Image Reconstruction with B0 Inhomogeneity using an Interpretable Deep Unrolled Network on an Open-bore MRI-Linac

MRI-Linac systems require fast image reconstruction with high geometric fidelity to localize and track tumours for radiotherapy treatments. However, B0 field inhomogeneity distortions and slow MR acquisition potentially limit the quality of the image guidance and tumour treatments. In this study, we develop an interpretable unrolled network, referred to as RebinNet, to reconstruct distortion-free images from B0 inhomogeneity-corrupted k-space for fast MRI-guided radiotherapy applications. RebinNet includes convolutional neural network (CNN) blocks to perform image regularizations and nonuniform fast Fourier Transform (NUFFT) modules to incorporate B0 inhomogeneity information. The RebinNet was trained on a publicly available MR dataset from eleven healthy volunteers for both fully sampled and subsampled acquisitions. Grid phantom and human brain images acquired from an open-bore 1T MRI-Linac scanner were used to evaluate the performance of the proposed network. The RebinNet was compared with the conventional regularization algorithm and our recently developed UnUNet method in terms of root mean squared error (RMSE), structural similarity (SSIM), residual distortions, and computation time. Imaging results demonstrated that the RebinNet reconstructed images with lowest RMSE (<0.05) and highest SSIM (>0.92) at four-time acceleration for simulated brain images. The RebinNet could better preserve structural details and substantially improve the computational efficiency (ten-fold faster) compared to the conventional regularization methods, and had better generalization ability than the UnUNet method. The proposed RebinNet can achieve rapid image reconstruction and overcome the B0 inhomogeneity distortions simultaneously, which would facilitate accurate and fast image guidance in radiotherapy treatments.

Impact of Preference Noise on the Alignment Performance of Generative Language Models

A key requirement in developing Generative Language Models (GLMs) is to have their values aligned with human values. Preference-based alignment is a widely used paradigm for this purpose, in which preferences over generation pairs are first elicited from human annotators or AI systems, and then fed into some alignment techniques, e.g., Direct Preference Optimization. However, a substantial percent (20 - 40%) of the preference pairs used in GLM alignment are noisy, and it remains unclear how the noise affects the alignment performance and how to mitigate its negative impact. In this paper, we propose a framework to inject desirable amounts and types of noise to the preferences, and systematically study the impact of preference noise on the alignment performance in two tasks (summarization and dialogue generation). We find that the alignment performance can be highly sensitive to the noise rates in the preference data: e.g., a 10 percentage points (pp) increase of the noise rate can lead to 30 pp drop in the alignment performance (in win rate). To mitigate the impact of noise, confidence-based data filtering shows significant benefit when certain types of noise are present. We hope our work can help the community better understand and mitigate the impact of preference noise in GLM alignment.

Constructing and Exploring Intermediate Domains in Mixed Domain Semi-supervised Medical Image Segmentation

Both limited annotation and domain shift are prevalent challenges in medical image segmentation. Traditional semi-supervised segmentation and unsupervised domain adaptation methods address one of these issues separately. However, the coexistence of limited annotation and domain shift is quite common, which motivates us to introduce a novel and challenging scenario: Mixed Domain Semi-supervised medical image Segmentation (MiDSS). In this scenario, we handle data from multiple medical centers, with limited annotations available for a single domain and a large amount of unlabeled data from multiple domains. We found that the key to solving the problem lies in how to generate reliable pseudo labels for the unlabeled data in the presence of domain shift with labeled data. To tackle this issue, we employ Unified Copy-Paste (UCP) between images to construct intermediate domains, facilitating the knowledge transfer from the domain of labeled data to the domains of unlabeled data. To fully utilize the information within the intermediate domain, we propose a symmetric Guidance training strategy (SymGD), which additionally offers direct guidance to unlabeled data by merging pseudo labels from intermediate samples. Subsequently, we introduce a Training Process aware Random Amplitude MixUp (TP-RAM) to progressively incorporate style-transition components into intermediate samples. Compared with existing state-of-the-art approaches, our method achieves a notable 13.57% improvement in Dice score on Prostate dataset, as demonstrated on three public datasets. Our code is available at https://github.com/MQinghe/MiDSS .

