Resolving the bias-precision paradox with stochastic causal representation learning for personalized medicine

Estimating individualized treatment effects from longitudinal observational data is central to data-driven medicine, yet existing methods face a fundamental limitation: reducing confounding bias often suppresses clinically informative heterogeneity, degrading patient-specific predictions. Here, we identify this tension as a bias-precision paradox in causal representation learning and introduce sampling-based maximum mean discrepancy (sMMD), a stochastic alignment strategy that replaces global adversarial balancing with subset-level matching. We instantiate this approach in a framework for counterfactual outcome prediction with attribution-grounded interpretability. Across two large-scale ICU cohorts (n = 27,783), our framework improves accuracy under distribution shift, reducing error by up to 11.5% and substantially increasing recall in high-risk tasks. Mechanistic analyses show that sMMD selectively preserves clinically decisive variables. In human-AI evaluation, our method outperforms clinicians-in-training and large language models, and improves clinician accuracy by 14.7% while reducing decision time, enabling interpretable, real-time clinical decision support.

Think, then Score: Decoupled Reasoning and Scoring for Video Reward Modeling

Recent advances in generative video models are increasingly driven by post-training and test-time scaling, both of which critically depend on the quality of video reward models (RMs). An ideal reward model should predict accurate rewards that align with human preferences across diverse scenarios. However, existing paradigms face a fundamental dilemma: \textit{Discriminative RMs} regress rewards directly on features extracted by multimodal large language models (MLLMs) without explicit reasoning, making them prone to shortcut learning and heavily reliant on massive data scaling for generalization. In contrast, \textit{Generative RMs} with Chain-of-Thought (CoT) reasoning exhibit superior interpretability and generalization potential, as they leverage fine-grained semantic supervision to internalize the rationales behind human preferences. However, they suffer from inherent optimization bottlenecks due to the coupling of reasoning and scoring within a single autoregressive inference chain. To harness the generalization benefits of CoT reasoning while mitigating the training instability of coupled reasoning and scoring, we introduce DeScore, a training-efficient and generalizable video reward model. DeScore employs a decoupled ``think-then-score'' paradigm: an MLLM first generates an explicit CoT, followed by a dedicated discriminative scoring module consisting of a learnable query token and a regression head that predicts the final reward. DeScore is optimized via a two-stage framework: (1) a discriminative cold start incorporating a random mask mechanism to ensure robust scoring capabilities, and (2) a dual-objective reinforcement learning stage that independently refines CoT reasoning quality and calibrates the final reward, ensuring that higher-quality reasoning directly translates to superior model performance.

Omni-o3: Deep Nested Omnimodal Deduction for Deliberative Audio-Visual Reasoning

Omnimodal understanding entails a massive, highly redundant search space of cross-modal interactions, demanding focused and deliberative reasoning. Current reasoning paradigms rely on either sequential step-by-step generation or parallel sample-by-sample rollouts, leading to isolated reasoning trajectories. This inability to share promising intermediate paths severely limits exploration efficiency and causes compounding errors in complex audio-visual tasks. To break this bottleneck, we introduce Omni-o3, a novel framework driven by a deep nested deduction policy. By formulating reasoning as a dynamic recursive search, Omni-o3 inherently shares reasoning prefixes across branches, enabling the iterative execution of four atomic cognitive actions: expansion, selection, simulation, and backpropagation. To empower this framework, we propose a robust two-stage training paradigm: (1) cold-start supervised fine-tuning on 101K high-quality, long-chain trajectories distilled from 3.5M diverse omnimodal samples, enabling necessary recursive search patterns; and (2) nested group rollout-driven exploratory reinforcement learning on 18K complex multi-turn samples, explicitly guided by a novel multi-step reward model to stimulate deep nested reasoning. Extensive experiments demonstrate that Omni-o3 achieves competitive performance across 11 benchmarks, unlocking advanced capabilities in comprehensive audio-visual, visual-centric, and audio-centric reasoning tasks.

