Tabular LLMs for Interpretable Few-Shot Alzheimer's Disease Prediction with Multimodal Biomedical Data

Accurate diagnosis of Alzheimer's disease (AD) requires handling tabular biomarker data, yet such data are often small and incomplete, where deep learning models frequently fail to outperform classical methods. Pretrained large language models (LLMs) offer few-shot generalization, structured reasoning, and interpretable outputs, providing a powerful paradigm shift for clinical prediction. We propose TAP-GPT Tabular Alzheimer's Prediction GPT, a domain-adapted tabular LLM framework built on TableGPT2 and fine-tuned for few-shot AD classification using tabular prompts rather than plain texts. We evaluate TAP-GPT across four ADNI-derived datasets, including QT-PAD biomarkers and region-level structural MRI, amyloid PET, and tau PET for binary AD classification. Across multimodal and unimodal settings, TAP-GPT improves upon its backbone models and outperforms traditional machine learning baselines in the few-shot setting while remaining competitive with state-of-the-art general-purpose LLMs. We show that feature selection mitigates degradation in high-dimensional inputs and that TAP-GPT maintains stable performance under simulated and real-world missingness without imputation. Additionally, TAP-GPT produces structured, modality-aware reasoning aligned with established AD biology and shows greater stability under self-reflection, supporting its use in iterative multi-agent systems. To our knowledge, this is the first systematic application of a tabular-specialized LLM to multimodal biomarker-based AD prediction, demonstrating that such pretrained models can effectively address structured clinical prediction tasks and laying the foundation for tabular LLM-driven multi-agent clinical decision-support systems. The source code is publicly available on GitHub: https://github.com/sophie-kearney/TAP-GPT.

Topo-R1: Detecting Topological Anomalies via Vision-Language Models

Topological correctness is crucial for tubular structures such as blood vessels, nerve fibers, and road networks. Existing topology-preserving methods rely on domain-specific ground truth, which is costly and rarely transfers across domains. When deployed to a new domain without annotations, a key question arises: how can we detect topological anomalies without ground-truth supervision? We reframe this as topological anomaly detection, a structured visual reasoning task requiring a model to locate and classify topological errors in predicted segmentation masks. Vision-Language Models (VLMs) are natural candidates; however, we find that state-of-the-art VLMs perform nearly at random, lacking the fine-grained, topology-aware perception needed to identify sparse connectivity errors in dense structures. To bridge this gap, we develop an automated data-curation pipeline that synthesizes diverse topological anomalies with verifiable annotations across progressively difficult levels, thereby constructing the first large-scale, multi-domain benchmark for this task. We then introduce Topo-R1, a framework that endows VLMs with topology-aware perception via two-stage training: supervised fine-tuning followed by reinforcement learning with Group Relative Policy Optimization (GRPO). Central to our approach is a topology-aware composite reward that integrates type-aware Hungarian matching for structured error classification, spatial localization scoring, and a centerline Dice (clDice) reward that directly penalizes connectivity disruptions, thereby jointly incentivizing semantic precision and structural fidelity. Extensive experiments demonstrate that Topo-R1 establishes a new paradigm for annotation-free topological quality assessment, consistently outperforming general-purpose VLMs and supervised baselines across all evaluation protocols.

HE-VPR: Height Estimation Enabled Aerial Visual Place Recognition Against Scale Variance

In this work, we propose HE-VPR, a visual place recognition (VPR) framework that incorporates height estimation. Our system decouples height inference from place recognition, allowing both modules to share a frozen DINOv2 backbone. Two lightweight bypass adapter branches are integrated into our system. The first estimates the height partition of the query image via retrieval from a compact height database, and the second performs VPR within the corresponding height-specific sub-database. The adaptation design reduces training cost and significantly decreases the search space of the database. We also adopt a center-weighted masking strategy to further enhance the robustness against scale differences. Experiments on two self-collected challenging multi-altitude datasets demonstrate that HE-VPR achieves up to 6.1\% Recall@1 improvement over state-of-the-art ViT-based baselines and reduces memory usage by up to 90\%. These results indicate that HE-VPR offers a scalable and efficient solution for height-aware aerial VPR, enabling practical deployment in GNSS-denied environments. All the code and datasets for this work have been released on https://github.com/hmf21/HE-VPR.

