Advancing Real-time Pandemic Forecasting Using Large Language Models: A COVID-19 Case Study

Forecasting the short-term spread of an ongoing disease outbreak is a formidable challenge due to the complexity of contributing factors, some of which can be characterized through interlinked, multi-modality variables such as epidemiological time series data, viral biology, population demographics, and the intersection of public policy and human behavior. Existing forecasting model frameworks struggle with the multifaceted nature of relevant data and robust results translation, which hinders their performances and the provision of actionable insights for public health decision-makers. Our work introduces PandemicLLM, a novel framework with multi-modal Large Language Models (LLMs) that reformulates real-time forecasting of disease spread as a text reasoning problem, with the ability to incorporate real-time, complex, non-numerical information that previously unattainable in traditional forecasting models. This approach, through a unique AI-human cooperative prompt design and time series representation learning, encodes multi-modal data for LLMs. The model is applied to the COVID-19 pandemic, and trained to utilize textual public health policies, genomic surveillance, spatial, and epidemiological time series data, and is subsequently tested across all 50 states of the U.S. Empirically, PandemicLLM is shown to be a high-performing pandemic forecasting framework that effectively captures the impact of emerging variants and can provide timely and accurate predictions. The proposed PandemicLLM opens avenues for incorporating various pandemic-related data in heterogeneous formats and exhibits performance benefits over existing models. This study illuminates the potential of adapting LLMs and representation learning to enhance pandemic forecasting, illustrating how AI innovations can strengthen pandemic responses and crisis management in the future.

An Optimization-Based Planner with B-spline Parameterized Continuous-Time Reference Signals

For the cascaded planning and control modules implemented for robot navigation, the frequency gap between the planner and controller has received limited attention. In this study, we introduce a novel B-spline parameterized optimization-based planner (BSPOP) designed to address the frequency gap challenge with limited onboard computational power in robots. The proposed planner generates continuous-time control inputs for low-level controllers running at arbitrary frequencies to track. Furthermore, when considering the convex control action sets, BSPOP uses the convex hull property to automatically constrain the continuous-time control inputs within the convex set. Consequently, compared with the discrete-time optimization-based planners, BSPOP reduces the number of decision variables and inequality constraints, which improves computational efficiency as a byproduct. Simulation results demonstrate that our approach can achieve a comparable planning performance to the high-frequency baseline optimization-based planners while demanding less computational power. Both simulation and experiment results show that the proposed method performs better in planning compared with baseline planners in the same frequency.

MEBS: Multi-task End-to-end Bid Shading for Multi-slot Display Advertising

Online bidding and auction are crucial aspects of the online advertising industry. Conventionally, there is only one slot for ad display and most current studies focus on it. Nowadays, multi-slot display advertising is gradually becoming popular where many ads could be displayed in a list and shown as a whole to users. However, multi-slot display advertising leads to different cost-effectiveness. Advertisers have the incentive to adjust bid prices so as to win the most economical ad positions. In this study, we introduce bid shading into multi-slot display advertising for bid price adjustment with a Multi-task End-to-end Bid Shading(MEBS) method. We prove the optimality of our method theoretically and examine its performance experimentally. Through extensive offline and online experiments, we demonstrate the effectiveness and efficiency of our method, and we obtain a 7.01% lift in Gross Merchandise Volume, a 7.42% lift in Return on Investment, and a 3.26% lift in ad buy count.

OHTA: One-shot Hand Avatar via Data-driven Implicit Priors

In this paper, we delve into the creation of one-shot hand avatars, attaining high-fidelity and drivable hand representations swiftly from a single image. With the burgeoning domains of the digital human, the need for quick and personalized hand avatar creation has become increasingly critical. Existing techniques typically require extensive input data and may prove cumbersome or even impractical in certain scenarios. To enhance accessibility, we present a novel method OHTA (One-shot Hand avaTAr) that enables the creation of detailed hand avatars from merely one image. OHTA tackles the inherent difficulties of this data-limited problem by learning and utilizing data-driven hand priors. Specifically, we design a hand prior model initially employed for 1) learning various hand priors with available data and subsequently for 2) the inversion and fitting of the target identity with prior knowledge. OHTA demonstrates the capability to create high-fidelity hand avatars with consistent animatable quality, solely relying on a single image. Furthermore, we illustrate the versatility of OHTA through diverse applications, encompassing text-to-avatar conversion, hand editing, and identity latent space manipulation.

Deciphering the lmpact of Pretraining Data on Large Language Models through Machine Unlearning

Through pretraining on a corpus with various sources, Large Language Models (LLMs) have gained impressive performance. However, the impact of each component of the pretraining corpus remains opaque. As a result, the organization of the pretraining corpus is still empirical and may deviate from the optimal. To address this issue, we systematically analyze the impact of 48 datasets from 5 major categories of pretraining data of LLMs and measure their impacts on LLMs using benchmarks about nine major categories of model capabilities. Our analyses provide empirical results about the contribution of multiple corpora on the performances of LLMs, along with their joint impact patterns, including complementary, orthogonal, and correlational relationships. We also identify a set of ``high-impact data'' such as Books that is significantly related to a set of model capabilities. These findings provide insights into the organization of data to support more efficient pretraining of LLMs.

