Sanity Checks for Agentic Data Science

Agentic data science (ADS) pipelines have grown rapidly in both capability and adoption, with systems such as OpenAI Codex now able to directly analyze datasets and produce answers to statistical questions. However, these systems can reach falsely optimistic conclusions that are difficult for users to detect. To address this, we propose a pair of lightweight sanity checks grounded in the Predictability-Computability-Stability (PCS) framework for veridical data science. These checks use reasonable perturbations to screen whether an agent can reliably distinguish signal from noise, acting as a falsifiability constraint that can expose affirmative conclusions as unsupported. Together, the two checks characterize the trustworthiness of an ADS output, e.g. whether it has found stable signal, is responding to noise, or is sensitive to incidental aspects of the input. We validate the approach on synthetic data with controlled signal-to-noise ratios, confirming that the sanity checks track ground-truth signal strength. We then demonstrate the checks on 11 real-world datasets using OpenAI Codex, characterizing the trustworthiness of each conclusion and finding that in 6 of the datasets an affirmative conclusion is not well-supported, even though a single ADS run may support one. We further analyze failure modes of ADS systems and find that ADS self-reported confidence is poorly calibrated to the empirical stability of its conclusions.

CDR-Agent: Intelligent Selection and Execution of Clinical Decision Rules Using Large Language Model Agents

Clinical decision-making is inherently complex and fast-paced, particularly in emergency departments (EDs) where critical, rapid and high-stakes decisions are made. Clinical Decision Rules (CDRs) are standardized evidence-based tools that combine signs, symptoms, and clinical variables into decision trees to make consistent and accurate diagnoses. CDR usage is often hindered by the clinician's cognitive load, limiting their ability to quickly recall and apply the appropriate rules. We introduce CDR-Agent, a novel LLM-based system designed to enhance ED decision-making by autonomously identifying and applying the most appropriate CDRs based on unstructured clinical notes. To validate CDR-Agent, we curated two novel ED datasets: synthetic and CDR-Bench, although CDR-Agent is applicable to non ED clinics. CDR-Agent achieves a 56.3\% (synthetic) and 8.7\% (CDR-Bench) accuracy gain relative to the standalone LLM baseline in CDR selection. Moreover, CDR-Agent significantly reduces computational overhead. Using these datasets, we demonstrated that CDR-Agent not only selects relevant CDRs efficiently, but makes cautious yet effective imaging decisions by minimizing unnecessary interventions while successfully identifying most positively diagnosed cases, outperforming traditional LLM prompting approaches. Code for our work can be found at: https://github.com/zhenxianglance/medagent-cdr-agent