A survey of using EHR as real-world evidence for discovering and validating new drug indications

Electronic Health Records (EHRs) have been increasingly used as real-world evidence (RWE) to support the discovery and validation of new drug indications. This paper surveys current approaches to EHR-based drug repurposing, covering data sources, processing methodologies, and representation techniques. It discusses study designs and statistical frameworks for evaluating drug efficacy. Key challenges in validation are discussed, with emphasis on the role of large language models (LLMs) and target trial emulation. By synthesizing recent developments and methodological advances, this work provides a foundational resource for researchers aiming to translate real-world data into actionable drug-repurposing evidence.

RA-CLAP: Relation-Augmented Emotional Speaking Style Contrastive Language-Audio Pretraining For Speech Retrieval

The Contrastive Language-Audio Pretraining (CLAP) model has demonstrated excellent performance in general audio description-related tasks, such as audio retrieval. However, in the emerging field of emotional speaking style description (ESSD), cross-modal contrastive pretraining remains largely unexplored. In this paper, we propose a novel speech retrieval task called emotional speaking style retrieval (ESSR), and ESS-CLAP, an emotional speaking style CLAP model tailored for learning relationship between speech and natural language descriptions. In addition, we further propose relation-augmented CLAP (RA-CLAP) to address the limitation of traditional methods that assume a strict binary relationship between caption and audio. The model leverages self-distillation to learn the potential local matching relationships between speech and descriptions, thereby enhancing generalization ability. The experimental results validate the effectiveness of RA-CLAP, providing valuable reference in ESSD.

Zero-Shot Streaming Text to Speech Synthesis with Transducer and Auto-Regressive Modeling

Zero-shot streaming text-to-speech is an important research topic in human-computer interaction. Existing methods primarily use a lookahead mechanism, relying on future text to achieve natural streaming speech synthesis, which introduces high processing latency. To address this issue, we propose SMLLE, a streaming framework for generating high-quality speech frame-by-frame. SMLLE employs a Transducer to convert text into semantic tokens in real time while simultaneously obtaining duration alignment information. The combined outputs are then fed into a fully autoregressive (AR) streaming model to reconstruct mel-spectrograms. To further stabilize the generation process, we design a Delete < Bos > Mechanism that allows the AR model to access future text introducing as minimal delay as possible. Experimental results suggest that the SMLLE outperforms current streaming TTS methods and achieves comparable performance over sentence-level TTS systems. Samples are available on https://anonymous.4open.science/w/demo_page-48B7/.

Enhancing Generalization of Speech Large Language Models with Multi-Task Behavior Imitation and Speech-Text Interleaving

Large language models (LLMs) have shown remarkable generalization across tasks, leading to increased interest in integrating speech with LLMs. These speech LLMs (SLLMs) typically use supervised fine-tuning to align speech with text-based LLMs. However, the lack of annotated speech data across a wide range of tasks hinders alignment efficiency, resulting in poor generalization. To address these issues, we propose a novel multi-task 'behavior imitation' method with speech-text interleaving, called MTBI, which relies solely on paired speech and transcripts. By ensuring the LLM decoder generates equivalent responses to paired speech and text, we achieve a more generalized SLLM. Interleaving is used to further enhance alignment efficiency. We introduce a simple benchmark to evaluate prompt and task generalization across different models. Experimental results demonstrate that our MTBI outperforms SOTA SLLMs on both prompt and task generalization, while requiring less supervised speech data.

CosyVoice 3: Towards In-the-wild Speech Generation via Scaling-up and Post-training

In our prior works, we introduced a scalable streaming speech synthesis model, CosyVoice 2, which integrates a large language model (LLM) and a chunk-aware flow matching (FM) model, and achieves low-latency bi-streaming speech synthesis and human-parity quality. Despite these advancements, CosyVoice 2 exhibits limitations in language coverage, domain diversity, data volume, text formats, and post-training techniques. In this paper, we present CosyVoice 3, an improved model designed for zero-shot multilingual speech synthesis in the wild, surpassing its predecessor in content consistency, speaker similarity, and prosody naturalness. Key features of CosyVoice 3 include: 1) A novel speech tokenizer to improve prosody naturalness, developed via supervised multi-task training, including automatic speech recognition, speech emotion recognition, language identification, audio event detection, and speaker analysis. 2) A new differentiable reward model for post-training applicable not only to CosyVoice 3 but also to other LLM-based speech synthesis models. 3) Dataset Size Scaling: Training data is expanded from ten thousand hours to one million hours, encompassing 9 languages and 18 Chinese dialects across various domains and text formats. 4) Model Size Scaling: Model parameters are increased from 0.5 billion to 1.5 billion, resulting in enhanced performance on our multilingual benchmark due to the larger model capacity. These advancements contribute significantly to the progress of speech synthesis in the wild. We encourage readers to listen to the demo at https://funaudiollm.github.io/cosyvoice3.

Pushing the Frontiers of Self-Distillation Prototypes Network with Dimension Regularization and Score Normalization

Developing robust speaker verification (SV) systems without speaker labels has been a longstanding challenge. Earlier research has highlighted a considerable performance gap between self-supervised and fully supervised approaches. In this paper, we enhance the non-contrastive self-supervised framework, Self-Distillation Prototypes Network (SDPN), by introducing dimension regularization that explicitly addresses the collapse problem through the application of regularization terms to speaker embeddings. Moreover, we integrate score normalization techniques from fully supervised SV to further bridge the gap toward supervised verification performance. SDPN with dimension regularization and score normalization sets a new state-of-the-art on the VoxCeleb1 speaker verification evaluation benchmark, achieving Equal Error Rate 1.29%, 1.60%, and 2.80% for trial VoxCeleb1-{O,E,H} respectively. These results demonstrate relative improvements of 28.3%, 19.6%, and 22.6% over the current best self-supervised methods, thereby advancing the frontiers of SV technology.