Understanding and Mitigating Spurious Signal Amplification in Test-Time Reinforcement Learning for Math Reasoning

Test-time reinforcement learning (TTRL) always adapts models at inference time via pseudo-labeling, leaving it vulnerable to spurious optimization signals from label noise. Through an empirical study, we observe that responses with medium consistency form an ambiguity region and constitute the primary source of reward noise. Crucially, we find that such spurious signals can be even amplified through group-relative advantage estimation. Motivated by these findings, we propose a unified framework, Debiased and Denoised test-time Reinforcement Learning (DDRL), to mitigate spurious signals. Concretely, DDRL first applies a frequency-based sampling strategy to exclude ambiguous samples while maintaining a balanced set of positive and negative examples. It then adopts a debiased advantage estimation with fixed advantages, removing the bias introduced by group-relative policy optimization. Finally, DDRL incorporates a consensus-based off-policy refinement stage, which leverages the rejection-sampled dataset to enable efficient and stable model updates. Experiments on three large language models across multiple mathematical reasoning benchmarks demonstrate that DDRL consistently outperforms existing TTRL baselines. The code will soon be released at https://github.com/yuyongcan/DDRL.

WebUncertainty: Dual-Level Uncertainty Driven Planning and Reasoning For Autonomous Web Agent

Recent advancements in large language models (LLMs) have empowered autonomous web agents to execute natural language instructions directly on real-world webpages. However, existing agents often struggle with complex tasks involving dynamic interactions and long-horizon execution due to rigid planning strategies and hallucination-prone reasoning. To address these limitations, we propose WebUncertainty, a novel autonomous agent framework designed to tackle dual-level uncertainty in planning and reasoning. Specifically, we design a Task Uncertainty-Driven Adaptive Planning Mechanism that adaptively selects planning modes to navigate unknown environments. Furthermore, we introduce an Action Uncertainty-Driven Monte Carlo tree search (MCTS) Reasoning Mechanism. This mechanism incorporates the Confidence-induced Action Uncertainty (ConActU) strategy to quantify both aleatoric uncertainty (AU) and epistemic uncertainty (EU), thereby optimizing the search process and guiding robust decision-making. Experimental results on the WebArena and WebVoyager benchmarks demonstrate that WebUncertainty achieves superior performance compared to state-of-the-art baselines.

Bidirectional Learning of Facial Action Units and Expressions via Structured Semantic Mapping across Heterogeneous Datasets

Facial action unit (AU) detection and facial expression (FE) recognition can be jointly viewed as affective facial behavior tasks, representing fine-grained muscular activations and coarse-grained holistic affective states, respectively. Despite their inherent semantic correlation, existing studies predominantly focus on knowledge transfer from AUs to FEs, while bidirectional learning remains insufficiently explored. In practice, this challenge is further compounded by heterogeneous data conditions, where AU and FE datasets differ in annotation paradigms (frame-level vs.\ clip-level), label granularity, and data availability and diversity, hindering effective joint learning. To address these issues, we propose a Structured Semantic Mapping (SSM) framework for bidirectional AU--FE learning under different data domains and heterogeneous supervision. SSM consists of three key components: (1) a shared visual backbone that learns unified facial representations from dynamic AU and FE videos; (2) semantic mediation via a Textual Semantic Prototype (TSP) module, which constructs structured semantic prototypes from fixed textual descriptions augmented with learnable context prompts, serving as supervision signals and cross-task alignment anchors in a shared semantic space; and (3) a Dynamic Prior Mapping (DPM) module that incorporates prior knowledge derived from the Facial Action Coding System and learns a data-driven association matrix in a high-level feature space, enabling explicit and bidirectional knowledge transfer. Extensive experiments on popular AU detection and FE recognition benchmarks show that SSM achieves state-of-the-art performance on both tasks simultaneously, and demonstrate that holistic expression semantics can in turn enhance fine-grained AU learning even across heterogeneous datasets.

Efficient Quantization of Mixture-of-Experts with Theoretical Generalization Guarantees

Sparse Mixture-of-Experts (MoE) allows scaling of language and vision models efficiently by activating only a small subset of experts per input. While this reduces computation, the large number of parameters still incurs substantial memory overhead during inference. Post-training quantization has been explored to address this issue. Because uniform quantization suffers from significant accuracy loss at low bit-widths, mixed-precision methods have been recently explored; however, they often require substantial computation for bit-width allocation and overlook the varying sensitivity of model performance to the quantization of different experts. We propose a theoretically grounded expert-wise mixed precision strategy that assigns bit-width to each expert primarily based on their change in routers l2 norm during training. Experts with smaller changes are shown to capture less frequent but critical features, and model performance is more sensitive to the quantization of these experts, thus requiring higher precision. Furthermore, to avoid allocating experts to lower precision that inject high quantization noise, experts with large maximum intra-neuron variance are also allocated higher precision. Experiments on large-scale MoE models, including Switch Transformer and Mixtral, show that our method achieves higher accuracy than existing approaches, while also reducing inference cost and incurring only negligible overhead for bit-width assignment.

