Joint sparse coding and temporal dynamics support context reconfiguration

Adaptive behavior requires the brain to transition between distinct contexts while maintaining representations of prior experience. The ability to reconfigure neural representations without erasing previously acquired knowledge is central to learning in dynamic environments, yet the neural mechanisms that support this balance remain unclear. Understanding these mechanisms is also critical for addressing catastrophic forgetting in artificial systems designed for lifelong learning. Here, we identify joint sparse coding and temporal dynamics in both the mouse medial prefrontal cortex (mPFC) and computational networks as mechanisms that help preserve prior representations during context transitions. Specifically, sparsity in context-dependent representations reduces cross-context interference, whereas temporal dynamics within the network activity further enhance context separability across time. Strikingly, networks endowed with both properties, such as spiking neural networks, exhibit improved retention during lifelong learning without auxiliary heuristics. These findings establish joint sparse coding and temporal dynamics as a core mechanism supporting flexible context reconfiguration in lifelong learning and, through their activity constraining nature, as an energy-efficient architectural principle for stable adaptation. Together, they provide a mechanistic framework for understanding how the brain preserves prior knowledge while flexibly adapting to new contexts.

Agri-CPJ: A Training-Free Explainable Framework for Agricultural Pest Diagnosis Using Caption-Prompt-Judge and LLM-as-a-Judge

Crop disease diagnosis from field photographs faces two recurring problems: models that score well on benchmarks frequently hallucinate species names, and when predictions are correct, the reasoning behind them is typically inaccessible to the practitioner. This paper describes Agri-CPJ (Caption-Prompt-Judge), a training-free few-shot framework in which a large vision-language model first generates a structured morphological caption, iteratively refined through multi-dimensional quality gating, before any diagnostic question is answered. Two candidate responses are then generated from complementary viewpoints, and an LLM judge selects the stronger one based on domain-specific criteria. Caption refinement is the component with the largest individual impact: ablations confirm that skipping it consistently degrades downstream accuracy across both models tested. On CDDMBench, pairing GPT-5-Nano with GPT-5-mini-generated captions yields \textbf{+22.7} pp in disease classification and \textbf{+19.5} points in QA score over no-caption baselines. Evaluated without modification on AgMMU-MCQs, GPT-5-Nano reached 77.84\% and Qwen-VL-Chat reached 64.54\%, placing them at or above most open-source models of comparable scale despite the format shift from open-ended to multiple-choice. The structured caption and judge rationale together constitute a readable audit trail: a practitioner who disagrees with a diagnosis can identify the specific caption observation that was incorrect. Code and data are publicly available https://github.com/CPJ-Agricultural/CPJ-Agricultural-Diagnosis

MorphSNN: Adaptive Graph Diffusion and Structural Plasticity for Spiking Neural Networks

Spiking Neural Networks (SNNs) currently face a critical bottleneck: while individual neurons exhibit dynamic biological properties, their macro-scopic architectures remain confined within conventional connectivity patterns that are static and hierarchical. This discrepancy between neuron-level dynamics and network-level fixed connectivity eliminates critical brain-like lateral interactions, limiting adaptability in changing environments. To address this, we propose MorphSNN, a backbone framework inspired by biological non-synaptic diffusion and structural plasticity. Specifically, we introduce a Graph Diffusion (GD)mechanism to facilitate efficient undirected signal propagation, complementing the feedforward hierarchy. Furthermore, it incorporates a Spatio-Temporal Structural Plasticity (STSP) mechanism, endowing the network with the capability for instance-specific, dynamic topological reorganization, thereby overcoming the limitations of fixed topologies. Experiments demonstrate that MorphSNN achieves state-of-the-art accuracy on static and neuromorphic datasets; for instance, it reaches 83.35% accuracy on N-Caltech101 with only 5 timesteps. More importantly, its self-evolving topology functions as an intrinsic distribution fingerprint, enabling superior Out-of- Distribution (OOD) detection without auxiliary training. The code is available at anonymous.4open.science/r/MorphSNN-B0BC.

