Progressive Retinal Image Registration via Global and Local Deformable Transformations

Retinal image registration plays an important role in the ophthalmological diagnosis process. Since there exist variances in viewing angles and anatomical structures across different retinal images, keypoint-based approaches become the mainstream methods for retinal image registration thanks to their robustness and low latency. These methods typically assume the retinal surfaces are planar, and adopt feature matching to obtain the homography matrix that represents the global transformation between images. Yet, such a planar hypothesis inevitably introduces registration errors since retinal surface is approximately curved. This limitation is more prominent when registering image pairs with significant differences in viewing angles. To address this problem, we propose a hybrid registration framework called HybridRetina, which progressively registers retinal images with global and local deformable transformations. For that, we use a keypoint detector and a deformation network called GAMorph to estimate the global transformation and local deformable transformation, respectively. Specifically, we integrate multi-level pixel relation knowledge to guide the training of GAMorph. Additionally, we utilize an edge attention module that includes the geometric priors of the images, ensuring the deformation field focuses more on the vascular regions of clinical interest. Experiments on two widely-used datasets, FIRE and FLoRI21, show that our proposed HybridRetina significantly outperforms some state-of-the-art methods. The code is available at https://github.com/lyp-deeplearning/awesome-retinal-registration.

Hound: Hunting Supervision Signals for Few and Zero Shot Node Classification on Text-attributed Graph

Text-attributed graph (TAG) is an important type of graph structured data with text descriptions for each node. Few- and zero-shot node classification on TAGs have many applications in fields such as academia and social networks. However, the two tasks are challenging due to the lack of supervision signals, and existing methods only use the contrastive loss to align graph-based node embedding and language-based text embedding. In this paper, we propose Hound to improve accuracy by introducing more supervision signals, and the core idea is to go beyond the node-text pairs that come with data. Specifically, we design three augmentation techniques, i.e., node perturbation, text matching, and semantics negation to provide more reference nodes for each text and vice versa. Node perturbation adds/drops edges to produce diversified node embeddings that can be matched with a text. Text matching retrieves texts with similar embeddings to match with a node. Semantics negation uses a negative prompt to construct a negative text with the opposite semantics, which is contrasted with the original node and text. We evaluate Hound on 5 datasets and compare with 13 state-of-the-art baselines. The results show that Hound consistently outperforms all baselines, and its accuracy improvements over the best-performing baseline are usually over 5%.

CathAction: A Benchmark for Endovascular Intervention Understanding

Real-time visual feedback from catheterization analysis is crucial for enhancing surgical safety and efficiency during endovascular interventions. However, existing datasets are often limited to specific tasks, small scale, and lack the comprehensive annotations necessary for broader endovascular intervention understanding. To tackle these limitations, we introduce CathAction, a large-scale dataset for catheterization understanding. Our CathAction dataset encompasses approximately 500,000 annotated frames for catheterization action understanding and collision detection, and 25,000 ground truth masks for catheter and guidewire segmentation. For each task, we benchmark recent related works in the field. We further discuss the challenges of endovascular intentions compared to traditional computer vision tasks and point out open research questions. We hope that CathAction will facilitate the development of endovascular intervention understanding methods that can be applied to real-world applications. The dataset is available at https://airvlab.github.io/cathdata/.

SMILE: Zero-Shot Sparse Mixture of Low-Rank Experts Construction From Pre-Trained Foundation Models

Deep model training on extensive datasets is increasingly becoming cost-prohibitive, prompting the widespread adoption of deep model fusion techniques to leverage knowledge from pre-existing models. From simple weight averaging to more sophisticated methods like AdaMerging, model fusion effectively improves model performance and accelerates the development of new models. However, potential interference between parameters of individual models and the lack of interpretability in the fusion progress remain significant challenges. Existing methods often try to resolve the parameter interference issue by evaluating attributes of parameters, such as their magnitude or sign, or by parameter pruning. In this study, we begin by examining the fine-tuning of linear layers through the lens of subspace analysis and explicitly define parameter interference as an optimization problem to shed light on this subject. Subsequently, we introduce an innovative approach to model fusion called zero-shot Sparse MIxture of Low-rank Experts (SMILE) construction, which allows for the upscaling of source models into an MoE model without extra data or further training. Our approach relies on the observation that fine-tuning mostly keeps the important parts from the pre-training, but it uses less significant or unused areas to adapt to new tasks. Also, the issue of parameter interference, which is intrinsically intractable in the original parameter space, can be managed by expanding the dimensions. We conduct extensive experiments across diverse scenarios, such as image classification and text generalization tasks, using full fine-tuning and LoRA fine-tuning, and we apply our method to large language models (CLIP models, Flan-T5 models, and Mistral-7B models), highlighting the adaptability and scalability of SMILE. Code is available at https://github.com/tanganke/fusion_bench

