CXR-LT 2024: A MICCAI challenge on long-tailed, multi-label, and zero-shot disease classification from chest X-ray

The CXR-LT series is a community-driven initiative designed to enhance lung disease classification using chest X-rays (CXR). It tackles challenges in open long-tailed lung disease classification and enhances the measurability of state-of-the-art techniques. The first event, CXR-LT 2023, aimed to achieve these goals by providing high-quality benchmark CXR data for model development and conducting comprehensive evaluations to identify ongoing issues impacting lung disease classification performance. Building on the success of CXR-LT 2023, the CXR-LT 2024 expands the dataset to 377,110 chest X-rays (CXRs) and 45 disease labels, including 19 new rare disease findings. It also introduces a new focus on zero-shot learning to address limitations identified in the previous event. Specifically, CXR-LT 2024 features three tasks: (i) long-tailed classification on a large, noisy test set, (ii) long-tailed classification on a manually annotated "gold standard" subset, and (iii) zero-shot generalization to five previously unseen disease findings. This paper provides an overview of CXR-LT 2024, detailing the data curation process and consolidating state-of-the-art solutions, including the use of multimodal models for rare disease detection, advanced generative approaches to handle noisy labels, and zero-shot learning strategies for unseen diseases. Additionally, the expanded dataset enhances disease coverage to better represent real-world clinical settings, offering a valuable resource for future research. By synthesizing the insights and innovations of participating teams, we aim to advance the development of clinically realistic and generalizable diagnostic models for chest radiography.

Multi-Waveguide Pinching Antennas for ISAC

Recently, a novel flexible-antenna technology, called pinching antennas, has attracted growing academic interest. By inserting discrete dielectric materials, pinching antennas can be activated at arbitrary points along waveguides, allowing for flexible customization of large-scale path loss. This paper investigates a multi-waveguide pinching-antenna integrated sensing and communications (ISAC) system, where transmit pinching antennas (TPAs) and receive pinching antennas (RPAs) coordinate to simultaneously detect one potential target and serve one downlink user. We formulate a communication rate maximization problem subject to radar signal-to-noise ratio (SNR) requirement, transmit power budget, and the allowable movement region of the TPAs, by jointly optimizing TPA locations and transmit beamforming design. To address the non-convexity of the problem, we propose a novel fine-tuning approximation method to reformulate it into a tractable form, followed by a successive convex approximation (SCA)-based algorithm to obtain the solution efficiently. Extensive simulations validate both the system design and the proposed algorithm. Results show that the proposed method achieves near-optimal performance compared with the computational-intensive exhaustive search-based benchmark, and pinching-antenna ISAC systems exhibit a distinct communication-sensing trade-off compared with conventional systems.

Progressive Data Dropout: An Embarrassingly Simple Approach to Faster Training

The success of the machine learning field has reliably depended on training on large datasets. While effective, this trend comes at an extraordinary cost. This is due to two deeply intertwined factors: the size of models and the size of datasets. While promising research efforts focus on reducing the size of models, the other half of the equation remains fairly mysterious. Indeed, it is surprising that the standard approach to training remains to iterate over and over, uniformly sampling the training dataset. In this paper we explore a series of alternative training paradigms that leverage insights from hard-data-mining and dropout, simple enough to implement and use that can become the new training standard. The proposed Progressive Data Dropout reduces the number of effective epochs to as little as 12.4% of the baseline. This savings actually do not come at any cost for accuracy. Surprisingly, the proposed method improves accuracy by up to 4.82%. Our approach requires no changes to model architecture or optimizer, and can be applied across standard training pipelines, thus posing an excellent opportunity for wide adoption. Code can be found here: https://github.com/bazyagami/LearningWithRevision

A simple estimator of the correlation kernel matrix of a determinantal point process

The Determinantal Point Process (DPP) is a parameterized model for multivariate binary variables, characterized by a correlation kernel matrix. This paper proposes a closed form estimator of this kernel, which is particularly easy to implement and can also be used as a starting value of learning algorithms for maximum likelihood estimation. We prove the consistency and asymptotic normality of our estimator, as well as its large deviation properties.

Versatile Distributed Maneuvering with Generalized Formations using Guiding Vector Fields

This paper presents a unified approach to realize versatile distributed maneuvering with generalized formations. Specifically, we decompose the robots' maneuvers into two independent components, i.e., interception and enclosing, which are parameterized by two independent virtual coordinates. Treating these two virtual coordinates as dimensions of an abstract manifold, we derive the corresponding singularity-free guiding vector field (GVF), which, along with a distributed coordination mechanism based on the consensus theory, guides robots to achieve various motions (i.e., versatile maneuvering), including (a) formation tracking, (b) target enclosing, and (c) circumnavigation. Additional motion parameters can generate more complex cooperative robot motions. Based on GVFs, we design a controller for a nonholonomic robot model. Besides the theoretical results, extensive simulations and experiments are performed to validate the effectiveness of the approach.

FATE: A Prompt-Tuning-Based Semi-Supervised Learning Framework for Extremely Limited Labeled Data

Semi-supervised learning (SSL) has achieved significant progress by leveraging both labeled data and unlabeled data. Existing SSL methods overlook a common real-world scenario when labeled data is extremely scarce, potentially as limited as a single labeled sample in the dataset. General SSL approaches struggle to train effectively from scratch under such constraints, while methods utilizing pre-trained models often fail to find an optimal balance between leveraging limited labeled data and abundant unlabeled data. To address this challenge, we propose Firstly Adapt, Then catEgorize (FATE), a novel SSL framework tailored for scenarios with extremely limited labeled data. At its core, the two-stage prompt tuning paradigm FATE exploits unlabeled data to compensate for scarce supervision signals, then transfers to downstream tasks. Concretely, FATE first adapts a pre-trained model to the feature distribution of downstream data using volumes of unlabeled samples in an unsupervised manner. It then applies an SSL method specifically designed for pre-trained models to complete the final classification task. FATE is designed to be compatible with both vision and vision-language pre-trained models. Extensive experiments demonstrate that FATE effectively mitigates challenges arising from the scarcity of labeled samples in SSL, achieving an average performance improvement of 33.74% across seven benchmarks compared to state-of-the-art SSL methods. Code is available at https://anonymous.4open.science/r/Semi-supervised-learning-BA72.

