New Benchmarking Shows Limited Generalization Power of TCR Antigenic Epitope Prediction Models

Accurate computational prediction of T cell receptor (TCR) antigen specificity would transform the study of T cell biology and enable scalable immune engineering, yet existing models lack sufficient sensitivity and specificity for broad applications. A major limitation is the absence of rigorously defined, unseen benchmark datasets that allow unbiased evaluation of model performance and generalizability. Here, we describe two complementary classes of datasets that meet this criterion and argue that they provide both a robust framework for model assessment and a foundation for next-generation TCR-antigen prediction algorithm development.

Quantifying the Energy Floor: Direct Measurement and Replay Buffer Bias in SAC-Based HVAC Control on sbsim

We quantify the energy floor -- the minimum achievable cost given action space constraints -- for Soft Actor-Critic (SAC) HVAC control on the sbsim calibrated building simulator. Through minimum-action experiments, we directly measure this floor at USD 35.51/day, dominated by continuous electrical loads (USD 35.44, 99.8%) with negligible gas consumption. The standard SAC baseline, initialized with schedule-policy replay buffer transitions, converges to USD 37.18/day, 4.7% above the floor. We identify buffer initialization as the dominant source of sub-optimality in this scenario: training from an empty buffer reduces cost to USD 35.57/day, eliminating 96% of the gap. Expanding the supply water temperature range by 10 K yields negligible additional savings (USD 0.03/day), and further expansion triggers physical constraint violations. We additionally uncover a discount factor coupling (gamma_eff = 0.891) shrinking the effective planning horizon from 8.3 h to 46 min -- a benchmark-wide issue warranting audit. Systematic ablation across planning horizon, reward weights, and observation enrichment confirms all pre-filled-buffer configurations cluster within 0.7% (USD 37.18--USD 37.42), demonstrating that equipment minimum power -- not algorithmic design -- imposes the binding constraint.

DrugClaw and DrugAudit: A Primary-Source-Grounded Agent and Authority-Aware Benchmark for Drug-Information Question Answering

Drug-information question answering is a high-stakes setting where hallucinated facts can mislead clinical decision-making and the provenance of each cited fact matters as much as the fact itself. We present DrugClaw, a multi-agent retrieval-augmented system that queries a registry of drug and pharmacovigilance skills via a reflection-driven state-machine workflow and returns answers grounded in primary regulatory or peer-reviewed records. We also contribute DrugAudit, a 3,772-item authority-aware benchmark with an evaluation panel that scores upstream-of-gold source match, token-level semantic snippet overlap, and citation faithfulness under a dual-judge LLM-as-judge protocol with inter-judge kappa = 0.88 (almost-perfect). Across DrugAudit plus drug-related subsets of MedQA (751) and PubMedQA (512), DrugClaw is top-1 on every column of the headline table: composite Evidence Index under both judges, judge-mediated answer correctness, primary-source rate (0.918, +10.1 pp over next-best), faithfulness (0.887, +5.9 pp), MedQA (0.920), and PubMedQA (0.693).

From Pixels to Words -- Towards Native One-Vision Models at Scale

Current vision-language models (VLMs) typically stitch together separate image encoders and language decoders via multi-stage alignment, a modular framework that inevitably fragments pixel-level signals across frames and scatters early pixel-word interactions. In parallel, native VLMs, despite impressive performance on single images, remain largely unexplored in multi-image, video understanding, and spatial intelligence. Hence, we introduce NEO-ov, a native foundation model that learns cross-frame and pixel-word correspondence end-to-end, without any external encoders, auxiliary adapters, or post-hoc fusion. By eliminating module boundaries entirely, NEO-ov enables fine-grained and unified spatiotemporal modeling to emerge natively inside the model. Notably, NEO-ov largely narrows the gap to modular counterparts while excelling at fine-grained visual perception, validating that native "one-vision" architectures are not only feasible but competitive at scale. Beyond empirical performance, we unveil systematic architectural analyses and detailed training recipes to facilitate subsequent native multimodal modeling. Our code and models are publicly available at: https://github.com/EvolvingLMMs-Lab/NEO.

