Silence is Not Consensus: Disrupting Agreement Bias in Multi-Agent LLMs via Catfish Agent for Clinical Decision Making

Large language models (LLMs) have demonstrated strong potential in clinical question answering, with recent multi-agent frameworks further improving diagnostic accuracy via collaborative reasoning. However, we identify a recurring issue of Silent Agreement, where agents prematurely converge on diagnoses without sufficient critical analysis, particularly in complex or ambiguous cases. We present a new concept called Catfish Agent, a role-specialized LLM designed to inject structured dissent and counter silent agreement. Inspired by the ``catfish effect'' in organizational psychology, the Catfish Agent is designed to challenge emerging consensus to stimulate deeper reasoning. We formulate two mechanisms to encourage effective and context-aware interventions: (i) a complexity-aware intervention that modulates agent engagement based on case difficulty, and (ii) a tone-calibrated intervention articulated to balance critique and collaboration. Evaluations on nine medical Q&A and three medical VQA benchmarks show that our approach consistently outperforms both single- and multi-agent LLMs frameworks, including leading commercial models such as GPT-4o and DeepSeek-R1.

Benchmarking Laparoscopic Surgical Image Restoration and Beyond

In laparoscopic surgery, a clear and high-quality visual field is critical for surgeons to make accurate intraoperative decisions. However, persistent visual degradation, including smoke generated by energy devices, lens fogging from thermal gradients, and lens contamination due to blood or tissue fluid splashes during surgical procedures, severely impair visual clarity. These degenerations can seriously hinder surgical workflow and pose risks to patient safety. To systematically investigate and address various forms of surgical scene degradation, we introduce a real-world open-source surgical image restoration dataset covering laparoscopic environments, called SurgClean, which involves multi-type image restoration tasks, e.g., desmoking, defogging, and desplashing. SurgClean comprises 1,020 images with diverse degradation types and corresponding paired reference labels. Based on SurgClean, we establish a standardized evaluation benchmark and provide performance for 22 representative generic task-specific image restoration approaches, including 12 generic and 10 task-specific image restoration approaches. Experimental results reveal substantial performance gaps relative to clinical requirements, highlighting a critical opportunity for algorithm advancements in intelligent surgical restoration. Furthermore, we explore the degradation discrepancies between surgical and natural scenes from structural perception and semantic understanding perspectives, providing fundamental insights for domain-specific image restoration research. Our work aims to empower the capabilities of restoration algorithms to increase surgical environments and improve the efficiency of clinical procedures.

Medical Large Vision Language Models with Multi-Image Visual Ability

Medical large vision-language models (LVLMs) have demonstrated promising performance across various single-image question answering (QA) benchmarks, yet their capability in processing multi-image clinical scenarios remains underexplored. Unlike single image based tasks, medical tasks involving multiple images often demand sophisticated visual understanding capabilities, such as temporal reasoning and cross-modal analysis, which are poorly supported by current medical LVLMs. To bridge this critical gap, we present the Med-MIM instruction dataset, comprising 83.2K medical multi-image QA pairs that span four types of multi-image visual abilities (temporal understanding, reasoning, comparison, co-reference). Using this dataset, we fine-tune Mantis and LLaVA-Med, resulting in two specialized medical VLMs: MIM-LLaVA-Med and Med-Mantis, both optimized for multi-image analysis. Additionally, we develop the Med-MIM benchmark to comprehensively evaluate the medical multi-image understanding capabilities of LVLMs. We assess eight popular LVLMs, including our two models, on the Med-MIM benchmark. Experimental results show that both Med-Mantis and MIM-LLaVA-Med achieve superior performance on the held-in and held-out subsets of the Med-MIM benchmark, demonstrating that the Med-MIM instruction dataset effectively enhances LVLMs' multi-image understanding capabilities in the medical domain.

