Department of Biostatistics and Bioinformatics, Duke University, Durham, USA
Abstract:Generalist pathology foundation models (PFMs), pretrained on large-scale multi-organ datasets, have demonstrated remarkable predictive capabilities across diverse clinical applications. However, their proficiency on the full spectrum of clinically essential tasks within a specific organ system remains an open question due to the lack of large-scale validation cohorts for a single organ as well as the absence of a tailored training paradigm that can effectively translate broad histomorphological knowledge into the organ-specific expertise required for specialist-level interpretation. In this study, we propose BRIGHT, the first PFM specifically designed for breast pathology, trained on approximately 210 million histopathology tiles from over 51,000 breast whole-slide images derived from a cohort of over 40,000 patients across 19 hospitals. BRIGHT employs a collaborative generalist-specialist framework to capture both universal and organ-specific features. To comprehensively evaluate the performance of PFMs on breast oncology, we curate the largest multi-institutional cohorts to date for downstream task development and evaluation, comprising over 25,000 WSIs across 10 hospitals. The validation cohorts cover the full spectrum of breast pathology across 24 distinct clinical tasks spanning diagnosis, biomarker prediction, treatment response and survival prediction. Extensive experiments demonstrate that BRIGHT outperforms three leading generalist PFMs, achieving state-of-the-art (SOTA) performance in 21 of 24 internal validation tasks and in 5 of 10 external validation tasks with excellent heatmap interpretability. By evaluating on large-scale validation cohorts, this study not only demonstrates BRIGHT's clinical utility in breast oncology but also validates a collaborative generalist-specialist paradigm, providing a scalable template for developing PFMs on a specific organ system.
Abstract:We present DLIOS, a Large Language Model (LLM)-augmented real-time multi-modal interactive enhancement overlay system for Douyin (TikTok) live streaming. DLIOS employs a three-layer transparent window architecture for independent rendering of danmaku (scrolling text), gift and like particle effects, and VIP entrance animations, built around an event-driven WebView2 capture pipeline and a thread-safe event bus. On top of this foundation we contribute an LLM broadcast automation framework comprising: (1) a per-song four-segment prompt scheduling system (T1 opening/transition, T2 empathy, T3 era story/production notes, T4 closing) that generates emotionally coherent radio-style commentary from lyric metadata; (2) a JSON-serializable RadioPersonaConfig schema supporting hot-swap multi-persona broadcasting; (3) a real-time danmaku quick-reaction engine with keyword routing to static urgent speech or LLM-generated empathetic responses; and (4) the Suwan Li AI singer-songwriter persona case study -- over 100 AI-generated songs produced with Suno. A 36-hour stress test demonstrates: zero danmaku overlap, zero deadlock crashes, gift effect P95 latency <= 180 ms, LLM-to-TTS segment P95 latency <= 2.1 s, and TTS integrated loudness gain of 9.5 LUFS. live streaming; danmaku; large language model; prompt engineering; virtual persona; WebView2; WINMM; TTS; Suno; loudness normalization; real-time scheduling
Abstract:Despite achieving state-of-the-art generation quality, diffusion models are hindered by the substantial computational burden of their iterative sampling process. While feature caching techniques achieve effective acceleration at higher step counts (e.g., 50 steps), they exhibit critical limitations in the practical low-step regime of 20-30 steps. As the interval between steps increases, polynomial-based extrapolators like TaylorSeer suffer from error accumulation and trajectory drift. Meanwhile, conventional caching strategies often overlook the distinct dynamical properties of different denoising phases. To address these challenges, we propose Trajectory-Consistent Padé approximation, a feature prediction framework grounded in Padé approximation. By modeling feature evolution through rational functions, our approach captures asymptotic and transitional behaviors more accurately than Taylor-based methods. To enable stable and trajectory-consistent sampling under reduced step counts, TC-Padé incorporates (1) adaptive coefficient modulation that leverages historical cached residuals to detect subtle trajectory transitions, and (2) step-aware prediction strategies tailored to the distinct dynamics of early, mid, and late sampling stages. Extensive experiments on DiT-XL/2, FLUX.1-dev, and Wan2.1 across both image and video generation demonstrate the effectiveness of TC-Padé. For instance, TC-Padé achieves 2.88x acceleration on FLUX.1-dev and 1.72x on Wan2.1 while maintaining high quality across FID, CLIP, Aesthetic, and VBench-2.0 metrics, substantially outperforming existing feature caching methods.