PathOrchestra: A Comprehensive Foundation Model for Computational Pathology with Over 100 Diverse Clinical-Grade Tasks

The complexity and variability inherent in high-resolution pathological images present significant challenges in computational pathology. While pathology foundation models leveraging AI have catalyzed transformative advancements, their development demands large-scale datasets, considerable storage capacity, and substantial computational resources. Furthermore, ensuring their clinical applicability and generalizability requires rigorous validation across a broad spectrum of clinical tasks. Here, we present PathOrchestra, a versatile pathology foundation model trained via self-supervised learning on a dataset comprising 300K pathological slides from 20 tissue and organ types across multiple centers. The model was rigorously evaluated on 112 clinical tasks using a combination of 61 private and 51 public datasets. These tasks encompass digital slide preprocessing, pan-cancer classification, lesion identification, multi-cancer subtype classification, biomarker assessment, gene expression prediction, and the generation of structured reports. PathOrchestra demonstrated exceptional performance across 27,755 WSIs and 9,415,729 ROIs, achieving over 0.950 accuracy in 47 tasks, including pan-cancer classification across various organs, lymphoma subtype diagnosis, and bladder cancer screening. Notably, it is the first model to generate structured reports for high-incidence colorectal cancer and diagnostically complex lymphoma-areas that are infrequently addressed by foundational models but hold immense clinical potential. Overall, PathOrchestra exemplifies the feasibility and efficacy of a large-scale, self-supervised pathology foundation model, validated across a broad range of clinical-grade tasks. Its high accuracy and reduced reliance on extensive data annotation underline its potential for clinical integration, offering a pathway toward more efficient and high-quality medical services.

Synthesizing Public Opinions with LLMs: Role Creation, Impacts, and the Future to eDemorcacy

This paper investigates the use of Large Language Models (LLMs) to synthesize public opinion data, addressing challenges in traditional survey methods like declining response rates and non-response bias. We introduce a novel technique: role creation based on knowledge injection, a form of in-context learning that leverages RAG and specified personality profiles from the HEXACO model and demographic information, and uses that for dynamically generated prompts. This method allows LLMs to simulate diverse opinions more accurately than existing prompt engineering approaches. We compare our results with pre-trained models with standard few-shot prompts. Experiments using questions from the Cooperative Election Study (CES) demonstrate that our role-creation approach significantly improves the alignment of LLM-generated opinions with real-world human survey responses, increasing answer adherence. In addition, we discuss challenges, limitations and future research directions.

Mind the Gap: Confidence Discrepancy Can Guide Federated Semi-Supervised Learning Across Pseudo-Mismatch

Federated Semi-Supervised Learning (FSSL) aims to leverage unlabeled data across clients with limited labeled data to train a global model with strong generalization ability. Most FSSL methods rely on consistency regularization with pseudo-labels, converting predictions from local or global models into hard pseudo-labels as supervisory signals. However, we discover that the quality of pseudo-label is largely deteriorated by data heterogeneity, an intrinsic facet of federated learning. In this paper, we study the problem of FSSL in-depth and show that (1) heterogeneity exacerbates pseudo-label mismatches, further degrading model performance and convergence, and (2) local and global models' predictive tendencies diverge as heterogeneity increases. Motivated by these findings, we propose a simple and effective method called Semi-supervised Aggregation for Globally-Enhanced Ensemble (SAGE), that can flexibly correct pseudo-labels based on confidence discrepancies. This strategy effectively mitigates performance degradation caused by incorrect pseudo-labels and enhances consensus between local and global models. Experimental results demonstrate that SAGE outperforms existing FSSL methods in both performance and convergence. Our code is available at https://github.com/Jay-Codeman/SAGE

Classifying Long-tailed and Label-noise Data via Disentangling and Unlearning

In real-world datasets, the challenges of long-tailed distributions and noisy labels often coexist, posing obstacles to the model training and performance. Existing studies on long-tailed noisy label learning (LTNLL) typically assume that the generation of noisy labels is independent of the long-tailed distribution, which may not be true from a practical perspective. In real-world situaiton, we observe that the tail class samples are more likely to be mislabeled as head, exacerbating the original degree of imbalance. We call this phenomenon as ``tail-to-head (T2H)'' noise. T2H noise severely degrades model performance by polluting the head classes and forcing the model to learn the tail samples as head. To address this challenge, we investigate the dynamic misleading process of the nosiy labels and propose a novel method called Disentangling and Unlearning for Long-tailed and Label-noisy data (DULL). It first employs the Inner-Feature Disentangling (IFD) to disentangle feature internally. Based on this, the Inner-Feature Partial Unlearning (IFPU) is then applied to weaken and unlearn incorrect feature regions correlated to wrong classes. This method prevents the model from being misled by noisy labels, enhancing the model's robustness against noise. To provide a controlled experimental environment, we further propose a new noise addition algorithm to simulate T2H noise. Extensive experiments on both simulated and real-world datasets demonstrate the effectiveness of our proposed method.