ELLMob: Event-Driven Human Mobility Generation with Self-Aligned LLM Framework

Human mobility generation aims to synthesize plausible trajectory data, which is widely used in urban system research. While Large Language Model-based methods excel at generating routine trajectories, they struggle to capture deviated mobility during large-scale societal events. This limitation stems from two critical gaps: (1) the absence of event-annotated mobility datasets for design and evaluation, and (2) the inability of current frameworks to reconcile competitions between users' habitual patterns and event-imposed constraints when making trajectory decisions. This work addresses these gaps with a twofold contribution. First, we construct the first event-annotated mobility dataset covering three major events: Typhoon Hagibis, COVID-19, and the Tokyo 2021 Olympics. Second, we propose ELLMob, a self-aligned LLM framework that first extracts competing rationales between habitual patterns and event constraints, based on Fuzzy-Trace Theory, and then iteratively aligns them to generate trajectories that are both habitually grounded and event-responsive. Extensive experiments show that ELLMob wins state-of-the-art baselines across all events, demonstrating its effectiveness. Our codes and datasets are available at https://github.com/deepkashiwa20/ELLMob.

Beyond Static Artifacts: A Forensic Benchmark for Video Deepfake Reasoning in Vision Language Models

Current Vision-Language Models (VLMs) for deepfake detection excel at identifying spatial artifacts but overlook a critical dimension: temporal inconsistencies in video forgeries. Adapting VLMs to reason about these dynamic cues remains a distinct challenge. To bridge this gap, we propose Forensic Answer-Questioning (FAQ), a large-scale benchmark that formulates temporal deepfake analysis as a multiple-choice task. FAQ introduces a three-level hierarchy to progressively evaluate and equip VLMs with forensic capabilities: (1) Facial Perception, testing the ability to identify static visual artifacts; (2) Temporal Deepfake Grounding, requiring the localization of dynamic forgery artifacts across frames; and (3) Forensic Reasoning, challenging models to synthesize evidence for final authenticity verdicts. We evaluate a range of VLMs on FAQ and generate a corresponding instruction-tuning set, FAQ-IT. Extensive experiments show that models fine-tuned on FAQ-IT achieve advanced performance on both in-domain and cross-dataset detection benchmarks. Ablation studies further validate the impact of our key design choices, confirming that FAQ is the driving force behind the temporal reasoning capabilities of these VLMs.

BMAM: Brain-inspired Multi-Agent Memory Framework

Language-model-based agents operating over extended interaction horizons face persistent challenges in preserving temporally grounded information and maintaining behavioral consistency across sessions, a failure mode we term soul erosion. We present BMAM (Brain-inspired Multi-Agent Memory), a general-purpose memory architecture that models agent memory as a set of functionally specialized subsystems rather than a single unstructured store. Inspired by cognitive memory systems, BMAM decomposes memory into episodic, semantic, salience-aware, and control-oriented components that operate at complementary time scales. To support long-horizon reasoning, BMAM organizes episodic memories along explicit timelines and retrieves evidence by fusing multiple complementary signals. Experiments on the LoCoMo benchmark show that BMAM achieves 78.45 percent accuracy under the standard long-horizon evaluation setting, and ablation analyses confirm that the hippocampus-inspired episodic memory subsystem plays a critical role in temporal reasoning.

MMPG: MoE-based Adaptive Multi-Perspective Graph Fusion for Protein Representation Learning

Graph Neural Networks (GNNs) have been widely adopted for Protein Representation Learning (PRL), as residue interaction networks can be naturally represented as graphs. Current GNN-based PRL methods typically rely on single-perspective graph construction strategies, which capture partial properties of residue interactions, resulting in incomplete protein representations. To address this limitation, we propose MMPG, a framework that constructs protein graphs from multiple perspectives and adaptively fuses them via Mixture of Experts (MoE) for PRL. MMPG constructs graphs from physical, chemical, and geometric perspectives to characterize different properties of residue interactions. To capture both perspective-specific features and their synergies, we develop an MoE module, which dynamically routes perspectives to specialized experts, where experts learn intrinsic features and cross-perspective interactions. We quantitatively verify that MoE automatically specializes experts in modeling distinct levels of interaction from individual representations, to pairwise inter-perspective synergies, and ultimately to a global consensus across all perspectives. Through integrating this multi-level information, MMPG produces superior protein representations and achieves advanced performance on four different downstream protein tasks.

MCGM: Multi-stage Clustered Global Modeling for Long-range Interactions in Molecules

Geometric graph neural networks (GNNs) excel at capturing molecular geometry, yet their locality-biased message passing hampers the modeling of long-range interactions. Current solutions have fundamental limitations: extending cutoff radii causes computational costs to scale cubically with distance; physics-inspired kernels (e.g., Coulomb, dispersion) are often system-specific and lack generality; Fourier-space methods require careful tuning of multiple parameters (e.g., mesh size, k-space cutoff) with added computational overhead. We introduce Multi-stage Clustered Global Modeling (MCGM), a lightweight, plug-and-play module that endows geometric GNNs with hierarchical global context through efficient clustering operations. MCGM builds a multi-resolution hierarchy of atomic clusters, distills global information via dynamic hierarchical clustering, and propagates this context back through learned transformations, ultimately reinforcing atomic features via residual connections. Seamlessly integrated into four diverse backbone architectures, MCGM reduces OE62 energy prediction error by an average of 26.2%. On AQM, MCGM achieves state-of-the-art accuracy (17.0 meV for energy, 4.9 meV/{\AA} for forces) while using 20% fewer parameters than Neural P3M. Code will be made available upon acceptance.

