refining support features to enhance prototypes, our method is based on correlation optimization, referred to as Correlation Optimization Segmentation (COSeg). Specifically, we compute Class-specific Multi-prototypical Correlation (CMC) for each query point, representing its correlations to category prototypes. Then, we propose the Hyper Correlation Augmentation (HCA) module to enhance CMC. Furthermore, tackling the inherent property of few-shot training to incur base susceptibility for models, we propose to learn non-parametric prototypes for the base classes during training. The learned base prototypes are used to calibrate correlations for the background class through a Base Prototypes Calibration (BPC) module. Experiments on popular datasets demonstrate the superiority of COSeg over existing methods. The code is available at: https://github.com/ZhaochongAn/COSeg

Closing the AI generalization gap by adjusting for dermatology condition distribution differences across clinical settings

Recently, there has been great progress in the ability of artificial intelligence (AI) algorithms to classify dermatological conditions from clinical photographs. However, little is known about the robustness of these algorithms in real-world settings where several factors can lead to a loss of generalizability. Understanding and overcoming these limitations will permit the development of generalizable AI that can aid in the diagnosis of skin conditions across a variety of clinical settings. In this retrospective study, we demonstrate that differences in skin condition distribution, rather than in demographics or image capture mode are the main source of errors when an AI algorithm is evaluated on data from a previously unseen source. We demonstrate a series of steps to close this generalization gap, requiring progressively more information about the new source, ranging from the condition distribution to training data enriched for data less frequently seen during training. Our results also suggest comparable performance from end-to-end fine tuning versus fine tuning solely the classification layer on top of a frozen embedding model. Our approach can inform the adaptation of AI algorithms to new settings, based on the information and resources available.

MINT: A wrapper to make multi-modal and multi-image AI models interactive

During the diagnostic process, doctors incorporate multimodal information including imaging and the medical history - and similarly medical AI development has increasingly become multimodal. In this paper we tackle a more subtle challenge: doctors take a targeted medical history to obtain only the most pertinent pieces of information; how do we enable AI to do the same? We develop a wrapper method named MINT (Make your model INTeractive) that automatically determines what pieces of information are most valuable at each step, and ask for only the most useful information. We demonstrate the efficacy of MINT wrapping a skin disease prediction model, where multiple images and a set of optional answers to $25$ standard metadata questions (i.e., structured medical history) are used by a multi-modal deep network to provide a differential diagnosis. We show that MINT can identify whether metadata inputs are needed and if so, which question to ask next. We also demonstrate that when collecting multiple images, MINT can identify if an additional image would be beneficial, and if so, which type of image to capture. We showed that MINT reduces the number of metadata and image inputs needed by 82% and 36.2% respectively, while maintaining predictive performance. Using real-world AI dermatology system data, we show that needing fewer inputs can retain users that may otherwise fail to complete the system submission and drop off without a diagnosis. Qualitative examples show MINT can closely mimic the step-by-step decision making process of a clinical workflow and how this is different for straight forward cases versus more difficult, ambiguous cases. Finally we demonstrate how MINT is robust to different underlying multi-model classifiers and can be easily adapted to user requirements without significant model re-training.

TACO: Benchmarking Generalizable Bimanual Tool-ACtion-Object Understanding

Humans commonly work with multiple objects in daily life and can intuitively transfer manipulation skills to novel objects by understanding object functional regularities. However, existing technical approaches for analyzing and synthesizing hand-object manipulation are mostly limited to handling a single hand and object due to the lack of data support. To address this, we construct TACO, an extensive bimanual hand-object-interaction dataset spanning a large variety of tool-action-object compositions for daily human activities. TACO contains 2.5K motion sequences paired with third-person and egocentric views, precise hand-object 3D meshes, and action labels. To rapidly expand the data scale, we present a fully-automatic data acquisition pipeline combining multi-view sensing with an optical motion capture system. With the vast research fields provided by TACO, we benchmark three generalizable hand-object-interaction tasks: compositional action recognition, generalizable hand-object motion forecasting, and cooperative grasp synthesis. Extensive experiments reveal new insights, challenges, and opportunities for advancing the studies of generalizable hand-object motion analysis and synthesis. Our data and code are available at https://taco2024.github.io.

