HiGraphDTI: Hierarchical Graph Representation Learning for Drug-Target Interaction Prediction

The discovery of drug-target interactions (DTIs) plays a crucial role in pharmaceutical development. The deep learning model achieves more accurate results in DTI prediction due to its ability to extract robust and expressive features from drug and target chemical structures. However, existing deep learning methods typically generate drug features via aggregating molecular atom representations, ignoring the chemical properties carried by motifs, i.e., substructures of the molecular graph. The atom-drug double-level molecular representation learning can not fully exploit structure information and fails to interpret the DTI mechanism from the motif perspective. In addition, sequential model-based target feature extraction either fuses limited contextual information or requires expensive computational resources. To tackle the above issues, we propose a hierarchical graph representation learning-based DTI prediction method (HiGraphDTI). Specifically, HiGraphDTI learns hierarchical drug representations from triple-level molecular graphs to thoroughly exploit chemical information embedded in atoms, motifs, and molecules. Then, an attentional feature fusion module incorporates information from different receptive fields to extract expressive target features.Last, the hierarchical attention mechanism identifies crucial molecular segments, which offers complementary views for interpreting interaction mechanisms. The experiment results not only demonstrate the superiority of HiGraphDTI to the state-of-the-art methods, but also confirm the practical ability of our model in interaction interpretation and new DTI discovery.

Enhancing Quality of Compressed Images by Mitigating Enhancement Bias Towards Compression Domain

Existing quality enhancement methods for compressed images focus on aligning the enhancement domain with the raw domain to yield realistic images. However, these methods exhibit a pervasive enhancement bias towards the compression domain, inadvertently regarding it as more realistic than the raw domain. This bias makes enhanced images closely resemble their compressed counterparts, thus degrading their perceptual quality. In this paper, we propose a simple yet effective method to mitigate this bias and enhance the quality of compressed images. Our method employs a conditional discriminator with the compressed image as a key condition, and then incorporates a domain-divergence regularization to actively distance the enhancement domain from the compression domain. Through this dual strategy, our method enables the discrimination against the compression domain, and brings the enhancement domain closer to the raw domain. Comprehensive quality evaluations confirm the superiority of our method over other state-of-the-art methods without incurring inference overheads.

Pixel Adapter: A Graph-Based Post-Processing Approach for Scene Text Image Super-Resolution

Current Scene text image super-resolution approaches primarily focus on extracting robust features, acquiring text information, and complex training strategies to generate super-resolution images. However, the upsampling module, which is crucial in the process of converting low-resolution images to high-resolution ones, has received little attention in existing works. To address this issue, we propose the Pixel Adapter Module (PAM) based on graph attention to address pixel distortion caused by upsampling. The PAM effectively captures local structural information by allowing each pixel to interact with its neighbors and update features. Unlike previous graph attention mechanisms, our approach achieves 2-3 orders of magnitude improvement in efficiency and memory utilization by eliminating the dependency on sparse adjacency matrices and introducing a sliding window approach for efficient parallel computation. Additionally, we introduce the MLP-based Sequential Residual Block (MSRB) for robust feature extraction from text images, and a Local Contour Awareness loss ($\mathcal{L}_{lca}$) to enhance the model's perception of details. Comprehensive experiments on TextZoom demonstrate that our proposed method generates high-quality super-resolution images, surpassing existing methods in recognition accuracy. For single-stage and multi-stage strategies, we achieved improvements of 0.7\% and 2.6\%, respectively, increasing the performance from 52.6\% and 53.7\% to 53.3\% and 56.3\%. The code is available at https://github.com/wenyu1009/RTSRN.

Uncertainty Guided Adaptive Warping for Robust and Efficient Stereo Matching

Correlation based stereo matching has achieved outstanding performance, which pursues cost volume between two feature maps. Unfortunately, current methods with a fixed model do not work uniformly well across various datasets, greatly limiting their real-world applicability. To tackle this issue, this paper proposes a new perspective to dynamically calculate correlation for robust stereo matching. A novel Uncertainty Guided Adaptive Correlation (UGAC) module is introduced to robustly adapt the same model for different scenarios. Specifically, a variance-based uncertainty estimation is employed to adaptively adjust the sampling area during warping operation. Additionally, we improve the traditional non-parametric warping with learnable parameters, such that the position-specific weights can be learned. We show that by empowering the recurrent network with the UGAC module, stereo matching can be exploited more robustly and effectively. Extensive experiments demonstrate that our method achieves state-of-the-art performance over the ETH3D, KITTI, and Middlebury datasets when employing the same fixed model over these datasets without any retraining procedure. To target real-time applications, we further design a lightweight model based on UGAC, which also outperforms other methods over KITTI benchmarks with only 0.6 M parameters.

Improving Grounded Language Understanding in a Collaborative Environment by Interacting with Agents Through Help Feedback

Many approaches to Natural Language Processing (NLP) tasks often treat them as single-step problems, where an agent receives an instruction, executes it, and is evaluated based on the final outcome. However, human language is inherently interactive, as evidenced by the back-and-forth nature of human conversations. In light of this, we posit that human-AI collaboration should also be interactive, with humans monitoring the work of AI agents and providing feedback that the agent can understand and utilize. Further, the AI agent should be able to detect when it needs additional information and proactively ask for help. Enabling this scenario would lead to more natural, efficient, and engaging human-AI collaborations. In this work, we explore these directions using the challenging task defined by the IGLU competition, an interactive grounded language understanding task in a MineCraft-like world. We explore multiple types of help players can give to the AI to guide it and analyze the impact of this help in AI behavior, resulting in performance improvements.