Abstract:Recent studies show that quantum neural networks (QNNs) generalize well in few-shot regimes. To extend this advantage to large-scale tasks, we propose Q-LoRA, a quantum-enhanced fine-tuning scheme that integrates lightweight QNNs into the low-rank adaptation (LoRA) adapter. Applied to AI-generated content (AIGC) detection, Q-LoRA consistently outperforms standard LoRA under few-shot settings. We analyze the source of this improvement and identify two possible structural inductive biases from QNNs: (i) phase-aware representations, which encode richer information across orthogonal amplitude-phase components, and (ii) norm-constrained transformations, which stabilize optimization via inherent orthogonality. However, Q-LoRA incurs non-trivial overhead due to quantum simulation. Motivated by our analysis, we further introduce H-LoRA, a fully classical variant that applies the Hilbert transform within the LoRA adapter to retain similar phase structure and constraints. Experiments on few-shot AIGC detection show that both Q-LoRA and H-LoRA outperform standard LoRA by over 5% accuracy, with H-LoRA achieving comparable accuracy at significantly lower cost in this task.
Abstract:With the rapid development of generative AI in medical imaging, synthetic Computed Tomography (CT) images have demonstrated great potential in applications such as data augmentation and clinical diagnosis, but they also introduce serious security risks. Despite the increasing security concerns, existing studies on CT forgery detection are still limited and fail to adequately address real-world challenges. These limitations are mainly reflected in two aspects: the absence of datasets that can effectively evaluate model generalization to reflect the real-world application requirements, and the reliance on detection methods designed for natural images that are insensitive to CT-specific forgery artifacts. In this view, we propose CTForensics, a comprehensive dataset designed to systematically evaluate the generalization capability of CT forgery detection methods, which includes ten diverse CT generative methods. Moreover, we introduce the Enhanced Spatial-Frequency CT Forgery Detector (ESF-CTFD), an efficient CNN-based neural network that captures forgery cues across the wavelet, spatial, and frequency domains. First, it transforms the input CT image into three scales and extracts features at each scale via the Wavelet-Enhanced Central Stem. Then, starting from the largest-scale features, the Spatial Process Block gradually performs feature fusion with the smaller-scale ones. Finally, the Frequency Process Block learns frequency-domain information for predicting the final results. Experiments demonstrate that ESF-CTFD consistently outperforms existing methods and exhibits superior generalization across different CT generative models.
Abstract:We propose a simple yet effective UHDPromer, a neural discrimination-prompted Transformer, for Ultra-High-Definition (UHD) image restoration and enhancement. Our UHDPromer is inspired by an interesting observation that there implicitly exist neural differences between high-resolution and low-resolution features, and exploring such differences can facilitate low-resolution feature representation. To this end, we first introduce Neural Discrimination Priors (NDP) to measure the differences and then integrate NDP into the proposed Neural Discrimination-Prompted Attention (NDPA) and Neural Discrimination-Prompted Network (NDPN). The proposed NDPA re-formulates the attention by incorporating NDP to globally perceive useful discrimination information, while the NDPN explores a continuous gating mechanism guided by NDP to selectively permit the passage of beneficial content. To enhance the quality of restored images, we propose a super-resolution-guided reconstruction approach, which is guided by super-resolving low-resolution features to facilitate final UHD image restoration. Experiments show that UHDPromer achieves the best computational efficiency while still maintaining state-of-the-art performance on $3$ UHD image restoration and enhancement tasks, including low-light image enhancement, image dehazing, and image deblurring. The source codes and pre-trained models will be made available at https://github.com/supersupercong/uhdpromer.
Abstract:Spiking neural networks (SNNs) offer an energy-efficient alternative to traditional neural networks due to their event-driven computing paradigm. However, recent advancements in spiking transformers have focused on improving accuracy with large-scale architectures, which require significant computational resources and limit deployment on resource-constrained devices. In this paper, we propose a simple yet effective token pruning method for spiking transformers, termed TP-Spikformer, that reduces storage and computational overhead while maintaining competitive performance. Specifically, we first introduce a heuristic spatiotemporal information-retaining criterion that comprehensively evaluates tokens' importance, assigning higher scores to informative tokens for retention and lower scores to uninformative ones for pruning. Based on this criterion, we propose an information-retaining token pruning framework that employs a block-level early stopping strategy for uninformative tokens, instead of removing them outright. This also helps preserve more information during token pruning. We demonstrate the effectiveness, efficiency and scalability of TP-Spikformer through extensive experiments across diverse architectures, including Spikformer, QKFormer and Spike-driven Transformer V1 and V3, and a range of tasks such as image classification, object detection, semantic segmentation and event-based object tracking. Particularly, TP-Spikformer performs well in a training-free manner. These results reveal its potential as an efficient and practical solution for deploying SNNs in real-world applications with limited computational resources.
