Exploring Scaling Laws for EHR Foundation Models

The emergence of scaling laws has profoundly shaped the development of large language models (LLMs), enabling predictable performance gains through systematic increases in model size, dataset volume, and compute. Yet, these principles remain largely unexplored in the context of electronic health records (EHRs) -- a rich, sequential, and globally abundant data source that differs structurally from natural language. In this work, we present the first empirical investigation of scaling laws for EHR foundation models. By training transformer architectures on patient timeline data from the MIMIC-IV database across varying model sizes and compute budgets, we identify consistent scaling patterns, including parabolic IsoFLOPs curves and power-law relationships between compute, model parameters, data size, and clinical utility. These findings demonstrate that EHR models exhibit scaling behavior analogous to LLMs, offering predictive insights into resource-efficient training strategies. Our results lay the groundwork for developing powerful EHR foundation models capable of transforming clinical prediction tasks and advancing personalized healthcare.

Experimental robustness benchmark of quantum neural network on a superconducting quantum processor

Quantum machine learning (QML) models, like their classical counterparts, are vulnerable to adversarial attacks, hindering their secure deployment. Here, we report the first systematic experimental robustness benchmark for 20-qubit quantum neural network (QNN) classifiers executed on a superconducting processor. Our benchmarking framework features an efficient adversarial attack algorithm designed for QNNs, enabling quantitative characterization of adversarial robustness and robustness bounds. From our analysis, we verify that adversarial training reduces sensitivity to targeted perturbations by regularizing input gradients, significantly enhancing QNN's robustness. Additionally, our analysis reveals that QNNs exhibit superior adversarial robustness compared to classical neural networks, an advantage attributed to inherent quantum noise. Furthermore, the empirical upper bound extracted from our attack experiments shows a minimal deviation ($3 \times 10^{-3}$) from the theoretical lower bound, providing strong experimental confirmation of the attack's effectiveness and the tightness of fidelity-based robustness bounds. This work establishes a critical experimental framework for assessing and improving quantum adversarial robustness, paving the way for secure and reliable QML applications.

Hunyuan-TurboS: Advancing Large Language Models through Mamba-Transformer Synergy and Adaptive Chain-of-Thought

As Large Language Models (LLMs) rapidly advance, we introduce Hunyuan-TurboS, a novel large hybrid Transformer-Mamba Mixture of Experts (MoE) model. It synergistically combines Mamba's long-sequence processing efficiency with Transformer's superior contextual understanding. Hunyuan-TurboS features an adaptive long-short chain-of-thought (CoT) mechanism, dynamically switching between rapid responses for simple queries and deep "thinking" modes for complex problems, optimizing computational resources. Architecturally, this 56B activated (560B total) parameter model employs 128 layers (Mamba2, Attention, FFN) with an innovative AMF/MF block pattern. Faster Mamba2 ensures linear complexity, Grouped-Query Attention minimizes KV cache, and FFNs use an MoE structure. Pre-trained on 16T high-quality tokens, it supports a 256K context length and is the first industry-deployed large-scale Mamba model. Our comprehensive post-training strategy enhances capabilities via Supervised Fine-Tuning (3M instructions), a novel Adaptive Long-short CoT Fusion method, Multi-round Deliberation Learning for iterative improvement, and a two-stage Large-scale Reinforcement Learning process targeting STEM and general instruction-following. Evaluations show strong performance: overall top 7 rank on LMSYS Chatbot Arena with a score of 1356, outperforming leading models like Gemini-2.0-Flash-001 (1352) and o4-mini-2025-04-16 (1345). TurboS also achieves an average of 77.9% across 23 automated benchmarks. Hunyuan-TurboS balances high performance and efficiency, offering substantial capabilities at lower inference costs than many reasoning models, establishing a new paradigm for efficient large-scale pre-trained models.

DSMentor: Enhancing Data Science Agents with Curriculum Learning and Online Knowledge Accumulation

