X-VC: Zero-shot Streaming Voice Conversion in Codec Space

Zero-shot voice conversion (VC) aims to convert a source utterance into the voice of an unseen target speaker while preserving its linguistic content. Although recent systems have improved conversion quality, building zero-shot VC systems for interactive scenarios remains challenging because high-fidelity speaker transfer and low-latency streaming inference are difficult to achieve simultaneously. In this work, we present X-VC, a zero-shot streaming VC system that performs one-step conversion in the latent space of a pretrained neural codec. X-VC uses a dual-conditioning acoustic converter that jointly models source codec latents and frame-level acoustic conditions derived from target reference speech, while injecting utterance-level target speaker information through adaptive normalization. To reduce the mismatch between training and inference, we train the model with generated paired data and a role-assignment strategy that combines standard, reconstruction, and reversed modes. For streaming inference, we further adopt a chunkwise inference scheme with overlap smoothing that is aligned with the segment-based training paradigm of the codec. Experiments on Seed-TTS-Eval show that X-VC achieves the best streaming WER in both English and Chinese, strong speaker similarity in same-language and cross-lingual settings, and substantially lower offline real-time factor than the compared baselines. These results suggest that codec-space one-step conversion is a practical approach for building high-quality low-latency zero-shot VC systems. Audio samples are available at https://x-vc.github.io. Our code and checkpoints will also be released.

Interactive ASR: Towards Human-Like Interaction and Semantic Coherence Evaluation for Agentic Speech Recognition

Recent years have witnessed remarkable progress in automatic speech recognition (ASR), driven by advances in model architectures and large-scale training data. However, two important aspects remain underexplored. First, Word Error Rate (WER), the dominant evaluation metric for decades, treats all words equally and often fails to reflect the semantic correctness of an utterance at the sentence level. Second, interactive correction-an essential component of human communication-has rarely been systematically studied in ASR research. In this paper, we integrate these two perspectives under an agentic framework for interactive ASR. We propose leveraging LLM-as-a-Judge as a semantic-aware evaluation metric to assess recognition quality beyond token-level accuracy. Furthermore, we design an LLM-driven agent framework to simulate human-like multi-turn interaction, enabling iterative refinement of recognition outputs through semantic feedback. Extensive experiments are conducted on standard benchmarks, including GigaSpeech (English), WenetSpeech (Chinese), the ASRU 2019 code-switching test set. Both objective and subjective evaluations demonstrate the effectiveness of the proposed framework in improving semantic fidelity and interactive correction capability. We will release the code to facilitate future research in interactive and agentic ASR.

TASU2: Controllable CTC Simulation for Alignment and Low-Resource Adaptation of Speech LLMs

Speech LLM post-training increasingly relies on efficient cross-modal alignment and robust low-resource adaptation, yet collecting large-scale audio-text pairs remains costly. Text-only alignment methods such as TASU reduce this burden by simulating CTC posteriors from transcripts, but they provide limited control over uncertainty and error rate, making curriculum design largely heuristic. We propose \textbf{TASU2}, a controllable CTC simulation framework that simulates CTC posterior distributions under a specified WER range, producing text-derived supervision that better matches the acoustic decoding interface. This enables principled post-training curricula that smoothly vary supervision difficulty without TTS. Across multiple source-to-target adaptation settings, TASU2 improves in-domain and out-of-domain recognition over TASU, and consistently outperforms strong baselines including text-only fine-tuning and TTS-based augmentation, while mitigating source-domain performance degradation.

Does Pass Rate Tell the Whole Story? Evaluating Design Constraint Compliance in LLM-based Issue Resolution

Repository-level issue resolution benchmarks have become a standard testbed for evaluating LLM-based agents, yet success is still predominantly measured by test pass rates. In practice, however, acceptable patches must also comply with project-specific design constraints, such as architectural conventions, error-handling policies, and maintainability requirements, which are rarely encoded in tests and are often documented only implicitly in code review discussions. This paper introduces \textit{design-aware issue resolution} and presents \bench{}, a benchmark that makes such implicit design constraints explicit and measurable. \bench{} is constructed by mining and validating design constraints from real-world pull requests, linking them to issue instances, and automatically checking patch compliance using an LLM-based verifier, yielding 495 issues and 1,787 validated constraints across six repositories, aligned with SWE-bench-Verified and SWE-bench-Pro. Experiments with state-of-the-art agents show that test-based correctness substantially overestimates patch quality: fewer than half of resolved issues are fully design-satisfying, design violations are widespread, and functional correctness exhibits negligible statistical association with design satisfaction. While providing issue-specific design guidance reduces violations, substantial non-compliance remains, highlighting a fundamental gap in current agent capabilities and motivating design-aware evaluation beyond functional correctness.

PRIME: Prototype-Driven Multimodal Pretraining for Cancer Prognosis with Missing Modalities

Multimodal self-supervised pretraining offers a promising route to cancer prognosis by integrating histopathology whole-slide images, gene expression, and pathology reports, yet most existing approaches require fully paired and complete inputs. In practice, clinical cohorts are fragmented and often miss one or more modalities, limiting both supervised fusion and scalable multimodal pretraining. We propose PRIME, a missing-aware multimodal self-supervised pretraining framework that learns robust and transferable representations from partially observed cohorts. PRIME maps heterogeneous modality embeddings into a unified token space and introduces a shared prototype memory bank for latent-space semantic imputation via patient-level consensus retrieval, producing structurally aligned tokens without reconstructing raw signals. Two complementary pretraining objectives: inter-modality alignment and post-fusion consistency under structured missingness augmentation, jointly learn representations that remain predictive under arbitrary modality subsets. We evaluate PRIME on The Cancer Genome Atlas with label-free pretraining on 32 cancer types and downstream 5-fold evaluation on five cohorts across overall survival prediction, 3-year mortality classification, and 3-year recurrence classification. PRIME achieves the best macro-average performance among all compared methods, reaching 0.653 C-index, 0.689 AUROC, and 0.637 AUROC on the three tasks, respectively, while improving robustness under test-time missingness and supporting parameter-efficient and label-efficient adaptation. These results support missing-aware multimodal pretraining as a practical strategy for prognosis modeling in fragmented clinical data settings.

