Enabling Ultra-Fast Cardiovascular Imaging Across Heterogeneous Clinical Environments with a Generalist Foundation Model and Multimodal Database

Multimodal cardiovascular magnetic resonance (CMR) imaging provides comprehensive and non-invasive insights into cardiovascular disease (CVD) diagnosis and underlying mechanisms. Despite decades of advancements, its widespread clinical adoption remains constrained by prolonged scan times and heterogeneity across medical environments. This underscores the urgent need for a generalist reconstruction foundation model for ultra-fast CMR imaging, one capable of adapting across diverse imaging scenarios and serving as the essential substrate for all downstream analyses. To enable this goal, we curate MMCMR-427K, the largest and most comprehensive multimodal CMR k-space database to date, comprising 427,465 multi-coil k-space data paired with structured metadata across 13 international centers, 12 CMR modalities, 15 scanners, and 17 CVD categories in populations across three continents. Building on this unprecedented resource, we introduce CardioMM, a generalist reconstruction foundation model capable of dynamically adapting to heterogeneous fast CMR imaging scenarios. CardioMM unifies semantic contextual understanding with physics-informed data consistency to deliver robust reconstructions across varied scanners, protocols, and patient presentations. Comprehensive evaluations demonstrate that CardioMM achieves state-of-the-art performance in the internal centers and exhibits strong zero-shot generalization to unseen external settings. Even at imaging acceleration up to 24x, CardioMM reliably preserves key cardiac phenotypes, quantitative myocardial biomarkers, and diagnostic image quality, enabling a substantial increase in CMR examination throughput without compromising clinical integrity. Together, our open-access MMCMR-427K database and CardioMM framework establish a scalable pathway toward high-throughput, high-quality, and clinically accessible cardiovascular imaging.

Kling-Omni Technical Report

We present Kling-Omni, a generalist generative framework designed to synthesize high-fidelity videos directly from multimodal visual language inputs. Adopting an end-to-end perspective, Kling-Omni bridges the functional separation among diverse video generation, editing, and intelligent reasoning tasks, integrating them into a holistic system. Unlike disjointed pipeline approaches, Kling-Omni supports a diverse range of user inputs, including text instructions, reference images, and video contexts, processing them into a unified multimodal representation to deliver cinematic-quality and highly-intelligent video content creation. To support these capabilities, we constructed a comprehensive data system that serves as the foundation for multimodal video creation. The framework is further empowered by efficient large-scale pre-training strategies and infrastructure optimizations for inference. Comprehensive evaluations reveal that Kling-Omni demonstrates exceptional capabilities in in-context generation, reasoning-based editing, and multimodal instruction following. Moving beyond a content creation tool, we believe Kling-Omni is a pivotal advancement toward multimodal world simulators capable of perceiving, reasoning, generating and interacting with the dynamic and complex worlds.

CogniEdit: Dense Gradient Flow Optimization for Fine-Grained Image Editing

Instruction-based image editing with diffusion models has achieved impressive results, yet existing methods struggle with fine-grained instructions specifying precise attributes such as colors, positions, and quantities. While recent approaches employ Group Relative Policy Optimization (GRPO) for alignment, they optimize only at individual sampling steps, providing sparse feedback that limits trajectory-level control. We propose a unified framework CogniEdit, combining multi-modal reasoning with dense reward optimization that propagates gradients across consecutive denoising steps, enabling trajectory-level gradient flow through the sampling process. Our method comprises three components: (1) Multi-modal Large Language Models for decomposing complex instructions into actionable directives, (2) Dynamic Token Focus Relocation that adaptively emphasizes fine-grained attributes, and (3) Dense GRPO-based optimization that propagates gradients across consecutive steps for trajectory-level supervision. Extensive experiments on benchmark datasets demonstrate that our CogniEdit achieves state-of-the-art performance in balancing fine-grained instruction following with visual quality and editability preservation

COMPARE: Clinical Optimization with Modular Planning and Assessment via RAG-Enhanced AI-OCT: Superior Decision Support for Percutaneous Coronary Intervention Compared to ChatGPT-5 and Junior Operators