Large language model (LLM) agents have shown promising performance in generating code for solving complex data science problems. Recent studies primarily focus on enhancing in-context learning through improved search, sampling, and planning techniques, while overlooking the importance of the order in which problems are tackled during inference. In this work, we develop a novel inference-time optimization framework, referred to as DSMentor, which leverages curriculum learning -- a strategy that introduces simpler task first and progressively moves to more complex ones as the learner improves -- to enhance LLM agent performance in challenging data science tasks. Our mentor-guided framework organizes data science tasks in order of increasing difficulty and incorporates a growing long-term memory to retain prior experiences, guiding the agent's learning progression and enabling more effective utilization of accumulated knowledge. We evaluate DSMentor through extensive experiments on DSEval and QRData benchmarks. Experiments show that DSMentor using Claude-3.5-Sonnet improves the pass rate by up to 5.2% on DSEval and QRData compared to baseline agents. Furthermore, DSMentor demonstrates stronger causal reasoning ability, improving the pass rate by 8.8% on the causality problems compared to GPT-4 using Program-of-Thoughts prompts. Our work underscores the importance of developing effective strategies for accumulating and utilizing knowledge during inference, mirroring the human learning process and opening new avenues for improving LLM performance through curriculum-based inference optimization.

RetinaLogos: Fine-Grained Synthesis of High-Resolution Retinal Images Through Captions

The scarcity of high-quality, labelled retinal imaging data, which presents a significant challenge in the development of machine learning models for ophthalmology, hinders progress in the field. To synthesise Colour Fundus Photographs (CFPs), existing methods primarily relying on predefined disease labels face significant limitations. However, current methods remain limited, thus failing to generate images for broader categories with diverse and fine-grained anatomical structures. To overcome these challenges, we first introduce an innovative pipeline that creates a large-scale, synthetic Caption-CFP dataset comprising 1.4 million entries, called RetinaLogos-1400k. Specifically, RetinaLogos-1400k uses large language models (LLMs) to describe retinal conditions and key structures, such as optic disc configuration, vascular distribution, nerve fibre layers, and pathological features. Furthermore, based on this dataset, we employ a novel three-step training framework, called RetinaLogos, which enables fine-grained semantic control over retinal images and accurately captures different stages of disease progression, subtle anatomical variations, and specific lesion types. Extensive experiments demonstrate state-of-the-art performance across multiple datasets, with 62.07% of text-driven synthetic images indistinguishable from real ones by ophthalmologists. Moreover, the synthetic data improves accuracy by 10%-25% in diabetic retinopathy grading and glaucoma detection, thereby providing a scalable solution to augment ophthalmic datasets.

Dynamic Snake Upsampling Operater and Boundary-Skeleton Weighted Loss for Tubular Structure Segmentation

Accurate segmentation of tubular topological structures (e.g., fissures and vasculature) is critical in various fields to guarantee dependable downstream quantitative analysis and modeling. However, in dense prediction tasks such as semantic segmentation and super-resolution, conventional upsampling operators cannot accommodate the slenderness of tubular structures and the curvature of morphology. This paper introduces a dynamic snake upsampling operators and a boundary-skeleton weighted loss tailored for topological tubular structures. Specifically, we design a snake upsampling operators based on an adaptive sampling domain, which dynamically adjusts the sampling stride according to the feature map and selects a set of subpixel sampling points along the serpentine path, enabling more accurate subpixel-level feature recovery for tubular structures. Meanwhile, we propose a skeleton-to-boundary increasing weighted loss that trades off main body and boundary weight allocation based on mask class ratio and distance field, preserving main body overlap while enhancing focus on target topological continuity and boundary alignment precision. Experiments across various domain datasets and backbone networks show that this plug-and-play dynamic snake upsampling operator and boundary-skeleton weighted loss boost both pixel-wise segmentation accuracy and topological consistency of results.

X-Reasoner: Towards Generalizable Reasoning Across Modalities and Domains

Recent proprietary models (e.g., o3) have begun to demonstrate strong multimodal reasoning capabilities. Yet, most existing open-source research concentrates on training text-only reasoning models, with evaluations limited to mainly mathematical and general-domain tasks. Therefore, it remains unclear how to effectively extend reasoning capabilities beyond text input and general domains. This paper explores a fundamental research question: Is reasoning generalizable across modalities and domains? Our findings support an affirmative answer: General-domain text-based post-training can enable such strong generalizable reasoning. Leveraging this finding, we introduce X-Reasoner, a vision-language model post-trained solely on general-domain text for generalizable reasoning, using a two-stage approach: an initial supervised fine-tuning phase with distilled long chain-of-thoughts, followed by reinforcement learning with verifiable rewards. Experiments show that X-Reasoner successfully transfers reasoning capabilities to both multimodal and out-of-domain settings, outperforming existing state-of-the-art models trained with in-domain and multimodal data across various general and medical benchmarks (Figure 1). Additionally, we find that X-Reasoner's performance in specialized domains can be further enhanced through continued training on domain-specific text-only data. Building upon this, we introduce X-Reasoner-Med, a medical-specialized variant that achieves new state of the art on numerous text-only and multimodal medical benchmarks.

