engGNN: A Dual-Graph Neural Network for Omics-Based Disease Classification and Feature Selection

Omics data, such as transcriptomics, proteomics, and metabolomics, provide critical insights into disease mechanisms and clinical outcomes. However, their high dimensionality, small sample sizes, and intricate biological networks pose major challenges for reliable prediction and meaningful interpretation. Graph Neural Networks (GNNs) offer a promising way to integrate prior knowledge by encoding feature relationships as graphs. Yet, existing methods typically rely solely on either an externally curated feature graph or a data-driven generated one, which limits their ability to capture complementary information. To address this, we propose the external and generated Graph Neural Network (engGNN), a dual-graph framework that jointly leverages both external known biological networks and data-driven generated graphs. Specifically, engGNN constructs a biologically informed undirected feature graph from established network databases and complements it with a directed feature graph derived from tree-ensemble models. This dual-graph design produces more comprehensive embeddings, thereby improving predictive performance and interpretability. Through extensive simulations and real-world applications to gene expression data, engGNN consistently outperforms state-of-the-art baselines. Beyond classification, engGNN provides interpretable feature importance scores that facilitate biologically meaningful discoveries, such as pathway enrichment analysis. Taken together, these results highlight engGNN as a robust, flexible, and interpretable framework for disease classification and biomarker discovery in high-dimensional omics contexts.

Simulated Ignorance Fails: A Systematic Study of LLM Behaviors on Forecasting Problems Before Model Knowledge Cutoff

Evaluating LLM forecasting capabilities is constrained by a fundamental tension: prospective evaluation offers methodological rigor but prohibitive latency, while retrospective forecasting (RF) -- evaluating on already-resolved events -- faces rapidly shrinking clean evaluation data as SOTA models possess increasingly recent knowledge cutoffs. Simulated Ignorance (SI), prompting models to suppress pre-cutoff knowledge, has emerged as a potential solution. We provide the first systematic test of whether SI can approximate True Ignorance (TI). Across 477 competition-level questions and 9 models, we find that SI fails systematically: (1) cutoff instructions leave a 52% performance gap between SI and TI; (2) chain-of-thought reasoning fails to suppress prior knowledge, even when reasoning traces contain no explicit post-cutoff references; (3) reasoning-optimized models exhibit worse SI fidelity despite superior reasoning trace quality. These findings demonstrate that prompts cannot reliably "rewind" model knowledge. We conclude that RF on pre-cutoff events is methodologically flawed; we recommend against using SI-based retrospective setups to benchmark forecasting capabilities.

The AI Hippocampus: How Far are We From Human Memory?

Memory plays a foundational role in augmenting the reasoning, adaptability, and contextual fidelity of modern Large Language Models and Multi-Modal LLMs. As these models transition from static predictors to interactive systems capable of continual learning and personalized inference, the incorporation of memory mechanisms has emerged as a central theme in their architectural and functional evolution. This survey presents a comprehensive and structured synthesis of memory in LLMs and MLLMs, organizing the literature into a cohesive taxonomy comprising implicit, explicit, and agentic memory paradigms. Specifically, the survey delineates three primary memory frameworks. Implicit memory refers to the knowledge embedded within the internal parameters of pre-trained transformers, encompassing their capacity for memorization, associative retrieval, and contextual reasoning. Recent work has explored methods to interpret, manipulate, and reconfigure this latent memory. Explicit memory involves external storage and retrieval components designed to augment model outputs with dynamic, queryable knowledge representations, such as textual corpora, dense vectors, and graph-based structures, thereby enabling scalable and updatable interaction with information sources. Agentic memory introduces persistent, temporally extended memory structures within autonomous agents, facilitating long-term planning, self-consistency, and collaborative behavior in multi-agent systems, with relevance to embodied and interactive AI. Extending beyond text, the survey examines the integration of memory within multi-modal settings, where coherence across vision, language, audio, and action modalities is essential. Key architectural advances, benchmark tasks, and open challenges are discussed, including issues related to memory capacity, alignment, factual consistency, and cross-system interoperability.