Chinese-LiPS: A Chinese audio-visual speech recognition dataset with Lip-reading and Presentation Slides

Incorporating visual modalities to assist Automatic Speech Recognition (ASR) tasks has led to significant improvements. However, existing Audio-Visual Speech Recognition (AVSR) datasets and methods typically rely solely on lip-reading information or speaking contextual video, neglecting the potential of combining these different valuable visual cues within the speaking context. In this paper, we release a multimodal Chinese AVSR dataset, Chinese-LiPS, comprising 100 hours of speech, video, and corresponding manual transcription, with the visual modality encompassing both lip-reading information and the presentation slides used by the speaker. Based on Chinese-LiPS, we develop a simple yet effective pipeline, LiPS-AVSR, which leverages both lip-reading and presentation slide information as visual modalities for AVSR tasks. Experiments show that lip-reading and presentation slide information improve ASR performance by approximately 8\% and 25\%, respectively, with a combined performance improvement of about 35\%. The dataset is available at https://kiri0824.github.io/Chinese-LiPS/

From Large to Super-Tiny: End-to-End Optimization for Cost-Efficient LLMs

In recent years, Large Language Models (LLMs) have significantly advanced artificial intelligence by optimizing traditional Natural Language Processing (NLP) pipelines, improving performance and generalization. This has spurred their integration into various systems. Many NLP systems, including ours, employ a "one-stage" pipeline directly incorporating LLMs. While effective, this approach incurs substantial costs and latency due to the need for large model parameters to achieve satisfactory outcomes. This paper introduces a three-stage cost-efficient end-to-end LLM deployment pipeline-including prototyping, knowledge transfer, and model compression-to tackle the cost-performance dilemma in LLM-based frameworks. Our approach yields a super tiny model optimized for cost and performance in online systems, simplifying the system architecture. Initially, by transforming complex tasks into a function call-based LLM-driven pipeline, an optimal performance prototype system is constructed to produce high-quality data as a teacher model. The second stage combine techniques like rejection fine-tuning, reinforcement learning and knowledge distillation to transfer knowledge to a smaller 0.5B student model, delivering effective performance at minimal cost. The final stage applies quantization and pruning to extremely compress model to 0.4B, achieving ultra-low latency and cost. The framework's modular design and cross-domain capabilities suggest potential applicability in other NLP areas.

LightFormer: A lightweight and efficient decoder for remote sensing image segmentation

Deep learning techniques have achieved remarkable success in the semantic segmentation of remote sensing images and in land-use change detection. Nevertheless, their real-time deployment on edge platforms remains constrained by decoder complexity. Herein, we introduce LightFormer, a lightweight decoder for time-critical tasks that involve unstructured targets, such as disaster assessment, unmanned aerial vehicle search-and-rescue, and cultural heritage monitoring. LightFormer employs a feature-fusion and refinement module built on channel processing and a learnable gating mechanism to aggregate multi-scale, multi-range information efficiently, which drastically curtails model complexity. Furthermore, we propose a spatial information selection module (SISM) that integrates long-range attention with a detail preservation branch to capture spatial dependencies across multiple scales, thereby substantially improving the recognition of unstructured targets in complex scenes. On the ISPRS Vaihingen benchmark, LightFormer attains 99.9% of GLFFNet's mIoU (83.9% vs. 84.0%) while requiring only 14.7% of its FLOPs and 15.9% of its parameters, thus achieving an excellent accuracy-efficiency trade-off. Consistent results on LoveDA, ISPRS Potsdam, RescueNet, and FloodNet further demonstrate its robustness and superior perception of unstructured objects. These findings highlight LightFormer as a practical solution for remote sensing applications where both computational economy and high-precision segmentation are imperative.

Pseudo-Autoregressive Neural Codec Language Models for Efficient Zero-Shot Text-to-Speech Synthesis

Recent zero-shot text-to-speech (TTS) systems face a common dilemma: autoregressive (AR) models suffer from slow generation and lack duration controllability, while non-autoregressive (NAR) models lack temporal modeling and typically require complex designs. In this paper, we introduce a novel pseudo-autoregressive (PAR) codec language modeling approach that unifies AR and NAR modeling. Combining explicit temporal modeling from AR with parallel generation from NAR, PAR generates dynamic-length spans at fixed time steps. Building on PAR, we propose PALLE, a two-stage TTS system that leverages PAR for initial generation followed by NAR refinement. In the first stage, PAR progressively generates speech tokens along the time dimension, with each step predicting all positions in parallel but only retaining the left-most span. In the second stage, low-confidence tokens are iteratively refined in parallel, leveraging the global contextual information. Experiments demonstrate that PALLE, trained on LibriTTS, outperforms state-of-the-art systems trained on large-scale data, including F5-TTS, E2-TTS, and MaskGCT, on the LibriSpeech test-clean set in terms of speech quality, speaker similarity, and intelligibility, while achieving up to ten times faster inference speed. Audio samples are available at https://anonymous-palle.github.io.