Fragment-Masked Molecular Optimization

Molecular optimization is a crucial aspect of drug discovery, aimed at refining molecular structures to enhance drug efficacy and minimize side effects, ultimately accelerating the overall drug development process. Many target-based molecular optimization methods have been proposed, significantly advancing drug discovery. These methods primarily on understanding the specific drug target structures or their hypothesized roles in combating diseases. However, challenges such as a limited number of available targets and a difficulty capturing clear structures hinder innovative drug development. In contrast, phenotypic drug discovery (PDD) does not depend on clear target structures and can identify hits with novel and unbiased polypharmacology signatures. As a result, PDD-based molecular optimization can reduce potential safety risks while optimizing phenotypic activity, thereby increasing the likelihood of clinical success. Therefore, we propose a fragment-masked molecular optimization method based on PDD (FMOP). FMOP employs a regression-free diffusion model to conditionally optimize the molecular masked regions without training, effectively generating new molecules with similar scaffolds. On the large-scale drug response dataset GDSCv2, we optimize the potential molecules across all 945 cell lines. The overall experiments demonstrate that the in-silico optimization success rate reaches 94.4%, with an average efficacy increase of 5.3%. Additionally, we conduct extensive ablation and visualization experiments, confirming that FMOP is an effective and robust molecular optimization method. The code is available at:https://anonymous.4open.science/r/FMOP-98C2.

Co-Fix3D: Enhancing 3D Object Detection with Collaborative Refinement

In the realm of autonomous driving,accurately detecting occluded or distant objects,referred to as weak positive sample ,presents significant challenges. These challenges predominantly arise during query initialization, where an over-reliance on heatmap confidence often results in a high rate of false positives, consequently masking weaker detections and impairing system performance. To alleviate this issue, we propose a novel approach, Co-Fix3D, which employs a collaborative hybrid multi-stage parallel query generation mechanism for BEV representations. Our method incorporates the Local-Global Feature Enhancement (LGE) module, which refines BEV features to more effectively highlight weak positive samples. It uniquely leverages the Discrete Wavelet Transform (DWT) for accurate noise reduction and features refinement in localized areas, and incorporates an attention mechanism to more comprehensively optimize global BEV features. Moreover, our method increases the volume of BEV queries through a multi-stage parallel processing of the LGE, significantly enhancing the probability of selecting weak positive samples. This enhancement not only improves training efficiency within the decoder framework but also boosts overall system performance. Notably, Co-Fix3D achieves superior results on the stringent nuScenes benchmark, outperforming all previous models with a 69.1% mAP and 72.9% NDS on the LiDAR-based benchmark, and 72.3% mAP and 74.1% NDS on the multi-modality benchmark, without relying on test-time augmentation or additional datasets. The source code will be made publicly available upon acceptance.

FADE: A Dataset for Detecting Falling Objects around Buildings in Video

Falling objects from buildings can cause severe injuries to pedestrians due to the great impact force they exert. Although surveillance cameras are installed around some buildings, it is challenging for humans to capture such events in surveillance videos due to the small size and fast motion of falling objects, as well as the complex background. Therefore, it is necessary to develop methods to automatically detect falling objects around buildings in surveillance videos. To facilitate the investigation of falling object detection, we propose a large, diverse video dataset called FADE (FAlling Object DEtection around Buildings) for the first time. FADE contains 1,881 videos from 18 scenes, featuring 8 falling object categories, 4 weather conditions, and 4 video resolutions. Additionally, we develop a new object detection method called FADE-Net, which effectively leverages motion information and produces small-sized but high-quality proposals for detecting falling objects around buildings. Importantly, our method is extensively evaluated and analyzed by comparing it with the previous approaches used for generic object detection, video object detection, and moving object detection on the FADE dataset. Experimental results show that the proposed FADE-Net significantly outperforms other methods, providing an effective baseline for future research. The dataset and code are publicly available at https://fadedataset.github.io/FADE.github.io/.