GenColor: Generative Color-Concept Association in Visual Design

Existing approaches for color-concept association typically rely on query-based image referencing, and color extraction from image references. However, these approaches are effective only for common concepts, and are vulnerable to unstable image referencing and varying image conditions. Our formative study with designers underscores the need for primary-accent color compositions and context-dependent colors (e.g., 'clear' vs. 'polluted' sky) in design. In response, we introduce a generative approach for mining semantically resonant colors leveraging images generated by text-to-image models. Our insight is that contemporary text-to-image models can resemble visual patterns from large-scale real-world data. The framework comprises three stages: concept instancing produces generative samples using diffusion models, text-guided image segmentation identifies concept-relevant regions within the image, and color association extracts primarily accompanied by accent colors. Quantitative comparisons with expert designs validate our approach's effectiveness, and we demonstrate the applicability through cases in various design scenarios and a gallery.

Tokenizing 3D Molecule Structure with Quantized Spherical Coordinates

The application of language models (LMs) to molecular structure generation using line notations such as SMILES and SELFIES has been well-established in the field of cheminformatics. However, extending these models to generate 3D molecular structures presents significant challenges. Two primary obstacles emerge: (1) the difficulty in designing a 3D line notation that ensures SE(3)-invariant atomic coordinates, and (2) the non-trivial task of tokenizing continuous coordinates for use in LMs, which inherently require discrete inputs. To address these challenges, we propose Mol-StrucTok, a novel method for tokenizing 3D molecular structures. Our approach comprises two key innovations: (1) We design a line notation for 3D molecules by extracting local atomic coordinates in a spherical coordinate system. This notation builds upon existing 2D line notations and remains agnostic to their specific forms, ensuring compatibility with various molecular representation schemes. (2) We employ a Vector Quantized Variational Autoencoder (VQ-VAE) to tokenize these coordinates, treating them as generation descriptors. To further enhance the representation, we incorporate neighborhood bond lengths and bond angles as understanding descriptors. Leveraging this tokenization framework, we train a GPT-2 style model for 3D molecular generation tasks. Results demonstrate strong performance with significantly faster generation speeds and competitive chemical stability compared to previous methods. Further, by integrating our learned discrete representations into Graphormer model for property prediction on QM9 dataset, Mol-StrucTok reveals consistent improvements across various molecular properties, underscoring the versatility and robustness of our approach.

Brain-inspired continual pre-trained learner via silent synaptic consolidation

Pre-trained models have demonstrated impressive generalization capabilities, yet they remain vulnerable to catastrophic forgetting when incrementally trained on new tasks. Existing architecture-based strategies encounter two primary challenges: 1) Integrating a pre-trained network with a trainable sub-network complicates the delicate balance between learning plasticity and memory stability across evolving tasks during learning. 2) The absence of robust interconnections between pre-trained networks and various sub-networks limits the effective retrieval of pertinent information during inference. In this study, we introduce the Artsy, inspired by the activation mechanisms of silent synapses via spike-timing-dependent plasticity observed in mature brains, to enhance the continual learning capabilities of pre-trained models. The Artsy integrates two key components: During training, the Artsy mimics mature brain dynamics by maintaining memory stability for previously learned knowledge within the pre-trained network while simultaneously promoting learning plasticity in task-specific sub-networks. During inference, artificial silent and functional synapses are utilized to establish precise connections between the pre-synaptic neurons in the pre-trained network and the post-synaptic neurons in the sub-networks, facilitated through synaptic consolidation, thereby enabling effective extraction of relevant information from test samples. Comprehensive experimental evaluations reveal that our model significantly outperforms conventional methods on class-incremental learning tasks, while also providing enhanced biological interpretability for architecture-based approaches. Moreover, we propose that the Artsy offers a promising avenue for simulating biological synaptic mechanisms, potentially advancing our understanding of neural plasticity in both artificial and biological systems.

Neural P$^3$M: A Long-Range Interaction Modeling Enhancer for Geometric GNNs

Geometric graph neural networks (GNNs) have emerged as powerful tools for modeling molecular geometry. However, they encounter limitations in effectively capturing long-range interactions in large molecular systems. To address this challenge, we introduce Neural P$^3$M, a versatile enhancer of geometric GNNs to expand the scope of their capabilities by incorporating mesh points alongside atoms and reimaging traditional mathematical operations in a trainable manner. Neural P$^3$M exhibits flexibility across a wide range of molecular systems and demonstrates remarkable accuracy in predicting energies and forces, outperforming on benchmarks such as the MD22 dataset. It also achieves an average improvement of 22% on the OE62 dataset while integrating with various architectures.

Advancing Cross-domain Discriminability in Continual Learning of Vison-Language Models

Continual learning (CL) with Vision-Language Models (VLMs) has overcome the constraints of traditional CL, which only focuses on previously encountered classes. During the CL of VLMs, we need not only to prevent the catastrophic forgetting on incrementally learned knowledge but also to preserve the zero-shot ability of VLMs. However, existing methods require additional reference datasets to maintain such zero-shot ability and rely on domain-identity hints to classify images across different domains. In this study, we propose Regression-based Analytic Incremental Learning (RAIL), which utilizes a recursive ridge regression-based adapter to learn from a sequence of domains in a non-forgetting manner and decouple the cross-domain correlations by projecting features to a higher-dimensional space. Cooperating with a training-free fusion module, RAIL absolutely preserves the VLM's zero-shot ability on unseen domains without any reference data. Additionally, we introduce Cross-domain Task-Agnostic Incremental Learning (X-TAIL) setting. In this setting, a CL learner is required to incrementally learn from multiple domains and classify test images from both seen and unseen domains without any domain-identity hint. We theoretically prove RAIL's absolute memorization on incrementally learned domains. Experiment results affirm RAIL's state-of-the-art performance in both X-TAIL and existing Multi-domain Task-Incremental Learning settings. The code will be released upon acceptance.