SymptomAI: Towards a Conversational AI Agent for Everyday Symptom Assessment

Language models excel at diagnostic assessments on currated medical case-studies and vignettes, performing on par with, or better than, clinical professionals. However, existing studies focus on complex scenarios with rich context making it difficult to draw conclusions about how these systems perform for patients reporting symptoms in everyday life. We deployed SymptomAI, a set of conversational AI agents for end-to-end patient interviewing and differential diagnosis (DDx), via the Fitbit app in a study that randomized participants (N=13,917) to interact with five AI agents. This corpus captures diverse communication and a realistic distribution of illnesses from a real world population. A subset of 1,228 participants reported a clinician-provided diagnosis, and 517 of these were further evaluated by a panel of clinicians during over 250 hours of annotation. SymptomAI DDx were significantly more accurate (OR = 2.47, p < 0.001) than those from independent clinicians given the same dialogue in a blinded randomized comparison. Moreover, agentic strategies which conduct a dedicated symptom interview that elicit additional symptom information before providing a diagnosis, perform substantially better than baseline, user-guided conversations (p < 0.001). An auxiliary analysis on 1,509 conversations from a general US population panel validated that these results generalize beyond wearable device users. We used SymptomAI diagnoses as labels for all 13,917 participants to analyze over 500,000 days of wearable metrics across nearly 400 unique conditions. We identified strong associations between acute infections and physiological shifts (e.g., OR > 7 for influenza). While limited by self-reported ground truth, these results demonstrate the benefits of a dedicated and complete symptom interview compared to a user-guided symptom discussion, which is the default of most consumer LLMs.

Compress Then Adapt? No, Do It Together via Task-aware Union of Subspaces

Adapting large pretrained models to diverse tasks is now routine, yet the two dominant strategies of parameter-efficient fine-tuning (PEFT) and low-rank compression are typically composed in sequence. This decoupled practice first compresses and then fine-tunes adapters, potentially misaligning the compressed subspace with downstream objectives and squandering a global parameter budget. To overcome this limitation, we introduce JACTUS (Joint Adaptation and Compression with a Task-aware Union of Subspaces), a single framework that unifies compression and adaptation. From a small calibration set, JACTUS estimates input and pre-activation gradient covariances, forms their orthogonal union with the pretrained weight subspace, performs a projected low-rank approximation inside this union, allocates rank globally by marginal gain per parameter, and trains only a compact core matrix. This explicitly mitigates the potential misalignment between the compressed subspace and downstream objectives by coupling the directions preserved for compression with those required for adaptation, yielding a deployable low-rank model that avoids retaining full frozen weights while enabling fast and robust tuning. On vision, JACTUS attains an average 89.2% accuracy on ViT-Base across eight datasets at 80% retained parameters, surpassing strong 100% PEFT baselines (e.g., DoRA 87.9%). On language, JACTUS achieves an 80.9% average on Llama2-7B commonsense QA at the same 80% retained-parameter budget, outperforming 100% PEFT (e.g., DoRA 79.7%) and exceeding prior compress-then-finetune pipelines under the same ratained-parameter budget. We will release code.

MedGemma 1.5 Technical Report

We introduce MedGemma 1.5 4B, the latest model in the MedGemma collection. MedGemma 1.5 expands on MedGemma 1 by integrating additional capabilities: high-dimensional medical imaging (CT/MRI volumes and histopathology whole slide images), anatomical localization via bounding boxes, multi-timepoint chest X-ray analysis, and improved medical document understanding (lab reports, electronic health records). We detail the innovations required to enable these modalities within a single architecture, including new training data, long-context 3D volume slicing, and whole-slide pathology sampling. Compared to MedGemma 1 4B, MedGemma 1.5 4B demonstrates significant gains in these new areas, improving 3D MRI condition classification accuracy by 11% and 3D CT condition classification by 3% (absolute improvements). In whole slide pathology imaging, MedGemma 1.5 4B achieves a 47% macro F1 gain. Additionally, it improves anatomical localization with a 35% increase in Intersection over Union on chest X-rays and achieves a 4% macro accuracy for longitudinal (multi-timepoint) chest x-ray analysis. Beyond its improved multimodal performance over MedGemma 1, MedGemma 1.5 improves on text-based clinical knowledge and reasoning, improving by 5% on MedQA accuracy and 22% on EHRQA accuracy. It also achieves an average of 18% macro F1 on 4 different lab report information extraction datasets (EHR Datasets 2, 3, 4, and Mendeley Clinical Laboratory Test Reports). Taken together, MedGemma 1.5 serves as a robust, open resource for the community, designed as an improved foundation on which developers can create the next generation of medical AI systems. Resources and tutorials for building upon MedGemma 1.5 can be found at https://goo.gle/MedGemma.

