An AI-native experimental laboratory for autonomous biomolecular engineering

Autonomous scientific research, capable of independently conducting complex experiments and serving non-specialists, represents a long-held aspiration. Achieving it requires a fundamental paradigm shift driven by artificial intelligence (AI). While autonomous experimental systems are emerging, they remain confined to areas featuring singular objectives and well-defined, simple experimental workflows, such as chemical synthesis and catalysis. We present an AI-native autonomous laboratory, targeting highly complex scientific experiments for applications like autonomous biomolecular engineering. This system autonomously manages instrumentation, formulates experiment-specific procedures and optimization heuristics, and concurrently serves multiple user requests. Founded on a co-design philosophy of models, experiments, and instruments, the platform supports the co-evolution of AI models and the automation system. This establishes an end-to-end, multi-user autonomous laboratory that handles complex, multi-objective experiments across diverse instrumentation. Our autonomous laboratory supports fundamental nucleic acid functions-including synthesis, transcription, amplification, and sequencing. It also enables applications in fields such as disease diagnostics, drug development, and information storage. Without human intervention, it autonomously optimizes experimental performance to match state-of-the-art results achieved by human scientists. In multi-user scenarios, the platform significantly improves instrument utilization and experimental efficiency. This platform paves the way for advanced biomaterials research to overcome dependencies on experts and resource barriers, establishing a blueprint for science-as-a-service at scale.

MagicTryOn: Harnessing Diffusion Transformer for Garment-Preserving Video Virtual Try-on

Video Virtual Try-On (VVT) aims to simulate the natural appearance of garments across consecutive video frames, capturing their dynamic variations and interactions with human body motion. However, current VVT methods still face challenges in terms of spatiotemporal consistency and garment content preservation. First, they use diffusion models based on the U-Net, which are limited in their expressive capability and struggle to reconstruct complex details. Second, they adopt a separative modeling approach for spatial and temporal attention, which hinders the effective capture of structural relationships and dynamic consistency across frames. Third, their expression of garment details remains insufficient, affecting the realism and stability of the overall synthesized results, especially during human motion. To address the above challenges, we propose MagicTryOn, a video virtual try-on framework built upon the large-scale video diffusion Transformer. We replace the U-Net architecture with a diffusion Transformer and combine full self-attention to jointly model the spatiotemporal consistency of videos. We design a coarse-to-fine garment preservation strategy. The coarse strategy integrates garment tokens during the embedding stage, while the fine strategy incorporates multiple garment-based conditions, such as semantics, textures, and contour lines during the denoising stage. Moreover, we introduce a mask-aware loss to further optimize garment region fidelity. Extensive experiments on both image and video try-on datasets demonstrate that our method outperforms existing SOTA methods in comprehensive evaluations and generalizes to in-the-wild scenarios.

SPAST: Arbitrary Style Transfer with Style Priors via Pre-trained Large-scale Model

Given an arbitrary content and style image, arbitrary style transfer aims to render a new stylized image which preserves the content image's structure and possesses the style image's style. Existing arbitrary style transfer methods are based on either small models or pre-trained large-scale models. The small model-based methods fail to generate high-quality stylized images, bringing artifacts and disharmonious patterns. The pre-trained large-scale model-based methods can generate high-quality stylized images but struggle to preserve the content structure and cost long inference time. To this end, we propose a new framework, called SPAST, to generate high-quality stylized images with less inference time. Specifically, we design a novel Local-global Window Size Stylization Module (LGWSSM)tofuse style features into content features. Besides, we introduce a novel style prior loss, which can dig out the style priors from a pre-trained large-scale model into the SPAST and motivate the SPAST to generate high-quality stylized images with short inference time.We conduct abundant experiments to verify that our proposed method can generate high-quality stylized images and less inference time compared with the SOTA arbitrary style transfer methods.

