Textual Gradients are a Flawed Metaphor for Automatic Prompt Optimization

A well-engineered prompt can increase the performance of large language models; automatic prompt optimization techniques aim to increase performance without requiring human effort to tune the prompts. One leading class of prompt optimization techniques introduces the analogy of textual gradients. We investigate the behavior of these textual gradient methods through a series of experiments and case studies. While such methods often result in a performance improvement, our experiments suggest that the gradient analogy does not accurately explain their behavior. Our insights may inform the selection of prompt optimization strategies, and development of new approaches.

Route-DETR: Pairwise Query Routing in Transformers for Object Detection

Detection Transformer (DETR) offers an end-to-end solution for object detection by eliminating hand-crafted components like non-maximum suppression. However, DETR suffers from inefficient query competition where multiple queries converge to similar positions, leading to redundant computations. We present Route-DETR, which addresses these issues through adaptive pairwise routing in decoder self-attention layers. Our key insight is distinguishing between competing queries (targeting the same object) versus complementary queries (targeting different objects) using inter-query similarity, confidence scores, and geometry. We introduce dual routing mechanisms: suppressor routes that modulate attention between competing queries to reduce duplication, and delegator routes that encourage exploration of different regions. These are implemented via learnable low-rank attention biases enabling asymmetric query interactions. A dual-branch training strategy incorporates routing biases only during training while preserving standard attention for inference, ensuring no additional computational cost. Experiments on COCO and Cityscapes demonstrate consistent improvements across multiple DETR baselines, achieving +1.7% mAP gain over DINO on ResNet-50 and reaching 57.6% mAP on Swin-L, surpassing prior state-of-the-art models.

Informing Acquisition Functions via Foundation Models for Molecular Discovery

Bayesian Optimization (BO) is a key methodology for accelerating molecular discovery by estimating the mapping from molecules to their properties while seeking the optimal candidate. Typically, BO iteratively updates a probabilistic surrogate model of this mapping and optimizes acquisition functions derived from the model to guide molecule selection. However, its performance is limited in low-data regimes with insufficient prior knowledge and vast candidate spaces. Large language models (LLMs) and chemistry foundation models offer rich priors to enhance BO, but high-dimensional features, costly in-context learning, and the computational burden of deep Bayesian surrogates hinder their full utilization. To address these challenges, we propose a likelihood-free BO method that bypasses explicit surrogate modeling and directly leverages priors from general LLMs and chemistry-specific foundation models to inform acquisition functions. Our method also learns a tree-structured partition of the molecular search space with local acquisition functions, enabling efficient candidate selection via Monte Carlo Tree Search. By further incorporating coarse-grained LLM-based clustering, it substantially improves scalability to large candidate sets by restricting acquisition function evaluations to clusters with statistically higher property values. We show through extensive experiments and ablations that the proposed method substantially improves scalability, robustness, and sample efficiency in LLM-guided BO for molecular discovery.

Learning Patient-Specific Disease Dynamics with Latent Flow Matching for Longitudinal Imaging Generation

Understanding disease progression is a central clinical challenge with direct implications for early diagnosis and personalized treatment. While recent generative approaches have attempted to model progression, key mismatches remain: disease dynamics are inherently continuous and monotonic, yet latent representations are often scattered, lacking semantic structure, and diffusion-based models disrupt continuity with random denoising process. In this work, we propose to treat the disease dynamic as a velocity field and leverage Flow Matching (FM) to align the temporal evolution of patient data. Unlike prior methods, it captures the intrinsic dynamic of disease, making the progression more interpretable. However, a key challenge remains: in latent space, Auto-Encoders (AEs) do not guarantee alignment across patients or correlation with clinical-severity indicators (e.g., age and disease conditions). To address this, we propose to learn patient-specific latent alignment, which enforces patient trajectories to lie along a specific axis, with magnitude increasing monotonically with disease severity. This leads to a consistent and semantically meaningful latent space. Together, we present $Δ$-LFM, a framework for modeling patient-specific latent progression with flow matching. Across three longitudinal MRI benchmarks, $Δ$-LFM demonstrates strong empirical performance and, more importantly, offers a new framework for interpreting and visualizing disease dynamics.

A Super-Learner with Large Language Models for Medical Emergency Advising

Medical decision-support and advising systems are critical for emergency physicians to quickly and accurately assess patients' conditions and make diagnosis. Artificial Intelligence (AI) has emerged as a transformative force in healthcare in recent years and Large Language Models (LLMs) have been employed in various fields of medical decision-support systems. We studied responses of a group of different LLMs to real cases in emergency medicine. The results of our study on five most renown LLMs showed significant differences in capabilities of Large Language Models for diagnostics acute diseases in medical emergencies with accuracy ranging between 58% and 65%. This accuracy significantly exceeds the reported accuracy of human doctors. We built a super-learner MEDAS (Medical Emergency Diagnostic Advising System) of five major LLMs - Gemini, Llama, Grok, GPT, and Claude). The super-learner produces higher diagnostic accuracy, 70%, even with a quite basic meta-learner. However, at least one of the integrated LLMs in the same super-learner produces 85% correct diagnoses. The super-learner integrates a cluster of LLMs using a meta-learner capable of learning different capabilities of each LLM to leverage diagnostic accuracy of the model by collective capabilities of all LLMs in the cluster. The results of our study showed that aggregated diagnostic accuracy provided by a meta-learning approach exceeds that of any individual LLM, suggesting that the super-learner can take advantage of the combined knowledge of the medical datasets used to train the group of LLMs.