Abstract:The rise of text-to-video generation models has raised growing concerns over content authenticity, copyright protection, and malicious misuse. Watermarking serves as an effective mechanism for regulating such AI-generated content, where high fidelity and strong robustness are particularly critical. Recent generative image watermarking methods provide a promising foundation by leveraging watermark information and pseudo-random keys to control the initial sampling noise, enabling lossless embedding. However, directly extending these techniques to videos introduces two key limitations: Existing designs implicitly rely on strict alignment between video frames and frame-dependent pseudo-random binary sequences used for watermark encryption. Once this alignment is disrupted, subsequent watermark extraction becomes unreliable; and Video-specific distortions, such as inter-frame compression, significantly degrade watermark reliability. To address these issues, we propose SKeDA, a generative watermarking framework tailored for text-to-video diffusion models. SKeDA consists of two components: (1) Shuffle-Key-based Distribution-preserving Sampling (SKe) employs a single base pseudo-random binary sequence for watermark encryption and derives frame-level encryption sequences through permutation. This design transforms watermark extraction from synchronization-sensitive sequence decoding into permutation-tolerant set-level aggregation, substantially improving robustness against frame reordering and loss; and (2) Differential Attention (DA), which computes inter-frame differences and dynamically adjusts attention weights during extraction, enhancing robustness against temporal distortions. Extensive experiments demonstrate that SKeDA preserves high video generation quality and watermark robustness.
Abstract:Quantum cloud platforms have become the most widely adopted and mainstream approach for accessing quantum computing resources, due to the scarcity and operational complexity of quantum hardware. In this service-oriented paradigm, quantum circuits, which constitute high-value intellectual property, are exposed to risks of unauthorized access, reuse, and misuse. Digital watermarking has been explored as a promising mechanism for protecting quantum circuits by embedding ownership information for tracing and verification. However, driven by recent advances in generative artificial intelligence, the paradigm of quantum circuit design is shifting from individually and manually constructed circuits to automated synthesis based on quantum circuit generative models (QCGMs). In such generative settings, protecting only individual output circuits is insufficient, and existing post hoc, circuit-centric watermarking methods are not designed to integrate with the generative process, often failing to simultaneously ensure stealthiness, functional correctness, and robustness at scale. These limitations highlight the need for a new watermarking paradigm that is natively integrated with quantum circuit generative models. In this work, we present the first watermarking framework for QCGMs, which embeds ownership signals into the generation process while preserving circuit fidelity. We introduce a symmetric sampling strategy that aligns watermark encoding with the model's Gaussian prior, and a synchronization mechanism that counteracts adversarial watermark attack through latent drift correction. Empirical results confirm that our method achieves high-fidelity circuit generation and robust watermark detection across a range of perturbations, paving the way for scalable, secure copyright protection in AI-powered quantum design.
Abstract:Spiking Neural Networks (SNNs) represent a promising paradigm for energy-efficient neuromorphic computing due to their bio-plausible and spike-driven characteristics. However, the robustness of SNNs in complex adversarial environments remains significantly constrained. In this study, we theoretically demonstrate that those threshold-neighboring spiking neurons are the key factors limiting the robustness of directly trained SNNs. We find that these neurons set the upper limits for the maximum potential strength of adversarial attacks and are prone to state-flipping under minor disturbances. To address this challenge, we propose a Threshold Guarding Optimization (TGO) method, which comprises two key aspects. First, we incorporate additional constraints into the loss function to move neurons' membrane potentials away from their thresholds. It increases SNNs' gradient sparsity, thereby reducing the theoretical upper bound of adversarial attacks. Second, we introduce noisy spiking neurons to transition the neuronal firing mechanism from deterministic to probabilistic, decreasing their state-flipping probability due to minor disturbances. Extensive experiments conducted in standard adversarial scenarios prove that our method significantly enhances the robustness of directly trained SNNs. These findings pave the way for advancing more reliable and secure neuromorphic computing in real-world applications.