A novel spatial-frequency domain network for zero-shot incremental learning

Zero-shot incremental learning aims to enable the model to generalize to new classes without forgetting previously learned classes. However, the semantic gap between old and new sample classes can lead to catastrophic forgetting. Additionally, existing algorithms lack capturing significant information from each sample image domain, impairing models' classification performance. Therefore, this paper proposes a novel Spatial-Frequency Domain Network (SFDNet) which contains a Spatial-Frequency Feature Extraction (SFFE) module and Attention Feature Alignment (AFA) module to improve the Zero-Shot Translation for Class Incremental algorithm. Firstly, SFFE module is designed which contains a dual attention mechanism for obtaining salient spatial-frequency feature information. Secondly, a novel feature fusion module is conducted for obtaining fused spatial-frequency domain features. Thirdly, the Nearest Class Mean classifier is utilized to select the most suitable category. Finally, iteration between tasks is performed using the Zero-Shot Translation model. The proposed SFDNet has the ability to effectively extract spatial-frequency feature representation from input images, improve the accuracy of image classification, and fundamentally alleviate catastrophic forgetting. Extensive experiments on the CUB 200-2011 and CIFAR100 datasets demonstrate that our proposed algorithm outperforms state-of-the-art incremental learning algorithms.

Federated Learning with New Knowledge: Fundamentals, Advances, and Futures

Federated Learning (FL) is a privacy-preserving distributed learning approach that is rapidly developing in an era where privacy protection is increasingly valued. It is this rapid development trend, along with the continuous emergence of new demands for FL in the real world, that prompts us to focus on a very important problem: Federated Learning with New Knowledge. The primary challenge here is to effectively incorporate various new knowledge into existing FL systems and evolve these systems to reduce costs, extend their lifespan, and facilitate sustainable development. In this paper, we systematically define the main sources of new knowledge in FL, including new features, tasks, models, and algorithms. For each source, we thoroughly analyze and discuss how to incorporate new knowledge into existing FL systems and examine the impact of the form and timing of new knowledge arrival on the incorporation process. Furthermore, we comprehensively discuss the potential future directions for FL with new knowledge, considering a variety of factors such as scenario setups, efficiency, and security. There is also a continuously updating repository for this topic: https://github.com/conditionWang/FLNK.

Audio-Infused Automatic Image Colorization by Exploiting Audio Scene Semantics

Automatic image colorization is inherently an ill-posed problem with uncertainty, which requires an accurate semantic understanding of scenes to estimate reasonable colors for grayscale images. Although recent interaction-based methods have achieved impressive performance, it is still a very difficult task to infer realistic and accurate colors for automatic colorization. To reduce the difficulty of semantic understanding of grayscale scenes, this paper tries to utilize corresponding audio, which naturally contains extra semantic information about the same scene. Specifically, a novel audio-infused automatic image colorization (AIAIC) network is proposed, which consists of three stages. First, we take color image semantics as a bridge and pretrain a colorization network guided by color image semantics. Second, the natural co-occurrence of audio and video is utilized to learn the color semantic correlations between audio and visual scenes. Third, the implicit audio semantic representation is fed into the pretrained network to finally realize the audio-guided colorization. The whole process is trained in a self-supervised manner without human annotation. In addition, an audiovisual colorization dataset is established for training and testing. Experiments demonstrate that audio guidance can effectively improve the performance of automatic colorization, especially for some scenes that are difficult to understand only from visual modality.

Empirical Evidence for the Fragment level Understanding on Drug Molecular Structure of LLMs

AI for drug discovery has been a research hotspot in recent years, and SMILES-based language models has been increasingly applied in drug molecular design. However, no work has explored whether and how language models understand the chemical spatial structure from 1D sequences. In this work, we pre-train a transformer model on chemical language and fine-tune it toward drug design objectives, and investigate the correspondence between high-frequency SMILES substrings and molecular fragments. The results indicate that language models can understand chemical structures from the perspective of molecular fragments, and the structural knowledge learned through fine-tuning is reflected in the high-frequency SMILES substrings generated by the model.

Instruct-Imagen: Image Generation with Multi-modal Instruction

This paper presents instruct-imagen, a model that tackles heterogeneous image generation tasks and generalizes across unseen tasks. We introduce *multi-modal instruction* for image generation, a task representation articulating a range of generation intents with precision. It uses natural language to amalgamate disparate modalities (e.g., text, edge, style, subject, etc.), such that abundant generation intents can be standardized in a uniform format. We then build instruct-imagen by fine-tuning a pre-trained text-to-image diffusion model with a two-stage framework. First, we adapt the model using the retrieval-augmented training, to enhance model's capabilities to ground its generation on external multimodal context. Subsequently, we fine-tune the adapted model on diverse image generation tasks that requires vision-language understanding (e.g., subject-driven generation, etc.), each paired with a multi-modal instruction encapsulating the task's essence. Human evaluation on various image generation datasets reveals that instruct-imagen matches or surpasses prior task-specific models in-domain and demonstrates promising generalization to unseen and more complex tasks.