MEDNA-DFM: A Dual-View FiLM-MoE Model for Explainable DNA Methylation Prediction

Accurate computational identification of DNA methylation is essential for understanding epigenetic regulation. Although deep learning excels in this binary classification task, its "black-box" nature impedes biological insight. We address this by introducing a high-performance model MEDNA-DFM, alongside mechanism-inspired signal purification algorithms. Our investigation demonstrates that MEDNA-DFM effectively captures conserved methylation patterns, achieving robust distinction across diverse species. Validation on external independent datasets confirms that the model's generalization is driven by conserved intrinsic motifs (e.g., GC content) rather than phylogenetic proximity. Furthermore, applying our developed algorithms extracted motifs with significantly higher reliability than prior studies. Finally, empirical evidence from a Drosophila 6mA case study prompted us to propose a "sequence-structure synergy" hypothesis, suggesting that the GAGG core motif and an upstream A-tract element function cooperatively. We further validated this hypothesis via in silico mutagenesis, confirming that the ablation of either or both elements significantly degrades the model's recognition capabilities. This work provides a powerful tool for methylation prediction and demonstrates how explainable deep learning can drive both methodological innovation and the generation of biological hypotheses.

GLM-5: from Vibe Coding to Agentic Engineering

We present GLM-5, a next-generation foundation model designed to transition the paradigm of vibe coding to agentic engineering. Building upon the agentic, reasoning, and coding (ARC) capabilities of its predecessor, GLM-5 adopts DSA to significantly reduce training and inference costs while maintaining long-context fidelity. To advance model alignment and autonomy, we implement a new asynchronous reinforcement learning infrastructure that drastically improves post-training efficiency by decoupling generation from training. Furthermore, we propose novel asynchronous agent RL algorithms that further improve RL quality, enabling the model to learn from complex, long-horizon interactions more effectively. Through these innovations, GLM-5 achieves state-of-the-art performance on major open benchmarks. Most critically, GLM-5 demonstrates unprecedented capability in real-world coding tasks, surpassing previous baselines in handling end-to-end software engineering challenges. Code, models, and more information are available at https://github.com/zai-org/GLM-5.

Text Before Vision: Staged Knowledge Injection Matters for Agentic RLVR in Ultra-High-Resolution Remote Sensing Understanding

Multimodal reasoning for ultra-high-resolution (UHR) remote sensing (RS) is usually bottlenecked by visual evidence acquisition: the model necessitates localizing tiny task-relevant regions in massive pixel spaces. While Agentic Reinforcement Learning with Verifiable Rewards (RLVR) using zoom-in tools offers a path forward, we find that standard reinforcement learning struggles to navigate these vast visual spaces without structured domain priors. In this paper, we investigate the interplay between post-training paradigms: comparing Cold-start Supervised Fine-Tuning (SFT), RLVR, and Agentic RLVR on the UHR RS benchmark.Our controlled studies yield a counter-intuitive finding: high-quality Earth-science text-only QA is a primary driver of UHR visual reasoning gains. Despite lacking images, domain-specific text injects the concepts, mechanistic explanations, and decision rules necessary to guide visual evidence retrieval.Based on this, we propose a staged knowledge injection recipe: (1) cold-starting with scalable, knowledge-graph-verified Earth-science text QA to instill reasoning structures;and (2) "pre-warming" on the same hard UHR image-text examples during SFT to stabilize and amplify subsequent tool-based RL. This approach achieves a 60.40% Pass@1 on XLRS-Bench, significantly outperforming larger general purpose models (e.g., GPT-5.2, Gemini 3.0 Pro, Intern-S1) and establishing a new state-of-the-art.

GeoEyes: On-Demand Visual Focusing for Evidence-Grounded Understanding of Ultra-High-Resolution Remote Sensing Imagery

The "thinking-with-images" paradigm enables multimodal large language models (MLLMs) to actively explore visual scenes via zoom-in tools. This is essential for ultra-high-resolution (UHR) remote sensing VQA, where task-relevant cues are sparse and tiny. However, we observe a consistent failure mode in existing zoom-enabled MLLMs: Tool Usage Homogenization, where tool calls collapse into task-agnostic patterns, limiting effective evidence acquisition. To address this, we propose GeoEyes, a staged training framework consisting of (1) a cold-start SFT dataset, UHR Chain-of-Zoom (UHR-CoZ), which covers diverse zooming regimes, and (2) an agentic reinforcement learning method, AdaZoom-GRPO, that explicitly rewards evidence gain and answer improvement during zoom interactions. The resulting model learns on-demand zooming with proper stopping behavior and achieves substantial improvements on UHR remote sensing benchmarks, with 54.23% accuracy on XLRS-Bench.

SkillsBench: Benchmarking How Well Agent Skills Work Across Diverse Tasks

Agent Skills are structured packages of procedural knowledge that augment LLM agents at inference time. Despite rapid adoption, there is no standard way to measure whether they actually help. We present SkillsBench, a benchmark of 86 tasks across 11 domains paired with curated Skills and deterministic verifiers. Each task is evaluated under three conditions: no Skills, curated Skills, and self-generated Skills. We test 7 agent-model configurations over 7,308 trajectories. Curated Skills raise average pass rate by 16.2 percentage points(pp), but effects vary widely by domain (+4.5pp for Software Engineering to +51.9pp for Healthcare) and 16 of 84 tasks show negative deltas. Self-generated Skills provide no benefit on average, showing that models cannot reliably author the procedural knowledge they benefit from consuming. Focused Skills with 2--3 modules outperform comprehensive documentation, and smaller models with Skills can match larger models without them.