Background: While intravascular imaging, particularly optical coherence tomography (OCT), improves percutaneous coronary intervention (PCI) outcomes, its interpretation is operator-dependent. General-purpose artificial intelligence (AI) shows promise but lacks domain-specific reliability. We evaluated the performance of CA-GPT, a novel large model deployed on an AI-OCT system, against that of the general-purpose ChatGPT-5 and junior physicians for OCT-guided PCI planning and assessment. Methods: In this single-center analysis of 96 patients who underwent OCT-guided PCI, the procedural decisions generated by the CA-GPT, ChatGPT-5, and junior physicians were compared with an expert-derived procedural record. Agreement was assessed using ten pre-specified metrics across pre-PCI and post-PCI phases. Results: For pre-PCI planning, CA-GPT demonstrated significantly higher median agreement scores (5[IQR 3.75-5]) compared to both ChatGPT-5 (3[2-4], P<0.001) and junior physicians (4[3-4], P<0.001). CA-GPT significantly outperformed ChatGPT-5 across all individual pre-PCI metrics and showed superior performance to junior physicians in stent diameter (90.3% vs. 72.2%, P<0.05) and length selection (80.6% vs. 52.8%, P<0.01). In post-PCI assessment, CA-GPT maintained excellent overall agreement (5[4.75-5]), significantly higher than both ChatGPT-5 (4[4-5], P<0.001) and junior physicians (5[4-5], P<0.05). Subgroup analysis confirmed CA-GPT's robust performance advantage in complex scenarios. Conclusion: The CA-GPT-based AI-OCT system achieved superior decision-making agreement versus a general-purpose large language model and junior physicians across both PCI planning and assessment phases. This approach provides a standardized and reliable method for intravascular imaging interpretation, demonstrating significant potential to augment operator expertise and optimize OCT-guided PCI.

IPR-1: Interactive Physical Reasoner

Humans learn by observing, interacting with environments, and internalizing physics and causality. Here, we aim to ask whether an agent can similarly acquire human-like reasoning from interaction and keep improving with more experience. We study this in a Game-to-Unseen (G2U) setting, curating 1,000+ heterogeneous games with diverse physical and causal mechanisms, and evaluate at three human-like levels: Survival, Curiosity, Utility, from primitive intuition to goal-driven reasoning. Our analysis reveals complementary failures: VLM/VLA agents reason but lack look-ahead in interactive settings, while world models imagine but imitate visual patterns rather than analyze physics and causality. We therefore propose IPR (Interactive Physical Reasoner), using world-model rollouts to score and reinforce a VLM's policy, and introduce PhysCode, a physics-centric action code aligning semantic intent with dynamics to provide a shared action space for prediction and reasoning. Pretrained on 1,000+ games, our IPR performs robustly on three levels, matches GPT-5 overall, and surpasses it on Curiosity. We find that performance improves with more training games and interaction steps, and that the model also zero-shot transfers to unseen games. These results support physics-centric interaction as a path to steadily improving physical reasoning.

A Novel Multi-Reference-Point Modeling Framework for Monostatic Background Channel: Toward 3GPP ISAC Standardization

Integrated Sensing and Communication (ISAC) has been identified as a key 6G application by ITU and 3GPP. A realistic, standard-compatible channel model is essential for ISAC system design. To characterize the impact of Sensing Targets (STs), 3GPP defines ISAC channel as a combination of target and background channels, comprising multipath components related to STs and those originating solely from the environment, respectively. Although the background channel does not carry direct ST information, its accurate modeling is critical for evaluating sensing performance, especially in complex environments. Existing communication standards characterize propagation between separated transmitter (Tx) and receiver (Rx). However, modeling background channels in the ISAC monostatic mode, where the Tx and Rx are co-located, remains a pressing challenge. In this paper, we firstly conduct ISAC monostatic background channel measurements for an indoor scenario at 28 GHz. Realistic channel parameters are extracted, revealing pronounced single-hop propagation and discrete multipath distribution. Inspired by these properties, a novel stochastic model is proposed to characterizing the ISAC monostatic background channel as the superposition of sub-channels between the monostatic Tx&Rx and multiple communication Rx-like Reference Points (RPs). This model is compatible with standardizations, and a 3GPP-extended implementation framework is introduced. Finally, a genetic algorithm-based method is proposed to extract the optimal number and placement of multi-RPs. The optimization approach and modeling framework are validated by comparing measured and simulated channel parameters. Results demonstrate that the proposed model effectively captures monostatic background channel characteristics, addresses a critical gap in ISAC channel modeling, and supports 6G standardization.

Centrum: Model-based Database Auto-tuning with Minimal Distributional Assumptions