ONNXPruner: ONNX-Based General Model Pruning Adapter

Recent advancements in model pruning have focused on developing new algorithms and improving upon benchmarks. However, the practical application of these algorithms across various models and platforms remains a significant challenge. To address this challenge, we propose ONNXPruner, a versatile pruning adapter designed for the ONNX format models. ONNXPruner streamlines the adaptation process across diverse deep learning frameworks and hardware platforms. A novel aspect of ONNXPruner is its use of node association trees, which automatically adapt to various model architectures. These trees clarify the structural relationships between nodes, guiding the pruning process, particularly highlighting the impact on interconnected nodes. Furthermore, we introduce a tree-level evaluation method. By leveraging node association trees, this method allows for a comprehensive analysis beyond traditional single-node evaluations, enhancing pruning performance without the need for extra operations. Experiments across multiple models and datasets confirm ONNXPruner's strong adaptability and increased efficacy. Our work aims to advance the practical application of model pruning.

InternLM-XComposer2-4KHD: A Pioneering Large Vision-Language Model Handling Resolutions from 336 Pixels to 4K HD

The Large Vision-Language Model (LVLM) field has seen significant advancements, yet its progression has been hindered by challenges in comprehending fine-grained visual content due to limited resolution. Recent efforts have aimed to enhance the high-resolution understanding capabilities of LVLMs, yet they remain capped at approximately 1500 x 1500 pixels and constrained to a relatively narrow resolution range. This paper represents InternLM-XComposer2-4KHD, a groundbreaking exploration into elevating LVLM resolution capabilities up to 4K HD (3840 x 1600) and beyond. Concurrently, considering the ultra-high resolution may not be necessary in all scenarios, it supports a wide range of diverse resolutions from 336 pixels to 4K standard, significantly broadening its scope of applicability. Specifically, this research advances the patch division paradigm by introducing a novel extension: dynamic resolution with automatic patch configuration. It maintains the training image aspect ratios while automatically varying patch counts and configuring layouts based on a pre-trained Vision Transformer (ViT) (336 x 336), leading to dynamic training resolution from 336 pixels to 4K standard. Our research demonstrates that scaling training resolution up to 4K HD leads to consistent performance enhancements without hitting the ceiling of potential improvements. InternLM-XComposer2-4KHD shows superb capability that matches or even surpasses GPT-4V and Gemini Pro in 10 of the 16 benchmarks. The InternLM-XComposer2-4KHD model series with 7B parameters are publicly available at https://github.com/InternLM/InternLM-XComposer.

Best-of-Venom: Attacking RLHF by Injecting Poisoned Preference Data

Reinforcement Learning from Human Feedback (RLHF) is a popular method for aligning Language Models (LM) with human values and preferences. RLHF requires a large number of preference pairs as training data, which are often used in both the Supervised Fine-Tuning and Reward Model training, and therefore publicly available datasets are commonly used. In this work, we study to what extent a malicious actor can manipulate the LMs generations by poisoning the preferences, i.e., injecting poisonous preference pairs into these datasets and the RLHF training process. We propose strategies to build poisonous preference pairs and test their performance by poisoning two widely used preference datasets. Our results show that preference poisoning is highly effective: by injecting a small amount of poisonous data (1-5% of the original dataset), we can effectively manipulate the LM to generate a target entity in a target sentiment (positive or negative). The findings from our experiments also shed light on strategies to defend against the preference poisoning attack.

