AbICL: In-Context Learning for Antigen-Specific Antibody Affinity Ranking

Accurate ranking of antibody candidates according to their binding affinity is essential for therapeutic antibody discovery. However, existing methods treat affinity comparisons independently and ignore the contextual information encoded in other labeled comparisons, limiting their ability to capture antigen-specific binding landscapes. For many target antigens, a small number of experimentally characterized affinity comparisons are often available. An important question is whether the model can exploit these existing comparisons to infer antigen-specific ranking patterns that facilitate subsequent affinity ranking. This form of learning from labeled demonstrations closely resembles the paradigm of In-Context Learning, motivating us to revisit antibody affinity ranking from an ICL perspective. To this end, we propose AbICL, an ICL framework for antigen-specific antibody affinity ranking. AbICL combines a pretrained structural encoder with a context ranking head and is trained with an episodic meta-training strategy that enables the model to leverage support demonstrations for test-time adaptation without gradient updates. Experiments on the AbRank benchmark demonstrate that AbICL consistently outperforms existing ranking baselines across almost all data splits and evaluation benchmarks. Further analysis shows that the value of contextual demonstrations depends on how well they match the target inference task, and becomes increasingly pronounced under distribution shift and fine-grained affinity discrimination. These findings highlight the potential of ICL as an effective paradigm for antigen-specific antibody affinity ranking, particularly in challenging settings where a single global ranking function is insufficient.

MultiMolecule: a modular ecosystem for biomolecular sequence-model workflows

Biomolecular sequence models are increasingly reused outside the studies in which they were introduced, but public checkpoints rarely preserve the execution context needed to inspect source-defined behavior, adapt models to new assays, compare models under shared task definitions or deploy biological predictions. MultiMolecule is an open-source Python ecosystem that turns heterogeneous RNA, DNA and protein sequence-model releases into complete, source-checked model-family implementations with shared loading, workflow and prediction interfaces. The Resource state reported here includes 53 complete model-family implementations with 112 standardized model checkpoints, together with 16 curated dataset resources released through 39 public dataset repositories and 10 user-facing prediction pipelines. Standardized components are linked to source provenance, conversion or preparation code, source-reference checks, Extended Data summaries and public documentation, allowing users to inspect what was standardized, what behavior was checked and how each component enters training, evaluation, inference or deployment. By shifting reuse from repository-specific checkpoints to executable implementations connected to standardized checkpoints, curated datasets, Runner workflows and biological prediction pipelines, MultiMolecule provides common infrastructure for preserving source-defined model behavior, adapting models to new assays, enabling controlled evaluation and deploying biomolecular predictions.

SciEval: A Benchmark for Automatic Evaluation of K-12 Science Instructional Materials

The need to evaluate instructional materials for K-12 science education has become increasingly important, as more educators use generative AI to create instructional materials. However, the review of instructional materials is time-consuming, expertise-intensive, and difficult to scale, motivating interest in automated evaluation approaches. While large language models (LLMs) have shown strong performance on general evaluation tasks, their performance and reliability on instructional materials remain unclear. To address this gap, we formulate Automatic Instructional Materials Evaluation (AIME) as a generative AI task that predicts scores and evidence using the rubric designed by the educator. We create a benchmark dataset and develop baseline models for AIME. First, we curate the first AIME dataset, SciEval, consisting of instructional materials annotated with pedagogy-aligned evaluation scores and evidence-based rationales. Expert annotations achieve high inter-rater reliability, resulting in a dataset of 273 lesson-level instructional materials evaluated across 13 criteria (N=3549) using the EQuIP rubric. Second, we test mainstream LLMs (GPT, Gemini, Llama, and Qwen) on SciEval and find that none achieve strong performance. Then we fine-tune Qwen3 on SciEval. Results on a held-out test set show that domain-aligned fine-tuning can achieve up to 11 percent performance gains, highlighting the importance of domain-specific fine-tuning for AIME and facilitating the use of LLMs in other educational tasks.

StateLinFormer: Stateful Training Enhancing Long-term Memory in Navigation

Effective navigation intelligence relies on long-term memory to support both immediate generalization and sustained adaptation. However, existing approaches face a dilemma: modular systems rely on explicit mapping but lack flexibility, while Transformer-based end-to-end models are constrained by fixed context windows, limiting persistent memory across extended interactions. We introduce StateLinFormer, a linear-attention navigation model trained with a stateful memory mechanism that preserves recurrent memory states across consecutive training segments instead of reinitializing them at each batch boundary. This training paradigm effectively approximates learning on infinitely long sequences, enabling the model to achieve long-horizon memory retention. Experiments across both MAZE and ProcTHOR environments demonstrate that StateLinFormer significantly outperforms its stateless linear-attention counterpart and standard Transformer baselines with fixed context windows. Notably, as interaction length increases, persistent stateful training substantially improves context-dependent adaptation, suggesting an enhancement in the model's In-Context Learning (ICL) capabilities for navigation tasks.