NTIRE 2026 3D Restoration and Reconstruction in Real-world Adverse Conditions: RealX3D Challenge Results

This paper presents a comprehensive review of the NTIRE 2026 3D Restoration and Reconstruction (3DRR) Challenge, detailing the proposed methods and results. The challenge seeks to identify robust reconstruction pipelines that are robust under real-world adverse conditions, specifically extreme low-light and smoke-degraded environments, as captured by our RealX3D benchmark. A total of 279 participants registered for the competition, of whom 33 teams submitted valid results. We thoroughly evaluate the submitted approaches against state-of-the-art baselines, revealing significant progress in 3D reconstruction under adverse conditions. Our analysis highlights shared design principles among top-performing methods and provides insights into effective strategies for handling 3D scene degradation.

Amped: Adaptive Multi-stage Non-edge Pruning for Edge Detection

Edge detection is a fundamental image analysis task that underpins numerous high-level vision applications. Recent advances in Transformer architectures have significantly improved edge quality by capturing long-range dependencies, but this often comes with computational overhead. Achieving higher pixel-level accuracy requires increased input resolution, further escalating computational cost and limiting practical deployment. Building on the strong representational capacity of recent Transformer-based edge detectors, we propose an Adaptive Multi-stage non-edge Pruning framework for Edge Detection(Amped). Amped identifies high-confidence non-edge tokens and removes them as early as possible to substantially reduce computation, thus retaining high accuracy while cutting GFLOPs and accelerating inference with minimal performance loss. Moreover, to mitigate the structural complexity of existing edge detection networks and facilitate their integration into real-world systems, we introduce a simple yet high-performance Transformer-based model, termed Streamline Edge Detector(SED). Applied to both existing detectors and our SED, the proposed pruning strategy provides a favorable balance between accuracy and efficiency-reducing GFLOPs by up to 40% with only a 0.4% drop in ODS F-measure. In addition, despite its simplicity, SED achieves a state-of-the-art ODS F-measure of 86.5%. The code will be released.

Make It Up: Fake Images, Real Gains in Generalized Few-shot Semantic Segmentation

Generalized few-shot semantic segmentation (GFSS) is fundamentally limited by the coverage of novel-class appearances under scarce annotations. While diffusion models can synthesize novel-class images at scale, practical gains are often hindered by insufficient coverage and noisy supervision when masks are unavailable or unreliable. We propose Syn4Seg, a generation-enhanced GFSS framework designed to expand novel-class coverage while improving pseudo-label quality. Syn4Seg first maximizes prompt-space coverage by constructing an embedding-deduplicated prompt bank for each novel class, yielding diverse yet class-consistent synthetic images. It then performs support-guided pseudo-label estimation via a two-stage refinement that i) filters low-consistency regions to obtain high-precision seeds and ii) relabels uncertain pixels with image-adaptive prototypes that combine global (support) and local (image) statistics. Finally, we refine only boundary-band and unlabeled pixels using a constrained SAM-based update to improve contour fidelity without overwriting high-confidence interiors. Extensive experiments on PASCAL-$5^i$ and COCO-$20^i$ demonstrate consistent improvements in both 1-shot and 5-shot settings, highlighting synthetic data as a scalable path for GFSS with reliable masks and precise boundaries.

Learning Athletic Humanoid Tennis Skills from Imperfect Human Motion Data

Human athletes demonstrate versatile and highly-dynamic tennis skills to successfully conduct competitive rallies with a high-speed tennis ball. However, reproducing such behaviors on humanoid robots is difficult, partially due to the lack of perfect humanoid action data or human kinematic motion data in tennis scenarios as reference. In this work, we propose LATENT, a system that Learns Athletic humanoid TEnnis skills from imperfect human motioN daTa. The imperfect human motion data consist only of motion fragments that capture the primitive skills used when playing tennis rather than precise and complete human-tennis motion sequences from real-world tennis matches, thereby significantly reducing the difficulty of data collection. Our key insight is that, despite being imperfect, such quasi-realistic data still provide priors about human primitive skills in tennis scenarios. With further correction and composition, we learn a humanoid policy that can consistently strike incoming balls under a wide range of conditions and return them to target locations, while preserving natural motion styles. We also propose a series of designs for robust sim-to-real transfer and deploy our policy on the Unitree G1 humanoid robot. Our method achieves surprising results in the real world and can stably sustain multi-shot rallies with human players. Project page: https://zzk273.github.io/LATENT/