GUI Agents for Continual Game Generation

Generating a game is not the same as making one that can be played. Despite advances in code generation, existing approaches treat game generation as one-shot translation from prompt to artifact, leaving interaction-level failures undetected. We argue that evaluating and improving game generation requires a player, and study two roles for graphical user interface (GUI) agents in this process: (1) as an objective evaluator, for which we introduce PlaytestArena, a new evaluation environment that pairs 200 browser-based game generation tasks across eight genres with rubrics of expected in-play behaviors, adjudicated by a GUI agent that loads each build in a browser and plays it; and (2) as a subjective playtester, for which we propose Play2Code, where a game agent and a GUI agent operate in a sustained loop with shared memory, turning game generation into a dialogue between coding and playing. Our experiments show that even frontier models struggle to generate playable games directly, while Play2Code achieves a 66.8\% rubric pass-rate, improving over single-pass and agentic-coding baselines by 37.1 and 14.6 points respectively. Further analysis shows that GUI playtester feedback is more traceable than a human report, yet idiosyncratic in ways reminiscent of human testers, establishing game playtesting as a critical testbed for interactive code generation. Our project website is available at https://continual-game-generation.vercel.app/.

LLaVA-OneVision-2: Towards Next-Generation Perceptual Intelligence

We introduce LLaVA-OneVision-2 (LLaVA-OV-2), the most capable vision-language model in the LLaVA-OneVision series to date, achieving superior performance across a broad range of multimodal benchmarks. The model builds on a native OneVision-Encoder and incorporates Windowed Attention for efficient local computation while maintaining native resolution. Its key advance is codec-stream tokenization: it treats compressed video as a continuous bit-cost stream, where bit-cost dynamics determine adaptive temporal groups, and motion-residual cues select salient spatial evidence into compact visual canvases. This allocation concentrates a limited token budget on event-bearing content, enabling more stable long-video token compression than fixed groups of pictures. A shared 3D RoPE further places codec canvases, sampled frames, and images in a unified spatiotemporal coordinate system. Furthermore, we build the LLaVA-OV-2 data and training stack around large-scale open supervision: approximately 8M re-captioned video samples for pretraining, a 4M-sample spatial corpus for fine-tuning. We also introduce JumpScore, a temporal-localization benchmark targeting fine-grained grounding in high-frequency, densely repeated motion, a regime underrepresented by existing video evaluations. A standout capability of LLaVA-OV-2 is its unified perception across video understanding, temporal grounding, spatial grounding, and manipulation-trace reasoning. On JumpScore, LLaVA-OneVision-2-8B reaches 74.9 JumpScore mAP, surpassing Qwen3-VL-8B (30.1) by +44.8 points; under matched visual-token budgets on the same benchmark, codec-stream inputs improve temporal grounding over frame sampling by +9.7 points. Across standard benchmarks, LLaVA-OneVision-2-8B further outperforms Qwen3-VL-8B by +4.3 average points on video tasks, +5.3 on spatial tasks, and +15.6 average J&F on tracking tasks.

Mix-MoE: Improving Multilingual Machine Translation of Large Language Models through Mixed MoEs

Large Language Models (LLMs) have shown great promise in multilingual machine translation (MT), even with limited bilingual supervision. However, fine-tuning LLMs with parallel corpora presents major challenges, namely parameter interference. To address these issues, we propose Mix-MoE, a mixed Mixture-of-Experts framework designed to train LLMs for multilingual MT. Our framework operates in two distinct stages: (1) post-pretraining with MoE on monolingual corpora, and (2) post-pretraining with MoE on parallel corpora. Crucially, we divide the MoE layers into two specialized groups: Language Model Experts (LM Experts) and Machine Translation Experts (MT Experts). LM Experts are designed to capture and retain the monolingual knowledge learned by the pre-trained LLM. MT Experts, on the other hand, are specifically trained to acquire and store bilingual translation knowledge. Furthermore, to facilitate effective interaction between these specialized experts and leverage potential underlying structural patterns in text, we introduce a routing mechanism enhanced by Fourier Transform features derived from model representations. The experimental results demonstrate that Mix-MoE excels in multilingual MT, significantly outperforming existing baselines and showing notable progress in mitigating parameter interference.