ICDAR 2025 Competition on End-to-End Document Image Machine Translation Towards Complex Layouts

Document Image Machine Translation (DIMT) seeks to translate text embedded in document images from one language to another by jointly modeling both textual content and page layout, bridging optical character recognition (OCR) and natural language processing (NLP). The DIMT 2025 Challenge advances research on end-to-end document image translation, a rapidly evolving area within multimodal document understanding. The competition features two tracks, OCR-free and OCR-based, each with two subtasks for small (less than 1B parameters) and large (greater than 1B parameters) models. Participants submit a single unified DIMT system, with the option to incorporate provided OCR transcripts. Running from December 10, 2024 to April 20, 2025, the competition attracted 69 teams and 27 valid submissions in total. Track 1 had 34 teams and 13 valid submissions, while Track 2 had 35 teams and 14 valid submissions. In this report, we present the challenge motivation, dataset construction, task definitions, evaluation protocol, and a summary of results. Our analysis shows that large-model approaches establish a promising new paradigm for translating complex-layout document images and highlight substantial opportunities for future research.

Mobile-Agent-v3.5: Multi-platform Fundamental GUI Agents

The paper introduces GUI-Owl-1.5, the latest native GUI agent model that features instruct/thinking variants in multiple sizes (2B/4B/8B/32B/235B) and supports a range of platforms (desktop, mobile, browser, and more) to enable cloud-edge collaboration and real-time interaction. GUI-Owl-1.5 achieves state-of-the-art results on more than 20+ GUI benchmarks on open-source models: (1) on GUI automation tasks, it obtains 56.5 on OSWorld, 71.6 on AndroidWorld, and 48.4 on WebArena; (2) on grounding tasks, it obtains 80.3 on ScreenSpotPro; (3) on tool-calling tasks, it obtains 47.6 on OSWorld-MCP, and 46.8 on MobileWorld; (4) on memory and knowledge tasks, it obtains 75.5 on GUI-Knowledge Bench. GUI-Owl-1.5 incorporates several key innovations: (1) Hybird Data Flywheel: we construct the data pipeline for UI understanding and trajectory generation based on a combination of simulated environments and cloud-based sandbox environments, in order to improve the efficiency and quality of data collection. (2) Unified Enhancement of Agent Capabilities: we use a unified thought-synthesis pipeline to enhance the model's reasoning capabilities, while placing particular emphasis on improving key agent abilities, including Tool/MCP use, memory and multi-agent adaptation; (3) Multi-platform Environment RL Scaling: We propose a new environment RL algorithm, MRPO, to address the challenges of multi-platform conflicts and the low training efficiency of long-horizon tasks. The GUI-Owl-1.5 models are open-sourced, and an online cloud-sandbox demo is available at https://github.com/X-PLUG/MobileAgent.

RelayGR: Scaling Long-Sequence Generative Recommendation via Cross-Stage Relay-Race Inference

Real-time recommender systems execute multi-stage cascades (retrieval, pre-processing, fine-grained ranking) under strict tail-latency SLOs, leaving only tens of milliseconds for ranking. Generative recommendation (GR) models can improve quality by consuming long user-behavior sequences, but in production their online sequence length is tightly capped by the ranking-stage P99 budget. We observe that the majority of GR tokens encode user behaviors that are independent of the item candidates, suggesting an opportunity to pre-infer a user-behavior prefix once and reuse it during ranking rather than recomputing it on the critical path. Realizing this idea at industrial scale is non-trivial: the prefix cache must survive across multiple pipeline stages before the final ranking instance is determined, the user population implies cache footprints far beyond a single device, and indiscriminate pre-inference would overload shared resources under high QPS. We present RelayGR, a production system that enables in-HBM relay-race inference for GR. RelayGR selectively pre-infers long-term user prefixes, keeps their KV caches resident in HBM over the request lifecycle, and ensures the subsequent ranking can consume them without remote fetches. RelayGR combines three techniques: 1) a sequence-aware trigger that admits only at-risk requests under a bounded cache footprint and pre-inference load, 2) an affinity-aware router that co-locates cache production and consumption by routing both the auxiliary pre-infer signal and the ranking request to the same instance, and 3) a memory-aware expander that uses server-local DRAM to capture short-term cross-request reuse while avoiding redundant reloads. We implement RelayGR on Huawei Ascend NPUs and evaluate it with real queries. Under a fixed P99 SLO, RelayGR supports up to 1.5$\times$ longer sequences and improves SLO-compliant throughput by up to 3.6$\times$.

