Physics-Informed Conditional Diffusion for Motion-Robust Retinal Temporal Laser Speckle Contrast Imaging

Retinal laser speckle contrast imaging (LSCI) is a noninvasive optical modality for monitoring retinal blood flow dynamics. However, conventional temporal LSCI (tLSCI) reconstruction relies on sufficiently long speckle sequences to obtain stable temporal statistics, which makes it vulnerable to acquisition disturbances and limits effective temporal resolution. A physically informed reconstruction framework, termed RetinaDiff (Retinal Diffusion Model), is proposed for retinal tLSCI that is robust to motion and requires only a few frames. In RetinaDiff, registration based on phase correlation is first applied to stabilize the raw speckle sequence before contrast computation, reducing interframe misalignment so that fluctuations at each pixel primarily reflect true flow dynamics. This step provides a physics prior corrected for motion and a high quality multiframe tLSCI reference. Next, guided by the physics prior, a conditional diffusion model performs inverse reconstruction by jointly conditioning on the registered speckle sequence and the corrected prior. Experiments on data acquired with a retinal LSCI system developed in house show improved structural continuity and statistical stability compared with direct reconstruction from few frames and representative baselines. The framework also remains effective in a small number of extremely challenging cases, where both the direct 5-frame input and the conventional multiframe reconstruction are severely degraded. Overall, this work provides a practical and physically grounded route for reliable retinal tLSCI reconstruction from extremely limited frames. The source code and model weights will be publicly available at https://github.com/QianChen113/RetinaDiff.

OGER: A Robust Offline-Guided Exploration Reward for Hybrid Reinforcement Learning

Recent advancements in Reinforcement Learning with Verifiable Rewards (RLVR) have significantly improved Large Language Model (LLM) reasoning, yet models often struggle to explore novel trajectories beyond their initial latent space. While offline teacher guidance and entropy-driven strategies have been proposed to address this, they often lack deep integration or are constrained by the model's inherent capacity. In this paper, we propose OGER, a novel framework that unifies offline teacher guidance and online reinforcement learning through a specialized reward modeling lens. OGER employs multi-teacher collaborative training and constructs an auxiliary exploration reward that leverages both offline trajectories and the model's own entropy to incentivize autonomous exploration. Extensive experiments across mathematical and general reasoning benchmarks demonstrate that OGER significantly outperforms competitive baselines, achieving substantial gains in mathematical reasoning while maintaining robust generalization to out-of-domain tasks. We provide a comprehensive analysis of training dynamics and conduct detailed ablation studies to validate the effectiveness of our entropy-aware reward modulation. Our code is available at https://github.com/ecoli-hit/OGER.git.

Beyond Scores: Diagnostic LLM Evaluation via Fine-Grained Abilities

Current evaluations of large language models aggregate performance across diverse tasks into single scores. This obscures fine-grained ability variation, limiting targeted model improvement and ability-guided selection for specific tasks. Motivated by this gap, we propose a cognitive diagnostic framework that estimates model abilities across multiple fine-grained dimensions. For mathematics, we construct a 35-dimensional ability taxonomy grounded in cognitive theory and domain knowledge. The framework employs multidimensional Item Response Theory with an item-ability association matrix to estimate fine-grained ability levels, which in turn enable prediction of performance on unseen items (questions of benchmark). Evaluated on 41 models, our approach demonstrates strong criterion validity, consistent ability estimates across benchmarks, and accurate prediction of unseen items with AUC ranging from 0.80 to 0.89 within benchmarks and from 0.77 to 0.86 across benchmarks, substantially exceeding trivial baselines. The framework generalizes across scientific domains, producing consistent diagnostic performance in physics (27 dimensions), chemistry (58 dimensions), and computer science (12 dimensions). This work establishes a principled framework for fine-grained assessment of abilities, with potential applications in targeted training, ability-guided model selection, and ability-aware benchmark design.

MO-RiskVAE: A Multi-Omics Variational Autoencoder for Survival Risk Modeling in Multiple MyelomaMO-RiskVAE

Multimodal variational autoencoders (VAEs) have emerged as a powerful framework for survival risk modeling in multiple myeloma by integrating heterogeneous omics and clinical data. However, when trained under survival supervision, standard latent regularization strategies often fail to preserve prognostically relevant variation, leading to unstable or overly constrained representations. Despite numerous proposed variants, it remains unclear which aspects of latent design fundamentally govern performance in this setting. In this work, we conduct a controlled investigation of latent modeling choices for multimodal survival prediction within a unified extension of the MyeVAE framework. By systematically isolating regularization scale, posterior geometry, and latent space structure under identical architectures and optimization protocols, we show that survival-driven training is primarily sensitive to the magnitude and structure of latent regularization rather than the specific divergence formulation. In particular, moderate relaxation of KL regularization consistently improves survival discrimination, while alternative divergence mechanisms such as MMD and HSIC provide limited benefit without appropriate scaling. We further demonstrate that structuring the latent space can improve alignment between learned representations and survival risk gradients. A hybrid continuous--discrete formulation based on Gumbel--Softmax enhances global risk ordering in the continuous latent subspace, even though stable discrete subtype discovery does not emerge under survival supervision. Guided by these findings, we instantiate a robust multimodal survival model, termed MO-RiskVAE, which consistently improves risk stratification over the original MyeVAE without introducing additional supervision or complex training heuristics.

