Hierarchical-level rain image generative model based on GAN

Autonomous vehicles are exposed to various weather during operation, which is likely to trigger the performance limitations of the perception system, leading to the safety of the intended functionality (SOTIF) problems. To efficiently generate data for testing the performance of visual perception algorithms under various weather conditions, a hierarchical-level rain image generative model, rain conditional CycleGAN (RCCycleGAN), is constructed. RCCycleGAN is based on the generative adversarial network (GAN) and can generate images of light, medium, and heavy rain. Different rain intensities are introduced as labels in conditional GAN (CGAN). Meanwhile, the model structure is optimized and the training strategy is adjusted to alleviate the problem of mode collapse. In addition, natural rain images of different intensities are collected and processed for model training and validation. Compared with the two baseline models, CycleGAN and DerainCycleGAN, the peak signal-to-noise ratio (PSNR) of RCCycleGAN on the test dataset is improved by 2.58 dB and 0.74 dB, and the structural similarity (SSIM) is improved by 18% and 8%, respectively. The ablation experiments are also carried out to validate the effectiveness of the model tuning.

A Surface-Based Federated Chow Test Model for Integrating APOE Status, Tau Deposition Measure, and Hippocampal Surface Morphometry

Background: Alzheimer's Disease (AD) is the most common type of age-related dementia, affecting 6.2 million people aged 65 or older according to CDC data. It is commonly agreed that discovering an effective AD diagnosis biomarker could have enormous public health benefits, potentially preventing or delaying up to 40% of dementia cases. Tau neurofibrillary tangles are the primary driver of downstream neurodegeneration and subsequent cognitive impairment in AD, resulting in structural deformations such as hippocampal atrophy that can be observed in magnetic resonance imaging (MRI) scans. Objective: To build a surface-based model to 1) detect differences between APOE subgroups in patterns of tau deposition and hippocampal atrophy, and 2) use the extracted surface-based features to predict cognitive decline. Methods: Using data obtained from different institutions, we develop a surface-based federated Chow test model to study the synergistic effects of APOE, a previously reported significant risk factor of AD, and tau on hippocampal surface morphometry. Results: We illustrate that the APOE-specific morphometry features correlate with AD progression and better predict future AD conversion than other MRI biomarkers. For example, a strong association between atrophy and abnormal tau was identified in hippocampal subregion cornu ammonis 1 (CA1 subfield) and subiculum in e4 homozygote cohort. Conclusion: Our model allows for identifying MRI biomarkers for AD and cognitive decline prediction and may uncover a corner of the neural mechanism of the influence of APOE and tau deposition on hippocampal morphology.

Relation-dependent Contrastive Learning with Cluster Sampling for Inductive Relation Prediction

Relation prediction is a task designed for knowledge graph completion which aims to predict missing relationships between entities. Recent subgraph-based models for inductive relation prediction have received increasing attention, which can predict relation for unseen entities based on the extracted subgraph surrounding the candidate triplet. However, they are not completely inductive because of their disability of predicting unseen relations. Moreover, they fail to pay sufficient attention to the role of relation as they only depend on the model to learn parameterized relation embedding, which leads to inaccurate prediction on long-tail relations. In this paper, we introduce Relation-dependent Contrastive Learning (ReCoLe) for inductive relation prediction, which adapts contrastive learning with a novel sampling method based on clustering algorithm to enhance the role of relation and improve the generalization ability to unseen relations. Instead of directly learning embedding for relations, ReCoLe allocates a pre-trained GNN-based encoder to each relation to strengthen the influence of relation. The GNN-based encoder is optimized by contrastive learning, which ensures satisfactory performance on long-tail relations. In addition, the cluster sampling method equips ReCoLe with the ability to handle both unseen relations and entities. Experimental results suggest that ReCoLe outperforms state-of-the-art methods on commonly used inductive datasets.

Improved Prediction of Beta-Amyloid and Tau Burden Using Hippocampal Surface Multivariate Morphometry Statistics and Sparse Coding

Background: Beta-amyloid (A$\beta$) plaques and tau protein tangles in the brain are the defining 'A' and 'T' hallmarks of Alzheimer's disease (AD), and together with structural atrophy detectable on brain magnetic resonance imaging (MRI) scans as one of the neurodegenerative ('N') biomarkers comprise the ''ATN framework'' of AD. Current methods to detect A$\beta$/tau pathology include cerebrospinal fluid (CSF; invasive), positron emission tomography (PET; costly and not widely available), and blood-based biomarkers (BBBM; promising but mainly still in development). Objective: To develop a non-invasive and widely available structural MRI-based framework to quantitatively predict the amyloid and tau measurements. Methods: With MRI-based hippocampal multivariate morphometry statistics (MMS) features, we apply our Patch Analysis-based Surface Correntropy-induced Sparse coding and max-pooling (PASCS-MP) method combined with the ridge regression model to individual amyloid/tau measure prediction. Results: We evaluate our framework on amyloid PET/MRI and tau PET/MRI datasets from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Each subject has one pair consisting of a PET image and MRI scan, collected at about the same time. Experimental results suggest that amyloid/tau measurements predicted with our PASCP-MP representations are closer to the real values than the measures derived from other approaches, such as hippocampal surface area, volume, and shape morphometry features based on spherical harmonics (SPHARM). Conclusion: The MMS-based PASCP-MP is an efficient tool that can bridge hippocampal atrophy with amyloid and tau pathology and thus help assess disease burden, progression, and treatment effects.

