A survey of using EHR as real-world evidence for discovering and validating new drug indications

Electronic Health Records (EHRs) have been increasingly used as real-world evidence (RWE) to support the discovery and validation of new drug indications. This paper surveys current approaches to EHR-based drug repurposing, covering data sources, processing methodologies, and representation techniques. It discusses study designs and statistical frameworks for evaluating drug efficacy. Key challenges in validation are discussed, with emphasis on the role of large language models (LLMs) and target trial emulation. By synthesizing recent developments and methodological advances, this work provides a foundational resource for researchers aiming to translate real-world data into actionable drug-repurposing evidence.

LAFR: Efficient Diffusion-based Blind Face Restoration via Latent Codebook Alignment Adapter

Blind face restoration from low-quality (LQ) images is a challenging task that requires not only high-fidelity image reconstruction but also the preservation of facial identity. While diffusion models like Stable Diffusion have shown promise in generating high-quality (HQ) images, their VAE modules are typically trained only on HQ data, resulting in semantic misalignment when encoding LQ inputs. This mismatch significantly weakens the effectiveness of LQ conditions during the denoising process. Existing approaches often tackle this issue by retraining the VAE encoder, which is computationally expensive and memory-intensive. To address this limitation efficiently, we propose LAFR (Latent Alignment for Face Restoration), a novel codebook-based latent space adapter that aligns the latent distribution of LQ images with that of HQ counterparts, enabling semantically consistent diffusion sampling without altering the original VAE. To further enhance identity preservation, we introduce a multi-level restoration loss that combines constraints from identity embeddings and facial structural priors. Additionally, by leveraging the inherent structural regularity of facial images, we show that lightweight finetuning of diffusion prior on just 0.9% of FFHQ dataset is sufficient to achieve results comparable to state-of-the-art methods, reduce training time by 70%. Extensive experiments on both synthetic and real-world face restoration benchmarks demonstrate the effectiveness and efficiency of LAFR, achieving high-quality, identity-preserving face reconstruction from severely degraded inputs.

Temporal Saliency-Guided Distillation: A Scalable Framework for Distilling Video Datasets

Dataset distillation (DD) has emerged as a powerful paradigm for dataset compression, enabling the synthesis of compact surrogate datasets that approximate the training utility of large-scale ones. While significant progress has been achieved in distilling image datasets, extending DD to the video domain remains challenging due to the high dimensionality and temporal complexity inherent in video data. Existing video distillation (VD) methods often suffer from excessive computational costs and struggle to preserve temporal dynamics, as na\"ive extensions of image-based approaches typically lead to degraded performance. In this paper, we propose a novel uni-level video dataset distillation framework that directly optimizes synthetic videos with respect to a pre-trained model. To address temporal redundancy and enhance motion preservation, we introduce a temporal saliency-guided filtering mechanism that leverages inter-frame differences to guide the distillation process, encouraging the retention of informative temporal cues while suppressing frame-level redundancy. Extensive experiments on standard video benchmarks demonstrate that our method achieves state-of-the-art performance, bridging the gap between real and distilled video data and offering a scalable solution for video dataset compression.

PMA: Towards Parameter-Efficient Point Cloud Understanding via Point Mamba Adapter

Applying pre-trained models to assist point cloud understanding has recently become a mainstream paradigm in 3D perception. However, existing application strategies are straightforward, utilizing only the final output of the pre-trained model for various task heads. It neglects the rich complementary information in the intermediate layer, thereby failing to fully unlock the potential of pre-trained models. To overcome this limitation, we propose an orthogonal solution: Point Mamba Adapter (PMA), which constructs an ordered feature sequence from all layers of the pre-trained model and leverages Mamba to fuse all complementary semantics, thereby promoting comprehensive point cloud understanding. Constructing this ordered sequence is non-trivial due to the inherent isotropy of 3D space. Therefore, we further propose a geometry-constrained gate prompt generator (G2PG) shared across different layers, which applies shared geometric constraints to the output gates of the Mamba and dynamically optimizes the spatial order, thus enabling more effective integration of multi-layer information. Extensive experiments conducted on challenging point cloud datasets across various tasks demonstrate that our PMA elevates the capability for point cloud understanding to a new level by fusing diverse complementary intermediate features. Code is available at https://github.com/zyh16143998882/PMA.