Delving into RL for Image Generation with CoT: A Study on DPO vs. GRPO

Recent advancements underscore the significant role of Reinforcement Learning (RL) in enhancing the Chain-of-Thought (CoT) reasoning capabilities of large language models (LLMs). Two prominent RL algorithms, Direct Preference Optimization (DPO) and Group Relative Policy Optimization (GRPO), are central to these developments, showcasing different pros and cons. Autoregressive image generation, also interpretable as a sequential CoT reasoning process, presents unique challenges distinct from LLM-based CoT reasoning. These encompass ensuring text-image consistency, improving image aesthetic quality, and designing sophisticated reward models, rather than relying on simpler rule-based rewards. While recent efforts have extended RL to this domain, these explorations typically lack an in-depth analysis of the domain-specific challenges and the characteristics of different RL strategies. To bridge this gap, we provide the first comprehensive investigation of the GRPO and DPO algorithms in autoregressive image generation, evaluating their in-domain performance and out-of-domain generalization, while scrutinizing the impact of different reward models on their respective capabilities. Our findings reveal that GRPO and DPO exhibit distinct advantages, and crucially, that reward models possessing stronger intrinsic generalization capabilities potentially enhance the generalization potential of the applied RL algorithms. Furthermore, we systematically explore three prevalent scaling strategies to enhance both their in-domain and out-of-domain proficiency, deriving unique insights into efficiently scaling performance for each paradigm. We hope our study paves a new path for inspiring future work on developing more effective RL algorithms to achieve robust CoT reasoning in the realm of autoregressive image generation. Code is released at https://github.com/ZiyuGuo99/Image-Generation-CoT

OPA-Pack: Object-Property-Aware Robotic Bin Packing

Robotic bin packing aids in a wide range of real-world scenarios such as e-commerce and warehouses. Yet, existing works focus mainly on considering the shape of objects to optimize packing compactness and neglect object properties such as fragility, edibility, and chemistry that humans typically consider when packing objects. This paper presents OPA-Pack (Object-Property-Aware Packing framework), the first framework that equips the robot with object property considerations in planning the object packing. Technical-wise, we develop a novel object property recognition scheme with retrieval-augmented generation and chain-of-thought reasoning, and build a dataset with object property annotations for 1,032 everyday objects. Also, we formulate OPA-Net, aiming to jointly separate incompatible object pairs and reduce pressure on fragile objects, while compacting the packing. Further, OPA-Net consists of a property embedding layer to encode the property of candidate objects to be packed, together with a fragility heightmap and an avoidance heightmap to keep track of the packed objects. Then, we design a reward function and adopt a deep Q-learning scheme to train OPA-Net. Experimental results manifest that OPA-Pack greatly improves the accuracy of separating incompatible object pairs (from 52% to 95%) and largely reduces pressure on fragile objects (by 29.4%), while maintaining good packing compactness. Besides, we demonstrate the effectiveness of OPA-Pack on a real packing platform, showcasing its practicality in real-world scenarios.

Hand-Shadow Poser

Hand shadow art is a captivating art form, creatively using hand shadows to reproduce expressive shapes on the wall. In this work, we study an inverse problem: given a target shape, find the poses of left and right hands that together best produce a shadow resembling the input. This problem is nontrivial, since the design space of 3D hand poses is huge while being restrictive due to anatomical constraints. Also, we need to attend to the input's shape and crucial features, though the input is colorless and textureless. To meet these challenges, we design Hand-Shadow Poser, a three-stage pipeline, to decouple the anatomical constraints (by hand) and semantic constraints (by shadow shape): (i) a generative hand assignment module to explore diverse but reasonable left/right-hand shape hypotheses; (ii) a generalized hand-shadow alignment module to infer coarse hand poses with a similarity-driven strategy for selecting hypotheses; and (iii) a shadow-feature-aware refinement module to optimize the hand poses for physical plausibility and shadow feature preservation. Further, we design our pipeline to be trainable on generic public hand data, thus avoiding the need for any specialized training dataset. For method validation, we build a benchmark of 210 diverse shadow shapes of varying complexity and a comprehensive set of metrics, including a novel DINOv2-based evaluation metric. Through extensive comparisons with multiple baselines and user studies, our approach is demonstrated to effectively generate bimanual hand poses for a large variety of hand shapes for over 85% of the benchmark cases.

CellVerse: Do Large Language Models Really Understand Cell Biology?

Recent studies have demonstrated the feasibility of modeling single-cell data as natural languages and the potential of leveraging powerful large language models (LLMs) for understanding cell biology. However, a comprehensive evaluation of LLMs' performance on language-driven single-cell analysis tasks still remains unexplored. Motivated by this challenge, we introduce CellVerse, a unified language-centric question-answering benchmark that integrates four types of single-cell multi-omics data and encompasses three hierarchical levels of single-cell analysis tasks: cell type annotation (cell-level), drug response prediction (drug-level), and perturbation analysis (gene-level). Going beyond this, we systematically evaluate the performance across 14 open-source and closed-source LLMs ranging from 160M to 671B on CellVerse. Remarkably, the experimental results reveal: (1) Existing specialist models (C2S-Pythia) fail to make reasonable decisions across all sub-tasks within CellVerse, while generalist models such as Qwen, Llama, GPT, and DeepSeek family models exhibit preliminary understanding capabilities within the realm of cell biology. (2) The performance of current LLMs falls short of expectations and has substantial room for improvement. Notably, in the widely studied drug response prediction task, none of the evaluated LLMs demonstrate significant performance improvement over random guessing. CellVerse offers the first large-scale empirical demonstration that significant challenges still remain in applying LLMs to cell biology. By introducing CellVerse, we lay the foundation for advancing cell biology through natural languages and hope this paradigm could facilitate next-generation single-cell analysis.