DAQE: Enhancing the Quality of Compressed Images by Finding the Secret of Defocus

Image defocus is inherent in the physics of image formation caused by the optical aberration of lenses, providing plentiful information on image quality. Unfortunately, the existing quality enhancement approaches for compressed images neglect the inherent characteristic of defocus, resulting in inferior performance. This paper finds that in compressed images, the significantly defocused regions are with better compression quality and two regions with different defocus values possess diverse texture patterns. These findings motivate our defocus-aware quality enhancement (DAQE) approach. Specifically, we propose a novel dynamic region-based deep learning architecture of the DAQE approach, which considers the region-wise defocus difference of compressed images in two aspects. (1) The DAQE approach employs fewer computational resources to enhance the quality of significantly defocused regions, while more resources on enhancing the quality of other regions; (2) The DAQE approach learns to separately enhance diverse texture patterns for the regions with different defocus values, such that texture-wise one-on-one enhancement can be achieved. Extensive experiments validate the superiority of our DAQE approach in terms of quality enhancement and resource-saving, compared with other state-of-the-art approaches.

Point is a Vector: A Feature Representation in Point Analysis

The irregularity and disorder of point clouds bring many challenges to point cloud analysis. PointMLP suggests that geometric information is not the only critical point in point cloud analysis. It achieves promising result based on a simple multi-layer perception (MLP) structure with geometric affine module. However, these MLP-like structures aggregate features only with fixed weights, while differences in the semantic information of different point features are ignored. So we propose a novel Point-Vector Representation of the point feature to improve feature aggregation by using inductive bias. The direction of the introduced vector representation can dynamically modulate the aggregation of two point features according to the semantic relationship. Based on it, we design a novel Point2Vector MLP architecture. Experiments show that it achieves state-of-the-art performance on the classification task of ScanObjectNN dataset, with 1% increase, compared with the previous best method. We hope our method can help people better understand the role of semantic information in point cloud analysis and lead to explore more and better feature representations or other ways.

Supporting Complex Information-Seeking Tasks with Implicit Constraints

Current interactive systems with natural language interface lack an ability to understand a complex information-seeking request which expresses several implicit constraints at once, and there is no prior information about user preferences, e.g., "find hiking trails around San Francisco which are accessible with toddlers and have beautiful scenery in summer", where output is a list of possible suggestions for users to start their exploration. In such scenarios, the user requests can be issued at once in the form of a complex and long query, unlike conversational and exploratory search models that require short utterances or queries where they often require to be fed into the system step by step. This advancement provides the final user more flexibility and precision in expressing their intent through the search process. Such systems are inherently helpful for day-today user tasks requiring planning that are usually time-consuming, sometimes tricky, and cognitively taxing. We have designed and deployed a platform to collect the data from approaching such complex interactive systems. In this paper, we propose an Interactive Agent (IA) that allows intricately refined user requests by making it complete, which should lead to better retrieval. To demonstrate the performance of the proposed modeling paradigm, we have adopted various pre-retrieval metrics that capture the extent to which guided interactions with our system yield better retrieval results. Through extensive experimentation, we demonstrated that our method significantly outperforms several robust baselines

Joint Learning of Visual-Audio Saliency Prediction and Sound Source Localization on Multi-face Videos

Visual and audio events simultaneously occur and both attract attention. However, most existing saliency prediction works ignore the influence of audio and only consider vision modality. In this paper, we propose a multitask learning method for visual-audio saliency prediction and sound source localization on multi-face video by leveraging visual, audio and face information. Specifically, we first introduce a large-scale database of multi-face video in visual-audio condition (MVVA), containing eye-tracking data and sound source annotations. Using this database, we find that sound influences human attention, and conversly attention offers a cue to determine sound source on multi-face video. Guided by these findings, a visual-audio multi-task network (VAM-Net) is introduced to predict saliency and locate sound source. VAM-Net consists of three branches corresponding to visual, audio and face modalities. Visual branch has a two-stream architecture to capture spatial and temporal information. Face and audio branches encode audio signals and faces, respectively. Finally, a spatio-temporal multi-modal graph (STMG) is constructed to model the interaction among multiple faces. With joint optimization of these branches, the intrinsic correlation of the tasks of saliency prediction and sound source localization is utilized and their performance is boosted by each other. Experiments show that the proposed method outperforms 12 state-of-the-art saliency prediction methods, and achieves competitive results in sound source localization.

Multi-level Wavelet-based Generative Adversarial Network for Perceptual Quality Enhancement of Compressed Video

The past few years have witnessed fast development in video quality enhancement via deep learning. Existing methods mainly focus on enhancing the objective quality of compressed video while ignoring its perceptual quality. In this paper, we focus on enhancing the perceptual quality of compressed video. Our main observation is that enhancing the perceptual quality mostly relies on recovering high-frequency sub-bands in wavelet domain. Accordingly, we propose a novel generative adversarial network (GAN) based on multi-level wavelet packet transform (WPT) to enhance the perceptual quality of compressed video, which is called multi-level wavelet-based GAN (MW-GAN). In MW-GAN, we first apply motion compensation with a pyramid architecture to obtain temporal information. Then, we propose a wavelet reconstruction network with wavelet-dense residual blocks (WDRB) to recover the high-frequency details. In addition, the adversarial loss of MW-GAN is added via WPT to further encourage high-frequency details recovery for video frames. Experimental results demonstrate the superiority of our method.