CharTool: Tool-Integrated Visual Reasoning for Chart Understanding

Charts are ubiquitous in scientific and financial literature for presenting structured data. However, chart reasoning remains challenging for multimodal large language models (MLLMs) due to the lack of high-quality training data, as well as the need for fine-grained visual grounding and precise numerical computation. To address these challenges, we first propose DuoChart, a scalable dual-source data pipeline that combines synthesized charts with real-world charts to construct diverse, high-quality chart training data. We then introduce CharTool, which equips MLLMs with external tools, including image cropping for localized visual perception and code-based computation for accurate numerical reasoning. Through agentic reinforcement learning on DuoChart, CharTool learns tool-integrated reasoning grounded in chart content. Extensive experiments on six chart benchmarks show that our method consistently improves over strong MLLM baselines across model scales. Notably, CharTool-7B outperforms the base model by **+8.0%** on CharXiv (Reasoning) and **+9.78%** on ChartQAPro, while achieving competitive performance with substantially larger or proprietary models. Moreover, CharTool demonstrates positive generalization to out-of-domain visual math reasoning benchmarks.

EpiScreen: Early Epilepsy Detection from Electronic Health Records with Large Language Models

Epilepsy and psychogenic non-epileptic seizures often present with similar seizure-like manifestations but require fundamentally different management strategies. Misdiagnosis is common and can lead to prolonged diagnostic delays, unnecessary treatments, and substantial patient morbidity. Although prolonged video-electroencephalography is the diagnostic gold standard, its high cost and limited accessibility hinder timely diagnosis. Here, we developed a low-cost, effective approach, EpiScreen, for early epilepsy detection by utilizing routinely collected clinical notes from electronic health records. Through fine-tuning large language models on labeled notes, EpiScreen achieved an AUC of up to 0.875 on the MIMIC-IV dataset and 0.980 on a private cohort of the University of Minnesota. In a clinician-AI collaboration setting, EpiScreen-assisted neurologists outperformed unaided experts by up to 10.9%. Overall, this study demonstrates that EpiScreen supports early epilepsy detection, facilitating timely and cost-effective screening that may reduce diagnostic delays and avoid unnecessary interventions, particularly in resource-limited regions.

SoulX-Duplug: Plug-and-Play Streaming State Prediction Module for Realtime Full-Duplex Speech Conversation

Recent advances in spoken dialogue systems have brought increased attention to human-like full-duplex voice interactions. However, our comprehensive review of this field reveals several challenges, including the difficulty in obtaining training data, catastrophic forgetting, and limited scalability. In this work, we propose SoulX-Duplug, a plug-and-play streaming state prediction module for full-duplex spoken dialogue systems. By jointly performing streaming ASR, SoulX-Duplug explicitly leverages textual information to identify user intent, effectively serving as a semantic VAD. To promote fair evaluation, we introduce SoulX-Duplug-Eval, extending widely used benchmarks with improved bilingual coverage. Experimental results show that SoulX-Duplug enables low-latency streaming dialogue state control, and the system built upon it outperforms existing full-duplex models in overall turn management and latency performance. We have open-sourced SoulX-Duplug and SoulX-Duplug-Eval.

HeartAgent: An Autonomous Agent System for Explainable Differential Diagnosis in Cardiology

Heart diseases remain a leading cause of morbidity and mortality worldwide, necessitating accurate and trustworthy differential diagnosis. However, existing artificial intelligence-based diagnostic methods are often limited by insufficient cardiology knowledge, inadequate support for complex reasoning, and poor interpretability. Here we present HeartAgent, a cardiology-specific agent system designed to support a reliable and explainable differential diagnosis. HeartAgent integrates customized tools and curated data resources and orchestrates multiple specialized sub-agents to perform complex reasoning while generating transparent reasoning trajectories and verifiable supporting references. Evaluated on the MIMIC dataset and a private electronic health records cohort, HeartAgent achieved over 36% and 20% improvements over established comparative methods, in top-3 diagnostic accuracy, respectively. Additionally, clinicians assisted by HeartAgent demonstrated gains of 26.9% in diagnostic accuracy and 22.7% in explanatory quality compared with unaided experts. These results demonstrate that HeartAgent provides reliable, explainable, and clinically actionable decision support for cardiovascular care.

G-STAR: End-to-End Global Speaker-Tracking Attributed Recognition

We study timestamped speaker-attributed ASR for long-form, multi-party speech with overlap, where chunk-wise inference must preserve meeting-level speaker identity consistency while producing time-stamped, speaker-labeled transcripts. Previous Speech-LLM systems tend to prioritize either local diarization or global labeling, but often lack the ability to capture fine-grained temporal boundaries or robust cross-chunk identity linking. We propose G-STAR, an end-to-end system that couples a time-aware speaker-tracking module with a Speech-LLM transcription backbone. The tracker provides structured speaker cues with temporal grounding, and the LLM generates attributed text conditioned on these cues. G-STAR supports both component-wise optimization and joint end-to-end training, enabling flexible learning under heterogeneous supervision and domain shift. Experiments analyze cue fusion, local versus long-context trade-offs and hierarchical objectives.