A prospective clinical feasibility study of a conversational diagnostic AI in an ambulatory primary care clinic

Large language model (LLM)-based AI systems have shown promise for patient-facing diagnostic and management conversations in simulated settings. Translating these systems into clinical practice requires assessment in real-world workflows with rigorous safety oversight. We report a prospective, single-arm feasibility study of an LLM-based conversational AI, the Articulate Medical Intelligence Explorer (AMIE), conducting clinical history taking and presentation of potential diagnoses for patients to discuss with their provider at urgent care appointments at a leading academic medical center. 100 adult patients completed an AMIE text-chat interaction up to 5 days before their appointment. We sought to assess the conversational safety and quality, patient and clinician experience, and clinical reasoning capabilities compared to primary care providers (PCPs). Human safety supervisors monitored all patient-AMIE interactions in real time and did not need to intervene to stop any consultations based on pre-defined criteria. Patients reported high satisfaction and their attitudes towards AI improved after interacting with AMIE (p < 0.001). PCPs found AMIE's output useful with a positive impact on preparedness. AMIE's differential diagnosis (DDx) included the final diagnosis, per chart review 8 weeks post-encounter, in 90% of cases, with 75% top-3 accuracy. Blinded assessment of AMIE and PCP DDx and management (Mx) plans suggested similar overall DDx and Mx plan quality, without significant differences for DDx (p = 0.6) and appropriateness and safety of Mx (p = 0.1 and 1.0, respectively). PCPs outperformed AMIE in the practicality (p = 0.003) and cost effectiveness (p = 0.004) of Mx. While further research is needed, this study demonstrates the initial feasibility, safety, and user acceptance of conversational AI in a real-world setting, representing crucial steps towards clinical translation.

VLM-Loc: Localization in Point Cloud Maps via Vision-Language Models

Text-to-point-cloud (T2P) localization aims to infer precise spatial positions within 3D point cloud maps from natural language descriptions, reflecting how humans perceive and communicate spatial layouts through language. However, existing methods largely rely on shallow text-point cloud correspondence without effective spatial reasoning, limiting their accuracy in complex environments. To address this limitation, we propose VLM-Loc, a framework that leverages the spatial reasoning capability of large vision-language models (VLMs) for T2P localization. Specifically, we transform point clouds into bird's-eye-view (BEV) images and scene graphs that jointly encode geometric and semantic context, providing structured inputs for the VLM to learn cross-modal representations bridging linguistic and spatial semantics. On top of these representations, we introduce a partial node assignment mechanism that explicitly associates textual cues with scene graph nodes, enabling interpretable spatial reasoning for accurate localization. To facilitate systematic evaluation across diverse scenes, we present CityLoc, a benchmark built from multi-source point clouds for fine-grained T2P localization. Experiments on CityLoc demonstrate VLM-Loc achieves superior accuracy and robustness compared to state-of-the-art methods. Our code, model, and dataset are available at \href{https://github.com/MCG-NKU/nku-3d-vision}{repository}.

Query as Anchor: Scenario-Adaptive User Representation via Large Language Model

Industrial-scale user representation learning requires balancing robust universality with acute task-sensitivity. However, existing paradigms primarily yield static, task-agnostic embeddings that struggle to reconcile the divergent requirements of downstream scenarios within unified vector spaces. Furthermore, heterogeneous multi-source data introduces inherent noise and modality conflicts, degrading representation. We propose Query-as-Anchor, a framework shifting user modeling from static encoding to dynamic, query-aware synthesis. To empower Large Language Models (LLMs) with deep user understanding, we first construct UserU, an industrial-scale pre-training dataset that aligns multi-modal behavioral sequences with user understanding semantics, and our Q-Anchor Embedding architecture integrates hierarchical coarse-to-fine encoders into dual-tower LLMs via joint contrastive-autoregressive optimization for query-aware user representation. To bridge the gap between general pre-training and specialized business logic, we further introduce Cluster-based Soft Prompt Tuning to enforce discriminative latent structures, effectively aligning model attention with scenario-specific modalities. For deployment, anchoring queries at sequence termini enables KV-cache-accelerated inference with negligible incremental latency. Evaluations on 10 Alipay industrial benchmarks show consistent SOTA performance, strong scalability, and efficient deployment. Large-scale online A/B testing in Alipay's production system across two real-world scenarios further validates its practical effectiveness. Our code is prepared for public release and will be available at: https://github.com/JhCircle/Q-Anchor.