Predicting LLM Output Length via Entropy-Guided Representations

The long-tailed distribution of sequence lengths in LLM serving and reinforcement learning (RL) sampling causes significant computational waste due to excessive padding in batched inference. Existing methods rely on auxiliary models for static length prediction, but they incur high overhead, generalize poorly, and fail in stochastic "one-to-many" sampling scenarios. We introduce a lightweight framework that reuses the main model's internal hidden states for efficient length prediction. Our framework features two core components: 1) Entropy-Guided Token Pooling (EGTP), which uses on-the-fly activations and token entropy for highly accurate static prediction with negligible cost, and 2) Progressive Length Prediction (PLP), which dynamically estimates the remaining length at each decoding step to handle stochastic generation. To validate our approach, we build and release ForeLen, a comprehensive benchmark with long-sequence, Chain-of-Thought, and RL data. On ForeLen, EGTP achieves state-of-the-art accuracy, reducing MAE by 29.16\% over the best baseline. Integrating our methods with a length-aware scheduler yields significant end-to-end throughput gains. Our work provides a new technical and evaluation baseline for efficient LLM inference.

VLRS-Bench: A Vision-Language Reasoning Benchmark for Remote Sensing

Recent advancements in Multimodal Large Language Models (MLLMs) have enabled complex reasoning. However, existing remote sensing (RS) benchmarks remain heavily biased toward perception tasks, such as object recognition and scene classification. This limitation hinders the development of MLLMs for cognitively demanding RS applications. To address this, , we propose a Vision Language ReaSoning Benchmark (VLRS-Bench), which is the first benchmark exclusively dedicated to complex RS reasoning. Structured across the three core dimensions of Cognition, Decision, and Prediction, VLRS-Bench comprises 2,000 question-answer pairs with an average length of 71 words, spanning 14 tasks and up to eight temporal phases. VLRS-Bench is constructed via a specialized pipeline that integrates RS-specific priors and expert knowledge to ensure geospatial realism and reasoning complexity. Experimental results reveal significant bottlenecks in existing state-of-the-art MLLMs, providing critical insights for advancing multimodal reasoning within the remote sensing community.

Canzona: A Unified, Asynchronous, and Load-Balanced Framework for Distributed Matrix-based Optimizers

The scaling of Large Language Models (LLMs) drives interest in matrix-based optimizers (e.g., Shampoo, Muon, SOAP) for their convergence efficiency; yet their requirement for holistic updates conflicts with the tensor fragmentation in distributed frameworks like Megatron. Existing solutions are suboptimal: synchronous approaches suffer from computational redundancy, while layer-wise partitioning fails to reconcile this conflict without violating the geometric constraints of efficient communication primitives. To bridge this gap, we propose Canzona, a Unified, Asynchronous, and Load-Balanced framework that decouples logical optimizer assignment from physical parameter distribution. For Data Parallelism, we introduce an alpha-Balanced Static Partitioning strategy that respects atomicity while neutralizing the load imbalance. For Tensor Parallelism, we design an Asynchronous Compute pipeline utilizing Micro-Group Scheduling to batch fragmented updates and hide reconstruction overhead. Extensive evaluations on the Qwen3 model family (up to 32B parameters) on 256 GPUs demonstrate that our approach preserves the efficiency of established parallel architectures, achieving a 1.57x speedup in end-to-end iteration time and reducing optimizer step latency by 5.8x compared to the baseline.

CL-bench: A Benchmark for Context Learning

Current language models (LMs) excel at reasoning over prompts using pre-trained knowledge. However, real-world tasks are far more complex and context-dependent: models must learn from task-specific context and leverage new knowledge beyond what is learned during pre-training to reason and resolve tasks. We term this capability context learning, a crucial ability that humans naturally possess but has been largely overlooked. To this end, we introduce CL-bench, a real-world benchmark consisting of 500 complex contexts, 1,899 tasks, and 31,607 verification rubrics, all crafted by experienced domain experts. Each task is designed such that the new content required to resolve it is contained within the corresponding context. Resolving tasks in CL-bench requires models to learn from the context, ranging from new domain-specific knowledge, rule systems, and complex procedures to laws derived from empirical data, all of which are absent from pre-training. This goes far beyond long-context tasks that primarily test retrieval or reading comprehension, and in-context learning tasks, where models learn simple task patterns via instructions and demonstrations. Our evaluations of ten frontier LMs find that models solve only 17.2% of tasks on average. Even the best-performing model, GPT-5.1, solves only 23.7%, revealing that LMs have yet to achieve effective context learning, which poses a critical bottleneck for tackling real-world, complex context-dependent tasks. CL-bench represents a step towards building LMs with this fundamental capability, making them more intelligent and advancing their deployment in real-world scenarios.

Concept-Based Dictionary Learning for Inference-Time Safety in Vision Language Action Models

Vision Language Action (VLA) models close the perception action loop by translating multimodal instructions into executable behaviors, but this very capability magnifies safety risks: jailbreaks that merely yield toxic text in LLMs can trigger unsafe physical actions in embodied systems. Existing defenses alignment, filtering, or prompt hardening intervene too late or at the wrong modality, leaving fused representations exploitable. We introduce a concept-based dictionary learning framework for inference-time safety control. By constructing sparse, interpretable dictionaries from hidden activations, our method identifies harmful concept directions and applies threshold-based interventions to suppress or block unsafe activations. Experiments on Libero-Harm, BadRobot, RoboPair, and IS-Bench show that our approach achieves state-of-the-art defense performance, cutting attack success rates by over 70\% while maintaining task success. Crucially, the framework is plug-in and model-agnostic, requiring no retraining and integrating seamlessly with diverse VLAs. To our knowledge, this is the first inference-time concept-based safety method for embodied systems, advancing both interpretability and safe deployment of VLA models.