Zero-Shot Document-Level Biomedical Relation Extraction via Scenario-based Prompt Design in Two-Stage with LLM

With the advent of artificial intelligence (AI), many researchers are attempting to extract structured information from document-level biomedical literature by fine-tuning large language models (LLMs). However, they face significant challenges such as the need for expensive hardware, like high-performance GPUs and the high labor costs associated with annotating training datasets, especially in biomedical realm. Recent research on LLMs, such as GPT-4 and Llama3, has shown promising performance in zero-shot settings, inspiring us to explore a novel approach to achieve the same results from unannotated full documents using general LLMs with lower hardware and labor costs. Our approach combines two major stages: named entity recognition (NER) and relation extraction (RE). NER identifies chemical, disease and gene entities from the document with synonym and hypernym extraction using an LLM with a crafted prompt. RE extracts relations between entities based on predefined relation schemas and prompts. To enhance the effectiveness of prompt, we propose a five-part template structure and a scenario-based prompt design principles, along with evaluation method to systematically assess the prompts. Finally, we evaluated our approach against fine-tuning and pre-trained models on two biomedical datasets: ChemDisGene and CDR. The experimental results indicate that our proposed method can achieve comparable accuracy levels to fine-tuning and pre-trained models but with reduced human and hardware expenses.

Lightweight LiDAR-Camera 3D Dynamic Object Detection and Multi-Class Trajectory Prediction

Service mobile robots are often required to avoid dynamic objects while performing their tasks, but they usually have only limited computational resources. So we present a lightweight multi-modal framework for 3D object detection and trajectory prediction. Our system synergistically integrates LiDAR and camera inputs to achieve real-time perception of pedestrians, vehicles, and riders in 3D space. The framework proposes two novel modules: 1) a Cross-Modal Deformable Transformer (CMDT) for object detection with high accuracy and acceptable amount of computation, and 2) a Reference Trajectory-based Multi-Class Transformer (RTMCT) for efficient and diverse trajectory prediction of mult-class objects with flexible trajectory lengths. Evaluations on the CODa benchmark demonstrate superior performance over existing methods across detection (+2.03% in mAP) and trajectory prediction (-0.408m in minADE5 of pedestrians) metrics. Remarkably, the system exhibits exceptional deployability - when implemented on a wheelchair robot with an entry-level NVIDIA 3060 GPU, it achieves real-time inference at 13.2 fps. To facilitate reproducibility and practical deployment, we release the related code of the method at https://github.com/TossherO/3D_Perception and its ROS inference version at https://github.com/TossherO/ros_packages.

Test-Time Domain Generalization via Universe Learning: A Multi-Graph Matching Approach for Medical Image Segmentation

Despite domain generalization (DG) has significantly addressed the performance degradation of pre-trained models caused by domain shifts, it often falls short in real-world deployment. Test-time adaptation (TTA), which adjusts a learned model using unlabeled test data, presents a promising solution. However, most existing TTA methods struggle to deliver strong performance in medical image segmentation, primarily because they overlook the crucial prior knowledge inherent to medical images. To address this challenge, we incorporate morphological information and propose a framework based on multi-graph matching. Specifically, we introduce learnable universe embeddings that integrate morphological priors during multi-source training, along with novel unsupervised test-time paradigms for domain adaptation. This approach guarantees cycle-consistency in multi-matching while enabling the model to more effectively capture the invariant priors of unseen data, significantly mitigating the effects of domain shifts. Extensive experiments demonstrate that our method outperforms other state-of-the-art approaches on two medical image segmentation benchmarks for both multi-source and single-source domain generalization tasks. The source code is available at https://github.com/Yore0/TTDG-MGM.

DyArtbank: Diverse Artistic Style Transfer via Pre-trained Stable Diffusion and Dynamic Style Prompt Artbank

Artistic style transfer aims to transfer the learned style onto an arbitrary content image. However, most existing style transfer methods can only render consistent artistic stylized images, making it difficult for users to get enough stylized images to enjoy. To solve this issue, we propose a novel artistic style transfer framework called DyArtbank, which can generate diverse and highly realistic artistic stylized images. Specifically, we introduce a Dynamic Style Prompt ArtBank (DSPA), a set of learnable parameters. It can learn and store the style information from the collection of artworks, dynamically guiding pre-trained stable diffusion to generate diverse and highly realistic artistic stylized images. DSPA can also generate random artistic image samples with the learned style information, providing a new idea for data augmentation. Besides, a Key Content Feature Prompt (KCFP) module is proposed to provide sufficient content prompts for pre-trained stable diffusion to preserve the detailed structure of the input content image. Extensive qualitative and quantitative experiments verify the effectiveness of our proposed method. Code is available: https://github.com/Jamie-Cheung/DyArtbank