Exploiting Inter-sample and Inter-feature Relations in Dataset Distillation

Dataset distillation has emerged as a promising approach in deep learning, enabling efficient training with small synthetic datasets derived from larger real ones. Particularly, distribution matching-based distillation methods attract attention thanks to its effectiveness and low computational cost. However, these methods face two primary limitations: the dispersed feature distribution within the same class in synthetic datasets, reducing class discrimination, and an exclusive focus on mean feature consistency, lacking precision and comprehensiveness. To address these challenges, we introduce two novel constraints: a class centralization constraint and a covariance matching constraint. The class centralization constraint aims to enhance class discrimination by more closely clustering samples within classes. The covariance matching constraint seeks to achieve more accurate feature distribution matching between real and synthetic datasets through local feature covariance matrices, particularly beneficial when sample sizes are much smaller than the number of features. Experiments demonstrate notable improvements with these constraints, yielding performance boosts of up to 6.6% on CIFAR10, 2.9% on SVHN, 2.5% on CIFAR100, and 2.5% on TinyImageNet, compared to the state-of-the-art relevant methods. In addition, our method maintains robust performance in cross-architecture settings, with a maximum performance drop of 1.7% on four architectures. Code is available at https://github.com/VincenDen/IID.

InternLM2 Technical Report

The evolution of Large Language Models (LLMs) like ChatGPT and GPT-4 has sparked discussions on the advent of Artificial General Intelligence (AGI). However, replicating such advancements in open-source models has been challenging. This paper introduces InternLM2, an open-source LLM that outperforms its predecessors in comprehensive evaluations across 6 dimensions and 30 benchmarks, long-context modeling, and open-ended subjective evaluations through innovative pre-training and optimization techniques. The pre-training process of InternLM2 is meticulously detailed, highlighting the preparation of diverse data types including text, code, and long-context data. InternLM2 efficiently captures long-term dependencies, initially trained on 4k tokens before advancing to 32k tokens in pre-training and fine-tuning stages, exhibiting remarkable performance on the 200k ``Needle-in-a-Haystack" test. InternLM2 is further aligned using Supervised Fine-Tuning (SFT) and a novel Conditional Online Reinforcement Learning from Human Feedback (COOL RLHF) strategy that addresses conflicting human preferences and reward hacking. By releasing InternLM2 models in different training stages and model sizes, we provide the community with insights into the model's evolution.

MQE: Unleashing the Power of Interaction with Multi-agent Quadruped Environment

The advent of deep reinforcement learning (DRL) has significantly advanced the field of robotics, particularly in the control and coordination of quadruped robots. However, the complexity of real-world tasks often necessitates the deployment of multi-robot systems capable of sophisticated interaction and collaboration. To address this need, we introduce the Multi-agent Quadruped Environment (MQE), a novel platform designed to facilitate the development and evaluation of multi-agent reinforcement learning (MARL) algorithms in realistic and dynamic scenarios. MQE emphasizes complex interactions between robots and objects, hierarchical policy structures, and challenging evaluation scenarios that reflect real-world applications. We present a series of collaborative and competitive tasks within MQE, ranging from simple coordination to complex adversarial interactions, and benchmark state-of-the-art MARL algorithms. Our findings indicate that hierarchical reinforcement learning can simplify task learning, but also highlight the need for advanced algorithms capable of handling the intricate dynamics of multi-agent interactions. MQE serves as a stepping stone towards bridging the gap between simulation and practical deployment, offering a rich environment for future research in multi-agent systems and robot learning. For open-sourced code and more details of MQE, please refer to https://ziyanx02.github.io/multiagent-quadruped-environment/ .

QSMDiff: Unsupervised 3D Diffusion Models for Quantitative Susceptibility Mapping

Quantitative Susceptibility Mapping (QSM) dipole inversion is an ill-posed inverse problem for quantifying magnetic susceptibility distributions from MRI tissue phases. While supervised deep learning methods have shown success in specific QSM tasks, their generalizability across different acquisition scenarios remains constrained. Recent developments in diffusion models have demonstrated potential for solving 2D medical imaging inverse problems. However, their application to 3D modalities, such as QSM, remains challenging due to high computational demands. In this work, we developed a 3D image patch-based diffusion model, namely QSMDiff, for robust QSM reconstruction across different scan parameters, alongside simultaneous super-resolution and image-denoising tasks. QSMDiff adopts unsupervised 3D image patch training and full-size measurement guidance during inference for controlled image generation. Evaluation on simulated and in-vivo human brains, using gradient-echo and echo-planar imaging sequences across different acquisition parameters, demonstrates superior performance. The method proposed in QSMDiff also holds promise for impacting other 3D medical imaging applications beyond QSM.