Message-Passing Receiver for OCDM over Multi-Lag Multi-Doppler Channels

As a new candidate waveform for the next generation wireless communications, orthogonal chirp division multiplexing (OCDM) has attracted growing attention for its ability to achieve full diversity in uncoded transmission, and its robustness to narrow-band interference or impulsive noise. Under high mobility channels with multiple lags and multiple Doppler-shifts (MLMD), the signal suffers doubly selective (DS) fadings in time and frequency domain, and data symbols modulated on orthogonal chirps are interfered by each other. To address the problem of symbol detection of OCDM over MLMD channel, under the assumption that path attenuation factors, delays, and Doppler shifts of the channel are available, we first derive the closed-form channel matrix in Fresnel domain, and then propose a low-complexity method to approximate it as a sparse matrix. Based on the approximated Fresnel-domain channel, we propose a message passing (MP) based detector to estimate the transmit symbols iteratively. Finally, under two MLMD channels (an underspread channel for terrestrial vehicular communication, and an overspread channel for narrow-band underwater acoustic communications), Monte Carlo simulation results and analysis are provided to validate its advantages as a promising detector for OCDM.

Towards Accurate Differential Diagnosis with Large Language Models

An accurate differential diagnosis (DDx) is a cornerstone of medical care, often reached through an iterative process of interpretation that combines clinical history, physical examination, investigations and procedures. Interactive interfaces powered by Large Language Models (LLMs) present new opportunities to both assist and automate aspects of this process. In this study, we introduce an LLM optimized for diagnostic reasoning, and evaluate its ability to generate a DDx alone or as an aid to clinicians. 20 clinicians evaluated 302 challenging, real-world medical cases sourced from the New England Journal of Medicine (NEJM) case reports. Each case report was read by two clinicians, who were randomized to one of two assistive conditions: either assistance from search engines and standard medical resources, or LLM assistance in addition to these tools. All clinicians provided a baseline, unassisted DDx prior to using the respective assistive tools. Our LLM for DDx exhibited standalone performance that exceeded that of unassisted clinicians (top-10 accuracy 59.1% vs 33.6%, [p = 0.04]). Comparing the two assisted study arms, the DDx quality score was higher for clinicians assisted by our LLM (top-10 accuracy 51.7%) compared to clinicians without its assistance (36.1%) (McNemar's Test: 45.7, p < 0.01) and clinicians with search (44.4%) (4.75, p = 0.03). Further, clinicians assisted by our LLM arrived at more comprehensive differential lists than those without its assistance. Our study suggests that our LLM for DDx has potential to improve clinicians' diagnostic reasoning and accuracy in challenging cases, meriting further real-world evaluation for its ability to empower physicians and widen patients' access to specialist-level expertise.

Mobile-Seed: Joint Semantic Segmentation and Boundary Detection for Mobile Robots

Precise and rapid delineation of sharp boundaries and robust semantics is essential for numerous downstream robotic tasks, such as robot grasping and manipulation, real-time semantic mapping, and online sensor calibration performed on edge computing units. Although boundary detection and semantic segmentation are complementary tasks, most studies focus on lightweight models for semantic segmentation but overlook the critical role of boundary detection. In this work, we introduce Mobile-Seed, a lightweight, dual-task framework tailored for simultaneous semantic segmentation and boundary detection. Our framework features a two-stream encoder, an active fusion decoder (AFD) and a dual-task regularization approach. The encoder is divided into two pathways: one captures category-aware semantic information, while the other discerns boundaries from multi-scale features. The AFD module dynamically adapts the fusion of semantic and boundary information by learning channel-wise relationships, allowing for precise weight assignment of each channel. Furthermore, we introduce a regularization loss to mitigate the conflicts in dual-task learning and deep diversity supervision. Compared to existing methods, the proposed Mobile-Seed offers a lightweight framework to simultaneously improve semantic segmentation performance and accurately locate object boundaries. Experiments on the Cityscapes dataset have shown that Mobile-Seed achieves notable improvement over the state-of-the-art (SOTA) baseline by 2.2 percentage points (pp) in mIoU and 4.2 pp in mF-score, while maintaining an online inference speed of 23.9 frames-per-second (FPS) with 1024x2048 resolution input on an RTX 2080 Ti GPU. Additional experiments on CamVid and PASCAL Context datasets confirm our method's generalizability. Code and additional results are publicly available at https://whu-usi3dv.github.io/Mobile-Seed/.