MM-NeuroOnco: A Multimodal Benchmark and Instruction Dataset for MRI-Based Brain Tumor Diagnosis

Accurate brain tumor diagnosis requires models to not only detect lesions but also generate clinically interpretable reasoning grounded in imaging manifestations, yet existing public datasets remain limited in annotation richness and diagnostic semantics. To bridge this gap, we introduce MM-NeuroOnco, a large-scale multimodal benchmark and instruction-tuning dataset for brain tumor MRI understanding, consisting of 24,726 MRI slices from 20 data sources paired with approximately 200,000 semantically enriched multimodal instructions spanning diverse tumor subtypes and imaging modalities. To mitigate the scarcity and high cost of diagnostic semantic annotations, we develop a multi-model collaborative pipeline for automated medical information completion and quality control, enabling the generation of diagnosis-related semantics beyond mask-only annotations. Building upon this dataset, we further construct MM-NeuroOnco-Bench, a manually annotated evaluation benchmark with a rejection-aware setting to reduce biases inherent in closed-ended question formats. Evaluation across ten representative models shows that even the strongest baseline, Gemini 3 Flash, achieves only 41.88% accuracy on diagnosis-related questions, highlighting the substantial challenges of multimodal brain tumor diagnostic understanding. Leveraging MM-NeuroOnco, we further propose NeuroOnco-GPT, which achieves a 27% absolute accuracy improvement on diagnostic questions following fine-tuning. This result demonstrates the effectiveness of our dataset and benchmark in advancing clinically grounded multimodal diagnostic reasoning. Code and dataset are publicly available at: https://github.com/gfnnnb/MM-NeuroOnco

BMAM: Brain-inspired Multi-Agent Memory Framework

Language-model-based agents operating over extended interaction horizons face persistent challenges in preserving temporally grounded information and maintaining behavioral consistency across sessions, a failure mode we term soul erosion. We present BMAM (Brain-inspired Multi-Agent Memory), a general-purpose memory architecture that models agent memory as a set of functionally specialized subsystems rather than a single unstructured store. Inspired by cognitive memory systems, BMAM decomposes memory into episodic, semantic, salience-aware, and control-oriented components that operate at complementary time scales. To support long-horizon reasoning, BMAM organizes episodic memories along explicit timelines and retrieves evidence by fusing multiple complementary signals. Experiments on the LoCoMo benchmark show that BMAM achieves 78.45 percent accuracy under the standard long-horizon evaluation setting, and ablation analyses confirm that the hippocampus-inspired episodic memory subsystem plays a critical role in temporal reasoning.

MMPG: MoE-based Adaptive Multi-Perspective Graph Fusion for Protein Representation Learning

Graph Neural Networks (GNNs) have been widely adopted for Protein Representation Learning (PRL), as residue interaction networks can be naturally represented as graphs. Current GNN-based PRL methods typically rely on single-perspective graph construction strategies, which capture partial properties of residue interactions, resulting in incomplete protein representations. To address this limitation, we propose MMPG, a framework that constructs protein graphs from multiple perspectives and adaptively fuses them via Mixture of Experts (MoE) for PRL. MMPG constructs graphs from physical, chemical, and geometric perspectives to characterize different properties of residue interactions. To capture both perspective-specific features and their synergies, we develop an MoE module, which dynamically routes perspectives to specialized experts, where experts learn intrinsic features and cross-perspective interactions. We quantitatively verify that MoE automatically specializes experts in modeling distinct levels of interaction from individual representations, to pairwise inter-perspective synergies, and ultimately to a global consensus across all perspectives. Through integrating this multi-level information, MMPG produces superior protein representations and achieves advanced performance on four different downstream protein tasks.

CogniSNN: Enabling Neuron-Expandability, Pathway-Reusability, and Dynamic-Configurability with Random Graph Architectures in Spiking Neural Networks

Spiking neural networks (SNNs), regarded as the third generation of artificial neural networks, are expected to bridge the gap between artificial intelligence and computational neuroscience. However, most mainstream SNN research directly adopts the rigid, chain-like hierarchical architecture of traditional artificial neural networks (ANNs), ignoring key structural characteristics of the brain. Biological neurons are stochastically interconnected, forming complex neural pathways that exhibit Neuron-Expandability, Pathway-Reusability, and Dynamic-Configurability. In this paper, we introduce a new SNN paradigm, named Cognition-aware SNN (CogniSNN), by incorporating Random Graph Architecture (RGA). Furthermore, we address the issues of network degradation and dimensional mismatch in deep pathways by introducing an improved pure spiking residual mechanism alongside an adaptive pooling strategy. Then, we design a Key Pathway-based Learning without Forgetting (KP-LwF) approach, which selectively reuses critical neural pathways while retaining historical knowledge, enabling efficient multi-task transfer. Finally, we propose a Dynamic Growth Learning (DGL) algorithm that allows neurons and synapses to grow dynamically along the internal temporal dimension. Extensive experiments demonstrate that CogniSNN achieves performance comparable to, or even surpassing, current state-of-the-art SNNs on neuromorphic datasets and Tiny-ImageNet. The Pathway-Reusability enhances the network's continuous learning capability across different scenarios, while the dynamic growth algorithm improves robustness against interference and mitigates the fixed-timestep constraints during neuromorphic chip deployment. This work demonstrates the potential of SNNs with random graph structures in advancing brain-inspired intelligence and lays the foundation for their practical application on neuromorphic hardware.