TextIM: Part-aware Interactive Motion Synthesis from Text

In this work, we propose TextIM, a novel framework for synthesizing TEXT-driven human Interactive Motions, with a focus on the precise alignment of part-level semantics. Existing methods often overlook the critical roles of interactive body parts and fail to adequately capture and align part-level semantics, resulting in inaccuracies and even erroneous movement outcomes. To address these issues, TextIM utilizes a decoupled conditional diffusion framework to enhance the detailed alignment between interactive movements and corresponding semantic intents from textual descriptions. Our approach leverages large language models, functioning as a human brain, to identify interacting human body parts and to comprehend interaction semantics to generate complicated and subtle interactive motion. Guided by the refined movements of the interacting parts, TextIM further extends these movements into a coherent whole-body motion. We design a spatial coherence module to complement the entire body movements while maintaining consistency and harmony across body parts using a part graph convolutional network. For training and evaluation, we carefully selected and re-labeled interactive motions from HUMANML3D to develop a specialized dataset. Experimental results demonstrate that TextIM produces semantically accurate human interactive motions, significantly enhancing the realism and applicability of synthesized interactive motions in diverse scenarios, even including interactions with deformable and dynamically changing objects.

SAT3D: Image-driven Semantic Attribute Transfer in 3D

GAN-based image editing task aims at manipulating image attributes in the latent space of generative models. Most of the previous 2D and 3D-aware approaches mainly focus on editing attributes in images with ambiguous semantics or regions from a reference image, which fail to achieve photographic semantic attribute transfer, such as the beard from a photo of a man. In this paper, we propose an image-driven Semantic Attribute Transfer method in 3D (SAT3D) by editing semantic attributes from a reference image. For the proposed method, the exploration is conducted in the style space of a pre-trained 3D-aware StyleGAN-based generator by learning the correlations between semantic attributes and style code channels. For guidance, we associate each attribute with a set of phrase-based descriptor groups, and develop a Quantitative Measurement Module (QMM) to quantitatively describe the attribute characteristics in images based on descriptor groups, which leverages the image-text comprehension capability of CLIP. During the training process, the QMM is incorporated into attribute losses to calculate attribute similarity between images, guiding target semantic transferring and irrelevant semantics preserving. We present our 3D-aware attribute transfer results across multiple domains and also conduct comparisons with classical 2D image editing methods, demonstrating the effectiveness and customizability of our SAT3D.

M^3:Manipulation Mask Manufacturer for Arbitrary-Scale Super-Resolution Mask

In the field of image manipulation localization (IML), the small quantity and poor quality of existing datasets have always been major issues. A dataset containing various types of manipulations will greatly help improve the accuracy of IML models. Images on the internet (such as those on Baidu Tieba's PS Bar) are manipulated using various techniques, and creating a dataset from these images will significantly enrich the types of manipulations in our data. However, images on the internet suffer from resolution and clarity issues, and the masks obtained by simply subtracting the manipulated image from the original contain various noises. These noises are difficult to remove, rendering the masks unusable for IML models. Inspired by the field of change detection, we treat the original and manipulated images as changes over time for the same image and view the data generation task as a change detection task. However, due to clarity issues between images, conventional change detection models perform poorly. Therefore, we introduced a super-resolution module and proposed the Manipulation Mask Manufacturer (MMM) framework. It enhances the resolution of both the original and tampered images, thereby improving image details for better comparison. Simultaneously, the framework converts the original and tampered images into feature embeddings and concatenates them, effectively modeling the context. Additionally, we created the Manipulation Mask Manufacturer Dataset (MMMD), a dataset that covers a wide range of manipulation techniques. We aim to contribute to the fields of image forensics and manipulation detection by providing more realistic manipulation data through MMM and MMMD. Detailed information about MMMD and the download link can be found at: the code and datasets will be made available.