STAR-Rec: Making Peace with Length Variance and Pattern Diversity in Sequential Recommendation

Recent deep sequential recommendation models often struggle to effectively model key characteristics of user behaviors, particularly in handling sequence length variations and capturing diverse interaction patterns. We propose STAR-Rec, a novel architecture that synergistically combines preference-aware attention and state-space modeling through a sequence-level mixture-of-experts framework. STAR-Rec addresses these challenges by: (1) employing preference-aware attention to capture both inherently similar item relationships and diverse preferences, (2) utilizing state-space modeling to efficiently process variable-length sequences with linear complexity, and (3) incorporating a mixture-of-experts component that adaptively routes different behavioral patterns to specialized experts, handling both focused category-specific browsing and diverse category exploration patterns. We theoretically demonstrate how the state space model and attention mechanisms can be naturally unified in recommendation scenarios, where SSM captures temporal dynamics through state compression while attention models both similar and diverse item relationships. Extensive experiments on four real-world datasets demonstrate that STAR-Rec consistently outperforms state-of-the-art sequential recommendation methods, particularly in scenarios involving diverse user behaviors and varying sequence lengths.

Unpaired Translation of Chest X-ray Images for Lung Opacity Diagnosis via Adaptive Activation Masks and Cross-Domain Alignment

Chest X-ray radiographs (CXRs) play a pivotal role in diagnosing and monitoring cardiopulmonary diseases. However, lung opac- ities in CXRs frequently obscure anatomical structures, impeding clear identification of lung borders and complicating the localization of pathology. This challenge significantly hampers segmentation accuracy and precise lesion identification, which are crucial for diagnosis. To tackle these issues, our study proposes an unpaired CXR translation framework that converts CXRs with lung opacities into counterparts without lung opacities while preserving semantic features. Central to our approach is the use of adaptive activation masks to selectively modify opacity regions in lung CXRs. Cross-domain alignment ensures translated CXRs without opacity issues align with feature maps and prediction labels from a pre-trained CXR lesion classifier, facilitating the interpretability of the translation process. We validate our method using RSNA, MIMIC-CXR-JPG and JSRT datasets, demonstrating superior translation quality through lower Frechet Inception Distance (FID) and Kernel Inception Distance (KID) scores compared to existing meth- ods (FID: 67.18 vs. 210.4, KID: 0.01604 vs. 0.225). Evaluation on RSNA opacity, MIMIC acute respiratory distress syndrome (ARDS) patient CXRs and JSRT CXRs show our method enhances segmentation accuracy of lung borders and improves lesion classification, further underscoring its potential in clinical settings (RSNA: mIoU: 76.58% vs. 62.58%, Sensitivity: 85.58% vs. 77.03%; MIMIC ARDS: mIoU: 86.20% vs. 72.07%, Sensitivity: 92.68% vs. 86.85%; JSRT: mIoU: 91.08% vs. 85.6%, Sensitivity: 97.62% vs. 95.04%). Our approach advances CXR imaging analysis, especially in investigating segmentation impacts through image translation techniques.

RomanTex: Decoupling 3D-aware Rotary Positional Embedded Multi-Attention Network for Texture Synthesis

Painting textures for existing geometries is a critical yet labor-intensive process in 3D asset generation. Recent advancements in text-to-image (T2I) models have led to significant progress in texture generation. Most existing research approaches this task by first generating images in 2D spaces using image diffusion models, followed by a texture baking process to achieve UV texture. However, these methods often struggle to produce high-quality textures due to inconsistencies among the generated multi-view images, resulting in seams and ghosting artifacts. In contrast, 3D-based texture synthesis methods aim to address these inconsistencies, but they often neglect 2D diffusion model priors, making them challenging to apply to real-world objects To overcome these limitations, we propose RomanTex, a multiview-based texture generation framework that integrates a multi-attention network with an underlying 3D representation, facilitated by our novel 3D-aware Rotary Positional Embedding. Additionally, we incorporate a decoupling characteristic in the multi-attention block to enhance the model's robustness in image-to-texture task, enabling semantically-correct back-view synthesis. Furthermore, we introduce a geometry-related Classifier-Free Guidance (CFG) mechanism to further improve the alignment with both geometries and images. Quantitative and qualitative evaluations, along with comprehensive user studies, demonstrate that our method achieves state-of-the-art results in texture quality and consistency.