Gaussian-Process-based Bayesian optimization (GP-BO), is a prevailing model-based framework for DBMS auto-tuning. However, recent work shows GP-BO-based DBMS auto-tuners significantly outperformed auto-tuners based on SMAC, which features random forest surrogate models; such results motivate us to rethink and investigate the limitations of GP-BO in auto-tuner design. We find the fundamental assumptions of GP-BO are widely violated when modeling and optimizing DBMS performance, while tree-ensemble-BOs (e.g., SMAC) can avoid the assumption pitfalls and deliver improved tuning efficiency and effectiveness. Moreover, we argue that existing tree-ensemble-BOs restrict further advancement in DBMS auto-tuning. First, existing tree-ensemble-BOs can only achieve distribution-free point estimates, but still impose unrealistic distributional assumptions on uncertainty estimates, compromising surrogate modeling and distort the acquisition function. Second, recent advances in gradient boosting, which can further enhance surrogate modeling against vanilla GP and random forest counterparts, have rarely been applied in optimizing DBMS auto-tuners. To address these issues, we propose a novel model-based DBMS auto-tuner, Centrum. Centrum improves distribution-free point and interval estimation in surrogate modeling with a two-phase learning procedure of stochastic gradient boosting ensembles. Moreover, Centrum adopts a generalized SGBE-estimated locally-adaptive conformal prediction to facilitate a distribution-free uncertainty estimation and acquisition function. To our knowledge, Centrum is the first auto-tuner to realize distribution-freeness, enhancing BO's practicality in DBMS auto-tuning, and the first to seamlessly fuse gradient boosting ensembles and conformal inference in BO. Extensive physical and simulation experiments on two DBMSs and three workloads show Centrum outperforms 21 SOTA methods.

GTCN-G: A Residual Graph-Temporal Fusion Network for Imbalanced Intrusion Detection (Preprint)

The escalating complexity of network threats and the inherent class imbalance in traffic data present formidable challenges for modern Intrusion Detection Systems (IDS). While Graph Neural Networks (GNNs) excel in modeling topological structures and Temporal Convolutional Networks (TCNs) are proficient in capturing time-series dependencies, a framework that synergistically integrates both while explicitly addressing data imbalance remains an open challenge. This paper introduces a novel deep learning framework, named Gated Temporal Convolutional Network and Graph (GTCN-G), engineered to overcome these limitations. Our model uniquely fuses a Gated TCN (G-TCN) for extracting hierarchical temporal features from network flows with a Graph Convolutional Network (GCN) designed to learn from the underlying graph structure. The core innovation lies in the integration of a residual learning mechanism, implemented via a Graph Attention Network (GAT). This mechanism preserves original feature information through residual connections, which is critical for mitigating the class imbalance problem and enhancing detection sensitivity for rare malicious activities (minority classes). We conducted extensive experiments on two public benchmark datasets, UNSW-NB15 and ToN-IoT, to validate our approach. The empirical results demonstrate that the proposed GTCN-G model achieves state-of-the-art performance, significantly outperforming existing baseline models in both binary and multi-class classification tasks.

UniAPO: Unified Multimodal Automated Prompt Optimization

Prompting is fundamental to unlocking the full potential of large language models. To automate and enhance this process, automatic prompt optimization (APO) has been developed, demonstrating effectiveness primarily in text-only input scenarios. However, extending existing APO methods to multimodal tasks, such as video-language generation introduces two core challenges: (i) visual token inflation, where long visual token sequences restrict context capacity and result in insufficient feedback signals; (ii) a lack of process-level supervision, as existing methods focus on outcome-level supervision and overlook intermediate supervision, limiting prompt optimization. We present UniAPO: Unified Multimodal Automated Prompt Optimization, the first framework tailored for multimodal APO. UniAPO adopts an EM-inspired optimization process that decouples feedback modeling and prompt refinement, making the optimization more stable and goal-driven. To further address the aforementioned challenges, we introduce a short-long term memory mechanism: historical feedback mitigates context limitations, while historical prompts provide directional guidance for effective prompt optimization. UniAPO achieves consistent gains across text, image, and video benchmarks, establishing a unified framework for efficient and transferable prompt optimization.

MUSE: Multi-Subject Unified Synthesis via Explicit Layout Semantic Expansion

Existing text-to-image diffusion models have demonstrated remarkable capabilities in generating high-quality images guided by textual prompts. However, achieving multi-subject compositional synthesis with precise spatial control remains a significant challenge. In this work, we address the task of layout-controllable multi-subject synthesis (LMS), which requires both faithful reconstruction of reference subjects and their accurate placement in specified regions within a unified image. While recent advancements have separately improved layout control and subject synthesis, existing approaches struggle to simultaneously satisfy the dual requirements of spatial precision and identity preservation in this composite task. To bridge this gap, we propose MUSE, a unified synthesis framework that employs concatenated cross-attention (CCA) to seamlessly integrate layout specifications with textual guidance through explicit semantic space expansion. The proposed CCA mechanism enables bidirectional modality alignment between spatial constraints and textual descriptions without interference. Furthermore, we design a progressive two-stage training strategy that decomposes the LMS task into learnable sub-objectives for effective optimization. Extensive experiments demonstrate that MUSE achieves zero-shot end-to-end generation with superior spatial accuracy and identity consistency compared to existing solutions, advancing the frontier of controllable image synthesis. Our code and model are available at https://github.com/pf0607/MUSE.