EchoInk-R1: Exploring Audio-Visual Reasoning in Multimodal LLMs via Reinforcement Learning

Multimodal large language models (MLLMs) have advanced perception across text, vision, and audio, yet they often struggle with structured cross-modal reasoning, particularly when integrating audio and visual signals. We introduce EchoInk-R1, a reinforcement learning framework that enhances such reasoning in MLLMs. Built upon the Qwen2.5-Omni-7B foundation and optimized with Group Relative Policy Optimization (GRPO), EchoInk-R1 tackles multiple-choice question answering over synchronized audio-image pairs. To enable this, we curate AVQA-R1-6K, a dataset pairing such audio-image inputs with multiple-choice questions derived from OmniInstruct-v1. EchoInk-R1-7B achieves 85.77% accuracy on the validation set, outperforming the base model, which scores 80.53%, using only 562 reinforcement learning steps. Beyond accuracy, EchoInk-R1 demonstrates reflective reasoning by revisiting initial interpretations and refining responses when facing ambiguous multimodal inputs. These results suggest that lightweight reinforcement learning fine-tuning enhances cross-modal reasoning in MLLMs. EchoInk-R1 is the first framework to unify audio, visual, and textual modalities for general open-world reasoning via reinforcement learning. Code and data are publicly released to facilitate further research.

T2I-R1: Reinforcing Image Generation with Collaborative Semantic-level and Token-level CoT

Recent advancements in large language models have demonstrated how chain-of-thought (CoT) and reinforcement learning (RL) can improve performance. However, applying such reasoning strategies to the visual generation domain remains largely unexplored. In this paper, we present T2I-R1, a novel reasoning-enhanced text-to-image generation model, powered by RL with a bi-level CoT reasoning process. Specifically, we identify two levels of CoT that can be utilized to enhance different stages of generation: (1) the semantic-level CoT for high-level planning of the prompt and (2) the token-level CoT for low-level pixel processing during patch-by-patch generation. To better coordinate these two levels of CoT, we introduce BiCoT-GRPO with an ensemble of generation rewards, which seamlessly optimizes both generation CoTs within the same training step. By applying our reasoning strategies to the baseline model, Janus-Pro, we achieve superior performance with 13% improvement on T2I-CompBench and 19% improvement on the WISE benchmark, even surpassing the state-of-the-art model FLUX.1. Code is available at: https://github.com/CaraJ7/T2I-R1

Landmark-Free Preoperative-to-Intraoperative Registration in Laparoscopic Liver Resection

Liver registration by overlaying preoperative 3D models onto intraoperative 2D frames can assist surgeons in perceiving the spatial anatomy of the liver clearly for a higher surgical success rate. Existing registration methods rely heavily on anatomical landmark-based workflows, which encounter two major limitations: 1) ambiguous landmark definitions fail to provide efficient markers for registration; 2) insufficient integration of intraoperative liver visual information in shape deformation modeling. To address these challenges, in this paper, we propose a landmark-free preoperative-to-intraoperative registration framework utilizing effective self-supervised learning, termed \ourmodel. This framework transforms the conventional 3D-2D workflow into a 3D-3D registration pipeline, which is then decoupled into rigid and non-rigid registration subtasks. \ourmodel~first introduces a feature-disentangled transformer to learn robust correspondences for recovering rigid transformations. Further, a structure-regularized deformation network is designed to adjust the preoperative model to align with the intraoperative liver surface. This network captures structural correlations through geometry similarity modeling in a low-rank transformer network. To facilitate the validation of the registration performance, we also construct an in-vivo registration dataset containing liver resection videos of 21 patients, called \emph{P2I-LReg}, which contains 346 keyframes that provide a global view of the liver together with liver mask annotations and calibrated camera intrinsic parameters. Extensive experiments and user studies on both synthetic and in-vivo datasets demonstrate the superiority and potential clinical applicability of our method.