Visual prompting reimagined: The power of the Activation Prompts

Visual prompting (VP) has emerged as a popular method to repurpose pretrained vision models for adaptation to downstream tasks. Unlike conventional model fine-tuning techniques, VP introduces a universal perturbation directly into the input data to facilitate task-specific fine-tuning rather than modifying model parameters. However, there exists a noticeable performance gap between VP and conventional fine-tuning methods, highlighting an unexplored realm in theory and practice to understand and advance the input-level VP to reduce its current performance gap. Towards this end, we introduce a generalized concept, termed activation prompt (AP), which extends the scope of the input-level VP by enabling universal perturbations to be applied to activation maps within the intermediate layers of the model. By using AP to revisit the problem of VP and employing it as an analytical tool, we demonstrate the intrinsic limitations of VP in both performance and efficiency, revealing why input-level prompting may lack effectiveness compared to AP, which exhibits a model-dependent layer preference. We show that AP is closely related to normalization tuning in convolutional neural networks and vision transformers, although each model type has distinct layer preferences for prompting. We also theoretically elucidate the rationale behind such a preference by analyzing global features across layers. Through extensive experiments across 29 datasets and various model architectures, we provide a comprehensive performance analysis of AP, comparing it with VP and parameter-efficient fine-tuning baselines. Our results demonstrate AP's superiority in both accuracy and efficiency, considering factors such as time, parameters, memory usage, and throughput.

PRIME: Prototype-Driven Multimodal Pretraining for Cancer Prognosis with Missing Modalities

Multimodal self-supervised pretraining offers a promising route to cancer prognosis by integrating histopathology whole-slide images, gene expression, and pathology reports, yet most existing approaches require fully paired and complete inputs. In practice, clinical cohorts are fragmented and often miss one or more modalities, limiting both supervised fusion and scalable multimodal pretraining. We propose PRIME, a missing-aware multimodal self-supervised pretraining framework that learns robust and transferable representations from partially observed cohorts. PRIME maps heterogeneous modality embeddings into a unified token space and introduces a shared prototype memory bank for latent-space semantic imputation via patient-level consensus retrieval, producing structurally aligned tokens without reconstructing raw signals. Two complementary pretraining objectives: inter-modality alignment and post-fusion consistency under structured missingness augmentation, jointly learn representations that remain predictive under arbitrary modality subsets. We evaluate PRIME on The Cancer Genome Atlas with label-free pretraining on 32 cancer types and downstream 5-fold evaluation on five cohorts across overall survival prediction, 3-year mortality classification, and 3-year recurrence classification. PRIME achieves the best macro-average performance among all compared methods, reaching 0.653 C-index, 0.689 AUROC, and 0.637 AUROC on the three tasks, respectively, while improving robustness under test-time missingness and supporting parameter-efficient and label-efficient adaptation. These results support missing-aware multimodal pretraining as a practical strategy for prognosis modeling in fragmented clinical data settings.

FreqPhys: Repurposing Implicit Physiological Frequency Prior for Robust Remote Photoplethysmography

Remote photoplethysmography (rPPG) enables contactless physiological monitoring by capturing subtle skin-color variations from facial videos. However, most existing methods predominantly rely on time-domain modeling, making them vulnerable to motion artifacts and illumination fluctuations, where weak physiological clues are easily overwhelmed by noise. To address these challenges, we propose FreqPhys, a frequency-guided rPPG framework that explicitly leverages physiological frequency priors for robust signal recovery. Specifically, FreqPhys first applies a Physiological Bandpass Filtering module to suppress out-of-band interference, and then performs Physiological Spectrum Modulation together with adaptive spectral selection to emphasize pulse-related frequency components while suppress residual in-band noise. A Cross-domain Representation Learning module further fuses these spectral priors with deep time-domain features to capture informative spatial--temporal dependencies. Finally, a frequency-aware conditional diffusion process progressively reconstructs high-fidelity rPPG signals. Extensive experiments on six benchmarks demonstrate that FreqPhys yields significant improvements over state-of-the-art approaches, particularly under challenging motion conditions. It highlights the importance of explicitly modeling physiological frequency priors. The source code will be released.