Predicting Tau Accumulation in Cerebral Cortex with Multivariate MRI Morphometry Measurements, Sparse Coding, and Correntropy

Biomarker-assisted diagnosis and intervention in Alzheimer's disease (AD) may be the key to prevention breakthroughs. One of the hallmarks of AD is the accumulation of tau plaques in the human brain. However, current methods to detect tau pathology are either invasive (lumbar puncture) or quite costly and not widely available (Tau PET). In our previous work, structural MRI-based hippocampal multivariate morphometry statistics (MMS) showed superior performance as an effective neurodegenerative biomarker for preclinical AD and Patch Analysis-based Surface Correntropy-induced Sparse coding and max-pooling (PASCS-MP) has excellent ability to generate low-dimensional representations with strong statistical power for brain amyloid prediction. In this work, we apply this framework together with ridge regression models to predict Tau deposition in Braak12 and Braak34 brain regions separately. We evaluate our framework on 925 subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Each subject has one pair consisting of a PET image and MRI scan which were collected at about the same times. Experimental results suggest that the representations from our MMS and PASCS-MP have stronger predictive power and their predicted Braak12 and Braak34 are closer to the real values compared to the measures derived from other approaches such as hippocampal surface area and volume, and shape morphometry features based on spherical harmonics (SPHARM).

Graph Capsule Aggregation for Unaligned Multimodal Sequences

Humans express their opinions and emotions through multiple modalities which mainly consist of textual, acoustic and visual modalities. Prior works on multimodal sentiment analysis mostly apply Recurrent Neural Network (RNN) to model aligned multimodal sequences. However, it is unpractical to align multimodal sequences due to different sample rates for different modalities. Moreover, RNN is prone to the issues of gradient vanishing or exploding and it has limited capacity of learning long-range dependency which is the major obstacle to model unaligned multimodal sequences. In this paper, we introduce Graph Capsule Aggregation (GraphCAGE) to model unaligned multimodal sequences with graph-based neural model and Capsule Network. By converting sequence data into graph, the previously mentioned problems of RNN are avoided. In addition, the aggregation capability of Capsule Network and the graph-based structure enable our model to be interpretable and better solve the problem of long-range dependency. Experimental results suggest that GraphCAGE achieves state-of-the-art performance on two benchmark datasets with representations refined by Capsule Network and interpretation provided.

Developing Univariate Neurodegeneration Biomarkers with Low-Rank and Sparse Subspace Decomposition

Cognitive decline due to Alzheimer's disease (AD) is closely associated with brain structure alterations captured by structural magnetic resonance imaging (sMRI). It supports the validity to develop sMRI-based univariate neurodegeneration biomarkers (UNB). However, existing UNB work either fails to model large group variances or does not capture AD dementia (ADD) induced changes. We propose a novel low-rank and sparse subspace decomposition method capable of stably quantifying the morphological changes induced by ADD. Specifically, we propose a numerically efficient rank minimization mechanism to extract group common structure and impose regularization constraints to encode the original 3D morphometry connectivity. Further, we generate regions-of-interest (ROI) with group difference study between common subspaces of $A\beta+$ AD and $A\beta-$ cognitively unimpaired (CU) groups. A univariate morphometry index (UMI) is constructed from these ROIs by summarizing individual morphological characteristics weighted by normalized difference between $A\beta+$ AD and $A\beta-$ CU groups. We use hippocampal surface radial distance feature to compute the UMIs and validate our work in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. With hippocampal UMIs, the estimated minimum sample sizes needed to detect a 25$\%$ reduction in the mean annual change with 80$\%$ power and two-tailed $P=0.05$ are 116, 279 and 387 for the longitudinal $A\beta+$ AD, $A\beta+$ mild cognitive impairment (MCI) and $A\beta+$ CU groups, respectively. Additionally, for MCI patients, UMIs well correlate with hazard ratio of conversion to AD ($4.3$, $95\%$ CI=$2.3-8.2$) within 18 months. Our experimental results outperform traditional hippocampal volume measures and suggest the application of UMI as a potential UNB.