An efficient framework based on large foundation model for cervical cytopathology whole slide image screening

Current cervical cytopathology whole slide image (WSI) screening primarily relies on detection-based approaches, which are limited in performance due to the expense and time-consuming annotation process. Multiple Instance Learning (MIL), a weakly supervised approach that relies solely on bag-level labels, can effectively alleviate these challenges. Nonetheless, MIL commonly employs frozen pretrained models or self-supervised learning for feature extraction, which suffers from low efficacy or inefficiency. In this paper, we propose an efficient framework for cervical cytopathology WSI classification using only WSI-level labels through unsupervised and weakly supervised learning. Given the sparse and dispersed nature of abnormal cells within cytopathological WSIs, we propose a strategy that leverages the pretrained foundation model to filter the top$k$ high-risk patches. Subsequently, we suggest parameter-efficient fine-tuning (PEFT) of a large foundation model using contrastive learning on the filtered patches to enhance its representation ability for task-specific signals. By training only the added linear adapters, we enhance the learning of patch-level features with substantially reduced time and memory consumption. Experiments conducted on the CSD and FNAC 2019 datasets demonstrate that the proposed method enhances the performance of various MIL methods and achieves state-of-the-art (SOTA) performance. The code and trained models are publicly available at https://github.com/CVIU-CSU/TCT-InfoNCE.

Mobile-Bench: An Evaluation Benchmark for LLM-based Mobile Agents

With the remarkable advancements of large language models (LLMs), LLM-based agents have become a research hotspot in human-computer interaction. However, there is a scarcity of benchmarks available for LLM-based mobile agents. Benchmarking these agents generally faces three main challenges: (1) The inefficiency of UI-only operations imposes limitations to task evaluation. (2) Specific instructions within a singular application lack adequacy for assessing the multi-dimensional reasoning and decision-making capacities of LLM mobile agents. (3) Current evaluation metrics are insufficient to accurately assess the process of sequential actions. To this end, we propose Mobile-Bench, a novel benchmark for evaluating the capabilities of LLM-based mobile agents. First, we expand conventional UI operations by incorporating 103 collected APIs to accelerate the efficiency of task completion. Subsequently, we collect evaluation data by combining real user queries with augmentation from LLMs. To better evaluate different levels of planning capabilities for mobile agents, our data is categorized into three distinct groups: SAST, SAMT, and MAMT, reflecting varying levels of task complexity. Mobile-Bench comprises 832 data entries, with more than 200 tasks specifically designed to evaluate multi-APP collaboration scenarios. Furthermore, we introduce a more accurate evaluation metric, named CheckPoint, to assess whether LLM-based mobile agents reach essential points during their planning and reasoning steps.

$Se^2$: Sequential Example Selection for In-Context Learning

The remarkable capability of large language models (LLMs) for in-context learning (ICL) needs to be activated by demonstration examples. Prior work has extensively explored the selection of examples for ICL, predominantly following the "select then organize" paradigm, such approaches often neglect the internal relationships between examples and exist an inconsistency between the training and inference. In this paper, we formulate the problem as a $\textit{se}$quential $\textit{se}$lection problem and introduce $Se^2$, a sequential-aware method that leverages the LLM's feedback on varying context, aiding in capturing inter-relationships and sequential information among examples, significantly enriching the contextuality and relevance of ICL prompts. Meanwhile, we utilize beam search to seek and construct example sequences, enhancing both quality and diversity. Extensive experiments across 23 NLP tasks from 8 distinct categories illustrate that $Se^2$ markedly surpasses competitive baselines and achieves 42% relative improvement over random selection. Further in-depth analysis show the effectiveness of proposed strategies, highlighting $Se^2$'s exceptional stability and adaptability across various scenarios. Our code will be released to facilitate future research.

Subobject-level Image Tokenization

Transformer-based vision models typically tokenize images into fixed-size square patches as input units, which lacks the adaptability to image content and overlooks the inherent pixel grouping structure. Inspired by the subword tokenization widely adopted in language models, we propose an image tokenizer at a subobject level, where the subobjects are represented by semantically meaningful image segments obtained by segmentation models (e.g., segment anything models). To implement a learning system based on subobject tokenization, we first introduced a Sequence-to-sequence AutoEncoder (SeqAE) to compress subobject segments of varying sizes and shapes into compact embedding vectors, then fed the subobject embeddings into a large language model for vision language learning. Empirical results demonstrated that our subobject-level tokenization significantly facilitates efficient learning of translating images into object and attribute descriptions compared to the traditional patch-level tokenization. Codes and models will be open-sourced at https://github.com/ChenDelong1999/subobjects.

Visual Instruction Tuning with Polite Flamingo

Recent research has demonstrated that the multi-task fine-tuning of multi-modal Large Language Models (LLMs) using an assortment of annotated downstream vision-language datasets significantly enhances their performance. Yet, during this process, a side effect, which we termed as the "multi-modal alignment tax", surfaces. This side effect negatively impacts the model's ability to format responses appropriately -- for instance, its "politeness" -- due to the overly succinct and unformatted nature of raw annotations, resulting in reduced human preference. In this paper, we introduce Polite Flamingo, a multi-modal response rewriter that transforms raw annotations into a more appealing, "polite" format. Polite Flamingo is trained to reconstruct high-quality responses from their automatically distorted counterparts and is subsequently applied to a vast array of vision-language datasets for response rewriting. After rigorous filtering, we generate the PF-1M dataset and further validate its value by fine-tuning a multi-modal LLM with it. Combined with novel methodologies including U-shaped multi-stage tuning and multi-turn augmentation, the resulting model, Clever Flamingo, demonstrates its advantages in both multi-modal understanding and response politeness according to automated and human evaluations.