Explanation-Guided Adversarial Training for Robust and Interpretable Models

Deep neural networks (DNNs) have achieved remarkable performance in many tasks, yet they often behave as opaque black boxes. Explanation-guided learning (EGL) methods steer DNNs using human-provided explanations or supervision on model attributions. These approaches improve interpretability but typically assume benign inputs and incur heavy annotation costs. In contrast, both predictions and saliency maps of DNNs could dramatically alter facing imperceptible perturbations or unseen patterns. Adversarial training (AT) can substantially improve robustness, but it does not guarantee that model decisions rely on semantically meaningful features. In response, we propose Explanation-Guided Adversarial Training (EGAT), a unified framework that integrates the strength of AT and EGL to simultaneously improve prediction performance, robustness, and explanation quality. EGAT generates adversarial examples on the fly while imposing explanation-based constraints on the model. By jointly optimizing classification performance, adversarial robustness, and attributional stability, EGAT is not only more resistant to unexpected cases, including adversarial attacks and out-of-distribution (OOD) scenarios, but also offer human-interpretable justifications for the decisions. We further formalize EGAT within the Probably Approximately Correct learning framework, demonstrating theoretically that it yields more stable predictions under unexpected situations compared to standard AT. Empirical evaluations on OOD benchmark datasets show that EGAT consistently outperforms competitive baselines in both clean accuracy and adversarial accuracy +37% while producing more semantically meaningful explanations, and requiring only a limited increase +16% in training time.

BAED: a New Paradigm for Few-shot Graph Learning with Explanation in the Loop

The challenges of training and inference in few-shot environments persist in the area of graph representation learning. The quality and quantity of labels are often insufficient due to the extensive expert knowledge required to annotate graph data. In this context, Few-Shot Graph Learning (FSGL) approaches have been developed over the years. Through sophisticated neural architectures and customized training pipelines, these approaches enhance model adaptability to new label distributions. However, compromises in \textcolor{black}{the model's} robustness and interpretability can result in overfitting to noise in labeled data and degraded performance. This paper introduces the first explanation-in-the-loop framework for the FSGL problem, called BAED. We novelly employ the belief propagation algorithm to facilitate label augmentation on graphs. Then, leveraging an auxiliary graph neural network and the gradient backpropagation method, our framework effectively extracts explanatory subgraphs surrounding target nodes. The final predictions are based on these informative subgraphs while mitigating the influence of redundant information from neighboring nodes. Extensive experiments on seven benchmark datasets demonstrate superior prediction accuracy, training efficiency, and explanation quality of BAED. As a pioneer, this work highlights the potential of the explanation-based research paradigm in FSGL.

Act Like a Pathologist: Tissue-Aware Whole Slide Image Reasoning

Computational pathology has advanced rapidly in recent years, driven by domain-specific image encoders and growing interest in using vision-language models to answer natural-language questions about diseases. Yet, the core problem behind pathology question-answering remains unsolved, considering that a gigapixel slide contains far more information than necessary for a given question. Pathologists naturally navigate tissue and morphology complexity by scanning broadly, and zooming in selectively according to the clinical questions. Current models, in contrast, rely on uniform patch sampling or broad attention maps, often attending equally to irrelevant regions while overlooking key visual evidence. In this work, we try to bring models closer to how humans actually examine slides. We propose a question-guided, tissue-aware, and coarse-to-fine retrieval framework, HistoSelect, that consists of two key components: a group sampler that identifies question-relevant tissue regions, followed by a patch selector that retrieves the most informative patches within those regions. By selecting only the most informative patches, our method becomes significantly more efficient: reducing visual token usage by 70% on average, while improving accuracy across three pathology QA tasks. Evaluated on 356,000 question-answer pairs, our approach outperforms existing methods and produces answers grounded in interpretable, pathologist-consistent regions. Our results suggest that bringing human-like search and attention patterns into WSI reasoning is a promising direction for building practical and reliable pathology VLMs.

MobilityBench: A Benchmark for Evaluating Route-Planning Agents in Real-World Mobility Scenarios

Route-planning agents powered by large language models (LLMs) have emerged as a promising paradigm for supporting everyday human mobility through natural language interaction and tool-mediated decision making. However, systematic evaluation in real-world mobility settings is hindered by diverse routing demands, non-deterministic mapping services, and limited reproducibility. In this study, we introduce MobilityBench, a scalable benchmark for evaluating LLM-based route-planning agents in real-world mobility scenarios. MobilityBench is constructed from large-scale, anonymized real user queries collected from Amap and covers a broad spectrum of route-planning intents across multiple cities worldwide. To enable reproducible, end-to-end evaluation, we design a deterministic API-replay sandbox that eliminates environmental variance from live services. We further propose a multi-dimensional evaluation protocol centered on outcome validity, complemented by assessments of instruction understanding, planning, tool use, and efficiency. Using MobilityBench, we evaluate multiple LLM-based route-planning agents across diverse real-world mobility scenarios and provide an in-depth analysis of their behaviors and performance. Our findings reveal that current models perform competently on Basic information retrieval and Route Planning tasks, yet struggle considerably with Preference-Constrained Route Planning, underscoring significant room for improvement in personalized mobility applications. We publicly release the benchmark data, evaluation toolkit, and documentation at https://github.com/AMAP-ML/MobilityBench .