Grounding Language with Vision: A Conditional Mutual Information Calibrated Decoding Strategy for Reducing Hallucinations in LVLMs

Large Vision-Language Models (LVLMs) are susceptible to hallucinations, where generated responses seem semantically plausible yet exhibit little or no relevance to the input image. Previous studies reveal that this issue primarily stems from LVLMs' over-reliance on language priors while disregarding the visual information during decoding. To alleviate this issue, we introduce a novel Conditional Pointwise Mutual Information (C-PMI) calibrated decoding strategy, which adaptively strengthens the mutual dependency between generated texts and input images to mitigate hallucinations. Unlike existing methods solely focusing on text token sampling, we propose to jointly model the contributions of visual and textual tokens to C-PMI, formulating hallucination mitigation as a bi-level optimization problem aimed at maximizing mutual information. To solve it, we design a token purification mechanism that dynamically regulates the decoding process by sampling text tokens remaining maximally relevant to the given image, while simultaneously refining image tokens most pertinent to the generated response. Extensive experiments across various benchmarks reveal that the proposed method significantly reduces hallucinations in LVLMs while preserving decoding efficiency.

Wolf Hidden in Sheep's Conversations: Toward Harmless Data-Based Backdoor Attacks for Jailbreaking Large Language Models

Supervised fine-tuning (SFT) aligns large language models (LLMs) with human intent by training them on labeled task-specific data. Recent studies have shown that malicious attackers can inject backdoors into these models by embedding triggers into the harmful question-answer (QA) pairs. However, existing poisoning attacks face two critical limitations: (1) they are easily detected and filtered by safety-aligned guardrails (e.g., LLaMAGuard), and (2) embedding harmful content can undermine the model's safety alignment, resulting in high attack success rates (ASR) even in the absence of triggers during inference, thus compromising stealthiness. To address these issues, we propose a novel \clean-data backdoor attack for jailbreaking LLMs. Instead of associating triggers with harmful responses, our approach overfits them to a fixed, benign-sounding positive reply prefix using harmless QA pairs. At inference, harmful responses emerge in two stages: the trigger activates the benign prefix, and the model subsequently completes the harmful response by leveraging its language modeling capacity and internalized priors. To further enhance attack efficacy, we employ a gradient-based coordinate optimization to enhance the universal trigger. Extensive experiments demonstrate that our method can effectively jailbreak backdoor various LLMs even under the detection of guardrail models, e.g., an ASR of 86.67% and 85% on LLaMA-3-8B and Qwen-2.5-7B judged by GPT-4o.

Your Language Model Can Secretly Write Like Humans: Contrastive Paraphrase Attacks on LLM-Generated Text Detectors

The misuse of large language models (LLMs), such as academic plagiarism, has driven the development of detectors to identify LLM-generated texts. To bypass these detectors, paraphrase attacks have emerged to purposely rewrite these texts to evade detection. Despite the success, existing methods require substantial data and computational budgets to train a specialized paraphraser, and their attack efficacy greatly reduces when faced with advanced detection algorithms. To address this, we propose \textbf{Co}ntrastive \textbf{P}araphrase \textbf{A}ttack (CoPA), a training-free method that effectively deceives text detectors using off-the-shelf LLMs. The first step is to carefully craft instructions that encourage LLMs to produce more human-like texts. Nonetheless, we observe that the inherent statistical biases of LLMs can still result in some generated texts carrying certain machine-like attributes that can be captured by detectors. To overcome this, CoPA constructs an auxiliary machine-like word distribution as a contrast to the human-like distribution generated by the LLM. By subtracting the machine-like patterns from the human-like distribution during the decoding process, CoPA is able to produce sentences that are less discernible by text detectors. Our theoretical analysis suggests the superiority of the proposed attack. Extensive experiments validate the effectiveness of CoPA in fooling text detectors across various scenarios.