HiSciBench: A Hierarchical Multi-disciplinary Benchmark for Scientific Intelligence from Reading to Discovery

The rapid advancement of large language models (LLMs) and multimodal foundation models has sparked growing interest in their potential for scientific research. However, scientific intelligence encompasses a broad spectrum of abilities ranging from understanding fundamental knowledge to conducting creative discovery, and existing benchmarks remain fragmented. Most focus on narrow tasks and fail to reflect the hierarchical and multi-disciplinary nature of real scientific inquiry. We introduce \textbf{HiSciBench}, a hierarchical benchmark designed to evaluate foundation models across five levels that mirror the complete scientific workflow: \textit{Scientific Literacy} (L1), \textit{Literature Parsing} (L2), \textit{Literature-based Question Answering} (L3), \textit{Literature Review Generation} (L4), and \textit{Scientific Discovery} (L5). HiSciBench contains 8,735 carefully curated instances spanning six major scientific disciplines, including mathematics, physics, chemistry, biology, geography, and astronomy, and supports multimodal inputs including text, equations, figures, and tables, as well as cross-lingual evaluation. Unlike prior benchmarks that assess isolated abilities, HiSciBench provides an integrated, dependency-aware framework that enables detailed diagnosis of model capabilities across different stages of scientific reasoning. Comprehensive evaluations of leading models, including GPT-5, DeepSeek-R1, and several multimodal systems, reveal substantial performance gaps: while models achieve up to 69\% accuracy on basic literacy tasks, performance declines sharply to 25\% on discovery-level challenges. HiSciBench establishes a new standard for evaluating scientific Intelligence and offers actionable insights for developing models that are not only more capable but also more reliable. The benchmark will be publicly released to facilitate future research.

High-Quality Proposal Encoding and Cascade Denoising for Imaginary Supervised Object Detection

Object detection models demand large-scale annotated datasets, which are costly and labor-intensive to create. This motivated Imaginary Supervised Object Detection (ISOD), where models train on synthetic images and test on real images. However, existing methods face three limitations: (1) synthetic datasets suffer from simplistic prompts, poor image quality, and weak supervision; (2) DETR-based detectors, due to their random query initialization, struggle with slow convergence and overfitting to synthetic patterns, hindering real-world generalization; (3) uniform denoising pressure promotes model overfitting to pseudo-label noise. We propose Cascade HQP-DETR to address these limitations. First, we introduce a high-quality data pipeline using LLaMA-3, Flux, and Grounding DINO to generate the FluxVOC and FluxCOCO datasets, advancing ISOD from weak to full supervision. Second, our High-Quality Proposal guided query encoding initializes object queries with image-specific priors from SAM-generated proposals and RoI-pooled features, accelerating convergence while steering the model to learn transferable features instead of overfitting to synthetic patterns. Third, our cascade denoising algorithm dynamically adjusts training weights through progressively increasing IoU thresholds across decoder layers, guiding the model to learn robust boundaries from reliable visual cues rather than overfitting to noisy labels. Trained for just 12 epochs solely on FluxVOC, Cascade HQP-DETR achieves a SOTA 61.04\% mAP@0.5 on PASCAL VOC 2007, outperforming strong baselines, with its competitive real-data performance confirming the architecture's universal applicability.

Context and Diversity Matter: The Emergence of In-Context Learning in World Models

The capability of predicting environmental dynamics underpins both biological neural systems and general embodied AI in adapting to their surroundings. Yet prevailing approaches rest on static world models that falter when confronted with novel or rare configurations. We investigate in-context environment learning (ICEL), shifting attention from zero-shot performance to the growth and asymptotic limits of the world model. Our contributions are three-fold: (1) we formalize in-context learning of a world model and identify two core mechanisms: environment recognition and environment learning; (2) we derive error upper-bounds for both mechanisms that expose how the mechanisms emerge; and (3) we empirically confirm that distinct ICL mechanisms exist in the world model, and we further investigate how data distribution and model architecture affect ICL in a manner consistent with theory. These findings demonstrate the potential of self-adapting world models and highlight the key factors behind the emergence of ICEL, most notably the necessity of long context and diverse environments.