Gaussian highpass guided image filtering

Guided image filtering (GIF) is a popular smoothing technique, in which an additional image is used as a structure guidance for noise removal with edge preservation. The original GIF and some of its subsequent improvements are derived from a two-parameter local affine model (LAM), where the filtering output is a local affine transformation of the guidance image, but the input image is not taken into account in the LAM formulation. In this paper, we first introduce a single-parameter Prior Model based on Gaussian (highpass/lowpass) Filtering (PM-GF), in which the filtering output is the sum of a weighted portion of Gaussian highpass filtering of the guidance image and Gaussian smoothing of the input image. In the PM-GF, the guidance structure determined by Gaussian highpass filtering is obviously transferred to the filtering output, thereby better revealing the structure transfer mechanism of guided filtering. Then we propose several Gaussian highpass GIFs (GH-GIFs) based on the PM-GF by emulating the original GIF and some improvements, i.e., using PM-GF instead of LAM in these GIFs. Experimental results illustrate that the proposed GIFs outperform their counterparts in several image processing applications.

Semantic Prior Distillation with Vision Foundation Model for Enhanced Rapid Bone Scintigraphy Image Restoration

Rapid bone scintigraphy is an essential tool for diagnosing skeletal diseases and tumor metastasis in pediatric patients, as it reduces scan time and minimizes patient discomfort. However, rapid scans often result in poor image quality, potentially affecting diagnosis due to reduced resolution and detail, which make it challenging to identify and evaluate finer anatomical structures. To address this issue, we propose the first application of SAM-based semantic priors for medical image restoration, leveraging the Segment Anything Model (SAM) to enhance rapid bone scintigraphy images in pediatric populations. Our method comprises two cascaded networks, $f^{IR1}$ and $f^{IR2}$, augmented by three key modules: a Semantic Prior Integration (SPI) module, a Semantic Knowledge Distillation (SKD) module, and a Semantic Consistency Module (SCM). The SPI and SKD modules incorporate domain-specific semantic information from a fine-tuned SAM, while the SCM maintains consistent semantic feature representation throughout the cascaded networks. In addition, we will release a novel Rapid Bone Scintigraphy dataset called RBS, the first dataset dedicated to rapid bone scintigraphy image restoration in pediatric patients. RBS consists of 137 pediatric patients aged between 0.5 and 16 years who underwent both standard and rapid bone scans. The dataset includes scans performed at 20 cm/min (standard) and 40 cm/min (rapid), representing a $2\times$ acceleration. We conducted extensive experiments on both the publicly available endoscopic dataset and RBS. The results demonstrate that our method outperforms all existing methods across various metrics, including PSNR, SSIM, FID, and LPIPS.

DualSpec: Text-to-spatial-audio Generation via Dual-Spectrogram Guided Diffusion Model

Text-to-audio (TTA), which generates audio signals from textual descriptions, has received huge attention in recent years. However, recent works focused on text to monaural audio only. As we know, spatial audio provides more immersive auditory experience than monaural audio, e.g. in virtual reality. To address this issue, we propose a text-to-spatial-audio (TTSA) generation framework named DualSpec.Specifically, it first trains variational autoencoders (VAEs) for extracting the latent acoustic representations from sound event audio. Then, given text that describes sound events and event directions, the proposed method uses the encoder of a pretrained large language model to transform the text into text features. Finally, it trains a diffusion model from the latent acoustic representations and text features for the spatial audio generation. In the inference stage, only the text description is needed to generate spatial audio. Particularly, to improve the synthesis quality and azimuth accuracy of the spatial sound events simultaneously, we propose to use two kinds of acoustic features. One is the Mel spectrograms which is good for improving the synthesis quality, and the other is the short-time Fourier transform spectrograms which is good at improving the azimuth accuracy. We provide a pipeline of constructing spatial audio dataset with text prompts, for the training of the VAEs and diffusion model. We also introduce new spatial-aware evaluation metrics to quantify the azimuth errors of the generated spatial audio recordings. Experimental results demonstrate that the proposed method can generate spatial audio with high directional and event consistency.