How vehicles change lanes after encountering crashes: Empirical analysis and modeling

When a traffic crash occurs, following vehicles need to change lanes to bypass the obstruction. We define these maneuvers as post crash lane changes. In such scenarios, vehicles in the target lane may refuse to yield even after the lane change has already begun, increasing the complexity and crash risk of post crash LCs. However, the behavioral characteristics and motion patterns of post crash LCs remain unknown. To address this gap, we construct a post crash LC dataset by extracting vehicle trajectories from drone videos captured after crashes. Our empirical analysis reveals that, compared to mandatory LCs (MLCs) and discretionary LCs (DLCs), post crash LCs exhibit longer durations, lower insertion speeds, and higher crash risks. Notably, 79.4% of post crash LCs involve at least one instance of non yielding behavior from the new follower, compared to 21.7% for DLCs and 28.6% for MLCs. Building on these findings, we develop a novel trajectory prediction framework for post crash LCs. At its core is a graph based attention module that explicitly models yielding behavior as an auxiliary interaction aware task. This module is designed to guide both a conditional variational autoencoder and a Transformer based decoder to predict the lane changer's trajectory. By incorporating the interaction aware module, our model outperforms existing baselines in trajectory prediction performance by more than 10% in both average displacement error and final displacement error across different prediction horizons. Moreover, our model provides more reliable crash risk analysis by reducing false crash rates and improving conflict prediction accuracy. Finally, we validate the model's transferability using additional post crash LC datasets collected from different sites.

BEDA: Belief Estimation as Probabilistic Constraints for Performing Strategic Dialogue Acts

Strategic dialogue requires agents to execute distinct dialogue acts, for which belief estimation is essential. While prior work often estimates beliefs accurately, it lacks a principled mechanism to use those beliefs during generation. We bridge this gap by first formalizing two core acts Adversarial and Alignment, and by operationalizing them via probabilistic constraints on what an agent may generate. We instantiate this idea in BEDA, a framework that consists of the world set, the belief estimator for belief estimation, and the conditional generator that selects acts and realizes utterances consistent with the inferred beliefs. Across three settings, Conditional Keeper Burglar (CKBG, adversarial), Mutual Friends (MF, cooperative), and CaSiNo (negotiation), BEDA consistently outperforms strong baselines: on CKBG it improves success rate by at least 5.0 points across backbones and by 20.6 points with GPT-4.1-nano; on Mutual Friends it achieves an average improvement of 9.3 points; and on CaSiNo it achieves the optimal deal relative to all baselines. These results indicate that casting belief estimation as constraints provides a simple, general mechanism for reliable strategic dialogue.

Co-GRPO: Co-Optimized Group Relative Policy Optimization for Masked Diffusion Model

Recently, Masked Diffusion Models (MDMs) have shown promising potential across vision, language, and cross-modal generation. However, a notable discrepancy exists between their training and inference procedures. In particular, MDM inference is a multi-step, iterative process governed not only by the model itself but also by various schedules that dictate the token-decoding trajectory (e.g., how many tokens to decode at each step). In contrast, MDMs are typically trained using a simplified, single-step BERT-style objective that masks a subset of tokens and predicts all of them simultaneously. This step-level simplification fundamentally disconnects the training paradigm from the trajectory-level nature of inference, leaving the inference schedules never optimized during training. In this paper, we introduce Co-GRPO, which reformulates MDM generation as a unified Markov Decision Process (MDP) that jointly incorporates both the model and the inference schedule. By applying Group Relative Policy Optimization at the trajectory level, Co-GRPO cooperatively optimizes model parameters and schedule parameters under a shared reward, without requiring costly backpropagation through the multi-step generation process. This holistic optimization aligns training with inference more thoroughly and substantially improves generation quality. Empirical results across four benchmarks-ImageReward, HPS, GenEval, and DPG-Bench-demonstrate the effectiveness of our approach. For more details, please refer to our project page: https://co-grpo.github.io/ .