Self-Calibrated Consistency can Fight Back for Adversarial Robustness in Vision-Language Models

Pre-trained vision-language models (VLMs) such as CLIP have demonstrated strong zero-shot capabilities across diverse domains, yet remain highly vulnerable to adversarial perturbations that disrupt image-text alignment and compromise reliability. Existing defenses typically rely on adversarial fine-tuning with labeled data, limiting their applicability in zero-shot settings. In this work, we identify two key weaknesses of current CLIP adversarial attacks -- lack of semantic guidance and vulnerability to view variations -- collectively termed semantic and viewpoint fragility. To address these challenges, we propose Self-Calibrated Consistency (SCC), an effective test-time defense. SCC consists of two complementary modules: Semantic consistency, which leverages soft pseudo-labels from counterattack warm-up and multi-view predictions to regularize cross-modal alignment and separate the target embedding from confusable negatives; and Spatial consistency, aligning perturbed visual predictions via augmented views to stabilize inference under adversarial perturbations. Together, these modules form a plug-and-play inference strategy. Extensive experiments on 22 benchmarks under diverse attack settings show that SCC consistently improves the zero-shot robustness of CLIP while maintaining accuracy, and can be seamlessly integrated with other VLMs for further gains. These findings highlight the great potential of establishing an adversarially robust paradigm from CLIP, with implications extending to broader vision-language domains such as BioMedCLIP.

Modest-Align: Data-Efficient Alignment for Vision-Language Models

Cross-modal alignment aims to map heterogeneous modalities into a shared latent space, as exemplified by models like CLIP, which benefit from large-scale image-text pretraining for strong recognition capabilities. However, when operating in resource-constrained settings with limited or low-quality data, these models often suffer from overconfidence and degraded performance due to the prevalence of ambiguous or weakly correlated image-text pairs. Current contrastive learning approaches, which rely on single positive pairs, further exacerbate this issue by reinforcing overconfidence on uncertain samples. To address these challenges, we propose Modest-Align, a lightweight alignment framework designed for robustness and efficiency. Our approach leverages two complementary strategies -- Random Perturbation, which introduces controlled noise to simulate uncertainty, and Embedding Smoothing, which calibrates similarity distributions in the embedding space. These mechanisms collectively reduce overconfidence and improve performance on noisy or weakly aligned samples. Extensive experiments across multiple benchmark datasets demonstrate that Modest-Align outperforms state-of-the-art methods in retrieval tasks, achieving competitive results with over 100x less training data and 600x less GPU time than CLIP. Our method offers a practical and scalable solution for cross-modal alignment in real-world, low-resource scenarios.

Beyond Classification Accuracy: Neural-MedBench and the Need for Deeper Reasoning Benchmarks

Recent advances in vision-language models (VLMs) have achieved remarkable performance on standard medical benchmarks, yet their true clinical reasoning ability remains unclear. Existing datasets predominantly emphasize classification accuracy, creating an evaluation illusion in which models appear proficient while still failing at high-stakes diagnostic reasoning. We introduce Neural-MedBench, a compact yet reasoning-intensive benchmark specifically designed to probe the limits of multimodal clinical reasoning in neurology. Neural-MedBench integrates multi-sequence MRI scans, structured electronic health records, and clinical notes, and encompasses three core task families: differential diagnosis, lesion recognition, and rationale generation. To ensure reliable evaluation, we develop a hybrid scoring pipeline that combines LLM-based graders, clinician validation, and semantic similarity metrics. Through systematic evaluation of state-of-the-art VLMs, including GPT-4o, Claude-4, and MedGemma, we observe a sharp performance drop compared to conventional datasets. Error analysis shows that reasoning failures, rather than perceptual errors, dominate model shortcomings. Our findings highlight the necessity of a Two-Axis Evaluation Framework: breadth-oriented large datasets for statistical generalization, and depth-oriented, compact benchmarks such as Neural-MedBench for reasoning fidelity. We release Neural-MedBench at https://neuromedbench.github.io/ as an open and extensible diagnostic testbed, which guides the expansion of future benchmarks and enables rigorous yet cost-effective assessment of clinically trustworthy AI.