UPRISE: Universal Prompt Retrieval for Improving Zero-Shot Evaluation

Large Language Models (LLMs) are popular for their impressive abilities, but the need for model-specific fine-tuning or task-specific prompt engineering can hinder their generalization. We propose UPRISE (Universal Prompt Retrieval for Improving zero-Shot Evaluation), which tunes a lightweight and versatile retriever that automatically retrieves prompts for a given zero-shot task input. Specifically, we demonstrate universality in a cross-task and cross-model scenario: the retriever is tuned on a diverse set of tasks, but tested on unseen task types; we use a small frozen LLM, GPT-Neo-2.7B, for tuning the retriever, but test the retriever on different LLMs of much larger scales, such as BLOOM-7.1B, OPT-66B and GPT3-175B. Additionally, we show that UPRISE mitigates the hallucination problem in our experiments with ChatGPT, suggesting its potential to improve even the strongest LLMs. Our model and code are available at https://github.com/microsoft/LMOps.

Orca: A Few-shot Benchmark for Chinese Conversational Machine Reading Comprehension

The conversational machine reading comprehension (CMRC) task aims to answer questions in conversations, which has been a hot research topic in recent years because of its wide applications. However, existing CMRC benchmarks in which each conversation is assigned a static passage are inconsistent with real scenarios. Thus, model's comprehension ability towards real scenarios are hard to evaluate reasonably. To this end, we propose the first Chinese CMRC benchmark Orca and further provide zero-shot/few-shot settings to evaluate model's generalization ability towards diverse domains. We collect 831 hot-topic driven conversations with 4,742 turns in total. Each turn of a conversation is assigned with a response-related passage, aiming to evaluate model's comprehension ability more reasonably. The topics of conversations are collected from social media platform and cover 33 domains, trying to be consistent with real scenarios. Importantly, answers in Orca are all well-annotated natural responses rather than the specific spans or short phrase in previous datasets. Besides, we implement three strong baselines to tackle the challenge in Orca. The results indicate the great challenge of our CMRC benchmark. Our datatset and checkpoints are available at https://github.com/nuochenpku/Orca.

Exploring Contextual Relationships for Cervical Abnormal Cell Detection

Cervical abnormal cell detection is a challenging task as the morphological discrepancies between abnormal and normal cells are usually subtle. To determine whether a cervical cell is normal or abnormal, cytopathologists always take surrounding cells as references to identify its abnormality. To mimic these behaviors, we propose to explore contextual relationships to boost the performance of cervical abnormal cell detection. Specifically, both contextual relationships between cells and cell-to-global images are exploited to enhance features of each region of interest (RoI) proposals. Accordingly, two modules, dubbed as RoI-relationship attention module (RRAM) and global RoI attention module (GRAM), are developed and their combination strategies are also investigated. We establish a strong baseline by using Double-Head Faster R-CNN with feature pyramid network (FPN) and integrate our RRAM and GRAM into it to validate the effectiveness of the proposed modules. Experiments conducted on a large cervical cell detection dataset reveal that the introduction of RRAM and GRAM both achieves better average precision (AP) than the baseline methods. Moreover, when cascading RRAM and GRAM, our method outperforms the state-of-the-art (SOTA) methods. Furthermore, we also show the proposed feature enhancing scheme can facilitate both image-level and smear-level classification. The code and trained models are publicly available at https://github.com/CVIU-CSU/CR4CACD.

GoChat: Goal-oriented Chatbots with Hierarchical Reinforcement Learning

A chatbot that converses like a human should be goal-oriented (i.e., be purposeful in conversation), which is beyond language generation. However, existing dialogue systems often heavily rely on cumbersome hand-crafted rules or costly labelled datasets to reach the goals. In this paper, we propose Goal-oriented Chatbots (GoChat), a framework for end-to-end training chatbots to maximize the longterm return from offline multi-turn dialogue datasets. Our framework utilizes hierarchical reinforcement learning (HRL), where the high-level policy guides the conversation towards the final goal by determining some sub-goals, and the low-level policy fulfills the sub-goals by generating the corresponding utterance for response. In our experiments on a real-world dialogue dataset for anti-fraud in financial, our approach outperforms previous methods on both the quality of response generation as well as the success rate of accomplishing the goal.

Applying Cyclical Learning Rate to Neural Machine Translation

In training deep learning networks, the optimizer and related learning rate are often used without much thought or with minimal tuning, even though it is crucial in ensuring a fast convergence to a good quality minimum of the loss function that can also generalize well on the test dataset. Drawing inspiration from the successful application of cyclical learning rate policy for computer vision related convolutional networks and datasets, we explore how cyclical learning rate can be applied to train transformer-based neural networks for neural machine translation. From our carefully designed experiments, we show that the choice of optimizers and the associated cyclical learning rate policy can have a significant impact on the performance. In addition, we establish guidelines when applying cyclical learning rates to neural machine translation tasks. Thus with our work, we hope to raise awareness of the importance of selecting the right optimizers and the accompanying learning rate policy, at the same time, encourage further research into easy-to-use learning rate policies.