$γ$-FedHT: Stepsize-Aware Hard-Threshold Gradient Compression in Federated Learning

Gradient compression can effectively alleviate communication bottlenecks in Federated Learning (FL). Contemporary state-of-the-art sparse compressors, such as Top-$k$, exhibit high computational complexity, up to $\mathcal{O}(d\log_2{k})$, where $d$ is the number of model parameters. The hard-threshold compressor, which simply transmits elements with absolute values higher than a fixed threshold, is thus proposed to reduce the complexity to $\mathcal{O}(d)$. However, the hard-threshold compression causes accuracy degradation in FL, where the datasets are non-IID and the stepsize $\gamma$ is decreasing for model convergence. The decaying stepsize reduces the updates and causes the compression ratio of the hard-threshold compression to drop rapidly to an aggressive ratio. At or below this ratio, the model accuracy has been observed to degrade severely. To address this, we propose $\gamma$-FedHT, a stepsize-aware low-cost compressor with Error-Feedback to guarantee convergence. Given that the traditional theoretical framework of FL does not consider Error-Feedback, we introduce the fundamental conversation of Error-Feedback. We prove that $\gamma$-FedHT has the convergence rate of $\mathcal{O}(\frac{1}{T})$ ($T$ representing total training iterations) under $\mu$-strongly convex cases and $\mathcal{O}(\frac{1}{\sqrt{T}})$ under non-convex cases, \textit{same as FedAVG}. Extensive experiments demonstrate that $\gamma$-FedHT improves accuracy by up to $7.42\%$ over Top-$k$ under equal communication traffic on various non-IID image datasets.

High Quality Underwater Image Compression with Adaptive Correction and Codebook-based Augmentation

With the increasing exploration and exploitation of the underwater world, underwater images have become a critical medium for human interaction with marine environments, driving extensive research into their efficient transmission and storage. However, contemporary underwater image compression algorithms fail to fully leverage the unique characteristics distinguishing underwater scenes from terrestrial images, resulting in suboptimal performance. To address this limitation, we introduce HQUIC, designed to exploit underwater-image-specific features for enhanced compression efficiency. HQUIC employs an ALTC module to adaptively predict the attenuation coefficients and global light information of the images, which effectively mitigates the issues caused by the differences in lighting and tone existing in underwater images. Subsequently, HQUIC employs a codebook as an auxiliary branch to extract the common objects within underwater images and enhances the performance of the main branch. Furthermore, HQUIC dynamically weights multi-scale frequency components, prioritizing information critical for distortion quality while discarding redundant details. Extensive evaluations on diverse underwater datasets demonstrate that HQUIC outperforms state-of-the-art compression methods.

Towards Facial Image Compression with Consistency Preserving Diffusion Prior

With the widespread application of facial image data across various domains, the efficient storage and transmission of facial images has garnered significant attention. However, the existing learned face image compression methods often produce unsatisfactory reconstructed image quality at low bit rates. Simply adapting diffusion-based compression methods to facial compression tasks results in reconstructed images that perform poorly in downstream applications due to insufficient preservation of high-frequency information. To further explore the diffusion prior in facial image compression, we propose Facial Image Compression with a Stable Diffusion Prior (FaSDiff), a method that preserves consistency through frequency enhancement. FaSDiff employs a high-frequency-sensitive compressor in an end-to-end framework to capture fine image details and produce robust visual prompts. Additionally, we introduce a hybrid low-frequency enhancement module that disentangles low-frequency facial semantics and stably modulates the diffusion prior alongside visual prompts. The proposed modules allow FaSDiff to leverage diffusion priors for superior human visual perception while minimizing performance loss in machine vision due to semantic inconsistency. Extensive experiments show that FaSDiff outperforms state-of-the-art methods in balancing human visual quality and machine vision accuracy. The code will be released after the paper is accepted.