Predictive Regularization Against Visual Representation Degradation in Multimodal Large Language Models

While Multimodal Large Language Models (MLLMs) excel at vision-language tasks, the cost of their language-driven training on internal visual foundational competence remains unclear. In this paper, we conduct a detailed diagnostic analysis to unveil a pervasive issue: visual representation degradation in MLLMs. Specifically, we find that compared to the initial visual features, the visual representation in the middle layers of LLM exhibits both a degradation in global function and patch structure. We attribute this phenomenon to a visual sacrifice driven by the singular text-generation objective, where the model compromises its visual fidelity to optimize for answer generation. We argue that a robust MLLM requires both strong cross-modal reasoning and core visual competence, and propose Predictive Regularization (PRe) to force degraded intermediate features to predict initial visual features, thereby maintaining the inherent visual attributes of the MLLM's internal representations. Extensive experiments confirm that mitigating this visual degradation effectively boosts vision-language performance, underscoring the critical importance of fostering robust internal visual representations within MLLMs for comprehensive multimodal understanding.

Learning Like Humans: Analogical Concept Learning for Generalized Category Discovery

Generalized Category Discovery (GCD) seeks to uncover novel categories in unlabeled data while preserving recognition of known categories, yet prevailing visual-only pipelines and the loose coupling between supervised learning and discovery often yield brittle boundaries on fine-grained, look-alike categories. We introduce the Analogical Textual Concept Generator (ATCG), a plug-and-play module that analogizes from labeled knowledge to new observations, forming textual concepts for unlabeled samples. Fusing these analogical textual concepts with visual features turns discovery into a visual-textual reasoning process, transferring prior knowledge to novel data and sharpening category separation. ATCG attaches to both parametric and clustering style GCD pipelines and requires no changes to their overall design. Across six benchmarks, ATCG consistently improves overall, known-class, and novel-class performance, with the largest gains on fine-grained data. Our code is available at: https://github.com/zhou-9527/AnaLogical-GCD.

ZipServ: Fast and Memory-Efficient LLM Inference with Hardware-Aware Lossless Compression

Lossless model compression holds tremendous promise for alleviating the memory and bandwidth bottlenecks in bit-exact Large Language Model (LLM) serving. However, existing approaches often result in substantial inference slowdowns due to fundamental design mismatches with GPU architectures: at the kernel level, variable-length bitstreams produced by traditional entropy codecs break SIMT parallelism; at the system level, decoupled pipelines lead to redundant memory traffic. We present ZipServ, a lossless compression framework co-designed for efficient LLM inference. ZipServ introduces Tensor-Core-Aware Triple Bitmap Encoding (TCA-TBE), a novel fixed-length format that enables constant-time, parallel decoding, together with a fused decompression-GEMM (ZipGEMM) kernel that decompresses weights on-the-fly directly into Tensor Core registers. This "load-compressed, compute-decompressed" design eliminates intermediate buffers and maximizes compute intensity. Experiments show that ZipServ reduces the model size by up to 30%, achieves up to 2.21x kernel-level speedup over NVIDIA's cuBLAS, and expedites end-to-end inference by an average of 1.22x over vLLM. ZipServ is the first lossless compression system that provides both storage savings and substantial acceleration for LLM inference on GPUs.

Trajectory-Diversity-Driven Robust Vision-and-Language Navigation

Vision-and-Language Navigation (VLN) requires agents to navigate photo-realistic environments following natural language instructions. Current methods predominantly rely on imitation learning, which suffers from limited generalization and poor robustness to execution perturbations. We present NavGRPO, a reinforcement learning framework that learns goal-directed navigation policies through Group Relative Policy Optimization. By exploring diverse trajectories and optimizing via within-group performance comparisons, our method enables agents to distinguish effective strategies beyond expert paths without requiring additional value networks. Built on ScaleVLN, NavGRPO achieves superior robustness on R2R and REVERIE benchmarks with +3.0% and +1.71% SPL improvements in unseen environments. Under extreme early-stage perturbations, we demonstrate +14.89% SPL gain over the baseline, confirming that goal-directed RL training builds substantially more robust navigation policies. Code and models will be released.

GFPL: Generative Federated Prototype Learning for Resource-Constrained and Data-Imbalanced Vision Task

Federated learning (FL) facilitates the secure utilization of decentralized images, advancing applications in medical image recognition and autonomous driving. However, conventional FL faces two critical challenges in real-world deployment: ineffective knowledge fusion caused by model updates biased toward majority-class features, and prohibitive communication overhead due to frequent transmissions of high-dimensional model parameters. Inspired by the human brain's efficiency in knowledge integration, we propose a novel Generative Federated Prototype Learning (GFPL) framework to address these issues. Within this framework, a prototype generation method based on Gaussian Mixture Model (GMM) captures the statistical information of class-wise features, while a prototype aggregation strategy using Bhattacharyya distance effectively fuses semantically similar knowledge across clients. In addition, these fused prototypes are leveraged to generate pseudo-features, thereby mitigating feature distribution imbalance across clients. To further enhance feature alignment during local training, we devise a dual-classifier architecture, optimized via a hybrid loss combining Dot Regression and Cross-Entropy. Extensive experiments on benchmarks show that GFPL improves model accuracy by 3.6% under imbalanced data settings while maintaining low communication cost.

GOAL: Geometrically Optimal Alignment for Continual Generalized Category Discovery

Continual Generalized Category Discovery (C-GCD) requires identifying novel classes from unlabeled data while retaining knowledge of known classes over time. Existing methods typically update classifier weights dynamically, resulting in forgetting and inconsistent feature alignment. We propose GOAL, a unified framework that introduces a fixed Equiangular Tight Frame (ETF) classifier to impose a consistent geometric structure throughout learning. GOAL conducts supervised alignment for labeled samples and confidence-guided alignment for novel samples, enabling stable integration of new classes without disrupting old ones. Experiments on four benchmarks show that GOAL outperforms the prior method Happy, reducing forgetting by 16.1% and boosting novel class discovery by 3.2%, establishing a strong solution for long-horizon continual discovery.