Kunlun: Establishing Scaling Laws for Massive-Scale Recommendation Systems through Unified Architecture Design

Deriving predictable scaling laws that govern the relationship between model performance and computational investment is crucial for designing and allocating resources in massive-scale recommendation systems. While such laws are established for large language models, they remain challenging for recommendation systems, especially those processing both user history and context features. We identify poor scaling efficiency as the main barrier to predictable power-law scaling, stemming from inefficient modules with low Model FLOPs Utilization (MFU) and suboptimal resource allocation. We introduce Kunlun, a scalable architecture that systematically improves model efficiency and resource allocation. Our low-level optimizations include Generalized Dot-Product Attention (GDPA), Hierarchical Seed Pooling (HSP), and Sliding Window Attention. Our high-level innovations feature Computation Skip (CompSkip) and Event-level Personalization. These advances increase MFU from 17% to 37% on NVIDIA B200 GPUs and double scaling efficiency over state-of-the-art methods. Kunlun is now deployed in major Meta Ads models, delivering significant production impact.

(MGS)$^2$-Net: Unifying Micro-Geometric Scale and Macro-Geometric Structure for Cross-View Geo-Localization

Cross-view geo-localization (CVGL) is pivotal for GNSS-denied UAV navigation but remains brittle under the drastic geometric misalignment between oblique aerial views and orthographic satellite references. Existing methods predominantly operate within a 2D manifold, neglecting the underlying 3D geometry where view-dependent vertical facades (macro-structure) and scale variations (micro-scale) severely corrupt feature alignment. To bridge this gap, we propose (MGS)$^2$, a geometry-grounded framework. The core of our innovation is the Macro-Geometric Structure Filtering (MGSF) module. Unlike pixel-wise matching sensitive to noise, MGSF leverages dilated geometric gradients to physically filter out high-frequency facade artifacts while enhancing the view-invariant horizontal plane, directly addressing the domain shift. To guarantee robust input for this structural filtering, we explicitly incorporate a Micro-Geometric Scale Adaptation (MGSA) module. MGSA utilizes depth priors to dynamically rectify scale discrepancies via multi-branch feature fusion. Furthermore, a Geometric-Appearance Contrastive Distillation (GACD) loss is designed to strictly discriminate against oblique occlusions. Extensive experiments demonstrate that (MGS)$^2$ achieves state-of-the-art performance, recording a Recall@1 of 97.5\% on University-1652 and 97.02\% on SUES-200. Furthermore, the framework exhibits superior cross-dataset generalization against geometric ambiguity. The code is available at: \href{https://github.com/GabrielLi1473/MGS-Net}{https://github.com/GabrielLi1473/MGS-Net}.

Semi-supervised Liver Segmentation and Patch-based Fibrosis Staging with Registration-aided Multi-parametric MRI

Liver fibrosis poses a substantial challenge in clinical practice, emphasizing the necessity for precise liver segmentation and accurate disease staging. Based on the CARE Liver 2025 Track 4 Challenge, this study introduces a multi-task deep learning framework developed for liver segmentation (LiSeg) and liver fibrosis staging (LiFS) using multiparametric MRI. The LiSeg phase addresses the challenge of limited annotated images and the complexities of multi-parametric MRI data by employing a semi-supervised learning model that integrates image segmentation and registration. By leveraging both labeled and unlabeled data, the model overcomes the difficulties introduced by domain shifts and variations across modalities. In the LiFS phase, we employed a patchbased method which allows the visualization of liver fibrosis stages based on the classification outputs. Our approach effectively handles multimodality imaging data, limited labels, and domain shifts. The proposed method has been tested by the challenge organizer on an independent test set that includes in-distribution (ID) and out-of-distribution (OOD) cases using three-channel MRIs (T1, T2, DWI) and seven-channel MRIs (T1, T2, DWI, GED1-GED4). The code is freely available. Github link: https://github.com/mileywang3061/Care-Liver