UniABG: Unified Adversarial View Bridging and Graph Correspondence for Unsupervised Cross-View Geo-Localization

Cross-view geo-localization (CVGL) matches query images ($\textit{e.g.}$, drone) to geographically corresponding opposite-view imagery ($\textit{e.g.}$, satellite). While supervised methods achieve strong performance, their reliance on extensive pairwise annotations limits scalability. Unsupervised alternatives avoid annotation costs but suffer from noisy pseudo-labels due to intrinsic cross-view domain gaps. To address these limitations, we propose $\textit{UniABG}$, a novel dual-stage unsupervised cross-view geo-localization framework integrating adversarial view bridging with graph-based correspondence calibration. Our approach first employs View-Aware Adversarial Bridging (VAAB) to model view-invariant features and enhance pseudo-label robustness. Subsequently, Heterogeneous Graph Filtering Calibration (HGFC) refines cross-view associations by constructing dual inter-view structure graphs, achieving reliable view correspondence. Extensive experiments demonstrate state-of-the-art unsupervised performance, showing that UniABG improves Satellite $\rightarrow$ Drone AP by +10.63\% on University-1652 and +16.73\% on SUES-200, even surpassing supervised baselines. The source code is available at https://github.com/chenqi142/UniABG

OUGS: Active View Selection via Object-aware Uncertainty Estimation in 3DGS

Recent advances in 3D Gaussian Splatting (3DGS) have achieved state-of-the-art results for novel view synthesis. However, efficiently capturing high-fidelity reconstructions of specific objects within complex scenes remains a significant challenge. A key limitation of existing active reconstruction methods is their reliance on scene-level uncertainty metrics, which are often biased by irrelevant background clutter and lead to inefficient view selection for object-centric tasks. We present OUGS, a novel framework that addresses this challenge with a more principled, physically-grounded uncertainty formulation for 3DGS. Our core innovation is to derive uncertainty directly from the explicit physical parameters of the 3D Gaussian primitives (e.g., position, scale, rotation). By propagating the covariance of these parameters through the rendering Jacobian, we establish a highly interpretable uncertainty model. This foundation allows us to then seamlessly integrate semantic segmentation masks to produce a targeted, object-aware uncertainty score that effectively disentangles the object from its environment. This allows for a more effective active view selection strategy that prioritizes views critical to improving object fidelity. Experimental evaluations on public datasets demonstrate that our approach significantly improves the efficiency of the 3DGS reconstruction process and achieves higher quality for targeted objects compared to existing state-of-the-art methods, while also serving as a robust uncertainty estimator for the global scene.

RPG: A Repository Planning Graph for Unified and Scalable Codebase Generation

Large language models excel at function- and file-level code generation, yet generating complete repositories from scratch remains a fundamental challenge. This process demands coherent and reliable planning across proposal- and implementation-level stages, while natural language, due to its ambiguity and verbosity, is ill-suited for faithfully representing complex software structures. To address this, we introduce the Repository Planning Graph (RPG), a persistent representation that unifies proposal- and implementation-level planning by encoding capabilities, file structures, data flows, and functions in one graph. RPG replaces ambiguous natural language with an explicit blueprint, enabling long-horizon planning and scalable repository generation. Building on RPG, we develop ZeroRepo, a graph-driven framework for repository generation from scratch. It operates in three stages: proposal-level planning and implementation-level refinement to construct the graph, followed by graph-guided code generation with test validation. To evaluate this setting, we construct RepoCraft, a benchmark of six real-world projects with 1,052 tasks. On RepoCraft, ZeroRepo produces repositories averaging nearly 36K LOC, roughly 3.9$\times$ the strongest baseline (Claude Code) and about 64$\times$ other baselines. It attains 81.5% functional coverage and a 69.7% pass rate, exceeding Claude Code by 27.3 and 35.8 percentage points, respectively. Further analysis shows that RPG models complex dependencies, enables progressively more sophisticated planning through near-linear scaling, and enhances LLM understanding of repositories, thereby accelerating agent localization.

Hunyuan3D Studio: End-to-End AI Pipeline for Game-Ready 3D Asset Generation

The creation of high-quality 3D assets, a cornerstone of modern game development, has long been characterized by labor-intensive and specialized workflows. This paper presents Hunyuan3D Studio, an end-to-end AI-powered content creation platform designed to revolutionize the game production pipeline by automating and streamlining the generation of game-ready 3D assets. At its core, Hunyuan3D Studio integrates a suite of advanced neural modules (such as Part-level 3D Generation, Polygon Generation, Semantic UV, etc.) into a cohesive and user-friendly system. This unified framework allows for the rapid transformation of a single concept image or textual description into a fully-realized, production-quality 3D model complete with optimized geometry and high-fidelity PBR textures. We demonstrate that assets generated by Hunyuan3D Studio are not only visually compelling but also adhere to the stringent technical requirements of contemporary game engines, significantly reducing iteration time and lowering the barrier to entry for 3D content creation. By providing a seamless bridge from creative intent to technical asset, Hunyuan3D Studio represents a significant leap forward for AI-assisted workflows in game development and interactive media.

Bitrate-Controlled Diffusion for Disentangling Motion and Content in Video

We propose a novel and general framework to disentangle video data into its dynamic motion and static content components. Our proposed method is a self-supervised pipeline with less assumptions and inductive biases than previous works: it utilizes a transformer-based architecture to jointly generate flexible implicit features for frame-wise motion and clip-wise content, and incorporates a low-bitrate vector quantization as an information bottleneck to promote disentanglement and form a meaningful discrete motion space. The bitrate-controlled latent motion and content are used as conditional inputs to a denoising diffusion model to facilitate self-supervised representation learning. We validate our disentangled representation learning framework on real-world talking head videos with motion transfer and auto-regressive motion generation tasks. Furthermore, we also show that our method can generalize to other types of video data, such as pixel sprites of 2D cartoon characters. Our work presents a new perspective on self-supervised learning of disentangled video representations, contributing to the broader field of video analysis and generation.