VaaWIT: Visual-Aware Adaptation of Large Language Models for Multilingual Web Image Translation

Translating text embedded in Web images is crucial for improving content accessibility and cross-lingual information retrieval, particularly within social media and e-commerce domains. Although Large Vision-Language Models (LVLMs) have advanced multimodal understanding, applying them to Web image translation remains challenging due to the visual representation gap: standard encoders often prioritize high-level semantics over the fine-grained visual details required for recognizing diverse character morphologies. To address this challenge, we propose VaaWIT, an end-to-end framework that adapts Large Language Models for multilingual Web image translation. The framework introduces two key technical contributions: (1) a Dual-Stream Attention Module (DSAM), which facilitates bidirectional interaction between multilingual semantic features and detailed visual representations, thereby synthesizing unified features robust to textual variations; and (2) a Visual-Aware Adapter (VAA), a parameter-efficient fine-tuning strategy that dynamically injects these fused visual cues into the frozen LLM backbone. This design enables the model to align the visual context with linguistic reasoning effectively while minimizing computational costs. Extensive experiments on eight tasks on three public benchmarks demonstrate that VaaWIT significantly outperforms state-of-the-art (SOTA) open-source baselines and achieves competitive performance against proprietary models. These results validate the efficacy of integrating fine-grained visual perception into LLMs for complex Web content analysis.

Visual-Advantage On-Policy Distillation for Vision-Language Models

On-policy knowledge distillation has proven effective for language models, yet its application to vision-language models (VLMs) remains underexplored. We observe that standard on-policy distillation can improve a student's output quality while failing to strengthen its reliance on visual input: on vision-critical tokens, the student's predictions remain largely unchanged whether or not fine-grained visual detail is present, even though the teacher's predictions depend heavily on it.To make this difference observable, we introduce visual advantage (VA), the token-level log-probability difference when the teacher scores a student-generated rollout with versus without access to fine-grained visual detail. VA is concentrated in a small minority of tokens, and these high-VA tokens are the ones that actually carry the visual supervision signal. This motivates a distillation objective that treats them differently from language scaffolding, so their contribution is not diluted by the abundant surrounding language tokens.We propose Visual-Advantage On-Policy Distillation (VA-OPD), which uses VA at two granularities: rollout-level reweighting by trajectory-averaged VA, and token-level KL averaged within high-VA and low-VA groups separately. We train on two math datasets (Geometry3K and ViRL39K) and evaluate on eight benchmarks covering both mathematical reasoning and visual understanding, across three teacher sizes (4B, 8B, and 32B) on the Qwen3-VL family. VA-OPD improves over standard on-policy distillation on every benchmark, with the gain growing monotonically along both the teacher-size and data-scale axes, suggesting that these factors compound consistently.

ParaVT: Taming the Tool Prior Paradox for Parallel Tool Use in Agentic Video Reinforcement Learning

Training large multimodal models (LMMs) via reinforcement learning (RL) to natively invoke video-processing tools (e.g., cropping) has become a promising route to long-video understanding. However, existing native-RL methods dispatch tool calls sequentially (i.e., one per turn): a single wrong crop propagates errors without peer correction, multi-turn tool calls corrupt context, and inference cost scales linearly with the number of turns. We introduce ParaVT, the first multi-agent end-to-end RL-trained framework for Parallel Video Tool calling, dispatching multiple time-window crops in a single turn for cleaner context and better fault tolerance. Yet applying standard RL to ParaVT reveals an obstacle we term the Tool Prior Paradox: the pretrained tool priors that enable tool exploration also destabilize cold-started structural format and expose the skip-tool reward shortcut under temperature sampling. A cross-model contrast on a weaker-prior LMM supports this claim: format stays stable but RL elicits zero tool calls, indicating that prior strength is the shared driver of both format collapse and tool exploration. We propose PARA-GRPO (Parseability-Anchored and Ratio-gAted GRPO), which augments standard RL with two complementary mechanisms: (i) a targeted format reward applied only at the structural-token positions most prone to collapse, and (ii) a per-prompt frame-budget randomization that creates training prompts where calling the tool yields a measurable reward signal over skipping it. Across six long-video understanding benchmarks, ParaVT improves over the Qwen3-VL baseline by +7.9% on average, with PARA-GRPO lifting training-time format compliance from 0.13 to 0.64. As tool capabilities become increasingly internalized in modern LMMs, RL must cooperate with the resulting priors, and ParaVT offers a general recipe for agentic RL. Code, data, and model weights are publicly available.