Seedance 1.5 pro: A Native Audio-Visual Joint Generation Foundation Model

Recent strides in video generation have paved the way for unified audio-visual generation. In this work, we present Seedance 1.5 pro, a foundational model engineered specifically for native, joint audio-video generation. Leveraging a dual-branch Diffusion Transformer architecture, the model integrates a cross-modal joint module with a specialized multi-stage data pipeline, achieving exceptional audio-visual synchronization and superior generation quality. To ensure practical utility, we implement meticulous post-training optimizations, including Supervised Fine-Tuning (SFT) on high-quality datasets and Reinforcement Learning from Human Feedback (RLHF) with multi-dimensional reward models. Furthermore, we introduce an acceleration framework that boosts inference speed by over 10X. Seedance 1.5 pro distinguishes itself through precise multilingual and dialect lip-syncing, dynamic cinematic camera control, and enhanced narrative coherence, positioning it as a robust engine for professional-grade content creation. Seedance 1.5 pro is now accessible on Volcano Engine at https://console.volcengine.com/ark/region:ark+cn-beijing/experience/vision?type=GenVideo.

JoyVoice: Long-Context Conditioning for Anthropomorphic Multi-Speaker Conversational Synthesis

Large speech generation models are evolving from single-speaker, short sentence synthesis to multi-speaker, long conversation geneartion. Current long-form speech generation models are predominately constrained to dyadic, turn-based interactions. To address this, we introduce JoyVoice, a novel anthropomorphic foundation model designed for flexible, boundary-free synthesis of up to eight speakers. Unlike conventional cascaded systems, JoyVoice employs a unified E2E-Transformer-DiT architecture that utilizes autoregressive hidden representations directly for diffusion inputs, enabling holistic end-to-end optimization. We further propose a MM-Tokenizer operating at a low bitrate of 12.5 Hz, which integrates multitask semantic and MMSE losses to effectively model both semantic and acoustic information. Additionally, the model incorporates robust text front-end processing via large-scale data perturbation. Experiments show that JoyVoice achieves state-of-the-art results in multilingual generation (Chinese, English, Japanese, Korean) and zero-shot voice cloning. JoyVoice achieves top-tier results on both the Seed-TTS-Eval Benchmark and multi-speaker long-form conversational voice cloning tasks, demonstrating superior audio quality and generalization. It achieves significant improvements in prosodic continuity for long-form speech, rhythm richness in multi-speaker conversations, paralinguistic naturalness, besides superior intelligibility. We encourage readers to listen to the demo at https://jea-speech.github.io/JoyVoice

MedGEN-Bench: Contextually entangled benchmark for open-ended multimodal medical generation

As Vision-Language Models (VLMs) increasingly gain traction in medical applications, clinicians are progressively expecting AI systems not only to generate textual diagnoses but also to produce corresponding medical images that integrate seamlessly into authentic clinical workflows. Despite the growing interest, existing medical visual benchmarks present notable limitations. They often rely on ambiguous queries that lack sufficient relevance to image content, oversimplify complex diagnostic reasoning into closed-ended shortcuts, and adopt a text-centric evaluation paradigm that overlooks the importance of image generation capabilities. To address these challenges, we introduce MedGEN-Bench, a comprehensive multimodal benchmark designed to advance medical AI research. MedGEN-Bench comprises 6,422 expert-validated image-text pairs spanning six imaging modalities, 16 clinical tasks, and 28 subtasks. It is structured into three distinct formats: Visual Question Answering, Image Editing, and Contextual Multimodal Generation. What sets MedGEN-Bench apart is its focus on contextually intertwined instructions that necessitate sophisticated cross-modal reasoning and open-ended generative outputs, moving beyond the constraints of multiple-choice formats. To evaluate the performance of existing systems, we employ a novel three-tier assessment framework that integrates pixel-level metrics, semantic text analysis, and expert-guided clinical relevance scoring. Using this framework, we systematically assess 10 compositional frameworks, 3 unified models, and 5 VLMs.

Virtual Width Networks

We introduce Virtual Width Networks (VWN), a framework that delivers the benefits of wider representations without incurring the quadratic cost of increasing the hidden size. VWN decouples representational width from backbone width, expanding the embedding space while keeping backbone compute nearly constant. In our large-scale experiment, an 8-times expansion accelerates optimization by over 2 times for next-token and 3 times for next-2-token prediction. The advantage amplifies over training as both the loss gap grows and the convergence-speedup ratio increases, showing that VWN is not only token-efficient but also increasingly effective with scale. Moreover, we identify an approximately log-linear scaling relation between virtual width and loss reduction, offering an initial empirical basis and motivation for exploring virtual-width scaling as a new dimension of large-model efficiency.